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Diagnostic Histopathology最新文献

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Papillary cystadenoma of the epididymis: a benign mimic of malignancy 附睾乳头状囊腺瘤：一种恶性肿瘤的良性模拟
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-03-12 DOI: 10.1016/j.mpdhp.2026.02.008
Palzum Sherpa, Bibi Leila Ahmed
{"title":"Papillary cystadenoma of the epididymis: a benign mimic of malignancy","authors":"Palzum Sherpa,&nbsp;Bibi Leila Ahmed","doi":"10.1016/j.mpdhp.2026.02.008","DOIUrl":"10.1016/j.mpdhp.2026.02.008","url":null,"abstract":"<div><div>Papillary cystadenoma of the epididymis is a rare, benign tumour which can occur sporadically or in association with Von Hippel-Lindau syndrome. We present a case of an eighty year old male with a painless right scrotal lump. Testicular ultrasound showed a hypervascular solid mass with heterogeneous echotexture in the right epididymal head. The patient underwent a right orchidectomy. Histopathological examination aided by immunohistochemical studies revealed a papillary cystadenoma of the epididymis measuring up to 35 mm. This benign entity can mimic malignancy radiologically in addition to its histopathological resemblance to metastatic clear cell renal cell carcinoma. A panel of immunomarker comprising of but not limited to CK7, CD10 and RCC can facilitate accurate diagnosis and guide patient management.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 283-285"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147862807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The next chapter in renal cell carcinoma: emerging entities and diagnostic refinements beyond the WHO 5th edition (2022–2025) 肾细胞癌的下一章：新兴实体和超越世卫组织第5版（2022-2025）的诊断改进
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-03-12 DOI: 10.1016/j.mpdhp.2026.02.004
Rola M Saleeb, Vincent Francis Castillo, Manju Aron, Mahul B Amin
{"title":"The next chapter in renal cell carcinoma: emerging entities and diagnostic refinements beyond the WHO 5th edition (2022–2025)","authors":"Rola M Saleeb,&nbsp;Vincent Francis Castillo,&nbsp;Manju Aron,&nbsp;Mahul B Amin","doi":"10.1016/j.mpdhp.2026.02.004","DOIUrl":"10.1016/j.mpdhp.2026.02.004","url":null,"abstract":"<div><div>Renal tumor classification has moved quickly since the 2022 edition of <em>WHO Classification of Tumours</em>, because now routine molecular testing and pathway-based immunohistochemistry allow us to separate lesions that have a similar morphology but are biologically and clinically distinct. Herein, we highlight entities that have come into clearer diagnostic focus and are increasingly ready for routine practice and incorporation into future classification systems, including low-grade-oncocytic-tumor (LOT), eosinophilic-vacuolated-tumor (EVT), renal cell carcinoma with fibromyomatous-stroma (RCC FMS) (now best approached as at least two molecular subsets, <em>ELOC</em>-mutated and <em>TSC</em>/<em>MTOR</em>-altered, with a residual “not-otherwise-specified” category when molecular confirmation is unavailable), <em>FLCN</em>-mutated oncocytic renal neoplasms, the low-grade-like phenotype of FH-deficient RCC, and biphasic hyalinizing psammomatous RCC (BHPRCC). We also include select WHO-2022 recognized tumor types that have undergone important recent scholarship. A central theme is that “low grade eosinophilic” morphology is not a single bucket but instead reflects distinct driver pathways with different implications for prognosis, syndromic association, and therapy selection. Our goal is not to promote new nomenclature for its own sake, but to provide a practical framework that busy pathologists can use to link morphology with the most informative ancillary tests and to recognize when an apparently indolent tumor has broader clinical significance.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 252-271"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147862724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update on testicular sex cord stromal tumours: recent advances and diagnostic pearls 睾丸性索间质瘤的最新进展：最新进展和诊断珍珠
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-04-01 DOI: 10.1016/j.mpdhp.2026.02.002
João Lobo, Andres M Acosta
