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Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos最新文献

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ELISA assays utilizing aptamers for the detection of the NS5 protein of Zika virus 利用适体检测寨卡病毒NS5蛋白的ELISA测定
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/isi.sact.2019_32798
A. Abalo, A. Argondizzo, L. Morais, E. Valdez, Dílson Silva, S. Missailidis
{"title":"ELISA assays utilizing aptamers for the detection of the NS5 protein of Zika virus","authors":"A. Abalo, A. Argondizzo, L. Morais, E. Valdez, Dílson Silva, S. Missailidis","doi":"10.35259/isi.sact.2019_32798","DOIUrl":"https://doi.org/10.35259/isi.sact.2019_32798","url":null,"abstract":"Introduction: The infection caused by the flavivirus Zika (ZIKV) remained as a tropical neglected disease until November 2015, when cases of microcephaly in infants born after a ZIKV epidemic, together with an increase in cases of Guillain-Barré syndrome and other neurological disorders were associated with the ZIKV infection. Nonstructural protein 5 (NS5) is essential for replication of the genome, whose RdRp domain synthesizes viral RNA through a de novo synthetic mechanism. Aptamers are single stranded DNA (or RNA) molecules, which bind to a wide range of ligands with high specificity and affinity, and can be used as relevant molecular tools.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116872303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence of Human alphaherpesvirus 1 and Gammaherpesvirus callitrichine 3 in non-human free-living primates in the state of Rio de Janeiro 在里约热内卢州非人类自由生活的灵长类动物中发现人类α疱疹病毒1型和γ疱疹病毒3型的证据
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32757
Flávia Freitas de Oliveira Bonfim, M. A. Mares-Guia, M. Horta, M. A. Pinto, A. Filippis, V. Paula
{"title":"Evidence of Human alphaherpesvirus 1 and Gammaherpesvirus callitrichine 3 in non-human free-living primates in the state of Rio de Janeiro","authors":"Flávia Freitas de Oliveira Bonfim, M. A. Mares-Guia, M. Horta, M. A. Pinto, A. Filippis, V. Paula","doi":"10.35259/ISI.SACT.2019_32757","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32757","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"10 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132738496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repurposing Annita® drug against ZIKV infection on Human Placenta and Cervix cells 重新利用安妮塔®药物对抗人胎盘和子宫颈细胞的寨卡病毒感染
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/isi.sact.2019_32818
A. Souza, L. Torres, L. Lima, M. M. Almeida, A. M. Filippis, M. Batista, E. M. Souza
{"title":"Repurposing Annita® drug against ZIKV infection on Human Placenta and Cervix cells","authors":"A. Souza, L. Torres, L. Lima, M. M. Almeida, A. M. Filippis, M. Batista, E. M. Souza","doi":"10.35259/isi.sact.2019_32818","DOIUrl":"https://doi.org/10.35259/isi.sact.2019_32818","url":null,"abstract":"Introduction: Drug repurposing is the promptest way to obtain an effective drug during a global public health emergency as the spread of Zika virus that is associated with the congenital syndrome. Why the virus reaches the fetus is still unclear, however the placenta represents an important route of transmission, since the virus was detected in vivo and in vitro human and murine placenta. The fetal infection may occur by passing the virus through spaces created by lesions or inflammation that may break the placental barrier. Another hypothesis is that the virus crosses the placenta through infection of host cells, being possible the transmission of ZIKV to the fetus occur from sexual transmission. Despite the emerging severity caused by the ZIKV infection, there still no specific treatment for this disease. The antiparasitic and antiviral drug Annita® already approved through the Food and Drug Admistration and safe for pediatric use and for administration in pregnant women, being included in category B, could have activity against ZIKV due to broad aspect and affordable price.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125665517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental Transfer and Kinetics of Neutralizing Antibodies for Dengue Virus (DENV) in maternal-infant cohort community of Manguinhos 马金诺母婴队列社区登革病毒(DENV)中和抗体的胎盘转移和动力学
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32543
A. Duarte, Stephanie Almeida, K. Paulino, Renata Pedro Saraiva, F. Figueiredo, S. M. Lima, P. Brasil
{"title":"Placental Transfer and Kinetics of Neutralizing Antibodies for Dengue Virus (DENV) in maternal-infant cohort community of Manguinhos","authors":"A. Duarte, Stephanie Almeida, K. Paulino, Renata Pedro Saraiva, F. Figueiredo, S. M. Lima, P. Brasil","doi":"10.35259/ISI.SACT.2019_32543","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32543","url":null,"abstract":"Introdução: Dengue is an important arbovirus that is currently a serious public health problem in Brazil and in the world. The Dengue virus has been circulating in the country for several decades and it has been responsible for epidemics since its reintroduction. However, the epidemiological pattern has undergone changes in the age distribution and worsening of clinical symptoms in infants, which may be associated with the presence of maternal antiDengue antibodies in neonates. Despite that, the studies including this population group are unfrequently. In this context, a prospective study has been conducted with pregnant and infants from community of Manguinhos between 2012 and 2014.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131141783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ten years of consecutive influenza surveillance to neuraminidase inhibitors resistance Brazil 巴西对神经氨酸酶抑制剂耐药性的连续十年流感监测
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32855
A. Matos, Thiago Vinícius Ramos de Sousa, T. M. Souza, P. Resende, M. Miranda, M. I. Oliveira, B. Caetano, Cristiana C Garcia, F. Motta, M. Siqueira
