THREE-DIMENSIONAL IN VITRO MODELS FOR STUDYING THE CHEMOSENSITIVITY OF BREAST CANCER CELLS

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.6

S.Yu. Filippova, S. V. Timofeeva, T. V. Chembarova, I. Mezhevova, L.N. Vashchenko, E. Kechedzhieva, E.A. Andreyko

引用次数: 0

Abstract

Scientists agree that three-dimensional tumor cell cultures reflect the in vitro biological features of malignant tumors to a greater extent than it is the case with the conventional monolayer cultures. In particular, the results of assessing the effectiveness of anticancer drugs obtained in three-dimensional cell models are considered as more accurate and consistent with the tumor response in vivo, where sensitivity is usually lower than that found in the in vitro experiments. Some of the most developed cellular models are structures obtained using three-dimensional bioprinting, which include not only malignant cells, but also biogels to imitate the chemical and mechanical properties of the extracellular matrix of the tumor.

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用于研究乳腺癌细胞化学敏感性的三维体外模型

科学家们一致认为，三维肿瘤细胞培养物比传统的单层培养物更能反映恶性肿瘤的体外生物学特征。特别是，在三维细胞模型中获得的抗癌药物疗效评估结果被认为更准确，更符合体内肿瘤的反应，而体内肿瘤的敏感性通常低于体外实验。一些最先进的细胞模型是利用三维生物打印技术获得的结构，其中不仅包括恶性细胞，还包括用于模仿肿瘤细胞外基质化学和机械特性的生物凝胶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.