{"title":"An update on testicular sex cord stromal tumours: recent advances and diagnostic pearls","authors":"João Lobo,&nbsp;Andres M Acosta","doi":"10.1016/j.mpdhp.2026.02.002","DOIUrl":"10.1016/j.mpdhp.2026.02.002","url":null,"abstract":"<div><div>Testicular sex cord-stromal tumors (TSCSTs) are rare, comprising a relatively wide variety of tumors with sex cord, stroma, or mixed phenotypes. Classification is important for clinical management, since several tumor types are associated with tumor predisposition syndrome or other underlying medical conditions. Additionally, a subset of TSCSTs are clinically malignant and unresponsive to systemic treatments, highlighting the importance of recognizing neoplasms with malignant potential. Historically, their classification has relied largely on morphology since immunohistochemistry, with some notable exceptions, is largely non-specific. In recent years, several studies have generated new data that improved our understanding of these tumors, impacting classification and prognostication. In this review we provide a summary of the most relevant histologic types of TSCST, emphasizing recent advances with potential clinical application.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 231-242"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147862726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report of a usual metastatic lobular carcinoma of the breast into the bladder 乳腺小叶癌转移至膀胱1例报告
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-03-24 DOI: 10.1016/j.mpdhp.2026.02.006
Sinead McKenna Favier, Matthew Theodosiou, Elizabeth Crawford, Mona Jain, Kate Macdougall, Scarlet Brockmoeller
{"title":"Case report of a usual metastatic lobular carcinoma of the breast into the bladder","authors":"Sinead McKenna Favier,&nbsp;Matthew Theodosiou,&nbsp;Elizabeth Crawford,&nbsp;Mona Jain,&nbsp;Kate Macdougall,&nbsp;Scarlet Brockmoeller","doi":"10.1016/j.mpdhp.2026.02.006","DOIUrl":"10.1016/j.mpdhp.2026.02.006","url":null,"abstract":"<div><div>This is a case report of a 74-year-old female patient who clinically presented with urinary symptoms and bilateral hydronephrosis, with a previous history of recurrent metastatic lobular breast cancer, liver cirrhosis and duodenal perforation. Cystoscopy revealed a macroscopically ‘unusual’ bladder with further induration of the anterior vaginal wall. Histology from the transurethral bladder resection revealed bladder mucosa, including detrusor muscle, lined by bland reactive urothelium. Underlying the urothelium, highly atypical cells were noticed both singly, and in clusters, with formation of glandular structures and focal central mucinous secretions. Occasional signet ring cells were also observed. Immunohistochemical stains showed strong positivity for CK7 and GATA3, and focally weak staining for p63. Further CK20 (non-specific), CK5/6, CDX2 (blush) were interpreted as negative. E-cadherin showed a mixed pattern between complete negative and incomplete granular membranous staining. Hormonal receptor showed weak expression for oestrogen (3/8) and progesterone (3/8) and was negative for HER 2 (0). This adenocarcinoma sampled in the bladder has been found to demonstrate a similar expression of hormonal receptors as in the primary breast resection specimen in 2005. Overall, given the localization of the lesion in the bladder, the clinical impression at flexible cystoscopy, the morphological features on H&amp;E, the immunohistochemical staining pattern, the normal background urothelium, and most importantly the history of the patient we overall favoured a metastatic lobular breast carcinoma as opposed to a rare primary adenocarcinoma of the bladder. However, close clinical and pathological correlation with imaging and a full patient history is extremely beneficial in these cases. Multi-disciplinary team meeting discussion was performed on this case.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 275-279"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147862810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alveolar soft part sarcoma of the bladder: a rare tumour in an unusual location 膀胱肺泡软部肉瘤：罕见肿瘤，位置不寻常
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-03-18 DOI: 10.1016/j.mpdhp.2026.02.007
Harriet Hunter, Julia Patterson, Demetris Poyiatzis, Mohamed Ahmed
{"title":"Alveolar soft part sarcoma of the bladder: a rare tumour in an unusual location","authors":"Harriet Hunter,&nbsp;Julia Patterson,&nbsp;Demetris Poyiatzis,&nbsp;Mohamed Ahmed","doi":"10.1016/j.mpdhp.2026.02.007","DOIUrl":"10.1016/j.mpdhp.2026.02.007","url":null,"abstract":"<div><div>Alveolar soft part sarcoma (ASPS) is a rare tumour of uncertain histogenesis. While it most commonly occurs in deep soft tissue locations, we present a case occurring in the bladder neck. While rare, this tumour has a distinctive morphology and immunohistochemical phenotype, and the diagnosis can be confirmed by testing for the ASPSC::TFE3 fusion gene.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 280-282"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147862808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-grade oncocytic tumour: an emerging renal tumour with unique histopathologic features 低级别嗜瘤细胞肿瘤：一种新出现的肾肿瘤，具有独特的组织病理特征
