Talanta Open最新文献

{"title":"Multiplex detection of meningitis pathogens by a vertical flow paper microarray and signal enhancement suitable for low-resource settings: Proof of concept","authors":"Pedro Réu ,&nbsp;Giulia Gaudenzi ,&nbsp;Deborah Nanjebe ,&nbsp;Gustav Svedberg ,&nbsp;Dan Nyehangane ,&nbsp;Miren Urrutia Iturritza ,&nbsp;Phuthumani Mlotshwa ,&nbsp;Chris Hadjineophytou ,&nbsp;Jens Karlsson ,&nbsp;Jesper Gantelius ,&nbsp;Juliet Mwanga-Amumpaire ,&nbsp;Edmund Loh ,&nbsp;Helene Andersson Svahn ,&nbsp;Elias Kumbakumba ,&nbsp;Tobias Alfvén ,&nbsp;Yap Boum II ,&nbsp;Aman Russom","doi":"10.1016/j.talo.2024.100357","DOIUrl":"10.1016/j.talo.2024.100357","url":null,"abstract":"<div><h3>Objectives</h3><p>Meningitis is a medical emergency, and it is crucial to diagnose it accurately and promptly in order to manage patients effectively. It would, therefore, be essential to introduce and have fast, accurate, and user-friendly methods to determine the cause of these infections. This study aimed to demonstrate a potentially cost-effective new approach for detecting meningitis using a paper-based vertical flow microarray, which could be useful in settings with limited resources.</p></div><div><h3>Methods</h3><p>We describe a multiplex paper microarray for detecting <em>Neisseria meningitidis, Haemophilus influenzae, Streptococcus pneumoniae</em>, and <em>Salmonella</em> spp. by the passive vertical flow of PCR-amplified clinical samples. A multibiotinylated amplicon was obtained as a product of PCR in the presence of both a biotinylated primer and biotin-11-dUTP. An enhancement step based on an enzyme-free gold enhancement protocol was also used to facilitate visual detection.</p></div><div><h3>Results</h3><p>This study showed that the vertical flow microarray (previously evaluated for one pathogen) can discriminately detect the amplification results down to the 10² copies of DNA limit for four meningitis pathogens in a multiplexed set-up. The study further demonstrated the ability of this device and setup to detect three of the four pathogens from clinical biosamples.</p></div><div><h3>Discussion</h3><p>This study demonstrated the capacity of a vertical flow microarray device to detect amplification products for four prevalent meningitis pathogens in a multiplex format. The vertical flow microarray demonstrated consistent visualization of the expected gene amplification results; however, indicating limitations in the pre- and amplification steps. This study highlights the potential of this multiplexing method for diagnosing meningitis and other syndromic diseases caused by various pathogens, especially in resource-limited areas.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100357"},"PeriodicalIF":4.1,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000717/pdfft?md5=95c976abd77a047beb9b9d2bfa54c603&pid=1-s2.0-S2666831924000717-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affordable droplet-based flow analyzer with peristaltic micro-pumps for fluorescent ammonium sensing","authors":"Mingtao Sun ,&nbsp;Yiyu Jiang ,&nbsp;Wenshan Liang,&nbsp;Hui Zeng,&nbsp;Huiwen Chen,&nbsp;Min Zhang","doi":"10.1016/j.talo.2024.100356","DOIUrl":"10.1016/j.talo.2024.100356","url":null,"abstract":"<div><div>An affordable droplet-based flow analyzer incorporating peristaltic micro-pumps has been developed for fluorescent ammonium sensing. The cost-effective peristaltic micro-pumps, modified using 3D-printing techniques, feature a 3D-printed pump base integrated with a Hall sensor to monitor the rotation of the pump motor. This setup generates a pulse flow instead of a continuous flow, delivering specific volumes (typically between 3 to 4 μL) of solution with each rotation. By using separate pumps to deliver the aqueous and oil phases, these phases merge to form a droplet flowing stream. The relative standard deviation (RSD) values for droplet volumes range from 3.97 % to 5.99 % (<em>n</em>=50) across different pumps. The analyzer utilizes a reaction between ammonium, ortho-phthalaldehyde, and sulfite to produce a fluorescent derivative, allowing for sensitive detection of low ammonium concentrations. A custom light-emitting diode (LED)-based fluorescence detector has been fabricated using 3D printing, ensuring cost-effective production. The analyzer provides a limit of detection of 0.02 μM (3<em>σ</em>) and an RSD of 0.15 % (<em>n</em>=10, 1 μM ammonium). This analyzer offers several practical advantages, including reduced reagent consumption and the potential for further development in distributed on-site analysis. The use of 3D printing facilitates rapid prototyping and customization, making the system adaptable to various analytical applications.