Bio-Algorithms and Med-Systems最新文献

筛选
英文 中文
The bioinspired traffic sign classifier 仿生交通标志分类器
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2022-02-21 DOI: 10.1515/bams-2021-0159
Dominika Przewlocka-Rus, T. Kryjak
{"title":"The bioinspired traffic sign classifier","authors":"Dominika Przewlocka-Rus, T. Kryjak","doi":"10.1515/bams-2021-0159","DOIUrl":"https://doi.org/10.1515/bams-2021-0159","url":null,"abstract":"Abstract Objectives In this paper the research on developing convolutional spiking neural networks for traffic signs classification is presented. Unlike classical ones, spiking networks reflect the behaviour of biological neurons much more closely, by taking into account the time dimension and event-based operation. Spiking networks running on dedicated neuromorphic platforms, such as Intel Loihi, can operate with greater energy efficiency, hence they are an interesting approach for embedded solutions. Methods For convolutional spiking neural networks' design and simulation, Nengo and NengoDL libraries for Python language were used. Numerous experiments using the Leaky-Integrate-and-Fire (LIF) neuron model were conducted. The training results, with different augmentation methods and number of time steps for input image presentation were compared. Results Finally, an accuracy of up to 97% on the test set was achieved, depending on the number of time steps the input was presented to the SNN. Conclusions The proposed experiments show that using simple convolutional spiking neural network, one can achieve accuracy comparable to the classical network with the same architecture and trained on the same dataset. At the same time, running on dedicated neuromorphic hardware, such solution should be characterized by low latency and low energy consumption.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45838724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efim Liberman toward the comprehension of the phenomenon of life 艾菲姆·利伯曼对生命现象的理解
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2022-02-01 DOI: 10.1016/j.biosystems.2022.104650
V. Skulachev
{"title":"Efim Liberman toward the comprehension of the phenomenon of life","authors":"V. Skulachev","doi":"10.1016/j.biosystems.2022.104650","DOIUrl":"https://doi.org/10.1016/j.biosystems.2022.104650","url":null,"abstract":"","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77390835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Perspectives of brain imaging with PET systems PET系统的脑成像透视
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI: 10.1515/bams-2021-0178
S. Majewski
{"title":"Perspectives of brain imaging with PET systems","authors":"S. Majewski","doi":"10.1515/bams-2021-0178","DOIUrl":"https://doi.org/10.1515/bams-2021-0178","url":null,"abstract":"Abstract In this partial review and partial attempt at vision of what may be the future of dedicated brain PET scanners, the key implementations of the PET technique, we postulate that we are still on a development path and there is still a lot to be done in order to develop optimal brain imagers. Optimized for particular imaging tasks and protocols, and also mobile, that can be used outside the PET center, in addition to the expected improvements in sensitivity and resolution. For this multi-application concept to be more practical, flexible, adaptable designs are preferred. This task is greatly facilitated by the improved TOF performance that allows for more open, adjustable, limited angular coverage geometries without creating image artifacts. As achieving uniform very high resolution in the whole body is not practical due to technological limits and high costs, hybrid systems using a moderate-resolution total body scanner (such as J-PET) combined with a very high performing brain imager could be a very attractive approach. As well, as using magnification inserts in the total body or long-axial length imagers to visualize selected targets with higher resolution. In addition, multigamma imagers combining PET with Compton imaging should be developed to enable multitracer imaging.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48226489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Novel biomarker and drug delivery systems for theranostics – extracellular vesicles 用于治疗的新型生物标志物和药物传递系统——细胞外囊泡
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI: 10.1515/bams-2021-0183
E. Stępień, Carina Rząca, P. Moskal
{"title":"Novel biomarker and drug delivery systems for theranostics – extracellular vesicles","authors":"E. Stępień, Carina Rząca, P. Moskal","doi":"10.1515/bams-2021-0183","DOIUrl":"https://doi.org/10.1515/bams-2021-0183","url":null,"abstract":"Abstract Extracellular vesicles (EVs) are nano- and micro-sized double-layered membrane entities derived from most cell types and released into biological fluids. Biological properties (cell-uptake, biocompatibility), and chemical (composition, structure) or physical (size, density) characteristics make EVs a good candidate for drug delivery systems (DDS). Recent advances in the field of EVs (e.g., scaling-up production, purification) and developments of new imaging methods (total-body positron emission tomography [PET]) revealed benefits of radiolabeled EVs in diagnostic and interventional medicine as a potential DDs in theranostics.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45223145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine PET成像对医学研究和日常实践产生了无与伦比的革命性影响
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI: 10.1515/bams-2021-0186
A. Alavi, T. Werner, E. Stępień, P. Moskal
{"title":"Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine","authors":"A. Alavi, T. Werner, E. Stępień, P. Moskal","doi":"10.1515/bams-2021-0186","DOIUrl":"https://doi.org/10.1515/bams-2021-0186","url":null,"abstract":"Abstract Positron emission tomography (PET) imaging is the most quantitative modality for assessing disease activity at the molecular and cellular levels, and therefore, it allows monitoring its course and determining the efficacy of various therapeutic interventions. In this scientific communication, we describe the unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine. We emphasize the critical importance of the development and synthesis of novel radiotracers (starting from the enormous impact of F-Fluorodeouxyglucose (FDG) introduced by investigators at the University of Pennsylvania (PENN)) and PET instrumentation. These innovations have led to the total-body PET systems enabling dynamic and parametric molecular imaging of all organs in the body simultaneously. We also present our perspectives for future development of molecular imaging by multiphoton PET systems that will enable users to extract substantial information (owing to the evolving role of positronium imaging) about the related molecular and biological bases of various disorders, which are unachievable by the current PET imaging techniques.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43369799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Theranostics – present and future 治疗学——现在和未来
