Talanta Open最新文献

{"title":"Eco-friendly molecularly imprinted polymer-based sensing platforms towards pharmaceuticals: recent advances and future prospects","authors":"Rüstem Keçili ,&nbsp;Ghazanfar Hussain ,&nbsp;Chaudhery Mustansar Hussain ,&nbsp;Adil Denizli","doi":"10.1016/j.talo.2025.100446","DOIUrl":"10.1016/j.talo.2025.100446","url":null,"abstract":"<div><div>The gradually growing demand for the sensitive, selective and eco-friendly approaches for pharmaceutical detection has driven significant prograsses in molecularly imprinted polymer (MIP)-based sensing platforms. MIPs, known for their high specificity and robustness, have emerged as promising materials for the design and constrcution of eco-friendly sensing platforms capable of detecting pharmaceuticals in complex matrices. This review paper provides a comprehensive review of recent advances in the design, fabrication and application of eco-friendly MIP-based sensing platforms, with a focus on their eco-friendly and sustainable features and analytical performance. Furthermore, key apprıaches such as the incorporation of green synthesis methods, renewable resources and eco-friendly polymerization techniques are highlighted.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100446"},"PeriodicalIF":4.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive and selective detection of cancer biomarkers with molecularly imprinted biosensors","authors":"Sibel Büyüktiryaki","doi":"10.1016/j.talo.2025.100444","DOIUrl":"10.1016/j.talo.2025.100444","url":null,"abstract":"<div><div>Accurate and reliable detection of cancer biomarkers plays a pivotal role in early diagnosis, disease progression monitoring, and effective treatment strategies. Molecularly imprinted polymers (MIPs), with their high selectivity and stability, have emerged as powerful tools for biomarker detection. This review explores the fundamental principles of MIPs and their tailored synthesis for biological markers. Special emphasis is placed on integrating MIPs with analytical techniques such as optical and electrochemical sensing platforms. Moreover, it highlights their success in real biological matrices and addresses the challenges and opportunities for developing advanced solutions. Finally, the review addresses challenges and future directions, emphasizing the critical role of MIP technology in achieving ultra-sensitive, cost-effective, and portable diagnostic solutions. This review aims to highlight the potential of MIP-based sensors for the selective and sensitive detection of cancer biomarkers and to serve as a guide for researchers in the field.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100444"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Trends in Fluorescent and Quenching Nanomaterials for Viral detection: Innovations in Biological and Chemical sensing","authors":"Deeksha Nautiyal,&nbsp;Utkarsh Jain","doi":"10.1016/j.talo.2025.100430","DOIUrl":"10.1016/j.talo.2025.100430","url":null,"abstract":"<div><div>Optical biosensors doped with nanomaterials are the most technologically advanced in viral diagnostics, showing higher sensitivity, specificity, and speed of detection. This review describes the role of fluorescent and quenching nanomaterials in the development of optical biosensing techniques. These sensors enable real-time, non-invasive viral detection with minimal preparation of samples by exploiting unique optical properties of nanomaterials, such as increased fluorescence, efficient energy transfer, and significant signal amplification. It is worth noting that the material's application in point-of-care settings effectively bridges laboratory accuracy with the practical applicability of real-world applications. Moreover, these aspects were put into review, along with the latest advancements in the emerging dual-functional nanocomposites able to integrate the fluorescence and quenching mechanisms for multimodal detection, with emphasis on what has been recently achieved and how these efforts have been developed to tackle stability, reproducibility, and scalability concerns. This will enable optical biosensing through advances in nanotechnology and pave the way for designing next-generation diagnostic platforms capable of addressing current and emerging viral threats.