Biology and Life Sciences Forum最新文献_第3页

Modulation of Human Neutrophils’ Oxidative Burst by Hydroxylated 2-Styrylchromones: The Relevance of the Catechol Group 羟基化2-苯乙烯基色素对人中性粒细胞氧化爆发的调节:儿茶酚群的相关性

Biology and Life Sciences Forum Pub Date : 2021-06-01 DOI: 10.3390/ecb2021-10283

M. Lucas, M. Freitas, Artur M. S. Silva, E. Fernandes, D. Ribeiro

{"title":"Modulation of Human Neutrophils’ Oxidative Burst by Hydroxylated 2-Styrylchromones: The Relevance of the Catechol Group","authors":"M. Lucas, M. Freitas, Artur M. S. Silva, E. Fernandes, D. Ribeiro","doi":"10.3390/ecb2021-10283","DOIUrl":"https://doi.org/10.3390/ecb2021-10283","url":null,"abstract":"2-Styrylchromones (2-SC) are a group of oxygen-containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the C-2 position of their chromone core. Over the years, several biological activities have been attributed to 2-SC, such as antioxidant, anti-inflammatory, antimicrobial, antiviral, and antitumor activities [1,2]. Nonetheless, there are no reports in the literature about the effect of 2-SC on human neutrophils’ oxidative burst. Therefore, the present study aims to evaluate the modulation of human neutrophils’ oxidative burst by a panel of hydroxylated 2-SC, previously obtained by chemical synthesis, and to analyze the structure–activity relationship [3]. For that purpose, freshly isolated neutrophils from human blood were stimulated with phorbol-12-myristate-13-acetate, and a chemiluminescence method was applied to evaluate the oxidative burst, using luminol as a probe [4]. Considering the OH substituents present on the B-ring of 2-SC, the tested compounds can be divided into the following three groups: group 1, with a catechol group (C-3′ and C-4′); group 2, with an OH at C-4′; group 3, without any substitution on the B-ring. The 2-SC from group 1 were the most active, with IC50 values in the order of 1 µM. In conclusion, the catechol B-ring appears to play an important role in the modulation of human neutrophils’ oxidative burst by 2-SC.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131290372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypolipidemic Properties of Cocoa and Coffee By-Products after Simulated Gastrointestinal Digestion: A Comparative Approach 模拟胃肠消化后可可和咖啡副产物的降血脂特性:比较方法

Biology and Life Sciences Forum Pub Date : 2021-06-01 DOI: 10.3390/ecb2021-10288

C. Braojos, M. Rebollo-Hernanz, Silvia Cañas, Y. Aguilera, S. Arribas, M. Martín-Cabrejas, V. Benítez

{"title":"Hypolipidemic Properties of Cocoa and Coffee By-Products after Simulated Gastrointestinal Digestion: A Comparative Approach","authors":"C. Braojos, M. Rebollo-Hernanz, Silvia Cañas, Y. Aguilera, S. Arribas, M. Martín-Cabrejas, V. Benítez","doi":"10.3390/ecb2021-10288","DOIUrl":"https://doi.org/10.3390/ecb2021-10288","url":null,"abstract":"New sustainable ingredients with beneficial properties for health are a main goal for the food industry. In this regard, the cocoa shell (CS) and the coffee pulp (CP), by-products from the coffee and cocoa industry produced worldwide in large amounts, are suitable candidates. We previously stated that these by-products are sources of phytochemicals and dietary fiber with potential hypolipidemic properties. This study aimed to assess the hypolipidemic properties of CS and CP after simulated gastrointestinal digestion. The capacities of the residual fraction of each digestion phase to bind bile salts and cholesterol and inhibit the lipase activity were measured to establish the in vitro hypolipidemic properties of both by-products. Furthermore, the digested fractions’ effect on lipid accumulation was evaluated in the HepG2 cell line. From results, the CS showed a higher ability to bind cholesterol (4–24%) and bile salts (2–3%) in gastric and colonic phases. Meanwhile, during the gastrointestinal phase, CP showed a greater capacity to bind cholesterol (1–13%) and bile salts (2%). The capacity to inhibit lipase activity was more accentuated in the CS in gastrointestinal digestion (16%) whereas during gastric digestion in the CP (11%). Likewise, the digested fractions of both by-products (100 µg/mL) significantly alleviated the accumulation of fat (17–20%) in the HepG2 cell model after the stimulation of cells with palmitic acid. This comparative approach suggests that both by-products exhibit similar hypolipidemic properties after in vitro digestion. This research supports the revalorization of cocoa and coffee by-products as food ingredients and nutraceuticals with potential health benefits in preventing chronic metabolic diseases. due to their remarkable hypolipidemic properties.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127244447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic Activity of Gallic Acid and Myricetin against Ovarian Cancer Cells by Production of Reactive Oxygen Species 没食子酸和杨梅素通过产生活性氧对卵巢癌细胞的细胞毒活性