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI: 10.1515/bams-2021-0169
L. Królicki, Jolanta Kunikowska
{"title":"Theranostics – present and future","authors":"L. Królicki, Jolanta Kunikowska","doi":"10.1515/bams-2021-0169","DOIUrl":"https://doi.org/10.1515/bams-2021-0169","url":null,"abstract":"Abstract Theragnostics in nuclear medicine constitute an essential element of precision medicine. This notion integrates radionuclide diagnostics procedures and radionuclide therapies using appropriate radiopharmaceutics and treatment targeting specific biological pathways or receptors. The term theragnostics should also include another aspect of treatment: not only whether a given radioisotopic drug can be used, but also in what dose it ought to be used. Theragnostic procedures also allow predicting the effects of treatment based on the assessment of specific receptor density or the metabolic profile of neoplastic cells. The future of theragnostics depends not only on the use of new radiopharmaceuticals, but also on new gamma cameras. Modern theragnostics already require unambiguous pharmacokinetic and pharmacodynamic measurements based on absolute values. Only dynamic studies provide such a possibility. The introduction of the dynamic total-body PET-CT will enable this type of measurements characterizing metabolic processes and receptor expression on the basis of Patlak plot.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45710488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Progress and perspectives in total body PET systems instrumentation 全身PET系统仪器的进展与展望
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI: 10.1515/bams-2021-0187
S. Vandenberghe
{"title":"Progress and perspectives in total body PET systems instrumentation","authors":"S. Vandenberghe","doi":"10.1515/bams-2021-0187","DOIUrl":"https://doi.org/10.1515/bams-2021-0187","url":null,"abstract":"Abstract Total body positron emission tomography (PET) systems are being developed by different groups worldwide. These systems have potential to change the number of applications in which molecular imaging is used. The change from a short axial field of view (FOV) to a longer one is however associated with a linear increase in the cost of these systems. This may limit their application to a small number of centers (capable of obtaining sufficient research funding). Therefore it remains interesting to see if lower cost systems can be developed and bring total body PET to the clinic for an acceptable budget. The wider availability of this low cost system can also enable more researchers to further optimize and explore the full potential of total body PET.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48660117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Positronium as a biomarker of hypoxia 正电子作为缺氧的生物标志物
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI: 10.1515/bams-2021-0189
P. Moskal, E. Stępień
{"title":"Positronium as a biomarker of hypoxia","authors":"P. Moskal, E. Stępień","doi":"10.1515/bams-2021-0189","DOIUrl":"https://doi.org/10.1515/bams-2021-0189","url":null,"abstract":"Abstract In this review article, we present arguments demonstrating that the advent of high sensitivity total-body PET systems and the invention of the method of positronium imaging, open realistic perspectives for the application of positronium as a biomarker for in-vivo assessment of the degree of hypoxia. Hypoxia is a state or condition, in which the availability of oxygen is not sufficient to support physiological processes in tissue and organs. Positronium is a metastable atom formed from electron and positron which is copiously produced in the intramolecular spaces in the living organisms undergoing positron emission tomography (PET). Properties of positronium, such as e.g., lifetime, depend on the size of intramolecular spaces and the concentration in them of oxygen molecules. Therefore, information on the partial pressure of oxygen (pO2) in the tissue may be derived from the positronium lifetime measurement. The partial pressure of oxygen differs between healthy and cancer tissues in the range from 10 to 50 mmHg. Such differences of pO2 result in the change of ortho-positronium lifetime e.g., in water by about 2–7 ps. Thus, the application of positronium as a biomarker of hypoxia requires the determination of the mean positronium lifetime with the resolution in the order of 2 ps. We argue that such resolution is in principle achievable for organ-wise positronium imaging with the total-body PET systems.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42626552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
New trends in theranostics 治疗学的新趋势
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI: 10.1515/bams-2021-0204
P. Moskal, E. Stępień
{"title":"New trends in theranostics","authors":"P. Moskal, E. Stępień","doi":"10.1515/bams-2021-0204","DOIUrl":"https://doi.org/10.1515/bams-2021-0204","url":null,"abstract":"","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42833672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Combined BNCT and PET for theranostics 结合BNCT和PET进行治疗
IF 1.2
Bio-Algorithms and Med-Systems Pub Date : 2021-11-30 DOI: 10.1515/bams-2021-0140
M. Silarski, K. Dziedzic-Kocurek, M. Szczepanek
{"title":"Combined BNCT and PET for theranostics","authors":"M. Silarski, K. Dziedzic-Kocurek, M. Szczepanek","doi":"10.1515/bams-2021-0140","DOIUrl":"https://doi.org/10.1515/bams-2021-0140","url":null,"abstract":"Abstract This short review summarizes the issue of boron distribution monitoring in boron neutron capture therapy (BNCT), which remains a serious drawback of this powerful oncological treatment. Here we present the monitoring methods that are presently used with particular emphasis on the positron emission tomography (PET) which has the highest potential to be used for the real-time monitoring of boron biodistribution. We discuss the possibility of using present PET scanners to determine the boron uptake in vivo before the BNCT treatment with the use of p-boronphenylalanine (BPA) labeled with 18F isotope. Several examples of preclinical studies and clinical trials performed with the use of [18F]FBPA are shown. We also discuss shortly the perspectives of using other radiotracers and boron carriers which may significantly improve the boron imaging with the use of the state-of-the-art Total-Body PET scanners providing a theranostic approach in the BNCT.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47094072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信