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100356"},"PeriodicalIF":4.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000705/pdfft?md5=a87ae00c806aac22591c7aa4fe59acd8&pid=1-s2.0-S2666831924000705-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of spectrophotometric methods for estimation of arrhythmias drug-dronedarone hydrochloride in pure and dosage forms","authors":"Ragaa El Sheikh ,&nbsp;Ayman A. Gouda ,&nbsp;Ahmed A. Ghazy ,&nbsp;Nesma M. Jumaa ,&nbsp;Noha E.M. Elsaify ,&nbsp;Nehal S.A. Soliman ,&nbsp;Asmaa El Sayed ,&nbsp;Ahmed H. Moustafa ,&nbsp;Ahmad O. Babalghith ,&nbsp;Ahmed El Sayed ,&nbsp;Al-Sayed M．Abd El-Majeed","doi":"10.1016/j.talo.2024.100355","DOIUrl":"10.1016/j.talo.2024.100355","url":null,"abstract":"<div><p>Sensitive, simple, and accurate spectrophotometric methods have been developed for the assay of arrhythmias drug-dronedarone hydrochloride (DND) in bulk drug and pharmaceutical formulations. The proposed method is based on the oxidation reaction of DND with a known excess of cerium(IV) ammonium sulfate (Ce(IV)) as an oxidizing agent in acid medium, followed by the determination of the unreacted oxidant by adding a fixed amount of dye, e.g., amaranth (AM), methylene blue (MB), and indigocarmine (IC), followed by measuring the absorbance at 520, 664, and 610 nm, respectively. The effects of experimental conditions were studied and optimized. The beer's law was obeyed in the concentration ranges of 1.0–10, 1.0–15, and 1.0–8.0 μg mL^-1 using AM, MB, and IC dyes, respectively, with a correlation coefficient ≥ 0.9992. The calculated molar absorptivity values are 3.6527 × 10⁴, 3.1212 × 10⁴, and 4.229 × 10⁴ L mol^-1 cm^-1 using AM, MB, and IC dyes, respectively. The limits of detection and quantification were 0.30 and 1.0 µg mL^-1, respectively, for the three methods. Intra-day and inter-day accuracy and precision of the methods have been evaluated. No interference was observed from the additives. The proposed methods were successfully applied to the assay of DND in tablet preparations and the results were statistically compared with those of the reported method by applying Student's <em>t</em>-test and F-test. The reliability of the methods was further ascertained by performing recovery studies using the standard addition method.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100355"},"PeriodicalIF":4.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000699/pdfft?md5=f8ecd77d8a8d7d158b1cb91bf04e548c&pid=1-s2.0-S2666831924000699-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakthroughs in nanostructured-based chemical sensors for the detection of toxic metals","authors":"Tinsae F. Gezahegn ,&nbsp;Abera D. Ambaye ,&nbsp;Tewolde M. Mekoyete ,&nbsp;Mope E. Malefane ,&nbsp;Kabir O. Oyedotun ,&nbsp;Touhami Mokrani","doi":"10.1016/j.talo.2024.100354","DOIUrl":"10.1016/j.talo.2024.100354","url":null,"abstract":"<div><p>Globally, trace metals toxicity in wastewater poses health problems for humans even at truncated concentrations and warrants investigation. This review study focuses on the suitable cutting-edge advancements in nanotechnology-based electrochemical sensor technology for the apprehension of selected toxic metal ions such as arsenic(As), cadmium(Cd), chromium(Cr), lead(Pb), and uranium(Ur)) in wastewater samples. The discussion includes an examination of synthesis techniques for sensors based on Nanomaterials (NMs). Moreover, these electrochemical sensors are scrutinized to study the complex principles that describe their problem solving achievement, such as susceptibility, determination limit, duplicability, repeatability, and selectivity in wastewater matrices for trace metal detection. Most importantly, the discussion also considers the interactions between NMs, electrochemistry, and sensing mechanisms, providing a comprehensive view of the cooperative developments promoting improved advanced sensor technology. This review critically investigates the existing literature to assess and capture the progress landscape of nano-based electrochemical sensors. Ultimately, this review paper could significantly play a role towards the use of these attractive nano-based electrode materials in revamping paradigms for environmental monitoring and advancing precision in trace metal sensing in wastewater.