羧甲基纤维素钠盐对乳酸-壳聚糖复合物亲水性粉末性能的影响

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI:10.15259/PCACD.23.012

K. Małolepsza-Jarmołowska

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引用次数: 1

摘要

所研究的甲基纤维素基粉末显示出与阴道粘膜的良好粘附性，并且在患者的日常活动中都存在于其上。这种特性使药物能够连续24小时发挥作用。阴道炎症的治疗通常是漫长而困难的，因为经常复发。将粉末转化为凝胶并测试其性能。制备了具有不同pH和流变性质的制剂。试验表明了凝胶的粘附作用。乳酸与壳聚糖的比例为1:1和2:1的所有凝胶在37°C时显示出在生理范围内的pH。此外，羧甲基纤维素钠盐和赋形剂允许获得具有宽pH范围的各种制剂。流变学研究表明，与不含羧甲基纤维素钠盐的凝胶相比，含有乳酸与壳聚糖和羧甲基纤维素钠复合的制剂的动态粘度增加。

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THE EFFECT OF A CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.