DEK: AFF2融合阳性癌，一个潜在的误诊实体：组织学概述和诊断线索

Diagnostic Histopathology Pub Date : 2025-04-01 DOI:10.1016/j.mpdhp.2025.02.007

Lucy Ryan, Xin-Ying Kowa, Jonathan Joseph, Amrita Jay, Oluyori K Adegun

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引用次数: 0

摘要

我们报告一例88岁男性患者，其鼻大病变在临床和影像学上被认为是内翻性乳头状瘤，但随后病理诊断为癌，特别是具有明显DEK - AFF2融合的非角化鳞状细胞癌。这种头颈部癌的变体是一种新兴的实体，被认为具有独特的形态，应该促进分子研究。与良性乳头状瘤病变重叠的组织学特征强调了识别这种实体的必要性，因为它们与侵袭性临床病程相关，包括复发和远处转移。此外，特异性融合的鉴定可能潜在地增加治疗手段。

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DEK::AFF2 fusion positive carcinoma, a potentially misdiagnosed entity: overview of histology and diagnostic clues

We report a case of an 88-year-old male with a large nasal lesion thought to be an inverted papilloma clinically and on imaging, but subsequently diagnosed histologically as a carcinoma, specifically, a non-keratinizing squamous cell carcinoma with the distinct DEK - AFF2 fusion. This variant of carcinoma in the head and neck is an emerging entity thought to have a distinct morphology, that should prompt molecular studies. Overlapping histological features with benign papillomatous lesions emphasizes the need for identification of this entity, as they have been associated with an aggressive clinical course including relapse and distant metastases. In addition, identification of the specific fusion may potentially add to the therapeutic armamentarium.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.