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100430"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Castor oil-based molecularly imprinted nanoparticles for the detection of cardiac troponin I: Towards green molecularly imprinted nanoreceptors","authors":"Pinar Cakir Hatir ,&nbsp;Alice Marinangeli ,&nbsp;Alessandra Maria Bossi ,&nbsp;Gokhan Cayli","doi":"10.1016/j.talo.2025.100439","DOIUrl":"10.1016/j.talo.2025.100439","url":null,"abstract":"<div><div>Molecularly imprinted polymers (MIPs) are synthetic materials that selectively recognize target molecules, offering cost-effective and stable alternatives to antibodies. While MIP nanoparticles are ideal for biomedical applications for their high surface area and their biomolecule-compatible size, traditional monomers used in their synthesis can pose issues in biocompatibility. This study presents a sustainable approach to MIP nanoparticle production using acrylated methyl ricinoleate (AMR), a functional monomer derived from castor oil. These \"GreenNanoMIPs\" were designed to recognize cardiac troponin I (cTnI), a key biomarker for cardiovascular events. The nanoparticles, with an average size of 81 nm, exhibited exceptional homogeneity in suspension, with a low PDI value of 0.064, and outstanding stability, as no changes in particle size distribution or PDI were observed even after one year. GreenNanoMIPs did recognize the entire cTnI protein thorough the epitope approach. Furthermore, GreenNanoMIPs were successfully used for the detection of the cTnI biomarker directly in serum. The study highlights the potential of eco-friendly, biocompatible MIPs for applications in diagnostics, drug delivery, and environmental sensing.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100439"},"PeriodicalIF":4.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Argon versus helium as carrier gas for LA-ICP-MS impurity mapping on ice cores","authors":"Pascal Bohleber ,&nbsp;Kristina Mervič ,&nbsp;Remi Dallmayr ,&nbsp;Ciprian Stremtan ,&nbsp;Martin Šala","doi":"10.1016/j.talo.2025.100437","DOIUrl":"10.1016/j.talo.2025.100437","url":null,"abstract":"<div><div>Impurity records in polar ice cores have provided invaluable insights into atmospheric aerosol concentrations of the past environment. The investigation of the oldest, deepest and highly thinned ice core layers is one of the most pressing tasks in today’s state-of-the-art ice core research. This calls for impurity analysis at high spatial resolution, which has to take into account post-depositional processes through the interaction of impurities with the ice matrix. To this end, mapping the impurity distribution in ice with laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) has great potential. Here we explore to what extent the use of Ar as a carrier gas has merits in ice core impurity mapping with LA-ICP-MS. This is motivated by the fact that a) the use of Ar is more economical over He, especially when used in conjunction with large volume sample cells, and b) an increase in sensitivity has previously been reported when adding ”wet” Ar to He as a carrier gas. We show that, albeit not fully matching the single-pulse-performance of He, it is possible to achieve mapping at up to 500 Hz with Ar in a system that is originally designed for He. In contrast to what we find on NIST glass standards and a sample of decorative murrina glass, maps obtained on ice core samples show higher intensities in Ar than in He. In an extreme case example, we show how Ar may permit to obtain signals in a deep interglacial ice sample from Antarctica with very low impurity concentrations, which was not possible when using He with the same LA-ICP-MS system.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100437"},"PeriodicalIF":4.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective dual-mode detection of doxycycline using orange carbon dots/calcium-murexide composite system: From spectroscopic analysis to smartphone-based sensing","authors":"Fatma A.M. Abdel-aal ,&nbsp;Ashraf M. Mahmoud ,&nbsp;Azza H. Rageh ,&nbsp;Mohamed R. Elmasry ,&nbsp;Yousef A. Bin Jardan ,&nbsp;Mohamed M. El-Wekil ,&nbsp;Al-Montaser Bellah H. Ali","doi":"10.1016/j.talo.2025.100438","DOIUrl":"10.1016/j.talo.2025.100438","url":null,"abstract":"<div><div>A novel and selective analytical method has been developed for doxycycline (DOX) determination, addressing the critical need for monitoring this widely used antibiotic in environmental samples. The method employs a hybrid sensing system combining orange-emitting carbon dots (O-CDs) with a calcium-murexide (Ca@Mu) complex, offering a unique dual-mode detection approach. Unlike conventional methods that rely on direct fluorescence quenching by DOX, which often suffer from poor selectivity, this system utilizes the competitive binding between DOX and murexide for Ca²⁺ ions. Initially, the pink-colored Ca@Mu complex formed under alkaline conditions causes fluorescence quenching of O-CDs at 552 nm. Upon introduction of DOX, its stronger Ca²⁺-binding affinity leads to the formation of a calcium-DOX complex, liberating free Mu and triggering both colorimetric (pink to orange) and fluorometric (restoration of O-CDs emission) responses. Comprehensive characterization and mechanistic investigations employing different spectroscopic techniques confirmed the sensing mechanism. The method demonstrates excellent selectivity for DOX among other tetracyclines and potential interferents, along with impressive analytical performance including good linearity (1.0-35.0 μM), low detection limit (325 nM), and high precision. Additionally, a smartphone-based colorimetric platform was developed for convenient on-site analysis. The practical utility of this method was validated through successful determination of DOX in environmental water samples with excellent recovery rates, offering a reliable and user-friendly approach for environmental monitoring of this important antibiotic.