Talanta Open最新文献

{"title":"Intrinsic fluorescence in Moringa Oleifera seed extract","authors":"Namrah Azmi ,&nbsp;Sachin Rathod ,&nbsp;Bruno Telli Ceccato ,&nbsp;Rasmus Kranold Mikkelsen ,&nbsp;Jon Otto Fossum","doi":"10.1016/j.talo.2025.100500","DOIUrl":"10.1016/j.talo.2025.100500","url":null,"abstract":"<div><div>Autofluorescence, an intrinsic property of biological molecules that emit light upon excitation, is gaining significance as a noninvasive technique for studying plant-derived bioactive compounds. This phenomenon enables detection of biomolecules such as chlorophyll, lignin, flavonoids, and alkaloids without requiring external dyes or destructive extraction processes. Intrinsic fluorescence can also aid in detecting and identifying biomolecules that typically require extensive sample preparation (molecule labelling with external fluorophores), eliminating the need for external probes. The present study aims to report the intrinsic autofluorescence in the <em>Moringa Oleifera</em> plant, highlighting its potential to enhance noninvasive bioactive compound identification and quality assessment in plant-based products.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100500"},"PeriodicalIF":4.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of low-dimensional MoS2 as a smart nanoplatform for environmental technologies, therapeutic strategies, and biomedical sensing","authors":"Smriti Gaba,&nbsp;Mridul Sahu,&nbsp;Nidhi Chauhan,&nbsp;Utkarsh Jain","doi":"10.1016/j.talo.2025.100498","DOIUrl":"10.1016/j.talo.2025.100498","url":null,"abstract":"<div><div>As one of the representative layered transition metal dichalcogenides (LTMDC), molybdenum disulfide (MoS₂) has been widely researched as a promising nanoplatform for biomedicine as well as green technologies. The features of high surface-to-volume ratio, tunable bandgap, and good biocompatibility make it a promising candidate for therapeutic strategies, biomedical detection, and environmental applications. Low-dimensional MoS₂ has been widely investigated for drug delivery, bioimaging, photothermal therapy (PTT), photodynamic therapy (PDT), biosensing, and environmental innovations in the past few years, owing to its strong interaction with biomolecules and the cellular microenvironment. The utility of MoS₂ as an alternative to traditional nanomaterials has been assisted by various functionalization strategies to improve solubility, stability, and targeted applications. Moreover, MoS₂-based biosensors have demonstrated remarkable sensitivity for detecting biomolecules, pathogens, and disease-specific biomarkers that enable early and accurate disease diagnosis. This ability is critical to precision medicine, which allows for personalized treatment approaches, real-time health monitoring, and target activation or suppression of pathways based on a patient's biological profile. Additionally, it has become a beacon of environmental application innovation, providing long-term answers to urgent ecological problems. Because of special physicochemical characteristics, contaminants, including gases, organic compounds, heavy metals, and radionuclides, can be effectively removed from the environment, leading to cleaner air and water supplies. Nonetheless, industrial translation of MoS₂ requires the resolution of toxicity, long-term stability, and large-scale synthesis issues. This review aims to comprehensively discuss the recent development, biomedical and environmental applications, challenges, and future perspectives of low-dimensional MoS₂ in the field of next-generation sustainable technology.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100498"},"PeriodicalIF":4.1,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and fabrication of a rapid detection biosensor for Candida albicans diagnosis in a microfluidic platform","authors":"Shekoufeh Moradkhah ,&nbsp;Mohaddeseh Larypoor ,&nbsp;Abdollah Allahverdi","doi":"10.1016/j.talo.2025.100478","DOIUrl":"10.1016/j.talo.2025.100478","url":null,"abstract":"<div><div>Candida species are opportunistic fungi that can lead to a wide range of infections in humans, ranging from superficial to systemic. The diagnosis and treatment of Candida infections present significant challenges due to the diversity and resistance of these species, as well as the lack of rapid and sensitive detection methods. Microfluidics presents an opportunity to develop quick and highly sensitive diagnostic devices, enabling disease detection with minimal sample volumes. This study aimed to design and fabricate a microfluidic chip for the rapid and sensitive detection of <em>Candida albicans</em> in clinical samples. The dimensions of the chip were approximately 3.5 × 3.5 cm. The master chip was fabricated using soft lithography, and replicated in polydimethylsiloxane (PDMS), a biocompatible and transparent elastomer, which was treated with plasma to activate its surface. The study found that 150 samples (75 %) tested positive for Candida species, with <em>Candida albicans</em> being the most prevalent species at 58 %, followed by other non-albicans Candida species. Additionally, the study revealed that Candida infections were more common among women, young adults, the elderly, and patients with gastrointestinal diseases. The microfluidic chip demonstrated the ability to detect <em>Candida albicans</em> in clinical samples with a low detection limit of 10 CFU/mL. The study concluded that the microfluidic chip is a promising tool for diagnosing Candida infections in point-of-care settings and emphasized that Candida infections represent a common and diverse issue among patients.