Noor Naeem Jasim, Rasha M. A. Al-humairi, T. Hashim Mohammad, Ruwaida A. Hussein
{"title":"agnps合成青霉菌协同治疗白色念珠菌感染小鼠","authors":"Noor Naeem Jasim, Rasha M. A. Al-humairi, T. Hashim Mohammad, Ruwaida A. Hussein","doi":"10.21931/rb/css/2023.08.01.67","DOIUrl":null,"url":null,"abstract":"Penicillium chrysogenum has been used for the production of metal\nnanoparticles. It was experimentally shown that silver nitrate ions are reduced to\nsilver nanoparticles in biomass, and silver nanoparticles are synthesized from 1\nmM silver nitrate. The external morphology of ground AgNPs was established by\nSEM analysis and UV-visible spectrophotometry, and the size of AgNO3 particles was observed to be 23 nm, with particles being spherical by AFM. In vitro\ninvestigations, the antifungal susceptibility of Candida al was calculated, and the\nresults showed that the inhibitory effect of AgNPs synthesized with P. chrysogenum is increased with increasing the concentration of nanoparticles, and the effective fungicidal concentration (EC50) was 1 ppm, and the minimum fungicidal\nconcentration (MFC) was 100 ppm. Furthermore, the pathogenicity of C. albicans on kidneys in mice during infections was tested and thus indicated that the\nkidneys' ability was significantly enhanced when animals were treated with the\ncombination of AgNPs and P. chrysogenum. This study's data from examination\nprovide valuable preliminary statistics for using biosynthesized silver nanoparticles to manage various microorganisms.\nKeywords: Candida albicans, AgNPs Synthesis, Penicillium chrysogenum","PeriodicalId":443152,"journal":{"name":"Sumer 1","volume":"46 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synergistic Treatment of Candida albicans Infected Mice by AgNPs\\nSynthesis Penicillium chrysogenum\",\"authors\":\"Noor Naeem Jasim, Rasha M. A. Al-humairi, T. Hashim Mohammad, Ruwaida A. Hussein\",\"doi\":\"10.21931/rb/css/2023.08.01.67\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Penicillium chrysogenum has been used for the production of metal\\nnanoparticles. It was experimentally shown that silver nitrate ions are reduced to\\nsilver nanoparticles in biomass, and silver nanoparticles are synthesized from 1\\nmM silver nitrate. The external morphology of ground AgNPs was established by\\nSEM analysis and UV-visible spectrophotometry, and the size of AgNO3 particles was observed to be 23 nm, with particles being spherical by AFM. In vitro\\ninvestigations, the antifungal susceptibility of Candida al was calculated, and the\\nresults showed that the inhibitory effect of AgNPs synthesized with P. chrysogenum is increased with increasing the concentration of nanoparticles, and the effective fungicidal concentration (EC50) was 1 ppm, and the minimum fungicidal\\nconcentration (MFC) was 100 ppm. Furthermore, the pathogenicity of C. albicans on kidneys in mice during infections was tested and thus indicated that the\\nkidneys' ability was significantly enhanced when animals were treated with the\\ncombination of AgNPs and P. chrysogenum. This study's data from examination\\nprovide valuable preliminary statistics for using biosynthesized silver nanoparticles to manage various microorganisms.\\nKeywords: Candida albicans, AgNPs Synthesis, Penicillium chrysogenum\",\"PeriodicalId\":443152,\"journal\":{\"name\":\"Sumer 1\",\"volume\":\"46 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sumer 1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21931/rb/css/2023.08.01.67\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sumer 1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21931/rb/css/2023.08.01.67","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synergistic Treatment of Candida albicans Infected Mice by AgNPs
Synthesis Penicillium chrysogenum
Penicillium chrysogenum has been used for the production of metal
nanoparticles. It was experimentally shown that silver nitrate ions are reduced to
silver nanoparticles in biomass, and silver nanoparticles are synthesized from 1
mM silver nitrate. The external morphology of ground AgNPs was established by
SEM analysis and UV-visible spectrophotometry, and the size of AgNO3 particles was observed to be 23 nm, with particles being spherical by AFM. In vitro
investigations, the antifungal susceptibility of Candida al was calculated, and the
results showed that the inhibitory effect of AgNPs synthesized with P. chrysogenum is increased with increasing the concentration of nanoparticles, and the effective fungicidal concentration (EC50) was 1 ppm, and the minimum fungicidal
concentration (MFC) was 100 ppm. Furthermore, the pathogenicity of C. albicans on kidneys in mice during infections was tested and thus indicated that the
kidneys' ability was significantly enhanced when animals were treated with the
combination of AgNPs and P. chrysogenum. This study's data from examination
provide valuable preliminary statistics for using biosynthesized silver nanoparticles to manage various microorganisms.
Keywords: Candida albicans, AgNPs Synthesis, Penicillium chrysogenum