Diagnostic Histopathology最新文献_第6页

Molecular pathology of endometrial cancer: recent advances in classification, prognostication, and management 子宫内膜癌的分子病理学：分类、预后和管理方面的最新进展

Diagnostic Histopathology Pub Date : 2024-07-01 DOI: 10.1016/j.mpdhp.2024.06.003

Mona Alfaraidi, Jutta Huvila, C Blake Gilks

{"title":"Molecular pathology of endometrial cancer: recent advances in classification, prognostication, and management","authors":"Mona Alfaraidi, Jutta Huvila, C Blake Gilks","doi":"10.1016/j.mpdhp.2024.06.003","DOIUrl":"10.1016/j.mpdhp.2024.06.003","url":null,"abstract":"<div><p><span>Endometrial carcinoma<span><span> is the most common gynaecological malignancy in the UK and its incidence is increasing worldwide. The classification of endometrial carcinoma (EC) has been based on cell type (histotype) for decades, and this, together with grade, lymphovascular space invasion (LVSI) and stage of the tumor was used for risk assessment, guiding decisions about the extent of surgery and the need for post-surgical adjuvant treatment. There has been, and remains, considerable variation in clinical practice worldwide, with respect to both the extent of surgery (lymph node dissection, </span>omentectomy<span>, pelvic washings) and use of adjuvant therapy (radiation, chemotherapy, or both) for patients with identical risk factors but treated at different centers. Furthermore, EC has tended to be treated as a single disease, irrespective of histotype. In the past five years there has been a significant move to more personalized risk assessment and treatment with the introduction of routine molecular assessment of EC, and diagnosis of molecular subtype. The four EC molecular subtypes differ with respect to molecular pathology, </span></span></span>genetic and environmental risk factors, precursor lesions, prognosis and response to specific treatments. This review will discuss the assessment of EC molecular subtype in clinical practice and how this information impacts on risk assessment and treatment.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 9","pages":"Pages 499-510"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141709477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinguishing non-small-cell carcinoma from its histological mimics: diagnostic challenges in pulmonary pathology 区分非小细胞癌及其组织学模拟物：肺病理学诊断中的挑战

Diagnostic Histopathology Pub Date : 2024-07-01 DOI: 10.1016/j.mpdhp.2024.04.004

Andrew Robinson, Ayesha Azam, David Snead

{"title":"Distinguishing non-small-cell carcinoma from its histological mimics: diagnostic challenges in pulmonary pathology","authors":"Andrew Robinson, Ayesha Azam, David Snead","doi":"10.1016/j.mpdhp.2024.04.004","DOIUrl":"10.1016/j.mpdhp.2024.04.004","url":null,"abstract":"<div><p>Pulmonary pathologists often must make a diagnosis based on small specimens derived from aspirated or solid tissue fragments, extracted under radiological guidance, containing limited diagnostic material. This poses a diagnostic challenge. Advances in treatment also demand tissue is analysed for multiple molecular anomalies therefore pathologists must be judicious in their use of ancillary tests such as immunohistochemistry. Whilst the majority of tumours encountered are non-small cell lung carcinomas, the lungs and thorax are a common metastatic site and can display a wide variety of different tumour types. Some tumours can closely mimic the appearances of non-small cell carcinomas and failure to recognise these can result in misdiagnosis and incorrect treatment and management for the patient. In this article we specifically focus on a variety of different tumours that can masquerade as non-small cell carcinomas. This includes both benign and malignant primary lung tumours, sarcomas, melanomas and germ cell tumours. We describe how to approach and recognise these entities, with specific focus on the histological and immunohistochemical appearances, and identify potential pitfalls to avoid in routine practice.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 7","pages":"Pages 371-385"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-based biomarkers in pulmonary malignancies 肺部恶性肿瘤中基于蛋白质的生物标记物

Diagnostic Histopathology Pub Date : 2024-07-01 DOI: 10.1016/j.mpdhp.2024.04.002

Alexander K. Haragan

{"title":"Protein-based biomarkers in pulmonary malignancies","authors":"Alexander K. Haragan","doi":"10.1016/j.mpdhp.2024.04.002","DOIUrl":"10.1016/j.mpdhp.2024.04.002","url":null,"abstract":"<div><p>Targeted therapies have revolutionised the management of patients with lung cancer over the last 20 years. A crucial role for pulmonary pathologists is to provide high quality and timely analysis of predictive biomarkers that guide the use of these targeted treatments. Protein-based biomarkers, alongside nucleic acid analyses, are mostly used to predict response to therapies that inhibit oncogenic stimulation or utilise immune checkpoint inhibition. Despite the protein-based mechanism of action of targeted therapies, development of biomarkers for lung cancers have been chiefly focused on genomics. With ongoing expansion of targeted treatments, including novel classes of therapeutics such as antibody drug conjugates, and an increasing requirement for effective biomarkers, however, immunochemistry and related techniques may still continue to play a valuable and crucial role in predictive profiling. This review will focus on current and future protein-based biomarkers in pulmonary malignancies alongside the assays, underlying biology and appropriate clinical context required to effectively utilise them. This will provide an overview of the role of the pathologist in effectively guiding targeted treatments for lung cancer patients.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 7","pages":"Pages 351-361"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing for genomic biomarkers in non-small-cell lung cancer 测试非小细胞肺癌的基因组生物标志物