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100478"},"PeriodicalIF":4.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable biosensors in modern healthcare: Emerging trends and practical applications","authors":"Maumita Das Mukherjee ,&nbsp;Priyanshi Gupta ,&nbsp;Vanshika Kumari ,&nbsp;Ishika Rana ,&nbsp;Drishti Jindal ,&nbsp;Navya Sagar ,&nbsp;Jay Singh ,&nbsp;Chetna Dhand","doi":"10.1016/j.talo.2025.100486","DOIUrl":"10.1016/j.talo.2025.100486","url":null,"abstract":"<div><div>Wearable biosensor systems represent a significant breakthrough in the life sciences, offering real-time monitoring and quantitative assessment of various human health parameters. The escalating demand for continuous and immediate surveillance of both acute and chronic conditions, compounded by constraints in clinical infrastructure, has propelled extensive investigation into wearable biosensors. These systems have emerged as pivotal tools for furnishing physiological insights and facilitating non-invasive monitoring. They monitor various analytes through the analysis of sweat, epidermal, Interstitial fluids, breath and tears, and easily incorporated into flexible substrates ensuring long-term wear and continuous monitoring. However, these biosensors penetrate deeper into the body's fluid networks, providing a systemic approach to continuous monitoring of biomarkers, which is particularly useful for individuals with metabolic disorders. This comprehensive review explores recent trends and diverse applications of wearable biosensors. These applications empower individuals to dynamically assess their well-being, enabling informed healthcare decisions tailored to individual needs. The convergence of these approaches in wearable biosensors highlights a comprehensive approach to understand individual health. This integration holds the promise of transforming healthcare practice by providing continuous observance and remote monitoring. The result has been a paradigm shift towards active, personalized health care, leading to improved health outcomes and improved quality of life</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100486"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman spectroscopy as a rapid tool for monitoring lactic acid concentration during wine malolactic fermentation directly in the winery","authors":"Anna Lisa Gilioli ,&nbsp;Alessio Sacco ,&nbsp;Andrea Mario Giovannozzi ,&nbsp;Simone Giacosa ,&nbsp;Antonella Bosso ,&nbsp;Loretta Panero ,&nbsp;Silvia Raffaela Barera ,&nbsp;Stefano Messina ,&nbsp;Marco Lagori ,&nbsp;Silvia Motta ,&nbsp;Massimo Guaita ,&nbsp;Ettore Vittone ,&nbsp;Andrea Mario Rossi","doi":"10.1016/j.talo.2025.100494","DOIUrl":"10.1016/j.talo.2025.100494","url":null,"abstract":"<div><div>Lactic acid is mainly produced during the process of malolactic fermentation and evolution of its concentration is associated with the wine stabilization process and the quality of the final product. The quantitative analysis of lactic acid is carried out offline in the laboratory using various analytical techniques, the most used being high performance liquid chromatography (HPLC). Because of this, there is a clear demand in the winemaking community for analytical tools that allow real-time, fast and inexpensive quantification of lactic acid. An approach using Raman spectroscopy has positioned itself as a feasible alternative in this regard. The primary goal of this work is therefore to monitor the concentration of lactic acid (which changes rapidly during the malolactic fermentation process) in the analysed samples, specifically, Nebbiolo wine samples for making the Barolo wine. The collected Raman spectra using a portable Raman apparatus are processed using an algorithm that applies Partial Least Squares (PLS) regression to determine the lactic acid concentration for each sample. It proves to be a precise and reliable method that leads to the determination of a predictive model characterised by <span><math><mrow><msup><mrow><mi>R</mi></mrow><mn>2</mn></msup><mo>=</mo><mn>0.76</mn></mrow></math></span> (on the validation set), <span><math><mrow><msup><mrow><mi>R</mi></mrow><mn>2</mn></msup><mi>░</mi><mo>=</mo><mi>░</mi><mn>0.94</mn></mrow></math></span> (on the test set) and RMSE of the lactic acid concentration predicted by the model of 0.22 g/l (on the validation set) and 0.11 g/l (on the test set) respectively. This approach produces results comparable to those obtained via HPLC. Moreover, unlike the latter, it allows rapid and easy monitoring of the lactic acid concentration during fermentation directly in the winery.