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100438"},"PeriodicalIF":4.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the acetone sensing capabilities of metal-organic framework-derived SnO2/ZnO nanocomposite","authors":"M. Navaneethakannan ,&nbsp;J. Jayachandiran ,&nbsp;C. Venkateswaran ,&nbsp;D. Nedumaran","doi":"10.1016/j.talo.2025.100435","DOIUrl":"10.1016/j.talo.2025.100435","url":null,"abstract":"<div><div>Recent advancements in the quantification of gas molecules in human breath have opened new avenues for diagnosing diseases like diabetes and cancer. These gas molecules act as biomarkers for specific diseases reflecting changes in metabolism caused by diseased cells. Acetone, in particular, is recognized as a potential biomarker for both diabetes and cancer. However, the existing acetone sensors suffer from low sensitivity, long response and recovery times, high cost, and high-power consumption owing to the factors like material property, sensing mechanism and operational conditions. This study explored the benefits of metal-organic frameworks (MOFs), including high surface area, porosity, structural tunability, and diverse signal transduction capabilities. The MOF-derived SnO₂/ZnO nanocomposite was synthesized and analysed the material properties using TGA, XRD, FTIR, SEM/EDAX, HR-TEM, and XPS. These analyses confirmed the formation of the SnO₂/ZnO nanocomposite with a uniform surface morphology and an average crystalline size of 14.4 nm. The sensing material was then coated by e-beam evaporation onto Cr/Au interdigitated electrode (IDE) fabricated via photolithography and a bi-layer lift-off process. The fabricated sensor demonstrated enhanced electrical conductivity at higher operating temperatures, attributed to the presence of n-n heterojunctions in the material. Notably, the sensor exhibited a remarkable response of 81.88 % towards 10 ppm of acetone at 250 °C, with excellent selectivity over other gases and a detection limit of 600 ppb. Additionally, the sensor showed a rapid response/recovery time of 17/19 s to acetone molecules. These results confirm the sensor's ability to detect and quantifying acetone molecules from human breath.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100435"},"PeriodicalIF":4.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic determination of Pinus ponderosa using DART TOFMS, ICP-MS, and LIBS handheld analyzer","authors":"Erin R. Price ,&nbsp;Kierra R. Cano ,&nbsp;Caelin P. Celani ,&nbsp;Helder V. Carneiro ,&nbsp;Karl S. Booksh ,&nbsp;James A. Jordan ,&nbsp;Pamela J. McClure ,&nbsp;Megahn H. Pinedo ,&nbsp;Michael E. Ketterer ,&nbsp;Kent M. Elliott ,&nbsp;Tyler B. Coplen ,&nbsp;Edgard O. Espinoza","doi":"10.1016/j.talo.2025.100440","DOIUrl":"10.1016/j.talo.2025.100440","url":null,"abstract":"<div><div>Due to legal requirements on international imports, it is important for law enforcement and regulatory agencies to identify the geographical provenance of timber. Current methods for geographic identification utilize data generated by direct analysis in real time time-of-flight mass spectrometry (DART TOFMS), genetics, and isotope-ratio mass spectrometry (IRMS), but identification methods based on genetics and IRMS data require months to years to create usable databases. This study used machine learning algorithms to compare the results of DART TOFMS, inductively coupled plasma mass spectrometry (ICP-MS), and a handheld laser-induced breakdown spectroscopy (LIBS) analyzer for use in geographic identification of five populations of <em>Pinus ponderosa</em> spaced between 14 to 72 km apart. The results of the study showed comparable performances from machine learning algorithms applied to the ICP-MS and LIBS data with accuracy and kappa values over 90% while the DART TOFMS had an accuracy of 76% and a kappa value of 70%. This study demonstrated that data from the LIBS handheld analyzer is a viable and intriguing alternative to ICP-MS and DART TOFMS analyses in generating training databases and further indicates that trace elemental analysis via ICP-MS is a promising method for generating databases used to identify the origin of timber.