Marmara Medical Journal最新文献_第3页

Evaluation of pulmonary artery stiffness in patients with systemic sclerosis 系统性硬化症患者肺动脉僵硬度的评价

Marmara Medical Journal Pub Date : 2023-09-15 DOI: 10.5472/marumj.1378484

Dursun AKASLAN, Murat DEMİRCİ

引用次数: 0

Acute ECG changes and post-COVID arrhythmia incidence in patients with acute COVID-19 infection 急性COVID-19感染患者的急性心电图变化及术后心律失常发生率

Marmara Medical Journal Pub Date : 2023-09-06 DOI: 10.5472/marumj.1378494

Zekeriya DOĞAN, Çiğdem İLERİ

{"title":"Acute ECG changes and post-COVID arrhythmia incidence in patients with acute COVID-19 infection","authors":"Zekeriya DOĞAN, Çiğdem İLERİ","doi":"10.5472/marumj.1378494","DOIUrl":"https://doi.org/10.5472/marumj.1378494","url":null,"abstract":"Objective: During the COVID-19 pandemic, many patients have experienced cardiovascular complications, including a variety of arrhythmias. The aim of our study was to evaluate the acute electrocardiography (ECG) changes and post-COVID arrhythmia incidence in patients with acute COVID-19 infection. Patients and Methods: One hundred hospitalized COVID-19 patients were consecutively included. Patients were divided into two groups according to their troponin levels. Thirty subjects were included as controls. All patients underwent daily 12-lead ECG during hospitalization and were followed up for at least 12 months, by performing ECG and ambulatory ECG monitoring and questioning their symptoms at 3-month intervals. Results: Thirty-one patients had elevated high sensitive cardiac troponin I (hs-cTnI). These patients had significantly longer QT dispersion compared to COVID-19 patients with normal troponin levels and controls. Regardless of troponin elevation, COVID-19 patients had significantly longer Tp-e intervals and P wave (PW) durations compared to controls. During the follow-up period; palpitation, beta-blocker usage, and inappropriate sinus tachycardia were more common in the COVID-19 group with hs-cTnI than control group. Conclusion: Our study did not find any relation between serum fibroblast growth factor-21 levels and carotid intima-media thickness. Further researches with wider study population are needed.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of differential effects of CDP-choline and choline on parasympathetic activity and changes in choline levels with heart rate variability 评价cdp -胆碱和胆碱对副交感神经活动的差异影响以及胆碱水平随心率变异性的变化

Marmara Medical Journal Pub Date : 2023-09-06 DOI: 10.5472/marumj.1379856

Hasan KAZDAĞLI, Şüheda ALPAY, Hasan Fehmi ÖZEL, Elif BARIŞ

{"title":"Evaluation of differential effects of CDP-choline and choline on parasympathetic activity and changes in choline levels with heart rate variability","authors":"Hasan KAZDAĞLI, Şüheda ALPAY, Hasan Fehmi ÖZEL, Elif BARIŞ","doi":"10.5472/marumj.1379856","DOIUrl":"https://doi.org/10.5472/marumj.1379856","url":null,"abstract":"Objective: Heart rate variability (HRV) is used to evaluate the autonomic activity of heartbeat. This study aimed to investigate the effects of cholinomimetic drugs cytidine diphosphate-choline (CDP-choline) and choline, on short-term HRV parameters. Materials and Methods: Animals were randomized into three groups; control (0.9% NaCl), choline (100 mg/kg), CDP-choline (400 mg/kg). Electrocardiography recordings were obtained for 45-minutes after treatments with 15-minutes intervals. HRV analyses and total choline level measurements in serum and heart tissues were performed. Results: High frequency power and total power increased in treatment groups, while heart rates were decreased. Low frequency was decreased with choline while very low frequency power decreased with CDP-choline. Choline affected most of the HRV parameters in the first 15 minutes, while the effect of CDP-choline started within 30 minutes. Total choline levels were higher in both treatment groups than in the control while the levels were also higher in the choline group compared to CDP-choline group. Conclusion: This study showed that CDP-choline and choline treatments produced a rapid response to short-term HRV parameters, while increasing tissue choline levels. Moreover, the differences in effects and onset time between the drugs on HRV might be related to tissue choline concentration.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evaluation of the processes of problem based learning tutorials: Online or face-to-face? 基于问题的学习辅导过程的评估:在线还是面对面?

