戊型肝炎病毒在慢性肾病血液透析依赖患者中的流行

Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI:10.35259/ISI.SACT.2019_32756

A. Lemos, Camilla Rodrigues de Almeida Ribeiro, J. Barbosa, D. Lima, Jeová Keny Baima Colares, L. Villar, V. Paula

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引用次数: 1

摘要

戊型肝炎病毒(HEV)是世界范围内引起急性自限性疾病的主要原因，主要发生在免疫能力强的人群中。然而，根据病人的免疫状态，它可以以不同的形式表现出来。研究HEV感染的一个相关群体是慢性肾脏疾病血液透析依赖(HD)人群，这可能导致移植和免疫抑制治疗，主要是他克莫司及其类似物，这被描述为与慢性戊型肝炎有关。据报道，与HEV- gt3 (HEV -基因型3)循环国家的免疫正常人群相比，这一特殊群体的患病率更高。在巴西，HD患者中HEV的流行率仍然被低估。

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Hepatitis E virus prevalence among chronic kdney disease hemodialysis-dependent patients

Introduction: Hepatitis E virus (HEV) is responsible for acute self-limiting disease worldwide, mostly among immunocompetent person. However it can be manifested in different forms, according to the immune state of the patient. A relevant group for studies of HEV infection is the chronic kidney disease hemodialysis-dependent (HD) population, which may be lead to a transplant and immunosuppressive treatment, mainly with tacrolimus and its analogues, which have been described as related to chronic hepatitis E. Also this special group has been reported to present higher prevalence in comparison to immunocompetent populations in HEV-GT3 (HEV -Genotype 3) circulating countries. In Brazil, the prevalence of HEV is still underestimated among HD patients.

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Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos

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