Talanta Open最新文献

{"title":"Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility","authors":"Varun V. Sharma ,&nbsp;Danjo De Chavez ,&nbsp;Susan E. Slade ,&nbsp;Ingela Lanekoff","doi":"10.1016/j.talo.2024.100373","DOIUrl":"10.1016/j.talo.2024.100373","url":null,"abstract":"<div><h3>Background</h3><div>Identification and characterization of steroids from complex mixtures with isomeric precision is key to studying endocrine-related metabolism and disorders. Whereas the golden standard chromatography, including liquid chromatography and gas chromatography, can be coupled with mass spectrometry to separate steroids prior to ionization, this separation is time-consuming. Contrarily, direct infusion techniques can offer increased throughput; however, these are often hampered by limited structural specificity. Thus, it is important to develop new analytical tools for direct infusion mass spectrometry that will provide isomeric specificity.</div></div><div><h3>Results</h3><div>Herein, we show that direct infusion with electrospray ionization in combination with silver adduction and cyclic ion mobility mass spectrometry (cIMS) enables mobility separation and improves the detectability of steroid isomers. Specifically, silver ion adduction of steroids increases instrumental response up to 14 times and enables almost baseline mobility separation of closely related structural steroid isomers even at low cIMS resolution. By combining experimental and theoretical data, we show that the silver interacts with the steroid isomer at single or multiple sites, which introduces conformational changes that enable mobility separation. Moreover, we show that the combination of cIMS and silver adduct fragmentation in tandem mass spectrometry provides an additional dimension for annotation of steroid isomers. Thus, the simple introduction of silver ions into the electrospray solvent provides a great gain in the analytical discernment of steroid isomers.</div></div><div><h3>Significance</h3><div>For the first time, we show that the use of silver adduction introduces a conformational change in steroids that allows for them to be separated with low-resolution ion mobility spectrometry without any prior derivatization, chromatographic separation, or instrumental modification. This is a new and important tool for analyzing steroid isomers that can unravel their importance in biological systems.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100373"},"PeriodicalIF":4.1,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trace-level quantification of NDMA in levosulpuride active pharmaceutical ingredient and tablet formulation Using UFLC-MS/MS","authors":"Hemanth Vikram P․R ,&nbsp;Gunjan Kumar ,&nbsp;Rajashree Deka ,&nbsp;Umme Hani ,&nbsp;Nazima Haider ,&nbsp;Sirajunisa Talath ,&nbsp;Adil Farooq Wali ,&nbsp;Dilipkumar Reddy Kandula ,&nbsp;Narasimha M. Beeraka ,&nbsp;Sinchana B Gopalaiah ,&nbsp;Devi Sri Chiriki ,&nbsp;Namitha Bannimath ,&nbsp;Pramod Kumar ,&nbsp;Bannimath Gurupadayya","doi":"10.1016/j.talo.2024.100375","DOIUrl":"10.1016/j.talo.2024.100375","url":null,"abstract":"<div><div>Nitrosamine impurities identified in several pharmaceuticals during recent times has raised concerns leading to product recalls worldwide and necessitating sensitive liquid and gas chromatographic methods for trace level detection of nitrosamine impurities. This study developed and validated a ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method for the quantification of NDMA in Levosulpuride drug substance and tablet formulation. Current method utilizes a triple quadrupole analyzer, atmospheric pressure chemical ionization (APCI) ionization source and multiple reaction monitoring (MRM) scan mode for the analysis. Chromatographic separation was achieved on a Gemini NX-C18 column (150 × 4.6 mm, 3 µm) maintained at 40 °C. The mobile phase consisted of a binary gradient of solvent A (0.1 % formic acid in water) and solvent B (methanol), with a total run time of 18 minutes. Current method achieved excellent linearity, recovery, precision, and sensitivity. Greenness of the developed method was evaluated using the GAPI, AGREE, and AES metrics. Current method is sensitive and selective for NDMA in levosulpuride drug substance and tablet formulations and can be employed for routine quality control analysis in pharmaceutical industry.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100375"},"PeriodicalIF":4.1,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of nanomaterial-supported molecularly imprinted polymer/receptor-like sensor for the detection of rosuvastatin from binary mixtures","authors":"Mahdi Gharibi ,&nbsp;Ensar Piskin ,&nbsp;Nadia Bounoua ,&nbsp;Ahmet Cetinkaya ,&nbsp;Sibel A. Ozkan","doi":"10.1016/j.talo.2024.100376","DOIUrl":"10.1016/j.talo.2024.100376","url":null,"abstract":"<div><div>Statins reduce cholesterol synthesis by inhibiting the enzyme hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Rosuvastatin (ROS) is a statin drug used to prevent cardiovascular diseases and treat abnormal lipids. This study describes the design and fabrication of a nanomaterial-assisted molecularly imprinted polymer (MIP)-based electrochemical sensor for ROS determination. In addition, MIP-based electrochemical sensors were designed to detect ROS in both standard solutions and serum samples. In the MIP-based electrochemical sensor developed via the photopolymerization (PP) technique on the glassy carbon electrode (GCE) surface, were used zinc oxide nanoparticles (ZnO NPs) as a pore former, p-aminobenzoic acid (p-ABA) as functional monomer, ROS as template molecule. