Talanta Open最新文献

{"title":"Galvanic replacement synthesis of Cu@Zeolitic imidazolate framework-8 reinforced hollow fiber for hollow fiber solid-phase microextraction of diazinon and malathion followed by HPLC-UV determination","authors":"Zahra Doraghi ,&nbsp;Heshmatollah Alinezhad ,&nbsp;Milad Ghani","doi":"10.1016/j.talo.2025.100433","DOIUrl":"10.1016/j.talo.2025.100433","url":null,"abstract":"<div><div>This paper represents the synthesis of zinc-based metal-organic framework-8 by the solvothermal method followed by doping of copper (Cu) metal by the purely chemical galvanic replacement method in the synthesized ZIF-8 substrate. Subsequently, the Cu doped ZIF-8 was used as an adsorbent in the hollow fiber solid-phase microextraction (HF-SPME) method for the extraction and determination of organophosphorus pesticides (OPPs), especially diazinon and malathion, from real samples contentiously from tomato, cucumber, apple, and well water. Optimization was done through the Plackett-Burman design and Box-Behnken design. Limits of detection (LODs) of 0.29 µgL⁻¹ and 0.54 µgL⁻¹, while limits of quantification (LOQs) of 0.96 µgL⁻¹ and 1.79 µgL⁻¹ were recorded for diazinon and malathion, respectively. The linear dynamic ranges (LDRs) for both analytes were established as 1–200 µg L⁻¹ and 2–500 µg L⁻¹ with determination coefficients (R²) of 0.9953 for diazinon and 0.9968 for malathion, indicating excellent linearity. The enrichment factors (EFs) were determined to be 152 for diazinon and 146 for malathion. RSDs% were obtained in the range of 4.21 % - 5.78 % for intra-day and 3.53 % - 6.24 % for inter-day precision. The results obtained from the experiments indicate that the developed method has a significant ability to extract and analyze selected analytes in a wide range of real-world samples, which proves the effectiveness and reliability of the method.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100433"},"PeriodicalIF":4.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIP-based sensing strategies for the diagnosis of prostate and lung cancers","authors":"İnci Uludağ Anıl,&nbsp;Mustafa Kemal Sezgintürk","doi":"10.1016/j.talo.2025.100432","DOIUrl":"10.1016/j.talo.2025.100432","url":null,"abstract":"<div><div>Prostate and lung cancer are among the most prevalent and lethal forms of the disease, and, globally, cancer is a primary cause of mortality. Early diagnosis and the application of precise biomarkers are crucial for prolonging patient lifespan and enhancing quality of life. Molecularly imprinted polymers (MIPs) are synthetic substances capable of selectively identifying and binding specific target molecules. Besides their sensitivity to biomolecules, MIPs offer significant advantages in cancer biomarker detection due to their cost-effectiveness and flexible architectures. MIP-based biosensors designed for the detection of prostate and lung cancer-specific biomarkers provide unique solutions that enhance the diagnostic process and improve its accuracy. This study aims to assess the present state of MIP-based biosensors in the detection of biomarkers for prostate and lung cancer, as well as the potential opportunities provided by this technology. This study will present an overview of potential biomarkers for lung and prostate cancer, clarify the fundamental features of MIPs, and discuss their uses in MIP-based biosensors along with prospective future applications. In this context, our review is aimed to contribute to the development of innovative methods used in early cancer diagnosis.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100432"},"PeriodicalIF":4.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dummy template molecularly imprinted polymer-based sensors in analytical and bioanalytical applications","authors":"Alaa Bedair ,&nbsp;Mahmoud Hamed ,&nbsp;Mahmoud El Hassab ,&nbsp;Reham E. Kannouma ,&nbsp;Reda M. Abdelhameed ,&nbsp;Fotouh R. Mansour","doi":"10.1016/j.talo.2025.100431","DOIUrl":"10.1016/j.talo.2025.100431","url":null,"abstract":"<div><div>Molecular imprinting technology (MIT) is a method for the preparation of artificial receptors for a certain target molecule derived from synthetic polymers. The technique used in synthesizing the molecularly imprinted polymers (MIPs) results in the development of cavities that are properly matched to the exact structure, sizes, and functional groups of the targeted molecule. As a result, these MIPs are capable of specifically identifying the target molecules. In recent decades, it has been widely employed across various fields such as chromatography, antibody and receptor mimetics, solid-phase extraction, biosensors, and others. However, MIPs faced restrictions in selecting the template, mostly because of the insufficient safety and inadequate stability of the compound, making experimental procedures challenging. Furthermore, when utilizing the target analyte as the template, there is a possibility of template leakage or incomplete removal, leading to potential interference with the experimental outcomes. Consequently, the template molecule for MIT may not always be acceptable for direct utilization. The advent of the MIT dummy template offers a convenient and practical solution to prevent these scenarios. As a result, the dummy MIT (DMIT) has emerged as a promising approach. In this review, the roles of DMIT in sensing and biosensing are discussed.