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100354"},"PeriodicalIF":4.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000687/pdfft?md5=6c2d0fa9625d1952a188323616280d29&pid=1-s2.0-S2666831924000687-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools","authors":"Gabriel S. Gerlero ,&nbsp;Zahar I. Guerenstein ,&nbsp;Nicolás Franck ,&nbsp;Claudio L.A. Berli ,&nbsp;Pablo A. Kler","doi":"10.1016/j.talo.2024.100350","DOIUrl":"10.1016/j.talo.2024.100350","url":null,"abstract":"<div><p>Paper-based microfluidics has emerged as a promising field with diverse applications ranging from medical diagnostics to environmental monitoring. Despite significant progress in research and development, the translation of paper-based prototypes into practical end-user devices remains limited. This limitation stems from challenges related to devices not being sufficiently portable and autonomous, which paper-based microfluidics is expected to overcome. Yet for this purpose, we note the lack of comprehensive numerical modeling tools capable of simulating the intricate physicochemical phenomena involved in order to optimize the development process; hence, in this study, we introduce porousMicroTransport, a novel simulation package integrated with the open-source platform OpenFOAM®, designed to address these challenges. porousMicroTransport offers efficient solvers for fluid flow and transport phenomena in microfluidic porous media, including capillarity models and (bio)chemical reactions. Moreover, under horizontal flow conditions, porousMicroTransport application field can be extended to any porous media. We demonstrate the software’s effectiveness in two example cases, showcasing its ability to accurately reproduce complex phenomena involved in paper-based devices. By virtue of being an easy-to-use and computationally efficient tool, porousMicroTransport facilitates the design and optimization of devices, potentially enabling more devices to meet the WHO’s REASSURED criteria for point-of-care testing. We anticipate that this tool will accelerate the development and deployment of robust and portable diagnostic devices, bridging the gap between research and practical applications.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100350"},"PeriodicalIF":4.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266683192400064X/pdfft?md5=dc46e726f88d337b167a640b51aad49b&pid=1-s2.0-S266683192400064X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of nanomolecular platform based immunosensor for non-invasive electrochemical detection of oral cancer: An in vitro study","authors":"Meenakshi Choudhary ,&nbsp;Vinay Kumar ,&nbsp;Ashik Babu Parambath ,&nbsp;Shruti Caplash ,&nbsp;Birendra Kumar Yadav ,&nbsp;Satbir Kaur ,&nbsp;Sapna Ratan Shah ,&nbsp;Kavita Arora","doi":"10.1016/j.talo.2024.100352","DOIUrl":"10.1016/j.talo.2024.100352","url":null,"abstract":"<div><p>Silver nanoparticles (AgNPs)-Chitosan (Chi) functionalized cysteine (cys)-SAM (self-assembled monolayer) based electrochemical, label free, ultrasensitive, non-invasive immunosensing nanomolecular platform has been fabricated for the detection of novel OC biomarker S-100. This has been achieved through bio-functionalization of AgNPs-Chi/cys/mini gold slides by covalent immobilization of anti-S100 antibodies. Cyclic voltammetric (CV) studies establish successful fabrication of anti-S100/AgNPs-Chi/Au nanomolecular platform. Differential pulse voltammetric (DPV) measurements reveal that anti-S100/Chi-AgNPs/Au is able to sense 50 fg mL^-1 – 500 ng mL^-1 of S100 in buffer and in spiked saliva samples within 120 s interaction time having improved favorable shelf life and specificity. The fabricated platform is very selective and able to detect S100 in OC patient/s saliva samples warrants realization of simple non-invasive electrochemical immunosensor for <em>in situ</em> or <em>on-site</em> applications (especially for remote areas) for early diagnosis of OC while offering bio-compatibility at low cost.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100352"},"PeriodicalIF":4.