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and scanning electron microscopy (SEM) techniques were used to carry out detailed characterizations concerning surface morphology and electrochemistry. Under optimized experimental conditions, the linearity range of the designed sensor was found 1.0 × 10⁻¹³–1.0 × 10⁻¹² M. The superior selectivity of the MIP-based sensor against ROS in the presence of their binary mixtures was confirmed by interference studies. The recovery rates of the MIP-based sensors were calculated as 100.35 % and 99.16 % in commercial tablet form and serum samples, respectively. Moreover, the proposed sensor's relative selectivity coefficient (k′) was calculated, and it provided good selectivity for ROS over the NIP sensor. In conclusion, this newly developed sensor offers an advantageous approach for selective, sensitive, rapid and cost-effective analysis of ROS from binary mixtures. Additionally, this study is the first electrochemical sensor using nanomaterial-assisted MIP technology for ROS analysis, and its sensitivity is higher than that of other studies in the literature.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100376"},"PeriodicalIF":4.1,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal organic frameworks for bacterial detection in environmental samples","authors":"Hadeer M. Bedair ,&nbsp;Alaa Bedair ,&nbsp;Mahmoud Hamed ,&nbsp;Marcello Locatelli ,&nbsp;Fotouh R. Mansour","doi":"10.1016/j.talo.2024.100374","DOIUrl":"10.1016/j.talo.2024.100374","url":null,"abstract":"<div><div>Pathogenic bacteria pose significant threats to public health. Early and accurate detection of bacteria is crucial for infection control and prevention of outbreaks. This paper reviews recent advances in metal organic framework (MOF)-based methods for bacterial detection. MOFs are promising materials for biosensing due to their large surface areas, customizable properties, and ability to integrate various sensing capabilities. Several colorimetric and electrochemical detection techniques that utilize MOFs are discussed. Colorimetric assays combining MOFs with gold nanoparticles, peroxidase-mimicking activity, and aptamer recognition have achieved sensitive and specific detection of bacteria such as <em>E. coli</em> and <em>S. aureus</em>. Electrochemical biosensors integrating MOFs, antibodies, aptamers and quantum dots have also demonstrated low detection limits for various bacteria. Notably, techniques using MOF peroxidase-like activity coupled with magnetic separation or competitive binding assays show potential for point-of-care pathogen detection. Furthermore, optimization of MOF properties and integration within microfluidic platforms may lead to portable, low-cost and rapid methods suitable for on-site bacterial analysis in diverse settings. Continued exploration of MOF-based sensing strategies holds promise for improved bacteria monitoring and control of infectious diseases.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100374"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate low-dose exposure assessment of benzene and monoaromatic compounds by diffusive sampling: Sampling and analytical method validation according to ISO 23320 for radiello® samplers packed with graphitised charcoal and suitable for thermal desorption","authors":"Laura Zaratin ,&nbsp;Caterina Boaretto ,&nbsp;Riccardo Carnevale Schianca ,&nbsp;George Hinkal ,&nbsp;Elena Grignani ,&nbsp;Danilo Cottica","doi":"10.1016/j.talo.2024.100372","DOIUrl":"10.1016/j.talo.2024.100372","url":null,"abstract":"<div><div>This research was aimed at providing an accurate low-dose benzene exposure assessment method, prospectively suitable to exposure limit values in the low ppb range, such as in the present-day chemical, petrochemical, foundry and pharmaceutical industry. The project addresses the need for a robust and fully validated method of personal exposure measurements considering that the Occupational Exposure Limit Value for benzene will be significantly lowered in the next few years. Diffusive sampling offers a reliable alternative to pumped sampling methods, intrinsic safety in potentially explosive atmospheres, lightness and ease of use. The tested diffusive sampler is <em>radiello</em>® with the RAD145 adsorption substrate. This configuration is packed with graphitised charcoal suitable for thermal desorption and analysis by HRGC-FID or HRGC-MS.</div><div>The experiments have been conducted following the ISO 23320 standard in the range from 0.005 to 0.1 ppm (16 to 320 µg/m³), yielding a full validation of the sampling and analytical method. The sampler performances have fulfilled all requisites of the ISO 23320 standard, in particular: bias due to the selection of a non-ideal sorbent is lower than 10 % (no significant back diffusion of benzene due to concentration change in the atmosphere); bias due to storage of samples for up to 2 months is lower than 10 %; nominal uptake rate for benzene on RAD145 is 32.3 mL/min; expanded uncertainty of the sampling and analytical method is 22.1 % in the concentration range from 80 to 320 µg/m³. The sampling and analytical method is therefore fit-for-purpose for the personal exposure measurements aimed at testing compliance with lowered occupational exposure limit values for benzene. The method is also fit for short duration exposure monitoring related to specific tasks, and other volatile organic compounds, usually found in the same workplaces, such as aliphatic and aromatic hydrocarbons and some oxygenated compounds, have been also studied. In particular, n-hexane and isopropyl benzene (also known as cumene), whose classification is currently under revision, can be efficiently monitored by this technique.