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100431"},"PeriodicalIF":4.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cutting-edge design of a novel electrochemical voltammetric nanosensor modified with molecularly imprinted polymer along with multi-walled carbon nanotubes for selective safinamide recognition","authors":"Engy A. Ibrahim ,&nbsp;Samah S. Saad ,&nbsp;Maha A. Hegazy ,&nbsp;Laila E. Abdel Fattah ,&nbsp;Hoda M. Marzouk","doi":"10.1016/j.talo.2025.100428","DOIUrl":"10.1016/j.talo.2025.100428","url":null,"abstract":"<div><div>Safinamide mesylate (SAF) is an innovative adjuvant treatment for managing wearing-off symptoms in Parkinson's disease (PD). Our novel approach involves the development of a differential pulse voltammetric (DPV) technique for SAF determination. This method utilizes a carbon nanocomposite paste electrode that is modified by a molecularly imprinted polymer (MIP) to serve as a recognition element for SAF. Additionally, multi-walled carbon nanotubes (MWCNTs) are incorporated to enhance the electrode's sensitivity. The MIP was subjected to a thorough characterization process, including analysis of rebinding, differential scanning calorimetry, field emission scanning electron microscopy, and Fourier-transform infrared spectroscopy. The cavities of the MIP recognize and bind to the medication, functioning as reliable host-tailored artificial receptors. The resulting modified electrode functions as a voltammetric sensor, enabling the nano detection of SAF. The fabricated MIP/MWCNTs-CPE demonstrates a linear range from 0.3 to 22.0 μg/mL and excellent sensitivity, with a limit of detection (LOD) of 0.079 μg/mL. According to ICH guidelines, the enhanced method has been validated for quality control testing on the pharmaceutical product and spiked human plasma. The proposed method was found to be practical, reliable, cost-effective, and efficient means of estimating the investigated drug. The method's sustainability was assessed by analyzing its scores for greenness, blueness, and whiteness. Therefore, this method has the potential to be a long-term, practical analytical tool for in vitro studies and quality control laboratories.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100428"},"PeriodicalIF":4.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-assisted synthesis of watercress-derived N,S-doped carbon dots for sensitive spectrofluorimetric determination of rifaximin antibiotic: Greenness, blueness, and whiteness assessment","authors":"Rehab H. Elattar ,&nbsp;Asmaa Kamal El-Deen ,&nbsp;Randa A. Abdel Salam ,&nbsp;Ghada M. Hadad ,&nbsp;Anmar Anwar Khan ,&nbsp;Galal Magdy","doi":"10.1016/j.talo.2025.100426","DOIUrl":"10.1016/j.talo.2025.100426","url":null,"abstract":"<div><div>A rapid microwave-assisted method was developed for synthesizing watercress-derived nitrogen and sulfur carbon dots (N,S-CDs) in just one minute using thiourea as a nitrogen and sulfur source and watercress as a green carbon source. Different spectroscopic and microscopic techniques were used to characterize the N,S-CDs. The synthesized N,S-CDs exhibited maximum fluorescence emission at 386 nm after being excited at 320 nm. Rifaximin (RFX) could quench the native fluorescence of the N,S-CDs quantitatively based on the inner filter effect (IFE) and static quenching mechanisms. The results revealed a good linearity over the range of 0.2–30.0 µg/mL, with a correlation coefficient of 0.9996. The developed method demonstrated excellent accuracy, with recovery values between 99.16 % and 99.97 %, and good precision, as the %RSD values were ≤ 1.3 % for both intra-day and inter-day precision. The detection and quantitation limits were found to be 0.06 µg/mL and 0.19 µg/mL, respectively. The method was successfully applied for determining RFX in its tablets with high selectivity. The developed method produced comparable results to those obtained by the published HPLC method in terms of precision and accuracy. Finally, the developed method demonstrated excellent green, blue, and white characteristics based on the results obtained <em>via</em> the analytical Eco-scale, AGREE, MoGAPI, BAGI, and RGB12 tools. The suggested method offers a sensitive, fast, and eco-friendly spectrofluorimetric methodology for estimating the RFX without requiring hazardous organic solvents or complicated equipment.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100426"},"PeriodicalIF":4.