Talanta Open最新文献

{"title":"High-performance room-temperature formic acid vapor sensors based on multi-walled carbon nanotubes/polypyrrole composites","authors":"Rapiphun Janmanee ,&nbsp;Wasu Phanphaisarn ,&nbsp;Saengrawee Sriwichai ,&nbsp;Anurat Wisitsoraat ,&nbsp;Chaikarn Liewhiran","doi":"10.1016/j.talo.2025.100419","DOIUrl":"10.1016/j.talo.2025.100419","url":null,"abstract":"<div><div>In this research, functionalized multi-walled carbon nanotubes/polypyrrole (fMWCNTs/PPy) composites were synthesized by <em>in-situ</em> oxidative polymerization approach to fabricate sensing films for room-temperature formic acid (HCOOH) detection. The material properties were characterized by X-ray spectroscopy, infrared spectroscopy, transmission electron microscopy, and nitrogen adsorption analysis. The study results confirmed the formation of well-defined multiwalled nanotubes embedded on PPy nanoparticulate matrix with varying MWCNTs loading levels. From gas-sensing measurement results, the addition of 1 %wt fMWCNTs during PPy polymerization greatly enhanced the sensor response from 2.6 to ∼900 towards 1 vol% HCOOH with excellent selectivity against H₂, CO₂, CH₄, C₂H₅OH, CH₃OH, and C₃H₆O at 25 °C. The dispersion of functionalized MWCNTs-PPy heterointerfaces could play an important role in the significant improvement of gas-sensing properties. Therefore, the functionalized MWCNTs-embedded PPy-based sensor would be an attractive choice for formic acid detection at room temperature and useful in medical and environmental applications.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100419"},"PeriodicalIF":4.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-MIP based SPR sensor for tetracycline analysis in milk sample","authors":"Monireh Bakhshpour-Yücel,&nbsp;Melike Küçük,&nbsp;Elif Tümay Özer,&nbsp;Bilgen Osman","doi":"10.1016/j.talo.2025.100417","DOIUrl":"10.1016/j.talo.2025.100417","url":null,"abstract":"<div><div>Recent advancements in sensor technology have enabled the detection of antibiotics in food, ensuring human safety. In this study, we developed a surface plasmon resonance (SPR) sensor based on molecularly imprinted nanoparticles (MINps) for the real-time, sensitive, and in-situ detection of tetracycline (Tc). Firstly, Tc-imprinted nanoparticles (Tc-MINps) were synthesized using microemulsion polymerization. Then, the Tc-MINps were coated onto a bare gold SPR chip to develop the Tc-MINps SPR sensor. The sensor's performance was evaluated by detecting Tc in aqueous solutions. The results demonstrated a highly selective binding of Tc to the nanocavities on the surface of the Tc-MINps SPR sensor. The relationship between Tc molecules and the SPR sensor was analyzed at 0.5–20 mg/L Tc concentrations (pH 5.0). The Langmuir isotherm model was identified as the most appropriate binding model, indicating monolayer adsorption. The selectivity of the Tc-MINps SPR sensor was investigated using oxytetracycline, ciprofloxacin, and amoxicillin due to their structural similarity. The selectivity coefficients were determined as 5.54 for oxytetracycline, 23.66 for ciprofloxacin, and 28.39 for amoxicillin. Additionally, the limit of detection (LOD) for the Tc-MINps SPR sensor for Tc analysis in milk was found to be 0.45 mg/L, while the LOD for the HPLC method was 0.55 mg/L. The developed SPR sensor is suitable for Tc detection in milk due to its advantages, such as real-time monitoring, low cost, high selectivity, and reusability.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100417"},"PeriodicalIF":4.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinoid to benzenoid transition-driven glutathione sensing: Dual-emission carbon dots and smartphone-based ratiometric fluorescence analysis","authors":"Al-Montaser Bellah H. Ali ,&nbsp;Ashraf M. Mahmoud ,&nbsp;Yousef A. Bin Jardan ,&nbsp;Aya M. Mostafa ,&nbsp;James Barker ,&nbsp;Mohamed M. El-Wekil","doi":"10.1016/j.talo.2025.100418","DOIUrl":"10.1016/j.talo.2025.100418","url":null,"abstract":"<div><div>This study presents a novel and sensitive method for the determination of glutathione (GSH), a crucial antioxidant and cellular protectant, using dual blue/orange-emitting carbon dots (BO<img>CDs) and phenolphthalein (PHP). The sensing system operates at pH 9.0, exploiting the unique optical properties of BO<img>CDs with emission peaks at 420 nm and 570 nm. In alkaline conditions, PHP develops a pink color that selectively quenches the 570 nm emission of the CDs while leaving the 420 nm peak unaffected. Upon introduction of GSH, the quinoid structure of PHP is converted to its benzenoid form via Michael addition, resulting in the disappearance of the pink color and subsequent restoration of the 570 nm fluorescence. This mechanism, utilized for the first time in GSH detection, offers a distinct advantage over previous methods that primarily relied