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100372"},"PeriodicalIF":4.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing electrochemical sensing: A smart platform for accurate CRP level detection in neonatal septicaemia","authors":"Sapna Balayan ,&nbsp;Nidhi Chauhan ,&nbsp;Vinita Hooda ,&nbsp;Ramesh Chandra ,&nbsp;Warren Rosario ,&nbsp;Utkarsh Jain","doi":"10.1016/j.talo.2024.100369","DOIUrl":"10.1016/j.talo.2024.100369","url":null,"abstract":"<div><div>Neonatal septicaemia is an intricate systemic affliction induced in newborns. A multitude of fungi, viruses, and bacteria elicit this condition. Conventional methodologies such as radiological imaging, microbial testing, blood culture, and inflammatory markers suffer from an array of constraints for prompt detection of infection. This present study illustrates a cutting-edge smart electrochemical biosensing system. The fabricated system was meticulously engineered to discern the concentration of C-reactive protein (CRP). CRP is an irreplaceable prognostic indicator for neonatal sepsis. This work explicates the fabrication of a bioreceptor sensing platform (BioRe Sense) on a screen-printed miniaturized electrode. The surface of the electrode underwent modification with molybdenum disulfide nanosheets (MoS₂NSs). Further, the interface was designed with molecularly imprinted polymer (MIP) targeting CRP. An electrochemical technique carefully examined the electrode at each modification stage. The created sensing interface can detect a wide concentration range from 0.01 nM to 100 nM, with a lower detection limit of 0.01 nM.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100369"},"PeriodicalIF":4.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive analytical techniques utilized for the detection of contaminants attributed to food safety and security","authors":"Anjali Bharti,&nbsp;Utkarsh Jain,&nbsp;Nidhi Chauhan","doi":"10.1016/j.talo.2024.100368","DOIUrl":"10.1016/j.talo.2024.100368","url":null,"abstract":"<div><div>Food analysis and authentication are very crucial to assure safety, quality, and integrity of food and food-related products. Analysis of food products not only ensures the quality of food but also gives information about composition, physical characteristics, flavor, shelf-life, safety, microstructure, and processibility. Consequently, food is now regarded as an inexpensive means of preventing disease while also serving as a source of energy. Typically, a wide range of distinct chemical components make up the chemical composition of food. Furthermore, during processing or storage, food is always susceptible to structural alterations. Therefore, to assess the nutritional value and the quality of food products, food components must be analyzed and quantified. Food analysis mainly includes the preparation, examination, and identification of major food components, such as dietary fiber, phenolic compounds, carbohydrates, proteins, amino acids, peptides, enzymes, phospholipids, pesticides, alcohols, fat-soluble and water-soluble vitamins, organic acids, organic bases, bittering agents, pigments, and aroma compounds, as well as minor components including preservatives, antioxidants, colorants. Therefore, there are several advanced analytical techniques, including spectroscopy, mass spectrometry, chromatography, NMR, HSI, MALDI-TOF, RT-PCR, biosensors, etc. have been vital in the food science domain due to their high selectivity and sensitivity. This review emphasizes implementing various analytical techniques to analyze food safety and security.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100368"},"PeriodicalIF":4.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential volatile markers for characterizing Argentine wine vinegars based on their production process","authors":"Marcelo Wagner ,&nbsp;Jorgelina Zaldarriaga Heredia ,&nbsp;M. Pilar Segura-Borrego ,&nbsp;M. Lourdes Morales ,&nbsp;José M. Camiña ,&nbsp;Silvana M. Azcarate ,&nbsp;Raquel M. Callejón ,&nbsp;Rocío Ríos-Reina","doi":"10.1016/j.talo.2024.100370","DOIUrl":"10.1016/j.talo.2024.100370","url":null,"abstract":"<div><div>In Argentina, the production of quality wine vinegars has been barely exploited. Currently, most of the marketed vinegars are produced using rapid industrial fermentation systems obtaining vinegars with a high production rate, but with low quality and few organoleptic nuances. This work aims to study the volatile profile by headspace solid phase microextraction (HS-SPME) coupled to gas chromatography-mass spectrometry (GC–MS) and chemometrics to differentiate Argentinian wine vinegars according to their production process (industrial or traditional). A total of 92 volatile compounds were identified on the samples by using a strategy based on volatile profile processing using