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100494"},"PeriodicalIF":4.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancements in microcystin detection: A comprehensive review of immunosensors and nucleic acid-based biosensors for efficient monitoring in drinking water and human samples","authors":"Anahas Perianaika Matharasi Antonyraj ,&nbsp;Prasannabalaji Nainangu ,&nbsp;Ayyakannu Sundaram Ganeshraja ,&nbsp;Ajay Guru ,&nbsp;Kumaran Subramanian ,&nbsp;Manju Dhakad Tanwar ,&nbsp;Vairavel Parimelazhagan ,&nbsp;A. Santhana Krishna Kumar","doi":"10.1016/j.talo.2025.100495","DOIUrl":"10.1016/j.talo.2025.100495","url":null,"abstract":"<div><div>Cyanobacteria produce harmful peptides called microcystins (MCs), which are a major concern for the public's health and the water supply. The safety of the water supply depends on the accurate identification of these toxins. A state-of-the-art immunosensor that immobilizes MC variants targeted by monoclonal antibodies onto nanostructured substrates allows for fast and selective detection of MC, as discussed in this review article. Incorporating nanomaterials such as gold nanoparticles and carbon nanotubes, the detector improves the effectiveness of the signal, allowing it to identify as low as 0.05 ppb with a response time of &lt;10 min. With its stable performance over time, this type of sensor is excellent for field deployment and ongoing surveillance. Miniaturizing the device, improving its multifaceted tracking capabilities, and testing it in real-world events are the main goals of future research. The integration of novel technologies and nanomaterials is highlighted in the review as an approach to enhance sensitivity, accessibility, and exchange of data in real-time. Miniaturized portable devices, enhancement of signals, and connection with the Internet of Things are highlighted as significant innovations in environmental monitoring and public health protection. To protect ecosystems and public health, next-generation biosensing technologies could decrease MC contamination in water bodies.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100495"},"PeriodicalIF":4.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond conventional sensing: A multifunctional benzothiazole-based fluorophore with ESIPT-AIE-ICT synergy for the ultrasensitive determination of tebuconazole in environmental samples","authors":"Asmaa Kamal El-Deen ,&nbsp;Galal Magdy ,&nbsp;Eslam A. Ghaith ,&nbsp;Yhiya Amen ,&nbsp;Ahmed R. Ali","doi":"10.1016/j.talo.2025.100493","DOIUrl":"10.1016/j.talo.2025.100493","url":null,"abstract":"<div><div>Herein, we designed a novel benzothiazole-based fluorophore that combines aggregation-induced emission (AIE), excited-state intramolecular proton transfer (ESIPT), and intramolecular charge transfer (ICT) mechanisms in the behavior of “kill three birds with one stone”. The synthesized fluorophore exhibits a high fluorescence quantum yield and a large Stokes shift (&gt; 200 nm) arising from the synergistic effect of the three mechanisms. This enables effective separation of excitation and emission wavelengths, thereby reducing spectral interference and enhancing precision. The synergistic effect of these mechanisms has been thoroughly investigated and utilized as a multifaceted framework for developing an efficient fluorescent probe capable of determining tebuconazole in environmental water and soil samples. The probe demonstrates remarkable fluorescence quenching in the presence of tebuconazole with outstanding sensitivity over a linear range of 0.32–26.0 µM and a low detection limit of 0.08 µM. Furthermore, the quenching mechanisms were investigated. Static quenching was favored, and theoretical simulation studies confirmed the interaction mechanism. This work elucidates the fluorescence mechanisms, providing an innovative approach for the development of advanced probes with enhanced sensitivity across various fields, such as environmental monitoring and chemical analysis.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100493"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fluorescent composite of europium metal organic framework with carbon dots for highly sensitive and specific detection of ciprofloxacin","authors":"Chetna Sharma ,&nbsp;Prakriti Sharda ,&nbsp;Neha Bhardwaj ,&nbsp;Vanish Kumar ,&nbsp;Jyotsana Mehta","doi":"10.1016/j.talo.2025.100490","DOIUrl":"10.1016/j.talo.2025.100490","url":null,"abstract":"<div><div>The excessive and non-judicious use of antibiotics contributes to the majority of pharmaceutical contaminants, leading to negative influence on the environment and human health. Therefore, it is crucial to develop detection techniques for antibiotic contamination that can produce a rapid, sensitive, and antibiotic-selective response in diverse samples. In this study, a novel composite of europium-based MOFs and red emissive carbon dots (RCDs) was synthesized for sensitive and selective fluorometric sensing of ciprofloxacin (CIP). The RCDs@Eu-BTE composite was characterized using different microscopic and spectroscopic techniques. Notably, the composite demonstrated intense fluorescence emission as compared to Eu-BTE and RCDs alone. The enhanced fluorescence of RCDs@Eu-BTE composite resulted in greater sensitivity towards CIP with a limit of detection (LOD) of 0.13 µg/L over a wide linear detection range (0.1–100 µg/L). Moreover, the prepared RCDs@Eu-BTE composite exhibited good stability, easy regeneration, and efficient reusability, indicating its potential as an effective fluorescence probe for analytical applications.