{"title":"Ten years of consecutive influenza surveillance to neuraminidase inhibitors resistance Brazil","authors":"A. Matos, Thiago Vinícius Ramos de Sousa, T. M. Souza, P. Resende, M. Miranda, M. I. Oliveira, B. Caetano, Cristiana C Garcia, F. Motta, M. Siqueira","doi":"10.35259/ISI.SACT.2019_32855","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32855","url":null,"abstract":"Introduction: Influenza virus (IV) causes annual epidemics and has the potential for pandemics. IV infections treatment is currently performed with neuraminidase inhibitors (NAIs), mainly oseltamivir (OST). As IVs are constantly evolving, antiviral resistance due to adaptations in influenza genome may occur. Since the 2009 pandemic, NAIs resistant strains frequency has remained low (<2%) worldwide. In Brazil, our group has monitored these strains since 2009 and we have reported A(H1N1)pdm09 strains carrying NA substitutions associated with NAIs reduced inhibition (RI).","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133292778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment and evaluation of a transient expression method in Expi293F system for Fab monoclonal antibody fragment production Fab单克隆抗体在Expi293F系统中瞬时表达方法的建立及评价
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32696
F. Ramos, A. Araújo, Haroldo Cid da Silva Junior, J. Senna
{"title":"Establishment and evaluation of a transient expression method in Expi293F system for Fab monoclonal antibody fragment production","authors":"F. Ramos, A. Araújo, Haroldo Cid da Silva Junior, J. Senna","doi":"10.35259/ISI.SACT.2019_32696","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32696","url":null,"abstract":"Introduction: Monoclonal antibodies and their fragments produced by recombinant DNA technology represent a group of immunobiologicals with varied applications in immunotherapy and as a tool for immunodiagnostics assays development. Expression of these proteins require efficient cell culture systems that ensure agility in protein synthesis, acceptable benefit-cost ratios, high yields and expression of functional proteins for the desired applications.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"390 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131465036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upstream and downstream processing, stability and characterization studies of LigANI fragment: process development of a vaccine candidate LigANI片段的上下游加工、稳定性和特性研究:候选疫苗的工艺开发
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32539
G. Esteves, Mariana Garcia, Ana Andrade-Góes, H. Nascimento, P. Jurgilas, M. Medeiros
{"title":"Upstream and downstream processing, stability and characterization studies of LigANI fragment: process development of a vaccine candidate","authors":"G. Esteves, Mariana Garcia, Ana Andrade-Góes, H. Nascimento, P. Jurgilas, M. Medeiros","doi":"10.35259/ISI.SACT.2019_32539","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32539","url":null,"abstract":"Introduction: Leptospirosis is one of the most common zoonosis in the world according to WHO and the number of leptospirosis cases has been increasing over the years. Our group has been working with Leptospiral immunoglobulin-like proteins as diagnostic and subunit vaccine candidate. Initially, we cloned, expressed and purified different fragments of Lig proteins and in 2007, it was demonstrated the potential of the non-identical LigA region (LigANI) as a vaccine candidate, as it was able to protect 67-100% of the animals against lethal challenge, other groups also demonstrated the potential of this fragment as a vaccine candidate.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115739432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of host antiviral restriction factors by ccr5 and cxcr4 ligands ccr5和cxcr4配体对宿主抗病毒限制因子的调节
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32700
Thauane Silva, G. Vale, A. C. Ferreira, D. Bou-Habib, M. Siqueira, T. Lopes, M. Miranda
{"title":"Modulation of host antiviral restriction factors by ccr5 and cxcr4 ligands","authors":"Thauane Silva, G. Vale, A. C. Ferreira, D. Bou-Habib, M. Siqueira, T. Lopes, M. Miranda","doi":"10.35259/ISI.SACT.2019_32700","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32700","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121679638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis E virus prevalence among chronic kdney disease hemodialysis-dependent patients 戊型肝炎病毒在慢性肾病血液透析依赖患者中的流行
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32756
A. Lemos, Camilla Rodrigues de Almeida Ribeiro, J. Barbosa, D. Lima, Jeová Keny Baima Colares, L. Villar, V. Paula
{"title":"Hepatitis E virus prevalence among chronic kdney disease hemodialysis-dependent patients","authors":"A. Lemos, Camilla Rodrigues de Almeida Ribeiro, J. Barbosa, D. Lima, Jeová Keny Baima Colares, L. Villar, V. Paula","doi":"10.35259/ISI.SACT.2019_32756","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32756","url":null,"abstract":"Introduction: Hepatitis E virus (HEV) is responsible for acute self-limiting disease worldwide, mostly among immunocompetent person. However it can be manifested in different forms, according to the immune state of the patient. A relevant group for studies of HEV infection is the chronic kidney disease hemodialysis-dependent (HD) population, which may be lead to a transplant and immunosuppressive treatment, mainly with tacrolimus and its analogues, which have been described as related to chronic hepatitis E. Also this special group has been reported to present higher prevalence in comparison to immunocompetent populations in HEV-GT3 (HEV -Genotype 3) circulating countries. In Brazil, the prevalence of HEV is still underestimated among HD patients.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121194023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Identification and experimental validation of immunodominant B-cell epitopes present on hantavirus genotypes associated to hemorrhagic fever and renal syndrome 与出血热和肾综合征相关的汉坦病毒基因型中免疫显性b细胞表位的鉴定和实验验证
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32723
F. Conte, Thiago Santos Chaves, Thais Araujo, R. Oliveira, E. Lemos, P. C. Neves, Rodrigo Silva
{"title":"Identification and experimental validation of immunodominant B-cell epitopes present on hantavirus genotypes associated to hemorrhagic fever and renal syndrome","authors":"F. Conte, Thiago Santos Chaves, Thais Araujo, R. Oliveira, E. Lemos, P. C. Neves, Rodrigo Silva","doi":"10.35259/ISI.SACT.2019_32723","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32723","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115084907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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