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SEARCH FOR NEW INHIBITORS OF PROTEIN KINASE SIGNALING PATHWAYS USING MOLECULAR DYNAMICS AND MOLECULAR DOCKING METHODS 利用分子动力学和分子对接方法寻找蛋白激酶信号通路的新抑制剂
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.7
A.A. Glushko, I.P. Kodonidi, E. Frantsiyants, I. Kaplieva, A. S. Chiryapkin, E.V. Sergienko
{"title":"SEARCH FOR NEW INHIBITORS OF PROTEIN KINASE SIGNALING PATHWAYS USING MOLECULAR DYNAMICS AND MOLECULAR DOCKING METHODS","authors":"A.A. Glushko, I.P. Kodonidi, E. Frantsiyants, I. Kaplieva, A. S. Chiryapkin, E.V. Sergienko","doi":"10.18137/cardiometry.2023.29.conf.7","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.7","url":null,"abstract":"The development of new therapeutic strategies for the treatment of various diseases associated with impaired protein kinase activity is one of the most urgent tasks in modern medicine. The search for new protein kinase inhibitors is an effective approach in the struggle against cancer. However, the existing protein kinase inhibitors may have limitations in their effectiveness or may produce undesired side effects. Therefore, the development of new methods for searching for new inhibitors, which should be more effective and safe, is a topical issue. One of the promising areas is the use of molecular modeling to search for new protein kinase inhibitors.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MOLECULAR CELLULAR EFFECTS BY PROTON AND γ-IRRADIATION IN THE B16 MURINE MELANOMA MODEL IN VIVO 质子和γ-射线在活体 B16 细胞模型中的分子细胞效应
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.27
A. Yakimova, O. Matchuk, E. Selivanova, V.R. Gusarova, V.A. Mosina, S.N. Koryakin, I. Zamulaeva
{"title":"MOLECULAR CELLULAR EFFECTS BY PROTON AND γ-IRRADIATION IN THE B16 MURINE MELANOMA MODEL IN VIVO","authors":"A. Yakimova, O. Matchuk, E. Selivanova, V.R. Gusarova, V.A. Mosina, S.N. Koryakin, I. Zamulaeva","doi":"10.18137/cardiometry.2023.29.conf.27","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.27","url":null,"abstract":"Proton and photon (γ-) radiation is widely used in modern clinical practice for the treatment of malignant tumors of various locations. The relative biological effectiveness (RBE) of accelerated protons is about 1.1, as follows from the results of experimental studies of clonogenic survival of tumor cells in vitro. But however, despite the low RBE of proton radiation, a number of clinical studies have shown a significant increase in relapse-free and overall survival of patients after proton therapy compared with that after standard radiotherapy using photon radiation. The mechanisms, on which the differences recorded in vivo are based, are of significant scientific and practical interest, but have been poorly studied.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE INFLUENCE OF A PERIPHERAL TUMOR ON THE BEHAVIOR OF ANIMALS AND THE STRUCTURE OF NEURONS IN THE PREFRONTAL CORTEX 外周肿瘤对动物行为和前额叶皮层神经元结构的影响
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.18
N. A. Obanina, N.P. Bgatova
{"title":"THE INFLUENCE OF A PERIPHERAL TUMOR ON THE BEHAVIOR OF ANIMALS AND THE STRUCTURE OF NEURONS IN THE PREFRONTAL CORTEX","authors":"N. A. Obanina, N.P. Bgatova","doi":"10.18137/cardiometry.2023.29.conf.18","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.18","url":null,"abstract":"Melanoma is the most aggressive of the common forms of skin cancer. Proinflammatory cytokines produced by the tumor and delivered via the circulatory and lymphatic systems can lead to damage to the structures of the central nervous system. Damage to the blood-brain barrier and the endothelium of blood capillaries can cause dysfunction of neurons in the cerebral cortex, induce changes in neural plasticity, cognitive functions and result in the development of depression. Depression is observed in 20% of the cancer patients, and it affects quality of life, treatment effectiveness and survival. Depression has been linked to damage to the prefrontal cortex, which plays an important role in many brain functions, including cognition, emotion regulation, motivation and sociability.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"242 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STRESS IN PATHOGENESIS OF DEVELOPMENT OF TUMOR PATHOLOGY OF THE THYROID GLAND 甲状腺肿瘤病理发展的发病机制中的应激反应
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.29
D.V. Zima, O. R. Khabarov, O. F. Bezrukov, E.Yu. Zyablitskaya