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100490"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature-derived carbon dots for ratiometric analysis: Bismuth-doped fluorescent probe for oyster shell determination in tablet dosage forms","authors":"Mahmoud Hamed ,&nbsp;Noha Ibrahim ,&nbsp;Alaa Bedair ,&nbsp;Fotouh R. Mansour ,&nbsp;Samy Emara ,&nbsp;Walaa Zarad","doi":"10.1016/j.talo.2025.100492","DOIUrl":"10.1016/j.talo.2025.100492","url":null,"abstract":"<div><div>Wheat bran (WB), a major byproduct of the milling industry, is the most prevalent among various cereal bran residues. The substantial accumulation of WB biomass is driving the research community to seek innovative and economically viable applications for this bioresource. In this context, the potential for utilizing WB byproducts as nature-derived carbon quantum dots (n-CQDs) precursor has been highlighted. This research introduces an innovative, environmentally friendly, and effective WB-based n-CQDs (WB-n-CQDs) synthesized by microwave-assisted method. The developed WB-n-CQDs-based fluorescence probe, in combination with silver nitrate, demonstrates high sensitivity and selectivity for oyster shell calcium (OSC) quantification. The incorporation of bismuth oxide and folic acid as dopants effectively enhances the intensity of two emission peaks at 354 nm and 445 nm, thereby improving fluorescence ratiometric capabilities for measuring OSC. A variety of experimental techniques has been employed to investigate the structural, morphological, and optical characteristics of WB-n-CQDs, including Fourier-transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, fluorescence spectroscopy, UV–Vis spectroscopy, and high-resolution transmission electron microscopy. The experimental results demonstrated remarkable physical and chemical characteristics, highlighting the potential of WB-n-CQDs for their applications in green analytical chemistry. The fluorescence intensity of Ag-WB-n-CQDs demonstrated an acceptable linear correlation with OSC concentration levels ranging from 0.1 to 1.0 μg/mL, along with high recovery percentages that lie between 98 % and 102 %. The successful application of Ag-WB-n-CQDs for measuring OSC in its dosage forms demonstrates the promising potential of biomass-derived n-CQDs in sustainable and advanced sensing technologies.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100492"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Room-temperature upcycling of agricultural waste to carbon dots and its application as a selective fluorescence nanoprobe for iron (III) analysis in diverse samples","authors":"Heba M. Hashem ,&nbsp;Mahmoud El-Maghrabey ,&nbsp;Hadir Borg ,&nbsp;Galal Magdy ,&nbsp;Fathalla Belal ,&nbsp;Rania El-Shaheny","doi":"10.1016/j.talo.2025.100484","DOIUrl":"10.1016/j.talo.2025.100484","url":null,"abstract":"<div><div>A smart, green, practical, and scalable method has been developed for the upcycling of orange peels into carbon dots (C-dots) by room-temperature alkali treatment for the first time. The prepared C-dots showed excellent fluorescence emission at 428 nm upon excitation at 333 nm. As well, the C-dots exhibit high water stability and aqueous solubility, and a tiny particle size of 1.74 ± 0.44 nm. Based on the selective quenching of the synthesized C-dots fluorescence by Fe³⁺, a new fast and green fluorescence probe has been validated for the determination of Fe³⁺over the concentration range of 1.0–400.0 µM with a detection limit of 0.2 µM (11.2 ppb). The selectivity of the sensor has been established over various metal ions and insecticides. The developed sensor has been utilized for the determination of Fe³⁺ in different environmental water samples, such as river, irrigation, and tap water, with an excellent recovery % (99.08–108.24 %). Besides, the new probe has been applied for Fe³⁺ determination in ampoules with an average recovery % of 99.86±1.15. The environmental impact of the new method has been positively confirmed by ComplexGAPI and AGREE metrics. Furthermore, the method's blueness has been estimated by the blue applicability grade index (BAGI), and the obtained high score (70) demonstrates the high practicability of the method. The method whiteness has also been assessed by the RGB 12 algorithm, which gives a whiteness parameter of 92.5 that highlights its practicality, greenness, and analytical performance. Besides, the presented approach is the first to valorize agricultural waste by room-temperature treatment, a merit that opens the door for broad applications in limited-income laboratories.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100484"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}