Marmara Medical Journal Pub Date : 2023-09-06 DOI: 10.5472/marumj.1378475

Albena GAYEF, Ozge EMRE, Esra AKDENİZ, Mehmet Ali GÜLPINAR

{"title":"The evaluation of the processes of problem based learning tutorials: Online or face-to-face?","authors":"Albena GAYEF, Ozge EMRE, Esra AKDENİZ, Mehmet Ali GÜLPINAR","doi":"10.5472/marumj.1378475","DOIUrl":"https://doi.org/10.5472/marumj.1378475","url":null,"abstract":"Objective: The purpose of this research is to evaluate e-PBL tutorials and compare these sessions with face-to-face PBL sessions. Patients and Methods: This research is a program evaluation study in which quantitative methods were used. In the research, four 90-minute e-PBL sessions held between April and June 2020 were evaluated. Sessions conducted online were realised using the sevenstep approach in groups of 13-14 students and a tutor. Video recordings were analysed with the thin slicing method. In addition, various quantitative data on evaluation were analysed using multiple tools and materials, including the end-of-program evaluation form. Friedman test and Mann-Whitney U test were used in the analyses of quantitative data. Results: Upon evaluating the analyses of the feedback received from the students about the structure, content and process of the program regarding the e-PBL tutorials, the students gave a positive opinion of 80% or more. In regards with the cases, the students had positive opinions of over 80% in terms of “motivation for learning and researching”, “daily life and its relation to their individual development”, “suitability to their levels of knowledge and skills”, “reinforcement of topics”. Support, guidance and feedback received from the tutor as a group and individually during online tutorials were statistically significantly higher than the face-to-face PBL tutorials (P","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of upadacitinib and PD29 on oxidative damage and inflammation in bleomycin-induced scleroderma model kidney tissues upadacitinib和PD29对博莱霉素诱导的硬皮病模型肾组织氧化损伤和炎症的影响

Marmara Medical Journal Pub Date : 2023-09-06 DOI: 10.5472/marumj.1381649

Ayşe KOÇAK, Meliha KOLDEMİR GÜNDÜZ, Güllü KAYMAK, Elif AYDIN

{"title":"Effects of upadacitinib and PD29 on oxidative damage and inflammation in bleomycin-induced scleroderma model kidney tissues","authors":"Ayşe KOÇAK, Meliha KOLDEMİR GÜNDÜZ, Güllü KAYMAK, Elif AYDIN","doi":"10.5472/marumj.1381649","DOIUrl":"https://doi.org/10.5472/marumj.1381649","url":null,"abstract":"Objective: Scleroderma (SSc) is a rare autoimmune tissue disease. There is currently no effective treatment for SSc. The aim of this study was to investigate the antioxidant and anti-inflammatory effects of upadacitinib and PD29 on total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde (MDA), catalase (CAT), glutathione (GSH) peroxidase levels, and interleukin-6 (IL-6) and interleukin-13 ( IL-13) in kidney tissues of an experimental SSc model. Materials and Methods: The experimental design was established with five groups of eight mice: Control, bleomycin (BLM) (5 μg/kg), BLM + upadacitinib (3mg/kg), BLM + PD29 (5 mg/kg) and BLM + PD29 + upadacitinib group. BLM was administered subcutaneously once a day for 21 days. PD29 was administered subcutaneously and upadacitinib (gavage) were injected for 21 days. Renal tissues were collected at the end of the experiment. Renal TOS, TAS, MDA, CAT, GSH levels, and IL-6 and IL-13 gene expressions were evaluated. Results: Upadacitinib and PD29 affected oxidant status and TOS. MDA levels decreased, and GSH, CAT, and TAS levels increased. Also, upadacitinib and PD29 decreased inflammation via IL-6 and IL-13 cytokines. Conclusion: Upadacitinib and PD29 may have therapeutic roles for SSc renal crisis.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of laparoscopic sleeve gastrectomy on metabolic syndrome parameters during one year of follow-up 腹腔镜袖式胃切除术对1年随访期间代谢综合征参数的影响

Marmara Medical Journal Pub Date : 2023-09-06 DOI: 10.5472/marumj.1381218

Merve BAŞALAN, Mümtaz TAKIR, Cündullah TORUN, Medeni SERMET

引用次数: 0

The role of epidermal growth factor and cholinergic receptor agonists and antagonists in MAPK signal transduction in K562 cells 表皮生长因子和胆碱能受体激动剂和拮抗剂在K562细胞MAPK信号转导中的作用