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-reverse-signal ratiometric fluorescence probe for residual determination of chlorpyrifos pesticide in surface water based on scalable upcycling of rice straw to luminescent CQDs via energy-efficient alkali treatment","authors":"Rania El-Shaheny ,&nbsp;Lateefa Al-Khateeb ,&nbsp;Mahmoud El-Maghrabey ,&nbsp;Galal Magdy ,&nbsp;Heba M. Hashem","doi":"10.1016/j.talo.2025.100427","DOIUrl":"10.1016/j.talo.2025.100427","url":null,"abstract":"<div><div>A smart, green, practical, and simple method has been developed for the preparation of blue emissive carbon dots (RS-CDs). The developed synthesis protocol is accomplished at room temperature via an instrument-free approach using the alkali treatment of rice straw. The furnished RS-CDs were thoroughly characterized via transmission electron microscopy, energy-dispersive X-ray spectrometry, x-ray photoelectron spectroscopy, UV-Vis, and fluorescence spectroscopy. The RS-CDs exhibited excellent performance as a double-response-reverse type ratiometric fluorescence probe for the widely used insecticide chlorpyrifos. By systematically investigating and optimizing the experimental conditions, a new sensitive and accurate RS-CDs-based ratiometric fluorescence probe was constructed, taking advantage of the simultaneous decrease of emission intensity at 396 nm and increase of a new emission peak at 340 nm upon adding chlorpyrifos. The ratio of fluorescence intensity at 340 and 396 nm (F_340/396) showed excellent correlation to chlorpyrifos concentration over the range of 7.1 – 142.4 µM with a detection limit of 2.3 µM. Excellent recovery percentages have been obtained for chlorpyrifos in tap, river, and irrigation water, 102.24 ± 1.52, 104.33 ± 1.79, and 100.43 ± 2.51 %, respectively. The presented approach is the first to convert agricultural waste into nanomaterial by room temperature treatment. Boosting the value of rice straw via upcycling to luminescent CDs is one of the things that helps sustain the practice in limited-income labs. The environmental impact, greenness, practicality, economical, and analytical attributes of the developed method have been positively confirmed by different recent metrics.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100427"},"PeriodicalIF":4.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of eco-friendly sensitive HPLC method for determination of Letrozole and assessment of validation","authors":"Hayam Mahmoud Lotfy ,&nbsp;Asena Ayse Genc ,&nbsp;M. Soner Bay ,&nbsp;Gizem Tiris ,&nbsp;Reem H. Obaydo ,&nbsp;Nevin Erk","doi":"10.1016/j.talo.2025.100425","DOIUrl":"10.1016/j.talo.2025.100425","url":null,"abstract":"<div><div>The greening of analytical methods has gained interest in the field of quantitative analysis to reduce environmental impact and improve analyst's safety and health. For postmenopausal women with hormone-responsive advanced breast cancer, Letrozole (LTZ) has been a standard first-line endocrine therapy A green HPLC method was developed, optimized, validated, and applied for quantification of the LTZ in tablets. Experiments were conducted on the Inertsil ODS- 3® C18 (5 µm, 150 × 4.6 mm). An isocratic elution was applied using a mobile phase consisting of ethanol: water (50:50, v/v). A wavelength of 230.0 nm was chosen for the analysis. An experiment was finished 3.0 mins. Calibration graphs for each drug were rectilinear in the range of 0.1 – 40.0 µg/mL. Validation studies were carried out based on International Conference on Harmonization (ICH) recommendations. The student (t) test for means and the (F) test for standard deviations were used to compare the results. In this study, we utilized the ChlorTox Scale, Greenness Index, AGREE, GAPI, and NQS Indicator to comprehensively evaluate the environmental, safety, and sustainability aspects of analytical methodology, aligning our approach with the United Nations Sustainable Development Goals (SDGs). It can be applied to quality control, bioequivalence studies, and routine analysis.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100425"},"PeriodicalIF":4.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143553000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of polypyrrole deposition time on QCM sensitivity as aspergillus niger spore sensor","authors":"Yudyanto ,&nbsp;Masruroh ,&nbsp;Dionysius J.D.H. Santjojo ,&nbsp;Arinto Yudi Ponco Wardoyo","doi":"10.1016/j.talo.2025.100422","DOIUrl":"10.1016/j.talo.2025.100422","url":null,"abstract":"<div><div>The receptor layer on Quartz Crystal Microbalance (QCM) is vital in capturing analytes. We investigated how the morphology of the layer produced from polypyrrole (PPy) evaporated by vacuum thermal evaporator technique with varying deposition time on the porosity, wettability, and sensitivity of QCM as a sensor for <em>Aspergillus niger</em> (<em>A. niger</em>) spores. The morphology of the layer was observed using a Field Emission Scanning Electron Microscope (FESEM), porosity was taken from the results of the layer morphology analysis, wettability was taken from the measurement of the water contact angle with the layer surface, and sensitivity was obtained from the average gradient of the curve during changes in measurement frequency. The results show significant changes in these parameters with increasing deposition time. The morphology of the layer changes and the dimensions of the width and height of the platelets increase so that larger empty spaces between the platelets are created. Porosity increases from 56.43 to 71.11 % along with increasing deposition time from 10 to 50 s, and wettability also increases, which is marked by a decrease in the water contact angle from 51.49 to 30.83°. Sensitivity increases from 18.6 to 89.6 Hz/s due to the larger contact surface between the layer surface and the spores. The results of this study can be used as a reference in developing the addition of other materials with PPy matrix materials for appropriate analyte substances.