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10272

L. Varela-Rodríguez, P. Talamás-Rohana, B. Sanchez-Ramirez, V. Hernández-Ramírez, Hugo Varela-Rodríguez

{"title":"Cytotoxic Activity of Gallic Acid and Myricetin against Ovarian Cancer Cells by Production of Reactive Oxygen Species","authors":"L. Varela-Rodríguez, P. Talamás-Rohana, B. Sanchez-Ramirez, V. Hernández-Ramírez, Hugo Varela-Rodríguez","doi":"10.3390/ecb2021-10272","DOIUrl":"https://doi.org/10.3390/ecb2021-10272","url":null,"abstract":"Some studies demonstrate that gallic acid (GA) and myricetin (MYR) isolated from Rhus trilobata provide the therapeutic activity of this plant against cancer. However, few reports demonstrate that both compounds could also have therapeutic potential in ovarian cancer. Therefore, evaluating the cytotoxic activity of GA and MYR against ovarian cancer cells and determining the possible action mechanism present are important. For this purpose, SKOV-3 cells (ovarian adenocarcinoma; HTB-77™, ATCC®) were cultivated according to the supplier’s instructions (37 °C and 5% CO2) to determine the biological activity of GA and MYR by confocal/transmission electron microscopy, PI-flow cytometry, H2DCF-DA, MTT, and Annexin-V assays. Possible molecular targets of the compounds were determined by the Similarity Ensemble approach. Results showed that GA and MYR treatments decreased the viability of SKOV-3 cells at 50 and 166 μg/mL, respectively (p ≤ 0.05, ANOVA vs. vehicle group). They also induced morphological changes (cytoplasmic reduction, nuclear chromatin condensation, cytoplasmic vesicles increment, polymerized actin, and stabilized tubulin), cell cycle arrest (GA: 8.3% G2/M and MYR: 78% G1), and apoptosis induction (GA: 18.9% and MYR: 8.1%), due to ROS generation (34 to 42%) for 24 h (p ≤ 0.05, ANOVA vs. vehicle group). In silico studies demonstrated that GA and MYR interact with carbonic anhydrase-IX and PI3K, respectively. In conclusion, GA and MYR show cytotoxic activity against SKOV-3 cells through ROS production, which modifies the cytoskeleton and induces apoptosis. Therefore, GA and MYR could be considered as base compounds for the development of new treatments in chemotherapy for ovarian cancer.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128333152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Green Method to Synthesize Size-Controllable Gold Nanostars for Photothermal Therapy and Photoacoustic Imaging 光热治疗和光声成像用可控尺寸金纳米星的绿色合成方法

