THE INFLUENCE OF A PERIPHERAL TUMOR ON THE BEHAVIOR OF ANIMALS AND THE STRUCTURE OF NEURONS IN THE PREFRONTAL CORTEX

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.18

N. A. Obanina, N.P. Bgatova

引用次数: 0

Abstract

Melanoma is the most aggressive of the common forms of skin cancer. Proinflammatory cytokines produced by the tumor and delivered via the circulatory and lymphatic systems can lead to damage to the structures of the central nervous system. Damage to the blood-brain barrier and the endothelium of blood capillaries can cause dysfunction of neurons in the cerebral cortex, induce changes in neural plasticity, cognitive functions and result in the development of depression. Depression is observed in 20% of the cancer patients, and it affects quality of life, treatment effectiveness and survival. Depression has been linked to damage to the prefrontal cortex, which plays an important role in many brain functions, including cognition, emotion regulation, motivation and sociability.

查看原文本刊更多论文

外周肿瘤对动物行为和前额叶皮层神经元结构的影响

黑色素瘤是常见皮肤癌中最具侵袭性的一种。由肿瘤产生并通过循环和淋巴系统传递的促炎细胞因子可导致中枢神经系统结构受损。对血脑屏障和毛细血管内皮的损害可导致大脑皮层神经元功能障碍，诱发神经可塑性和认知功能的变化，并导致抑郁症的发生。20% 的癌症患者会出现抑郁，它会影响生活质量、治疗效果和生存期。抑郁症与前额叶皮质受损有关，前额叶皮质在认知、情绪调节、动机和社交能力等多项大脑功能中发挥着重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.