{"title":"Sio2NPs对雌性大鼠体重和甲状腺激素的亚慢性腹腔毒性","authors":"Riam Sabah Abbood, Noori M. Luaibi","doi":"10.21931/rb/css/2023.08.01.59","DOIUrl":null,"url":null,"abstract":"This study investigated the toxicity effect of Sio2NPs on body weight\nand thyroid gland in female rats; the experiment was included. The experimental\nanimals were randomly divided into three groups, including two treatment groups\n( treated with a low dose (25mg/Kg ) and high dose (100mg/Kg of body weight)\nof sio2 NPs and one group as a control. Each group of them was divided into\nthree subgroups according to the injection periods of exposure (10, 20, and 30)\ndays daily, then measure the body weight and Thyroid function hormones (T3,\nT4, TSH), the results showed that there was a significant decrease (p<0.05) in the\nbody weight of animals that exposed to SiO2 NPs at two doses (25 and 100\nmg/kg) during (10 days) while increased during (20, 30 days) but the highest value recorded in the animals that were treated for (30 days) at both doses. On the\nother side, the T3 findings recorded a significant decrease (p< 0.05) for the animals that exposed to SiO2 NPs at low and high doses (25 and 100 mg/kg) (during\n(10 days) when compared with the control group As well as, there was a significant decrease (p< 0.05) in the level of T3 for all animals that treated with these\ndoses during (20 and 3 days) in serum of animals that were treated with both doses of SiO2 NPs when compared with the control group (p< 0.05), while T4\nshowed s decreasing in the treated group during (10 and 20, 30 days) compared\nto a control group with highly significant ((p< 0.05), finally while TSH showed a\nhighly increasing in treated group during (10 and 20, 30 days) compared to control group (p< 0.05). The study revealed that Exposure to Sio2NPs at different\nconcentrations caused structural and functional and in the thyroid gland, characterized decrease in T3 and T4 hormone levels and an increase in the TSH hormone level and caused hypothyroidism This led to a decrease in the metabolism\nprocess and thus the body weight of animals gained a significant increase.\nKeywords: nanoparticles, Sio2NPs, Thyroid gland, T3, T4, TSH, Body weight,\nfemale rats.","PeriodicalId":443152,"journal":{"name":"Sumer 1","volume":"27 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Subchronic intraperitoneal toxicity of Sio2NPs on body weight and\\nthyroid gland hormones in female Rats\",\"authors\":\"Riam Sabah Abbood, Noori M. Luaibi\",\"doi\":\"10.21931/rb/css/2023.08.01.59\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study investigated the toxicity effect of Sio2NPs on body weight\\nand thyroid gland in female rats; the experiment was included. The experimental\\nanimals were randomly divided into three groups, including two treatment groups\\n( treated with a low dose (25mg/Kg ) and high dose (100mg/Kg of body weight)\\nof sio2 NPs and one group as a control. Each group of them was divided into\\nthree subgroups according to the injection periods of exposure (10, 20, and 30)\\ndays daily, then measure the body weight and Thyroid function hormones (T3,\\nT4, TSH), the results showed that there was a significant decrease (p<0.05) in the\\nbody weight of animals that exposed to SiO2 NPs at two doses (25 and 100\\nmg/kg) during (10 days) while increased during (20, 30 days) but the highest value recorded in the animals that were treated for (30 days) at both doses. On the\\nother side, the T3 findings recorded a significant decrease (p< 0.05) for the animals that exposed to SiO2 NPs at low and high doses (25 and 100 mg/kg) (during\\n(10 days) when compared with the control group As well as, there was a significant decrease (p< 0.05) in the level of T3 for all animals that treated with these\\ndoses during (20 and 3 days) in serum of animals that were treated with both doses of SiO2 NPs when compared with the control group (p< 0.05), while T4\\nshowed s decreasing in the treated group during (10 and 20, 30 days) compared\\nto a control group with highly significant ((p< 0.05), finally while TSH showed a\\nhighly increasing in treated group during (10 and 20, 30 days) compared to control group (p< 0.05). The study revealed that Exposure to Sio2NPs at different\\nconcentrations caused structural and functional and in the thyroid gland, characterized decrease in T3 and T4 hormone levels and an increase in the TSH hormone level and caused hypothyroidism This led to a decrease in the metabolism\\nprocess and thus the body weight of animals gained a significant increase.\\nKeywords: nanoparticles, Sio2NPs, Thyroid gland, T3, T4, TSH, Body weight,\\nfemale rats.\",\"PeriodicalId\":443152,\"journal\":{\"name\":\"Sumer 1\",\"volume\":\"27 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sumer 1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21931/rb/css/2023.08.01.59\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sumer 1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21931/rb/css/2023.08.01.59","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Subchronic intraperitoneal toxicity of Sio2NPs on body weight and
thyroid gland hormones in female Rats
This study investigated the toxicity effect of Sio2NPs on body weight
and thyroid gland in female rats; the experiment was included. The experimental
animals were randomly divided into three groups, including two treatment groups
( treated with a low dose (25mg/Kg ) and high dose (100mg/Kg of body weight)
of sio2 NPs and one group as a control. Each group of them was divided into
three subgroups according to the injection periods of exposure (10, 20, and 30)
days daily, then measure the body weight and Thyroid function hormones (T3,
T4, TSH), the results showed that there was a significant decrease (p<0.05) in the
body weight of animals that exposed to SiO2 NPs at two doses (25 and 100
mg/kg) during (10 days) while increased during (20, 30 days) but the highest value recorded in the animals that were treated for (30 days) at both doses. On the
other side, the T3 findings recorded a significant decrease (p< 0.05) for the animals that exposed to SiO2 NPs at low and high doses (25 and 100 mg/kg) (during
(10 days) when compared with the control group As well as, there was a significant decrease (p< 0.05) in the level of T3 for all animals that treated with these
doses during (20 and 3 days) in serum of animals that were treated with both doses of SiO2 NPs when compared with the control group (p< 0.05), while T4
showed s decreasing in the treated group during (10 and 20, 30 days) compared
to a control group with highly significant ((p< 0.05), finally while TSH showed a
highly increasing in treated group during (10 and 20, 30 days) compared to control group (p< 0.05). The study revealed that Exposure to Sio2NPs at different
concentrations caused structural and functional and in the thyroid gland, characterized decrease in T3 and T4 hormone levels and an increase in the TSH hormone level and caused hypothyroidism This led to a decrease in the metabolism
process and thus the body weight of animals gained a significant increase.
Keywords: nanoparticles, Sio2NPs, Thyroid gland, T3, T4, TSH, Body weight,
female rats.