质子和γ-射线在活体 B16 细胞模型中的分子细胞效应

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.27

A. Yakimova, O. Matchuk, E. Selivanova, V.R. Gusarova, V.A. Mosina, S.N. Koryakin, I. Zamulaeva

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引用次数: 0

摘要

质子和光子（γ-）辐射在现代临床实践中被广泛用于治疗不同部位的恶性肿瘤。根据肿瘤细胞体外克隆存活的实验研究结果，加速质子的相对生物有效性（RBE）约为 1.1。然而，尽管质子辐射的 RBE 很低，但许多临床研究表明，与使用光子辐射的标准放疗相比，质子治疗后患者的无复发生存率和总生存率显著提高。体内记录的差异所基于的机制具有重要的科学和实用价值，但对其的研究却很少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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MOLECULAR CELLULAR EFFECTS BY PROTON AND γ-IRRADIATION IN THE B16 MURINE MELANOMA MODEL IN VIVO

Proton and photon (γ-) radiation is widely used in modern clinical practice for the treatment of malignant tumors of various locations. The relative biological effectiveness (RBE) of accelerated protons is about 1.1, as follows from the results of experimental studies of clonogenic survival of tumor cells in vitro. But however, despite the low RBE of proton radiation, a number of clinical studies have shown a significant increase in relapse-free and overall survival of patients after proton therapy compared with that after standard radiotherapy using photon radiation. The mechanisms, on which the differences recorded in vivo are based, are of significant scientific and practical interest, but have been poorly studied.

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.