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100422"},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An improved sampling system for atmospheric mercury in remote areas","authors":"Teodor D. Andron ,&nbsp;Matthew A. Dexter ,&nbsp;Tony Rogers ,&nbsp;Warren T. Corns","doi":"10.1016/j.talo.2025.100424","DOIUrl":"10.1016/j.talo.2025.100424","url":null,"abstract":"<div><div>Monitoring atmospheric pollutants requires robust sampling and determination methods. Trace pollutants often necessitate prolonged sampling with pre-concentration, demanding careful management to maintain sampling integrity, stable flow, and accurate volume measurements. Certified flow devices and pumps can ensure stability, but in remote areas, challenges arise: availability of stable power, battery-operated equipment may run out of power during extended sampling, and flow accuracy can be compromised by power fluctuations or interruptions, common in battery-powered systems. In such situations, atmospheric passive samplers, which use a sorbent material and do not rely on active extraction, are an alternative. However, they face calibration issues in field conditions, and atmospheric factors like temperature, pressure, and humidity influence the sampling rate, leading to high uncertainty in uptake rates. Long periods are needed to achieve sufficient mass loadings due to low uptake rates. A new remote sampling system is proposed using an intelligent solar battery-powered pump for prolonged sampling. This system's key advantage is obtaining an accurate sampling volume via a datalogger that constantly records the flowrate. Two systems were tested in parallel for atmospheric mercury (Hg) sampling on gold Amasil™ Traps, verified by comparing with mains-powered mass-flow controllers (MFCs) and pumps, and online automated atmospheric Hg analysis. Indoor and outdoor sampling yielded comparable results. The combined uncertainty for determining atmospheric Hg via atomic fluorescence spectrometry (AFS) was under 5 % (<em>k</em> = 2) using the new system. The contribution of sampling volume determination to the overall uncertainty was under 1 %, which is a significant improvement over passive sampler devices. With the ability to back-calculate flowrate at any point, the final volume is more accurate compared to current remote sampling systems without electrical facilities. Volume loadings are significantly greater than passive samplers, providing improved time resolution for data and lower detection limits.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100424"},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrafast microwave-assisted green synthesis of nitrogen-doped carbon dots as turn-off fluorescent nanosensors for determination of the anticancer nintedanib: Monitoring of environmental water samples","authors":"Galal Magdy ,&nbsp;Asmaa Kamal El-Deen ,&nbsp;Aya Saad Radwan ,&nbsp;Fathalla Belal ,&nbsp;Heba Elmansi","doi":"10.1016/j.talo.2025.100423","DOIUrl":"10.1016/j.talo.2025.100423","url":null,"abstract":"<div><div>This study unveils a swift and sustainable approach for the synthesis of nitrogen-doped carbon quantum dots (N-CQDs) from radish leaves and urea, conducted by microwave assistance within only 50 seconds, showcasing remarkable efficiency. Comprehensive characterization confirmed the distinctive optical properties of the N-CQDs, with a quantum yield of 19.76 %, highlighting their potential as fluorescent nanosensors. The N-CQDs exhibit turn-off fluorescence properties for sensing the anticancer drug nintedanib in different environmental water samples, including hospital discharge water, sewage water, tap water, and river water. The method exhibits excellent linearity within a concentration range of 1.0–20.0 µg/mL, with a correlation coefficient exceeding 0.999 and a low detection limit down to 0.14 μg/mL. The assay of nintedanib in various environmental water samples demonstrated the applicability and sensitivity of the N-CQDs as a detection platform. The ComplexMoGAPI, AGREE, and Green Certificate-modified Eco-Scale metrics demonstrated the method's exceptional eco-friendliness and sustainability. Additionally, the BAGI tool was employed to assess the method's economic viability, applicability, and practicality. All the tools demonstrated the sustainability and feasibility of the developed approach, as well as its appropriateness for the routine analysis of the examined drug. This work is considered the first spectrofluorimetric approach for the analysis of nintedanib. This innovative study also paves the way for eco-friendly nanosensors with diverse applications in environmental monitoring.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100423"},"PeriodicalIF":4.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}