Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine

IF 1.2 Q3 Computer Science

Bio-Algorithms and Med-Systems Pub Date : 2021-12-01 DOI:10.1515/bams-2021-0186

A. Alavi, T. Werner, E. Stępień, P. Moskal

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引用次数: 18

Abstract

Abstract Positron emission tomography (PET) imaging is the most quantitative modality for assessing disease activity at the molecular and cellular levels, and therefore, it allows monitoring its course and determining the efficacy of various therapeutic interventions. In this scientific communication, we describe the unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine. We emphasize the critical importance of the development and synthesis of novel radiotracers (starting from the enormous impact of F-Fluorodeouxyglucose (FDG) introduced by investigators at the University of Pennsylvania (PENN)) and PET instrumentation. These innovations have led to the total-body PET systems enabling dynamic and parametric molecular imaging of all organs in the body simultaneously. We also present our perspectives for future development of molecular imaging by multiphoton PET systems that will enable users to extract substantial information (owing to the evolving role of positronium imaging) about the related molecular and biological bases of various disorders, which are unachievable by the current PET imaging techniques.

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PET成像对医学研究和日常实践产生了无与伦比的革命性影响

正电子发射断层扫描(PET)成像是在分子和细胞水平上评估疾病活动性的最定量的方式，因此，它可以监测其病程并确定各种治疗干预措施的疗效。在这个科学交流中，我们描述了PET成像对研究和日常医学实践的无与伦比的革命性影响。我们强调开发和合成新型放射性示踪剂(从宾夕法尼亚大学(PENN)的研究人员引入的f -氟二氧葡萄糖(FDG)的巨大影响开始)和PET仪器的关键重要性。这些创新导致了全身PET系统能够同时对身体所有器官进行动态和参数化的分子成像。我们还提出了我们对多光子PET系统分子成像未来发展的展望，该系统将使用户能够提取有关各种疾病的相关分子和生物学基础的大量信息(由于正电子成像的作用不断发展)，这是目前PET成像技术无法实现的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bio-Algorithms and Med-Systems MATHEMATICAL & COMPUTATIONAL BIOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

期刊介绍： The journal Bio-Algorithms and Med-Systems (BAMS), edited by the Jagiellonian University Medical College, provides a forum for the exchange of information in the interdisciplinary fields of computational methods applied in medicine, presenting new algorithms and databases that allows the progress in collaborations between medicine, informatics, physics, and biochemistry. Projects linking specialists representing these disciplines are welcome to be published in this Journal. Articles in BAMS are published in English. Topics Bioinformatics Systems biology Telemedicine E-Learning in Medicine Patient''s electronic record Image processing Medical databases.