PARADISe® software. The complete volatile profile of all the samples was submitted to partial least squares discriminant analysis (PLS-DA) for the selection of variables with importance in the projection (VIPs). Thus, 37 volatile compounds with the potential to be markers of the manufacturing process were selected. The results obtained revealed, for the first time, the volatile profile of Argentine wine vinegars showing that the compound groups that, on average, exhibited higher relative areas were esters, acids, and alcohols. Thus, certain acids, aldehydes and terpenes were noticeably present in industrial wine vinegar. Conversely, the alcohols were strongly associated with traditional ones. In the case of esters, they were connected to the different types of wine vinegars. These compounds could be considered as potential volatile markers of quality and authenticity of these types of vinegars.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100370"},"PeriodicalIF":4.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the greenness, blueness, and whiteness of spectroscopic and UPLC techniques for the simultaneous measurement of anti-glaucoma drugs and the preservation agent","authors":"Eman A. Assirey ,&nbsp;Noha S. katamesh ,&nbsp;Mahmoud A. Mohamed","doi":"10.1016/j.talo.2024.100367","DOIUrl":"10.1016/j.talo.2024.100367","url":null,"abstract":"<div><div>The pursuit of sustainable solutions is increasingly crucial in contemporary times. We propose inventive research that fulfills the criteria of whiteness and greenness in analytical chemistry. The endeavor aims to advance environmentally conscious techniques for the simultaneous detection of timolol maleate (TIM), dorzolamide HCl (DOR), and benzalkonium Cl (BNZ). The first method employed a sustainable mobile phase consisting of 0.02 M phosphate buffer: ethanol (68:32, v/v), and a flow rate of 0.6 mL/min with retention times 1.274, 1.798, and 2.483 min for DOR, TIM, and BNZ, respectively, with a UV detector at 210 nm. This methodology was easy, fast, and accurate. The approach showed low processing times, peak symmetry, and satisfactory resolution, with correlation values of 0.999. The linearity was between 0.001–0.064, 0.001–0.060 µg mL^-1, and 0.001–0.050 µg mL^-1for DOR, TIM, and BNZ, respectively. Furthermore, employing water as the solvent, complementary spectrophotometric methods such as Mean Centering of Ratio Spectra (MCR) and Successive Derivative Ratio Spectra (SRDS) were investigated as economical and environmentally friendly substitutes. All procedures demonstrated good linearity (r² &gt; 0.9990), acceptable accuracy, and precision (RSD ≤ 2 %). Furthermore, by proving the superiority of the current work over previously published methods regarding sustainability, analytical performance, economics, and practicality, the real-world implementation of four greenness and whiteness algorithms boosts the approval and overall sustainable development of the proposed methods. The suggested techniques offer low-cost, environmentally friendly substitutes for traditional methods, advancing the field of analytical chemistry towards more sustainable practices and fostering a less destructive future for quality control.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100367"},"PeriodicalIF":4.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absolute mass spectrometry: A theoretical analytical technique for quantification","authors":"Ignacio J. Rios,&nbsp;Fabiana C. Gennari","doi":"10.1016/j.talo.2024.100366","DOIUrl":"10.1016/j.talo.2024.100366","url":null,"abstract":"<div><div>Mass spectrometry (MS) is an analytical chemistry technique that requires calibration with standards in order to quantify an analyte in a sample. In many cases the reference standards may be difficult to obtain or unavailable. In fact, when MS is applied to study reactions that yield multiple products, their quantification requires several standards and involves time-consuming and tedious calibration procedures. In other applications like Mass Spectrometry Imaging (MSI), quantification becomes even more tedious when on-tissue standards or mimetic tissue models are required. In this work, we introduce a new measurement technique that we called the Absolute Mass Spectrometry (AbMS), which allows the absolute quantification of an analyte without the need for calibration standards. This technique is based on the “Influence Method” developed in 2015 for nuclear measurements which, when applied to MS, produces this improvement for analyte quantification. Two possible applications of this technique are presented. One is the conceptual development of a mass spectrometer with electronic ionization that does not require calibration to determine the amount of analyte. The other one describes how to apply this technique in a mass spectrometer with other ionization sources like MALDI, DESI, and SIMS, which are used in MSI. AbMS technique uses the conceptual basis of Influence Method and two consecutive measurements to estimate the amount of analyte. Specifically, AbMS can be directly employed as an absolute method for quantification in MSI. Therefore, it constitutes an attractive complement for research applications in pharmaceutical and health sciences.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100366"},"PeriodicalIF":4.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}