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10278

Thi Tuong Vy Phan

{"title":"A Green Method to Synthesize Size-Controllable Gold Nanostars for Photothermal Therapy and Photoacoustic Imaging","authors":"Thi Tuong Vy Phan","doi":"10.3390/ecb2021-10278","DOIUrl":"https://doi.org/10.3390/ecb2021-10278","url":null,"abstract":"Photothermal therapy (PTT) is a novel therapy for cancer treatment which is based on the conversion of photon energy into heat (>43 °C), and photoacoustic imaging (PAI) is a new bioimaging method for diagnosing and monitoring cancer. To enhance the impact depth of PTT and the signal of PAI, near-infrared (NIR)-absorbing photothermal agents are usually used. The development of novel NIR-absorbing photothermal agents with excellent properties, such as a high stability under long-term irradiation, strong absorption in the NIR range, and excellent biocompatibility, is needed in modern biomedicine. Previous research has proved that gold nanostars (AuNSs) have promising potential applications in photo-based therapies owing to their strong absorption in the NIR range and strong photothermal effects. However, the reported methods to synthesize AuNSs are complicated and toxic, which can limit its practical application. In this work, we proposed a new environmental strategy to synthesize AuNSs by using chitosan and vitamin C. Chitosan plays multiple roles, acting as stabilizing, shape-directing, and size-controllable agents in this method for the first time. The obtained AuNSs show strong NIR absorption and biocompatibility toward non-cancerous and cancerous cell lines. The in vitro tests proved the high efficiency of the obtained AuNSs in both PTT and PAI.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128885882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the Phytochemicals from the Cocoa Shell on the Prevention of Metabolic Syndrome by an Integrated Network Pharmacology Analysis 可可壳植物化学物质对代谢综合征预防作用的综合网络药理学分析

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10256

M. Rebollo-Hernanz, Silvia Cañas, C. Braojos, S. Arribas, M. Martín-Cabrejas

{"title":"Role of the Phytochemicals from the Cocoa Shell on the Prevention of Metabolic Syndrome by an Integrated Network Pharmacology Analysis","authors":"M. Rebollo-Hernanz, Silvia Cañas, C. Braojos, S. Arribas, M. Martín-Cabrejas","doi":"10.3390/ecb2021-10256","DOIUrl":"https://doi.org/10.3390/ecb2021-10256","url":null,"abstract":"The metabolic syndrome is a cluster of conditions that occur together, increasing the risk of chronic diseases such as obesity, type II diabetes, or cardiovascular disease. Nutritional interventions improving inflammation, bioenergetics, and oxidative stress are proposed as effective tools in preventing metabolic syndrome. The cocoa shell is a by-product generated in large amounts during cocoa production. This by-product contains alkaloids and phenolic compounds as main compounds and has been investigated as an anti-obesity and anti-diabetic agent. Here, we used network pharmacology to explore the potential mechanism of the phytochemicals from the cocoa shell. We searched the cocoa shell’s phytochemical composition; then, oral bioavailability and drug-likeness were screened. We predicted the targets for the phytochemicals found in this by-product and used different databases to search for compound–protein and compound–gene interactions, and then protein–protein interaction networks were constructed. Moreover, pathway enrichment analysis was performed, and biological processes and signaling pathways were identified and illustrated through bioinformatics analyses. Theobromine, caffeine, procyanidin B2, (−)-epicatechin, (+)-catechin, and protocatechuic acid were identified in the cocoa shell as main components. Those phytochemicals were associated with inflammation (TNF-α, NF-κB, JNK)-, oxidative stress (CAT, SOD)-, obesity (adiponectin, leptin, FASN, PPAR-α)-, and diabetes (insulin, AKT)-related pathways. Results demonstrated that cocoa shell phytochemicals could modulate multiple biological processes and signaling pathways in a multimechanistic manner. Hence, cocoa shell consumption could support the nutritional prevention of metabolic syndrome. Future in vivo and clinical investigations will be needed to validate this potential nutraceutical and healthy ingredient’s effects and mechanisms.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130519848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhythmically Enhanced Music as Analgesic for Chronic Pain: A Pilot, Non-Controlled Observational Study 节奏增强音乐作为慢性疼痛的镇痛剂:一项试点，非对照观察研究