on GSH's complexation capabilities. The analytical capabilities of the BO<img>CDs/PHP ratiometric probe were extensively evaluated through multiple spectroscopic methods to understand its sensing mechanism. Performance analysis revealed impressive analytical figures of merit: the method exhibited strong linearity with a correlation coefficient of 0.9985, provided sensitive detection across a broad concentration range from 0.01 to 8.0 μM, and achieved a remarkably low detection limit of 3.33 nM. The method's versatility was enhanced through the development of a dual-mode smartphone platform, enabling both colorimetric and fluorometric GSH detection. Practical validation using human serum samples demonstrated the method's robustness in complex biological matrices, achieving high recovery rates between 98.5 % and 101.0 %, confirming its suitability for real-world clinical applications. This novel strategy combines the sensitivity of ratiometric fluorescence with the convenience of smartphone-based detection, offering a promising tool for GSH monitoring in clinical and research settings.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100418"},"PeriodicalIF":4.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced LC-MS/MS method for selective quantification of nitrosamine impurities in Risperidone: Enhancing drug safety","authors":"Hitesh Thumbar ,&nbsp;Pankajkumar Nariya ,&nbsp;Bhavin Dhaduk","doi":"10.1016/j.talo.2025.100416","DOIUrl":"10.1016/j.talo.2025.100416","url":null,"abstract":"<div><div>In the current study, a simple, rapid, and sensitive analytical method was developed and validated for the determination and quantification of four nitrosamine drug substance-related impurities (NDSRIs) in Risperidone drug substance. Chromatographic separation was achieved on an ACE-5 PFP C18 column (150 mm × 4.6 mm × 3 µm) using gradient elution with 0.2 % formic acid and methanol. The method utilized a flow rate of 0.8 mL/min, an injection volume of 5 µL, and a column temperature of 40 °C. Positive electrospray ionization (ESI) in multiple reaction monitoring (MRM) mode was used for quantification. The limit of detection (LOD) and limit of quantification (LOQ) ranged from 0.12 to 0.46 and 0.23–0.93 µg/mL, respectively. The calibration curves for NDIRs impurities (0.23–185.72 µg/mL) exhibited <em>R²</em> values between 0.998 and 0.999. Recoveries ranged varied from 94.9 to 124.4 %, with % RSD &lt; 15.0 %. The results indicated that the method is reliable for monitoring all NINA, NBOP, NBP, and NB impurities in Risperidone.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100416"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable and smart multi-analyte HPTLC determination of tolperisone HCl together with three pain killers using smartphone camera as a detector: Comparative study with benchtop densitometry","authors":"Mohamed Rizk ,&nbsp;Emad Ramzy ,&nbsp;Safaa Toubar ,&nbsp;Amr M. Mahmoud ,&nbsp;Marwa I. Helmy","doi":"10.1016/j.talo.2025.100415","DOIUrl":"10.1016/j.talo.2025.100415","url":null,"abstract":"<div><div>The remarkable advancement in smartphone cameras has revolutionized their potential as highly accessible, portable, and manageable detectors in various analytical approaches. In this study, we developed a novel and cost-effective method for the simultaneous determination of four drugs (Tolperisone HCl (TOLP), aceclofenac(ACEC), Paracetamol (PARA), and etodolac (ETOD)). Our innovative approach combines high-performance thin-layer chromatography (HPTLC) with a smartphone's camera. Initially, chromatographic separation has been achieved utilizing HPTLC plates, employing an environmentally friendly mobile phase consisting of a mixture of ethyl acetate, methanol, and glacial acetic acid (8.5:1.5:0.25, by volume). The developed plates were visualized using a UV lamp and captured using the rear-facing camera of a smartphone fixed onto a specially designed chamber with a UV illumination source. Using ImageJ, a freely available image analysis program, the drug spot intensities were measured throughout a concentration range of 1.0–7.0 µg/band. Furthermore, the study expanded to include a comparison between the obtained results and a conventional benchtop densitometry method at a wavelength of 276.0 nm. The densitometry method exhibited a linear response within the range of 100.0 - 700.0 ng/band for TOLP, 100.0 - 600.0 ng/band for ACEC, and 150.0 - 600.0 ng/band for PARA and ETOD. The proposed HPTLC/smartphone method demonstrated its advantages of being fast, simple, reliable, and environmentally friendly, making it an outstanding platform for analyzing commercially available combined tablets. To evaluate the environmental impact and sustainability of the constructed methods and compare them with other published methods reported in the literature, the whiteness of the developed methods utilizing the RGB 12 algorithm combined with the two highly cited greenness assessment metrics, the analytical Eco-scale (AES) and the Analytical GREEnness (AGREE), were employed.