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000663/pdfft?md5=3345a9daaf0246157a50c3f630bbc45e&pid=1-s2.0-S2666831924000663-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatible bright orange emissive carbon dots: Multifunctional nanoprobes for highly specific sensing toxic Cr(VI) ions and mitochondrial targeting cancer cell imaging","authors":"Ramar Rajamanikandan ,&nbsp;D.S. Prabakaran ,&nbsp;Kandasamy Sasikumar ,&nbsp;Joo Seon Seok ,&nbsp;Gyeongchan Lee ,&nbsp;Heongkyu Ju","doi":"10.1016/j.talo.2024.100353","DOIUrl":"10.1016/j.talo.2024.100353","url":null,"abstract":"<div><p>Although several luminescent-based nanostructured materials are used as cellular imaging probes, creating a biocompatible subcellular imaging probe can be challenging. Instantaneously, it is crucial and urgently needed for certain fluorescent nanoprobes to identify possibly harmful heavy metal ions. We present a straightforward one-pot preparation of bright orange emissive (quantum yield approximately 16 %) Nitrogen/Sulfur co-doped carbon dots (N/S CDs) from citric acid and methylene blue as raw materials that will serve as a specific Cr(VI) ions sensor and an effective mitochondrial labeling in cancer cells. They had several benefits including low ecological impact, facile synthesis, good water solubility, photostability, and high stability. We found that N/S CDs photoluminescence (PL) could be reduced when Cr(VI) ions were present near them, and the PL reduction occurred highly sensitively to the presence of Cr(VI) compared to other metal ions including Cr(III) ions. This specific reduction of PL was due to the non-fluorescent complex formation through the inner filter effect (IFE). The established fluorescence-based sensing technique could serve for Cr(VI) ion quantification with exceptional sensing efficiency in the wide linear range of 7 to 70 μM (R₂ = 0.9873), with the limit of detection of 53.5 nM. It was also revealed that the current fluorescent probe could be encouragingly utilized to quantify the concentration of Cr(VI) ions in various water specimens such as tap water. In addition, they were shown to function as a mitochondria-targeting nanoprobe in human cancer cells (ME 180 cells and Hela cells) for cell imaging. Concludingly, it was envisioned that these fluorescent nanoprobes could find a use in real-time monitoring of Cr(VI) ions in water-based ecosystems with ultrahigh sensitivity and cell image tracking via mitochondria labeling as biocompatible nanoprobes.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100353"},"PeriodicalIF":4.1,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000675/pdfft?md5=d0503f24a32f487fc15d84b207254078&pid=1-s2.0-S2666831924000675-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and preparation of a fluorescent molecularly imprinted membrane for the selective detection of pepsin enzyme as a biomarker for gastroesophageal reflux disease","authors":"Aya M. Mostafa ,&nbsp;Stephen J. Barton ,&nbsp;Stephen P. Wren ,&nbsp;James Barker","doi":"10.1016/j.talo.2024.100351","DOIUrl":"10.1016/j.talo.2024.100351","url":null,"abstract":"<div><p>A novel fluorescent molecularly imprinted polymer membrane (FMIM) has been developed for the selective binding and qualitative detection of pepsin enzyme, a biomarker indicative of gastroesophageal reflux disease (GERD). This study utilises the high selectivity offered by molecular imprinting techniques to capture pepsin enzyme within complex biological matrices, such as human saliva. Additionally, fluorescent carbon dots integrated into the membrane matrix provide instant visual detection of pepsin. Various combinations of functional monomers and cross-linkers were systematically evaluated to investigate their impact on the binding capacity and mechanical stability of the resultant FMIMs. The optimum performance was achieved with a mixture of two hydrophilic monomers, namely N-(hydroxymethyl)acrylamide and acrylamide, in conjunction with N,N-methylenebis(acrylamide) as the cross-linking agent. The developed FMIM demonstrated a binding capacity of 21.56 mg g^-1, surpassing that of the fluorescent non-imprinted membrane (FNIM) at 8.49 mg g^-1. Moreover, the binding of FMIM to pepsin was tested against other competitor enzymes to verify its selectivity. Furthermore, comprehensive characterisation of both FMIM and FNIM was conducted using various analytical techniques to ensure their structural integrity and functionality. Ultimately, the developed FMIM exhibited effective binding of pepsin in standard solutions and samples, enabling enrichment and visual detection of the biomarker enzyme.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100351"},"PeriodicalIF":4.