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10266

Richard Merrill, M. Amin

{"title":"Rhythmically Enhanced Music as Analgesic for Chronic Pain: A Pilot, Non-Controlled Observational Study","authors":"Richard Merrill, M. Amin","doi":"10.3390/ecb2021-10266","DOIUrl":"https://doi.org/10.3390/ecb2021-10266","url":null,"abstract":"Chronic pain changes brain connectivity, brainwaves, and volume, often resulting in disability, anxiety, and depression. Opioid pain relievers impair function, with risk of addiction. Music analgesia research suggests that music for long-term analgesia includes slow tempo, pleasantness, and self-choice. Hypothesis: individuals listening to self-chosen music with embedded beats ½ h twice a day, could show brainwave entrainment (BWE) at healthy frequencies of healthy descending pain modulatory system. BWE may change brain activity, restoring organization in DPMS altered by chronic pain. Volunteers with chronic pain >1 year participated in a study of 4 weeks of listening to one half hour of music twice a day, and four weeks of non-listening, reporting pain and analgesic use bi-weekly using visual analog scale (VAS) and 0–10 numerical pain scores (NPS), medication types, and dosage. Volunteers selected from 27 half-hour pieces of music in several genres in a mobile app. Isochronic beats were embedded in the music with tempo, key, and isochronic theta frequencies proportional, to enhance the brain’s perception of rhythmic patterns and harmonics. Mean NPS showed a 26% reduction (p = 0.018). Significantly, mean medication dosage declined by over 60% (p = 0.008). Double-blind studies, larger populations are needed in future.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116308039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Metabolic Stability of Ligands of Serotonin Receptor 5-HT7 Using SHAP Values 利用SHAP值优化5-HT7受体配体代谢稳定性

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10258

Agnieszka Wojtuch, R. Jankowski, Sabina Podlewska

引用次数: 0

Molecular Docking Study on the Interaction of Rhodopsin-like Receptors with Tetracoordinated Gold(III) Complexes 紫红质样受体与四配位金(III)配合物相互作用的分子对接研究

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10264

Ana S. Kesić, D. Milenkovic, Marko R Antonijević, B. Petrović, Z. Marković

{"title":"Molecular Docking Study on the Interaction of Rhodopsin-like Receptors with Tetracoordinated Gold(III) Complexes","authors":"Ana S. Kesić, D. Milenkovic, Marko R Antonijević, B. Petrović, Z. Marković","doi":"10.3390/ecb2021-10264","DOIUrl":"https://doi.org/10.3390/ecb2021-10264","url":null,"abstract":"The pharmacologic properties of gold compounds have been known since the end of the 19th century. In the last decade gold complexes have received increased attention due to the variety of their applications. Rhodopsin-like receptors are a family of proteins that belong to the largest group of G-protein-coupled receptors (GPCRs). In this paper the molecular interactions between the active binding sites of rhodopsin-like receptors (RLRs) and synthesized gold(III) complexes ([Au(DPP)Cl2]+, where DPP = 4,7-diphenyl-1,10-phenanthroline) were investigated through molecular docking simulations. The crystal structure of investigated RLRs (PDB ID: 4A4M) was extracted from the RCSB Protein Data Bank in a PDB format. The native bound ligand (11-cis-retinal) was extracted from receptors and a binding pocket analysis was performed. Redocking was performed with gold(III) complexes to generate the same docking pose as found in the cocrystallized form of receptors. The binding energy of gold(III) complexes to RLRs was found to be −35.35 kJ/mol, as opposed to 11-cis-retinal, where it was about −40.5 kJ/mol. The obtained results revealed that gold(III) complexes bind at the same binding pockets to RLRs, as well as native bound ligands, via weak noncovalent interactions. The most prominent interactions are hydrogen bonds, alkyl–π and π–π interactions. The preliminary results suggest that gold(III) complexes showed good binding affinity against RLRs as well as the native bound ligand 11-cis-retinal, as evident from the free binding energy (ΔGbind in kJ/mol).","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132796343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effects of 5-Fluorouracil in Combination with Diosmetin in Colorectal Cancer Cells 5-氟尿嘧啶联合薯蓣皂苷对结直肠癌细胞的协同作用

