FEATURES OF GROWTH AND DEVELOPMENT OF B16 MELANOMA IN SEXUALLY MATURE MALE C57BLACK/6 MICE IN MODELING POST-TRAUMATIC STRESS DISORDER

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.15

M. V. Kondashevskaya, V. Aleksankina, V.V. Kudelkina, M. A. Kozlova, D. Areshidze

引用次数: 0

Abstract

It is well known that extraordinary stress or chronic exposure to stressors is characterized by adverse immunological consequences due to stress-induced immunosuppression. It has been established that stress causes an increased incidence of malignant tumors and also worsens the prognosis in patients with already existing tumors. Among the mechanisms of carcinogenesis under stress, there is an increase in the level of cortisol, which has a significant inhibitory effect on the immune system and the secretion of pro-inflammatory interleukins. Post-traumatic stress disorder (PTSD) involves inactivation of the hypothalamic-pituitary-adrenal (HPA) axis and decreased secretion of cortisol in humans, or corticosterone in rats and mice. However, the question of whether PTSD is a risk factor for the development of cancer or tumor growth remains practically undeveloped.

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性成熟雄性 C57black/6 小鼠 B16 黑色素瘤在创伤后应激障碍模型中的生长发育特征

众所周知，超常压力或长期暴露于压力源的特点是，压力诱发的免疫抑制会造成不良的免疫后果。已经证实，压力会导致恶性肿瘤的发病率增加，还会使已患有肿瘤的病人的预后恶化。在压力致癌的机制中，皮质醇水平的增加对免疫系统和促炎性白细胞介素的分泌有显著的抑制作用。创伤后应激障碍（PTSD）涉及下丘脑-垂体-肾上腺轴（HPA）失活，人类皮质醇分泌减少，大鼠和小鼠皮质酮分泌减少。然而，创伤后应激障碍是否是癌症发病或肿瘤生长的风险因素，这一问题实际上仍未得到深入研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.