Marmara Medical Journal Pub Date : 2023-08-23 DOI: 10.5472/marumj.1379868

Selda GÜLER ATMACA, Banu AYDIN, Hulya CABADAK

{"title":"The role of epidermal growth factor and cholinergic receptor agonists and antagonists in MAPK signal transduction in K562 cells","authors":"Selda GÜLER ATMACA, Banu AYDIN, Hulya CABADAK","doi":"10.5472/marumj.1379868","DOIUrl":"https://doi.org/10.5472/marumj.1379868","url":null,"abstract":"Objective: Muscarinic receptors (M1-M5) are members of the G protein-coupled receptor superfamily and are effective in physiological functions through G proteins. Recent studies suggested that cholinergic receptors mediate cellular activities in hematopoietic cells. The aim of this study was to investigate the potential role of mitogen-activated protein kinases (MAPK) signaling extracellular signalregulated kinases 1 and 2 (ERK1/2)/phosphorylated ERK1/ (pERK1/2) pathways in chronic myeloid leukemia (K562) cells. Materials and Methods: Chronic myeloid leukemia cells were cultured. Cells were incubated in the presence of muscarinic receptor agonist, antagonist and epidermal growth factor (EGF). To detect MAPK activation, ERK/pERK protein expression levels were determined by western blot method techniques. Results: Our study results showed that cholinergic agents and EGFs affect the MAPK pathway in the human K562 cell line. Conclusion: Cholinergic and EGF receptors may affect the MAPK pathway in K562 cells. Conclusion: Cholinergic and EGF receptors may affect the MAPK pathway in K562 cells.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135621217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

End-point nystagmus and EMDR 终末性眼震和EMDR

Marmara Medical Journal Pub Date : 2023-08-08 DOI: 10.5472/marumj.1379885

Borte GURBUZ OZGUR, Erdogan OZGUR, Mujdat KARABULUT

引用次数: 0

Successful diagnosis of a ruptured ectopic pregnancy: A woman without abdominal pain and vaginal bleeding 成功诊断一例宫外孕破裂:无腹痛和阴道出血的妇女

Marmara Medical Journal Pub Date : 2023-08-03 DOI: 10.5472/marumj.1379879

Emre KUDU, Sena Özge ASLAN, Dilan GENÇ, Oğuzhan DEMİR, Arzu DENİZBAŞI

引用次数: 0

Diagnostic performance between RT-PCR and chest CT in outpatients with clinically suspected COVID-19 RT-PCR与胸部CT在门诊临床疑似COVID-19患者中的诊断价值

Marmara Medical Journal Pub Date : 2023-08-03 DOI: 10.5472/marumj.1379916

Elif TÜKENMEZ TİGEN, Buket ERTURK SENGEL, Canan CİMSİT, Hande PERK GURUN, Çiğdem APAYDIN KAYA, Volkan KORTEN

{"title":"Diagnostic performance between RT-PCR and chest CT in outpatients with clinically suspected COVID-19","authors":"Elif TÜKENMEZ TİGEN, Buket ERTURK SENGEL, Canan CİMSİT, Hande PERK GURUN, Çiğdem APAYDIN KAYA, Volkan KORTEN","doi":"10.5472/marumj.1379916","DOIUrl":"https://doi.org/10.5472/marumj.1379916","url":null,"abstract":"Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19). Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled. CT severity-score (CT-SS) was calculated and data were matched with PCR results. Results: Of 812 patients, 54% (439/812) had positive RT-PCR results, and 47% (425/812) had a positive chest CT scan. With RT-PCR results as reference, the sensitivity, specificity, accuracy of chest CT in defining COVID-19 infection were 60%, (95% CI 56-65%, 265/439 patients), 57% (95% CI 52-62%, 213/373), 59% (95% CI 55-62%, 478/812), respectively. Three hundred eighty-seven (47%) patients had no CT findings, 380/812 (46.8%) had mild, 45/812 (5.5%) had moderate, and no patients in the severe group Conclusion: Chest CT did not show high sensitivity for the diagnosis of COVID-19 for outpatients. We suggest RT-PCR should be the primary diagnostic tool. Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test results, ensuring infection prevention and control measures can be preserved.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0