{"title":"STRESS IN PATHOGENESIS OF DEVELOPMENT OF TUMOR PATHOLOGY OF THE THYROID GLAND","authors":"D.V. Zima, O. R. Khabarov, O. F. Bezrukov, E.Yu. Zyablitskaya","doi":"10.18137/cardiometry.2023.29.conf.29","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.29","url":null,"abstract":"Our experience in the endocrine surgery at our clinics institution has shown a relationship between the appearance of nodules in the thyroid gland and a long-term exposure to stress. At present, the complicated geopolitical circumstances play a role of an active stressor, and until recently, it was also the COVID-19 pandemic, which caused a change in lifestyle, heavy material losses, and loss of loved ones. Oncogenic activity of cells is reflected in an imbalance of markers of proliferation and apoptosis. Many researchers associate thyroid pathology with molecular alterations as diagnostic markers (Styazhkina S.N., 2017; Romashchenko P.N. et al., 2021).","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139303623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VIROLOGICAL RESPONSE AND EFFECTIVENESS OF CHEMORADIATION THERAPY FOR ANAL CANCER: RELATIONSHIP AND PREDICTIVE CAPABILITIES 肛门癌的病毒学反应和化学放疗的有效性：关系和预测能力
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.30
T. A. Zykova, M. Gusareva, E. A. Shevyakova, E. Frantsiyants, E.A. Tolmacheva, M. Zinkovich, N. G. Kosheleva, A. Solntseva
{"title":"VIROLOGICAL RESPONSE AND EFFECTIVENESS OF CHEMORADIATION THERAPY FOR ANAL CANCER: RELATIONSHIP AND PREDICTIVE CAPABILITIES","authors":"T. A. Zykova, M. Gusareva, E. A. Shevyakova, E. Frantsiyants, E.A. Tolmacheva, M. Zinkovich, N. G. Kosheleva, A. Solntseva","doi":"10.18137/cardiometry.2023.29.conf.30","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.30","url":null,"abstract":"The effectiveness of chemoradiation therapy (CRT) is conventionally assessed in terms of achieving clinical complete response (CCR), overall and event-free survival. Anal cancer (AR) is considered as one of the cancer diseases with a proven etiological agent: the human papillomavirus (HPV). The search for biomarkers to predict the effectiveness of CRT is always relevant, and an assessment of virological response (VR) may be useful for this purpose. Aim: To compare rates of clinical complete response (CCR) and virological response (VR) to CRT for anal cancer.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE PATH TO GOOD HEALTH IS THROUGH MITOCHONDRIAL TRAINING.INTERMITTENT HYPOXIC TRAINING AS THE MAIN METHOD 健康之路在于线粒体训练，间歇性缺氧训练是主要方法
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.26
T. Voronina
{"title":"THE PATH TO GOOD HEALTH IS THROUGH MITOCHONDRIAL TRAINING.INTERMITTENT HYPOXIC TRAINING AS THE MAIN METHOD","authors":"T. Voronina","doi":"10.18137/cardiometry.2023.29.conf.26","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.26","url":null,"abstract":"All human health, from the cellular level to overall well-being, is inextricably linked to the health of our mitochondria. This article delves into the concept of mitochondrial training, focusing on Hypoxic Intermittent Training (HIT) as a central method for improving mitochondrial function. It is becoming increasingly clear that various diseases, stress, shock, inflammation, aging, and organ failure are primarily the result of respiratory problems that directly affect mitochondrial health. The regulation of metabolism is closely related to gas exchange, and the composition of the gases we breathe regulates our metabolism. Our main goal is to promote efficient mitochondrial function, a key biological imperative.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139299717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THREE-DIMENSIONAL IN VITRO MODELS FOR STUDYING THE CHEMOSENSITIVITY OF BREAST CANCER CELLS 用于研究乳腺癌细胞化学敏感性的三维体外模型
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.6
S.Yu. Filippova, S. V. Timofeeva, T. V. Chembarova, I. Mezhevova, L.N. Vashchenko, E. Kechedzhieva, E.A. Andreyko
{"title":"THREE-DIMENSIONAL IN VITRO MODELS FOR STUDYING THE CHEMOSENSITIVITY OF BREAST CANCER CELLS","authors":"S.Yu. Filippova, S. V. Timofeeva, T. V. Chembarova, I. Mezhevova, L.N. Vashchenko, E. Kechedzhieva, E.A. Andreyko","doi":"10.18137/cardiometry.2023.29.conf.6","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.6","url":null,"abstract":"Scientists agree that three-dimensional tumor cell cultures reflect the in vitro biological features of malignant tumors to a greater extent than it is the case with the conventional monolayer cultures. In particular, the results of assessing the effectiveness of anticancer drugs obtained in three-dimensional cell models are considered as more accurate and consistent with the tumor response in vivo, where sensitivity is usually lower than that found in the in vitro experiments. Some of the most developed cellular models are structures obtained using three-dimensional bioprinting, which include not only malignant cells, but also biogels to imitate the chemical and mechanical properties of the extracellular matrix of the tumor.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A MODERN APPROACH TO DISEASE MODELING FOR THE DEVELOPMENT OF ONCOLOGY DRUGS 开发肿瘤药物的现代疾病建模方法
