TPP交联壳聚糖/海藻酸盐复合电解质膜的抗坏血酸释放特性

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI:10.15259/PCACD.23.007

M. Gierszewska, J. Ostrowska-Czubenko, Ewelina Chrzanowska

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引用次数: 6

摘要

制备了含有抗坏血酸（AA）的三聚磷酸（TPP）交联壳聚糖/海藻酸盐复合电解质膜（Ch/Alg）。在不同的缓冲溶液中表征了Ch/Alg/TPP的动态溶胀行为和抗坏血酸从膜中的释放。研究发现，缓冲溶液的pH值会影响AA的溶胀和释放行为。在360分钟内观察到抗坏血酸的释放，表现出双相模式，其特征是快速的初始释放，然后是缓慢、持续的释放。采用不同的数学模型研究了Ch/Alg/TPP水凝胶中AA的动力学和传输机制。药物释放数据拟合到零级动力学模型和一级动力学模型。为了表征药物机制，将释放数据拟合到Higuchi和Korsmeyer-Peppas方程中。最初的爆发AA释放遵循零级动力学，本质上是准斐济式的。AA释放的第二步遵循一级动力学。

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CHARACTERISTICS OF ASCORBIC ACID RELEASE FROM TPP-CROSSLINKED CHITOSAN/ALGINATE POLYELECTROLYTE COMPLEX MEMBRANES

Chitosan/alginate polyelectrolyte complex membranes (Ch/Alg) additionally cross-linked with tripolyphosphate (TPP) and containing ascorbic acid (AA) were prepared. The dynamic swelling behaviour of Ch/Alg/TPP and ascorbic acid release from the membrane were characterised in different buffer solutions. It has been found that the pH of the buffer solution affects the swelling and release behaviour of AA. Ascorbic acid release, observed over a period of 360 min, exhibited a biphasic pattern, characterised by a fast initial burst release, followed by a slow, sustained release. Different mathematical models were used to study the kinetics and transport mechanism of AA from Ch/Alg/TPP hydrogels. Drug release data were fitted to the zero order kinetic model and first order kinetic model. To characterise the drug mechanism, the release data were fitted to the Higuchi and Korsmeyer-Peppas equations. The initial burst AA release followed zero order kinetics and was quasi-Fickian in nature. The second step of AA release followed first order kinetics.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.