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100415"},"PeriodicalIF":4.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trace analysis method for the determination of organophosphate esters based on solid-phase extraction-UPLC-MS/MS and its application to blood","authors":"Luyao Hang ,&nbsp;Lihong Duan ,&nbsp;Lixin Yang ,&nbsp;Hongmei Shi","doi":"10.1016/j.talo.2025.100414","DOIUrl":"10.1016/j.talo.2025.100414","url":null,"abstract":"<div><div>Measurement of organophosphate esters (OPEs) concentrations in human body fluids is important for understanding the level of exposure to OPEs in humans and for assessing human health risks. Currently. There are more analytical tests on the metabolite levels of OPEs in urine as biomarkers of human OPEs exposure, while there are fewer studies on the analysis of OPEs in human blood. In this study, an ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of 19 OPEs in human blood was developed based on the optimization of the pretreatment process and chromatographic separation. The serum samples were cleaned-up by an HMR extraction column, and the separation of the targets was performed on an Acquity BEHC18 column with a gradient elution using methanol and 5 mmol/L aqueous ammonium acetate as the mobile phases, and finally, the determination was carried out. Under the optimized detection conditions, the recoveries of the 19 OPEs ranged from 81.4 % to 117.8 % with the RSDs &lt;20 %, and the limits of detection (LODs) were in the range of 0.024∼0.058 ng/mL. The method is simple in sample pretreatment, sensitive, and suitable for the determination of OPEs in human serum samples. The results of the analysis of human serum samples showed that the exposure of OPEs in human body is relatively common and should be widely concerned.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100414"},"PeriodicalIF":4.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong toxic gas detection on penta-BCP monolayers: Insights from DFT calculations","authors":"Thanasee Thanasarnsurapong ,&nbsp;Suchanuch Sringamprom ,&nbsp;Pakpoom Reunchan ,&nbsp;Weekit Sirisaksoontorn ,&nbsp;Sirichok Jungthawan ,&nbsp;Piyanooch Nedkun ,&nbsp;Jariyanee Prasongkit ,&nbsp;Adisak Boonchun","doi":"10.1016/j.talo.2025.100412","DOIUrl":"10.1016/j.talo.2025.100412","url":null,"abstract":"<div><div>Rapid and accurate detection of toxic gases remains important for industrial safety and environmental well-being. This study examines the potential of penta-BCP monolayer as a high-performance toxic gas sensor utilizing the robust framework of density functional theory (DFT). Penta-BCP exhibits strong and selective interactions with specific toxic gas molecules, including CO, NO, and <span><math><msub><mtext>NO</mtext><mn>2</mn></msub></math></span>. This results in the remarkable ability to readily capture these harmful gases while demonstrating minimal interaction with non-toxic counterparts such as <span><math><msub><mi>H</mi><mn>2</mn></msub></math></span>, <span><math><msub><mi>N</mi><mn>2</mn></msub></math></span>, <span><math><msub><mtext>CO</mtext><mn>2</mn></msub></math></span>, and <span><math><msub><mtext>CH</mtext><mn>4</mn></msub></math></span>, underlining its exceptional selectivity. Furthermore, penta-BCP has a significantly shorter recovery time for NO and <span><math><msub><mtext>NO</mtext><mn>2</mn></msub></math></span> gases compared to penta-BCN, which has a similar structure. These findings collectively position penta-BCP as a frontrunner for the next generation of toxic gas sensors, paving the way for enhanced environmental monitoring and improved public health protection.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100412"},"PeriodicalIF":4.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the amplified oxidase-mimetic activity of MnCoO nanosheets for the ultra-sensitive determination of the long-acting beta-adrenoceptor agonist indacaterol","authors":"Amal A. El-Masry ,&nbsp;Heba Elmansi ,&nbsp;Nahed El-Enany","doi":"10.1016/j.talo.2025.100413","DOIUrl":"10.1016/j.talo.2025.100413","url":null,"abstract":"<div><div>The ability to determine indacaterol in different matrices is critical for the medication adherence assessment. In the current approach, we introduce a pioneering colorimetric detection approach for the sensitive quantitation of indacaterol using ultrathin MnCoO nanosheets with boosted oxidase-imitating properties. The nanosheets were synthesized under mild conditions through a one-step template-less simple hydrothermal process. These nanosheets demonstrated oxidase-imitating activity, enabling the change of (3,3′,5,5′-Tetramethylbenzidine ) TMB into blue-colored