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.12
V. Khokhlova, O. Bezborodova, G. V. Trunova, E. A. Plotnikova, N. Morozova, A. Plyutinskaya, M. S. Vorontsova, Yu. B. Venediktova, E. Nemtsova, A. Pankratov, P. V. Shegai
{"title":"A MODERN APPROACH TO DISEASE MODELING FOR THE DEVELOPMENT OF ONCOLOGY DRUGS","authors":"V. Khokhlova, O. Bezborodova, G. V. Trunova, E. A. Plotnikova, N. Morozova, A. Plyutinskaya, M. S. Vorontsova, Yu. B. Venediktova, E. Nemtsova, A. Pankratov, P. V. Shegai","doi":"10.18137/cardiometry.2023.29.conf.12","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.12","url":null,"abstract":"Oncological diseases are characterized by the complexity of pathogenesis and demonstrate a number of specific signs, such as uncontrolled proliferation, stimulation of angiogenesis, activation of invasion and metastasis. Molecular genetic testing to examine genetic abnormalities in tumor cells has been increasingly using in oncology. With an accumulation of the data on the repertoire of mutations or other events in the patient’s tumors, new goals for the development of more targeted and specific antitumor therapies appear. For example, membrane proteins EGFR, HER-2, PSMA and C-met are identified as such targets. Despite the large volume of research conducted, no more than 11% of the total drug candidates are approved by regulatory authorities for clinical use. This is often due to their lack of effectiveness and the incomparability of the results obtained in preclinical trials in animal models with actual results in patients. Therefore, the development of experimental approaches for modeling tumor processes in laboratory animals is an urgent problem.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FEATURES OF GROWTH AND DEVELOPMENT OF B16 MELANOMA IN SEXUALLY MATURE MALE C57BLACK/6 MICE IN MODELING POST-TRAUMATIC STRESS DISORDER 性成熟雄性 C57black/6 小鼠 B16 黑色素瘤在创伤后应激障碍模型中的生长发育特征
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.15
M. V. Kondashevskaya, V. Aleksankina, V.V. Kudelkina, M. A. Kozlova, D. Areshidze
{"title":"FEATURES OF GROWTH AND DEVELOPMENT OF B16 MELANOMA IN SEXUALLY MATURE MALE C57BLACK/6 MICE IN MODELING POST-TRAUMATIC STRESS DISORDER","authors":"M. V. Kondashevskaya, V. Aleksankina, V.V. Kudelkina, M. A. Kozlova, D. Areshidze","doi":"10.18137/cardiometry.2023.29.conf.15","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.15","url":null,"abstract":"It is well known that extraordinary stress or chronic exposure to stressors is characterized by adverse immunological consequences due to stress-induced immunosuppression. It has been established that stress causes an increased incidence of malignant tumors and also worsens the prognosis in patients with already existing tumors. Among the mechanisms of carcinogenesis under stress, there is an increase in the level of cortisol, which has a significant inhibitory effect on the immune system and the secretion of pro-inflammatory interleukins. Post-traumatic stress disorder (PTSD) involves inactivation of the hypothalamic-pituitary-adrenal (HPA) axis and decreased secretion of cortisol in humans, or corticosterone in rats and mice. However, the question of whether PTSD is a risk factor for the development of cancer or tumor growth remains practically undeveloped.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNA miR-204-5p IS A REGULATOR OF APOPTOSIS IN DACARBAZINE-RESISTANT MELANOMA CELLS 微RNA miR-204-5p 是抗达卡巴嗪骨髓细胞凋亡的调节因子
Cardiometry Pub Date : 2023-11-01 DOI: 10.18137/cardiometry.2023.29.conf.19
N.V. Palkina
{"title":"MicroRNA miR-204-5p IS A REGULATOR OF APOPTOSIS IN DACARBAZINE-RESISTANT MELANOMA CELLS","authors":"N.V. Palkina","doi":"10.18137/cardiometry.2023.29.conf.19","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.19","url":null,"abstract":"Therapy for skin melanoma in its disseminated form is ineffective, among other things, due to the development of tumor cell resistance, mediated by various mechanisms. The acquisition of a stable cell phenotype is associated both with genetic and epigenetic changes mediated by the regulatory non-coding microRNA molecules.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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