Sumer 1Pub Date : 2023-08-15DOI: 10.21931/rb/css/2023.08.01.67
Noor Naeem Jasim, Rasha M. A. Al-humairi, T. Hashim Mohammad, Ruwaida A. Hussein
{"title":"Synergistic Treatment of Candida albicans Infected Mice by AgNPs\u0000Synthesis Penicillium chrysogenum","authors":"Noor Naeem Jasim, Rasha M. A. Al-humairi, T. Hashim Mohammad, Ruwaida A. Hussein","doi":"10.21931/rb/css/2023.08.01.67","DOIUrl":"https://doi.org/10.21931/rb/css/2023.08.01.67","url":null,"abstract":"Penicillium chrysogenum has been used for the production of metal\u0000nanoparticles. It was experimentally shown that silver nitrate ions are reduced to\u0000silver nanoparticles in biomass, and silver nanoparticles are synthesized from 1\u0000mM silver nitrate. The external morphology of ground AgNPs was established by\u0000SEM analysis and UV-visible spectrophotometry, and the size of AgNO3 particles was observed to be 23 nm, with particles being spherical by AFM. In vitro\u0000investigations, the antifungal susceptibility of Candida al was calculated, and the\u0000results showed that the inhibitory effect of AgNPs synthesized with P. chrysogenum is increased with increasing the concentration of nanoparticles, and the effective fungicidal concentration (EC50) was 1 ppm, and the minimum fungicidal\u0000concentration (MFC) was 100 ppm. Furthermore, the pathogenicity of C. albicans on kidneys in mice during infections was tested and thus indicated that the\u0000kidneys' ability was significantly enhanced when animals were treated with the\u0000combination of AgNPs and P. chrysogenum. This study's data from examination\u0000provide valuable preliminary statistics for using biosynthesized silver nanoparticles to manage various microorganisms.\u0000Keywords: Candida albicans, AgNPs Synthesis, Penicillium chrysogenum","PeriodicalId":443152,"journal":{"name":"Sumer 1","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120975568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}