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000651/pdfft?md5=d46e3457559ceeeb6eae97f84e8b3175&pid=1-s2.0-S2666831924000651-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cannabis product mislabeling: The development of a unified cannabinoid LC-MS/MS method to analyze e-liquids and edible products","authors":"Ashleigh E. Outhous ,&nbsp;Alaina K. Holt ,&nbsp;Justin L. Poklis ,&nbsp;Michelle R. Peace","doi":"10.1016/j.talo.2024.100349","DOIUrl":"10.1016/j.talo.2024.100349","url":null,"abstract":"<div><p>The 2018 Agricultural Improvement Act federally legalized the cultivation of hemp and manufacture and sale of cannabidiol (CBD). The overproduction of CBD led to a significant drop in price. To maintain profitability, manufacturers began producing synthetic and semi-synthetic cannabinoids, marketing them as “legal” and “hemp-derived” due to their synthesis from CBD. The cannabis industry is adaptable, and laboratories have struggled to keep up with the rapid emergence of new compounds. This has resulted in products with unlabeled or mislabeled cannabinoids, causing unexpected adverse events. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the separation and quantitation of 21 cannabinoids. The method was applied in the analysis of 55 commercially available products. Results demonstrate significant issues with quality assurance and labeling in the unregulated cannabis market. Many products either did not contain the cannabinoids listed on their labels or contained cannabinoids that were not listed. When cannabinoids were present, their concentrations were often incorrect, with some products showing high concentrations that could pose a potential health risk. Moreover, safety, dosing, and other pharmacological data of these newly proliferated cannabinoids are lacking. Reports of adverse events are increasing to poison controls centers and emergency departments following cannabis product use. Often, the actual cannabinoids involved in the case reprots are not determined. It is critical to develop more comprehensive testing methodologies to determine the content of cannabis products and to implement stronger quality assurance measures and regulations to protect the public from low-quality and potentially dangerous products.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100349"},"PeriodicalIF":4.1,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000638/pdfft?md5=b1f10099a40bdac5e2d1478636d29b2a&pid=1-s2.0-S2666831924000638-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon quantum dots from natural sources as sustainable probes for metal ion sensing: Preparation, characterizations and applications","authors":"Mahmoud Hamed ,&nbsp;Sampath Chinnam ,&nbsp;Alaa Bedair ,&nbsp;Samy Emara ,&nbsp;Fotouh R. Mansour","doi":"10.1016/j.talo.2024.100348","DOIUrl":"10.1016/j.talo.2024.100348","url":null,"abstract":"<div><p>Carbon Quantum Dots from Natural Sources (NACQDs) is a novel type of carbon-based material that have garnered significant attention due to their remarkable features, including luminescence, photostability, nanoscale size, water solubility, low toxicity, biocompatibility, and cost-effectiveness. The synthesis of NACQDs involves a diverse range of natural sources, such as fruits, foods, beverages, human and animal derivatives, vegetables, leaves, and waste materials. Various synthesis methods, including electrochemical approach, chemical oxidation, hydrothermal carbonization, ultrasonic techniques, microwave-assisted synthesis, solvothermal method, laser ablation technique, thermolysis, and atmospheric plasma-based synthesis, have been explored to tailor the size and properties of NACQDs. Characterization techniques like Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TЕM), ultraviolet absorption, fluorescence properties, and nuclear magnetic resonance (NMR) have provided invaluable insights into the physical and chemical characteristics of NACQDs. This review highlights the immense potential of NACQDs in metal ion sensing applications and underscores the need for further investigation to enhance their reproducibility and precise control over their properties. NACQDs hold great promise as versatile nanomaterials for metal ion sensing and are poised to revolutionize diverse fields, ranging from environmental monitoring to biomedical diagnostics and chemical analysis.</p></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100348"},"PeriodicalIF":4.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666831924000626/pdfft?md5=f9018681d4c644fae4710683a18e546f&pid=1-s2.0-S2666831924000626-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}