oxidized TMB without the need for water. Yet, the presence of indacaterol impeded this action, leading to the transformation of oxidized TMB back to colorless TMB and a subsequent reduction in blue color intensity is observed. The colorimetric reaction showed a linear correlation with indacaterol concentrations ranging from 6.0 <img> 325.0 ng/mL. This ultra sensitivity permitted reaching a detection limit down to 1.77 ng/mL. Different characterization and kinetic experiments were conducted to elucidate the underlying mechanism. Additionally, the effectiveness of the sensing platform was evaluated by measuring indacaterol levels in its pharmaceuticals. A green assessment for this approach was introduced. This well-established methodology highlights the potential of nanomaterial-based sensing technologies in pharmaceutical analysis, and related fields.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100413"},"PeriodicalIF":4.1,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental sustainability profiles assessment of HPLC stability indicating method for quantitation of piracetam and vincamine in pharmaceutical medications","authors":"Samya Sh. Alenezi ,&nbsp;Ayman A. Gouda ,&nbsp;Ragaa El Sheikh ,&nbsp;Niaf A. Badahdah ,&nbsp;Muneer E Alzuhiri ,&nbsp;Ali H. Magrabi ,&nbsp;Asim L. Jilani ,&nbsp;Ahmed S. Darwish","doi":"10.1016/j.talo.2025.100407","DOIUrl":"10.1016/j.talo.2025.100407","url":null,"abstract":"<div><div>Recently, significant focus has been placed on the development of suitable stability-indicating studies in pharmaceutical analysis. A comprehensive eco-friendly stability-indicating RP-HPLC method has been developed and validated for the determination of piracetam and vincamine in hard gelatin capsule dosage forms. Both components were subjected to various stresses, following the International Conference on Harmonization (ICH) guidelines. Piracetam, vincamine, and their breakdown products were successfully separated using the isocratic elution technique, and both medicinal compounds' quantification was carried out on the Kromasil C₁₈ column at room temperature. The mobile phase consists of 0.05 M potassium dihydrogen phosphate buffer pH 3.5:ethanol absolute (60:40, by volume), at a flow rate of 1.0 ml/min. Detection was implemented at 220 nm, considering the concentration levels of 80–550 and 4.0–28 μg/ml for piracetam and vincamine, respectively. The total analysis time was &lt;5 min, establishing this mentioned chromatographic method as proper for regular quality control evaluations of both medications. The inclusion of ethanol absolute was required in order to obtain a sufficient resolution. Three methods were used to assess the environmental impact: Complementary modified green Analytical Procedure Index (ComplexMoGAPI), the eco-scale calculator, and the Analytical GREEnness metric (AGREE). The chromatographic method's eco-friendly is demonstrated by its final Eco-scale score of 76.5, AGREE score of 0.66, ComplexMoGAPI E-factor was 42 with five green segments, BAGI score of 82.5, and finally whiteness score of 97.5. Obviously, the simultaneous method is accurate, precise, ecofriendly, specific, robust, and rugged. Finally, it can be used successfully for regular quality control analysis of piracetam and vincamine in both their pure form and hard gelatin capsule dosage forms.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100407"},"PeriodicalIF":4.1,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doping of rare earth element: The effects in elevated physical and optical properties of ZnO","authors":"Uji Pratomo ,&nbsp;Natasha Fransisca ,&nbsp;Muchammad Dhuhri Adzani ,&nbsp;Irkham Irkham ,&nbsp;Allyn Pramudya Sulaeman ,&nbsp;Diana Rakhmawaty Eddy ,&nbsp;Jacob Yan Mulyana ,&nbsp;Indah Primadona","doi":"10.1016/j.talo.2025.100411","DOIUrl":"10.1016/j.talo.2025.100411","url":null,"abstract":"<div><div>Zinc oxide (ZnO) serves as a highly adaptable semiconductor with a crucial role in various applications because of its crystal structure compatibility and significant band gap. Fabricating ZnO nanomaterials with tailored characteristics has become a prevalent and current focus. Within this framework, the integration of rare earth metals sparks interest due to their distinctive 4f electronic configuration, providing an exceptional opportunity to manipulate ZnO's optical, luminescent, and surface properties. This article examines the impact of rare earth metal doping on ZnO's structural and optical attributes, as well as the resulting improvements in various applications. We hope this review article offers comprehensive insights to guide the reasoned design and advancement of rare earth-doped ZnO (ZnO/RE) metals for various applications.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100411"},"PeriodicalIF":4.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}