Diagnostic Histopathology Pub Date : 2024-07-01 DOI: 10.1016/j.mpdhp.2024.04.003

Oliver G Shutkever, Philip Bennett, David A Moore

引用次数: 0

Case report of spontaneous coronary artery dissection as a cause of death 自发性冠状动脉夹层致死病例报告

Diagnostic Histopathology Pub Date : 2024-07-01 DOI: 10.1016/j.mpdhp.2024.04.006

Stella Garvie, Ian SD Roberts

引用次数: 0

A low-grade mucinous neoplasm arising within an ovarian mature cystic teratoma: a case report 卵巢成熟囊性畸胎瘤内的低级别粘液瘤：病例报告

Diagnostic Histopathology Pub Date : 2024-06-29 DOI: 10.1016/j.mpdhp.2024.06.006

Donna O’Dwyer, Steven Nottley, Sarah Bell

引用次数: 0

Painting the path to precision: unraveling endocrine tumors with immunohistochemistry 绘制精准之路：用免疫组化揭开内分泌肿瘤的神秘面纱

Diagnostic Histopathology Pub Date : 2024-06-01 DOI: 10.1016/j.mpdhp.2024.03.003

L. Samuel Hellgren, C. Christofer Juhlin

{"title":"Painting the path to precision: unraveling endocrine tumors with immunohistochemistry","authors":"L. Samuel Hellgren, C. Christofer Juhlin","doi":"10.1016/j.mpdhp.2024.03.003","DOIUrl":"10.1016/j.mpdhp.2024.03.003","url":null,"abstract":"<div><p>While morphological assessment remains the primary cornerstone in tumor diagnostics, immunohistochemical (IHC) analyses hold immense value in surgical pathology. This is particularly true in endocrine pathology, which encompasses a multitude of tumors from various organs, often presenting with several morphological mimics. In many cases, IHC proves to be invaluable for practicing pathologists in reaching accurate diagnoses. Furthermore, IHC plays a pivotal role in prognosticating endocrine tumors, aiding pathologists in grading and assessing the risk associated with these lesions. Additionally, the identification of specific markers has enabled the recognition of subsets of endocrine tumors suitable for tailored therapies. Consequently, IHC assumes a crucial role in the comprehensive management of endocrine neoplasia, encompassing diagnosis, prognostication, and treatment. This review article comprehensively explores the fundamentals of IHC in the clinical workup of endocrine and neuroendocrine tumors, with a specific emphasis on what pathologists in training should be familiar with, encompassing both its strengths and potential pitfalls.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 6","pages":"Pages 324-338"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear features in thyroid cytology: features helpful for a morphological diagnosis in routine practice 甲状腺细胞学中的核特征：有助于常规形态学诊断的特征

Diagnostic Histopathology Pub Date : 2024-06-01 DOI: 10.1016/j.mpdhp.2024.04.001

Priya Bhagwat, Sabine Pomplun

引用次数: 0

The application of artificial intelligence to thyroid nodule assessment 人工智能在甲状腺结节评估中的应用

Diagnostic Histopathology Pub Date : 2024-06-01 DOI: 10.1016/j.mpdhp.2024.03.004

Paola Chiara Rizzo, Stefano Marletta, Nicolò Caldonazzi, Alessia Nottegar, Albino Eccher, Fabio Pagni, Vincenzo L'Imperio, Liron Pantanowitz

引用次数: 0

Rectal gastric heterotopia with fundic gland polyps, mimicking a high-risk primary anorectal neoplasm: histological evidence of the effects of gastric acid-suppressing medication in a rectal ‘outlet patch’ 直肠胃异位伴胃底腺息肉，模仿高风险原发性肛门直肠肿瘤：直肠 "出口斑块 "胃酸抑制药物作用的组织学证据

Diagnostic Histopathology Pub Date : 2024-06-01 DOI: 10.1016/j.mpdhp.2024.03.005

Ethan Clarke, Khine Thu, Tim Bracey

引用次数: 0