巴西对神经氨酸酶抑制剂耐药性的连续十年流感监测

Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI:10.35259/ISI.SACT.2019_32855

A. Matos, Thiago Vinícius Ramos de Sousa, T. M. Souza, P. Resende, M. Miranda, M. I. Oliveira, B. Caetano, Cristiana C Garcia, F. Motta, M. Siqueira

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摘要

简介:流感病毒(IV)每年引起流行，并具有大流行的潜力。静脉感染治疗目前使用神经氨酸酶抑制剂(NAIs)，主要是奥司他韦(OST)。随着病毒的不断进化，流感基因组的适应可能会产生抗病毒耐药性。自2009年大流行以来，全球耐药菌株的频率一直很低(<2%)。在巴西，我们的研究小组自2009年以来一直监测这些毒株，我们报告了携带NA替换的甲型H1N1 pdm09毒株，这些替换与NAIs抑制降低(RI)相关。

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Ten years of consecutive influenza surveillance to neuraminidase inhibitors resistance Brazil

Introduction: Influenza virus (IV) causes annual epidemics and has the potential for pandemics. IV infections treatment is currently performed with neuraminidase inhibitors (NAIs), mainly oseltamivir (OST). As IVs are constantly evolving, antiviral resistance due to adaptations in influenza genome may occur. Since the 2009 pandemic, NAIs resistant strains frequency has remained low (<2%) worldwide. In Brazil, our group has monitored these strains since 2009 and we have reported A(H1N1)pdm09 strains carrying NA substitutions associated with NAIs reduced inhibition (RI).

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Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos

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