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10276

Sareh Kamran, A. Sinniah, M. Alshawsh

{"title":"Synergistic Effects of 5-Fluorouracil in Combination with Diosmetin in Colorectal Cancer Cells","authors":"Sareh Kamran, A. Sinniah, M. Alshawsh","doi":"10.3390/ecb2021-10276","DOIUrl":"https://doi.org/10.3390/ecb2021-10276","url":null,"abstract":"Colorectal cancer (CRC) is among the most commonly occurring cancers. The management of CRC includes laparoscopic surgery, radiotherapy, chemotherapies and neoadjuvant treatment. However, conventional chemotherapies have poor impact on combating CRC and are associated with severe toxic effects and high rates of relapse. Therefore, searching for a new combination regimen is a favorable consideration. The aim of this study was to elucidate the synergistic effect of 5-fluorouracil (5-FU) and diosmetin in an in vitro model on colorectal cancer cells. An MTT assay was conducted on HCT-116 cancer cells and they were treated with a concentration gradient of 5-FU and diosmetin individually and in combination. The combination index (CI) and dose reduction index (DRI) were calculated using CompuSyn software. Isobologram analysis and synergism determination were performed using the Combenefit software tool and the synergy score was calculated using the SynergyFinder 2.0 software tool. The apoptotic features of the cells were determined via an AO/PI double staining assay and an annexin V assay using a fluorescent microscope and the flow cytometry technique, respectively. The findings showed that the DRI of 5-FU was three-fold lower in the combination with a CI value of less than one, which indicates that there was a synergistic effect. The AO/PI microscopic results revealed signs of apoptosis and dead cells after 72 h of treatment. Flow cytometry analysis confirmed that the apoptotic effect of the combination was more prominent compared to 5-FU alone. The findings of this study offer a potential strategy for reducing the cytotoxicity and enhancing the efficacy of 5-FU on colorectal cancer cells through a synergistic study model.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133036187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Study of Natural Compounds as Antidepressants by Bioinformatics Methods 用生物信息学方法研究天然化合物抗抑郁药

Biology and Life Sciences Forum Pub Date : 2021-05-31 DOI: 10.3390/ecb2021-10268

S. Avram, M. Stan, A. Udrea, C. Buiu, M. Mernea

{"title":"The Study of Natural Compounds as Antidepressants by Bioinformatics Methods","authors":"S. Avram, M. Stan, A. Udrea, C. Buiu, M. Mernea","doi":"10.3390/ecb2021-10268","DOIUrl":"https://doi.org/10.3390/ecb2021-10268","url":null,"abstract":"According to the World Health Organization, neuropsychiatric disorders pose an increasingly greater burden on health, society, and economy of countries. Currently, there are strategies to prevent some of these disorders, and there are treatments or means to alleviate their symptoms. In the case of depression, the medication consists of antidepressant drugs. Such drugs can also be used in other conditions like anxiety, pain, or insomnia. A shortcoming of the currently used antidepressants is the occurrence of side effects that sometimes are unbearable for the patient. In this respect, a promising direction is the usage of medicinal plants. Plant parts are rich in phytochemicals that could be beneficial in mental disorders by acting on various targets. Here, we investigated the antidepressant effect of ten natural compounds from sage, mint, and citrus. The biological activity of these compounds was investigated by calculating pKi values and affinities for dopamine receptor D2, serotonin transporter (SERT), and 5-hydroxytryptamine receptor 1A (5-HT1A) using quantitative structure-activity relationship (QSAR) models. Our results showed that linalyl acetate, 1,8-cineole, and neryl acetate could be efficient antidepressants and neuroleptics.","PeriodicalId":400770,"journal":{"name":"Biology and Life Sciences Forum","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114461738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2