结合BNCT和PET进行治疗

IF 1.2 Q3 Computer Science

Bio-Algorithms and Med-Systems Pub Date : 2021-11-30 DOI:10.1515/bams-2021-0140

M. Silarski, K. Dziedzic-Kocurek, M. Szczepanek

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引用次数: 6

摘要

本文简要综述了硼中子俘获治疗(BNCT)中硼分布监测的问题，这是这种强大的肿瘤治疗的一个严重缺陷。在这里，我们介绍了目前使用的监测方法，特别强调正电子发射断层扫描(PET)，它具有最大的潜力，可用于实时监测硼的生物分布。我们讨论了在使用18F同位素标记的对硼苯丙氨酸(BPA)进行BNCT治疗之前，使用现有PET扫描仪确定体内硼摄取的可能性。以下是使用[18F]FBPA进行的临床前研究和临床试验的几个例子。我们还简要讨论了使用其他放射性示踪剂和硼载体的前景，这可能会显著改善硼成像，使用最先进的全身PET扫描仪为BNCT提供治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Combined BNCT and PET for theranostics

Abstract This short review summarizes the issue of boron distribution monitoring in boron neutron capture therapy (BNCT), which remains a serious drawback of this powerful oncological treatment. Here we present the monitoring methods that are presently used with particular emphasis on the positron emission tomography (PET) which has the highest potential to be used for the real-time monitoring of boron biodistribution. We discuss the possibility of using present PET scanners to determine the boron uptake in vivo before the BNCT treatment with the use of p-boronphenylalanine (BPA) labeled with 18F isotope. Several examples of preclinical studies and clinical trials performed with the use of [18F]FBPA are shown. We also discuss shortly the perspectives of using other radiotracers and boron carriers which may significantly improve the boron imaging with the use of the state-of-the-art Total-Body PET scanners providing a theranostic approach in the BNCT.

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来源期刊

Bio-Algorithms and Med-Systems MATHEMATICAL & COMPUTATIONAL BIOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

期刊介绍： The journal Bio-Algorithms and Med-Systems (BAMS), edited by the Jagiellonian University Medical College, provides a forum for the exchange of information in the interdisciplinary fields of computational methods applied in medicine, presenting new algorithms and databases that allows the progress in collaborations between medicine, informatics, physics, and biochemistry. Projects linking specialists representing these disciplines are welcome to be published in this Journal. Articles in BAMS are published in English. Topics Bioinformatics Systems biology Telemedicine E-Learning in Medicine Patient''s electronic record Image processing Medical databases.