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100440"},"PeriodicalIF":4.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative green stability-indicating HPLC method coupled with fluorescence detection for determination of antidiabetic agent canagliflozin","authors":"Nada Nabil ,&nbsp;Ghada A. Sedik ,&nbsp;Hala E. Zaazaa ,&nbsp;Sally S. El-Mosallamy","doi":"10.1016/j.talo.2025.100436","DOIUrl":"10.1016/j.talo.2025.100436","url":null,"abstract":"<div><div>This study exhibits a sustainable, easy, and reliable stability indicating HPLC approach utilizing fluorometric detection for quantification of canagliflozin (CANA) in the presence of its hepatotoxic oxidative degradation product (OXD). The chromatographic separation was accomplished using Symmetry® C18 column (3.5 μm, 4.6 × 100 mm). The mobile phase consists of 0.1 M phosphate buffer pH 2 and ethanol (40:60 v/v) pumped at a flow rate of 1.0 mL/min throughout the run. The eluted peaks were monitored by the fluorescence detector, and the chromatogram was extracted at emission wavelength of 410 nm for CANA and OXD after excitation at 290 nm which was suitable for both CANA and OXD. Performance of the suggested approach was assessed in accordance with ICH guidelines for linearity, accuracy, precision, robustness, detection, and quantitation limits. Linear relationship was achieved in the range of 0.50–10.00 μg/mL and 0.10–2.00 μg/mL for CANA and OXD, respectively with correlation coefficient 0.9999 for both components. The validated method was effectively utilized for the analysis of CANA in its pure form and drug tablets. The environmental sustainability of the suggested approach was evaluated and validated using various tools, including the analytical eco-scale, the Green Analytical Procedure Index (GAPI), and AGREE. Additional applications were employed to evaluate the ideas of 'blueness' and 'whiteness' through the newly developed Blue Applicability Grade Index (BAGI) and Red-Green-Blue 12 (RGB 12) algorithms. The elevated BAGI score (85) signified exceptional applicability, while the RGB12 score (92.2) verified the cost-effectiveness and sustainability of the used approach.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100436"},"PeriodicalIF":4.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water-stable, sensitive sensors based on lanthanoid ions and a V-shaped linker 4,4′-(hexafluoroisopropylidene)bis(benzoic acid) for the detection of the antibiotic sulfathiazole and potentially hazardous ions in polluted waters","authors":"Denitsa Elenkova,&nbsp;Magdalina Popova,&nbsp;Maria Milanova","doi":"10.1016/j.talo.2025.100434","DOIUrl":"10.1016/j.talo.2025.100434","url":null,"abstract":"<div><div>As long as metal-organic frames, MOFs, are known to possess properties such as good crystallinity, tunable pores, large surface area, they can be considered suitable for sensing of ions and organic molecules in waters. Powder samples with the composition ([Ln₂(FPB)₃]_∞ (Ln = Eu, Tb) and [Eu_0.2Tb_1.8(FPB)₃] are synthesized under solvothermal conditions to be tested as sensors; the fluorinated organic molecule 4,4′-(hexafluoroisopropylidene)bis(benzoic acid) (H₂FPB) is used as a linker. The structure of the synthesized materials is elucidated by powder X-ray diffraction combined with structure having similar composition. Based on the adsorption/desorption isotherms the specific surface area is determined; values of 281, 257, and 286 m²/g for [Eu₂(FPB)₃], [Tb₂(FPB)₃] and [Eu_0.2Tb_1.8(FPB)₃] are attained, important for the Ln-MOFs as sensory materials. By diffuse-reflectance UV–Vis spectroscopy the light absorption of the samples is elucidated as well as by photoluminescence spectroscopy the action of the samples in solid state and in water suspension is followed. The behavior of the samples in media with different acidity is studied showing their stability in acidic and basic solutions in the pH interval 4–9. The luminescence of Ln-MOFs in the presence of different ions and antibiotics is studied in order to evaluate the sensitivity of the samples. Highest sensitivity to the presence of the antibiotic sulfathiazole (SFT) and to the ions Fe (III), Ag (I), Cr (VI), MnO₄^-, C₂O₄^2-, and H₂PO₄^- is detected. The response of the Ln-MOFs to the quenchers SFT, H₂PO₄^- and Cr(III) and Cr (VI) is evaluated based on the Stern-Volmer constants. Both the static and dynamic quenching mechanism are taken into consideration but the static mechanism is evidenced by the Stern Volmer linear dependence of the lifetime by the concentration of the analyte.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100434"},"PeriodicalIF":4.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}