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-03-23 DOI: 10.1016/j.mpdhp.2026.02.001
Angad Singh, Alphy Varughese, Greta Rodrigues
{"title":"Low-grade oncocytic tumour: an emerging renal tumour with unique histopathologic features","authors":"Angad Singh,&nbsp;Alphy Varughese,&nbsp;Greta Rodrigues","doi":"10.1016/j.mpdhp.2026.02.001","DOIUrl":"10.1016/j.mpdhp.2026.02.001","url":null,"abstract":"<div><div>There has been a recent addition of entities categorized as emerging renal tumours in the WHO 2022 classification of renal tumours, particularly among oncocytic renal tumours. These emerging entities include low grade oncocytic tumour and eosinophilic vacuolated tumour. Low grade oncocytic tumour (LOT) is a reproducible entity with characteristic histomorphologic and immunohistochemical features. We describe four cases of low grade oncocytic tumour diagnosed at Hull Royal Infirmary and discuss their morphologic, immunohistochemical findings along with a short review of the current literature.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 227-230"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147858107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed neuroendocrine (small cell) and sarcomatoid carcinoma of the renal pelvis 肾盂混合性神经内分泌（小细胞）和肉瘤样癌
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-03-21 DOI: 10.1016/j.mpdhp.2026.02.005
Anjana Kalladathil Sreenivasan, Surabhi Agrawal, Sumiti Vanjani, Matthew Sephton, Limi Mohandas
{"title":"Mixed neuroendocrine (small cell) and sarcomatoid carcinoma of the renal pelvis","authors":"Anjana Kalladathil Sreenivasan,&nbsp;Surabhi Agrawal,&nbsp;Sumiti Vanjani,&nbsp;Matthew Sephton,&nbsp;Limi Mohandas","doi":"10.1016/j.mpdhp.2026.02.005","DOIUrl":"10.1016/j.mpdhp.2026.02.005","url":null,"abstract":"<div><div>Invasive urothelial carcinoma is the most common malignancy of the bladder and renal pelvis, but may occasionally exhibit variant histology or divergent differentiation, such as squamous, glandular, or neuroendocrine features. Recognition of unusual morphological patterns, including small cell carcinoma of the renal pelvis and its coexistence with sarcomatoid squamous cell carcinoma, represents an aggressive tumour phenotype and is critical for accurate diagnosis. Such histological variants pose diagnostic and therapeutic challenges due to their atypical morphology, rapid progression, and poor prognosis. This case highlights the clinical presentation, histopathological features, and immunohistochemical confirmation of this rare biphasic tumour.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 272-274"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147862809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What's new in penile neoplasia: an update for the practising pathologist 什么是新的阴茎瘤：为执业病理学家更新
Diagnostic Histopathology Pub Date : 2026-05-01 Epub Date: 2026-03-19 DOI: 10.1016/j.mpdhp.2026.02.003
Aswathy Menon, Aiman Haider, Lara R Harik, Santosh Menon
{"title":"What's new in penile neoplasia: an update for the practising pathologist","authors":"Aswathy Menon,&nbsp;Aiman Haider,&nbsp;Lara R Harik,&nbsp;Santosh Menon","doi":"10.1016/j.mpdhp.2026.02.003","DOIUrl":"10.1016/j.mpdhp.2026.02.003","url":null,"abstract":"<div><div>Penile squamous cell carcinoma (pSCC) remains a rare but increasingly important malignancy with pronounced geographic heterogeneity and a projected rise in global incidence. Contemporary classification recognizes two principal pathogenetic pathways— Human papilloma virus (HPV)-associated and HPV-independent—with distinctive morphologic, immunophenotypic, and molecular features. This review summarizes recent updates relevant to diagnostic practice, including molecular pathogenesis of penile cancer, morphologic spectrum of invasive and pre-invasive disease, pragmatic use of ancillary tests, addressing potential pitfalls and staging refinements. We aim to provide a concise, practice-focused guide for pathologists reporting penile tumours, underscoring standardized terminology, reproducible ancillary testing, and essential data elements that directly influence multidisciplinary care.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 5","pages":"Pages 243-251"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147862725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical applications of genomic panel testing for salivary gland cancers 唾液腺癌基因组面板检测的临床应用
Diagnostic Histopathology Pub Date : 2026-04-01 Epub Date: 2026-02-24 DOI: 10.1016/j.mpdhp.2026.01.010
Orla Busby, N.N. Patel, I. Boon, K. Moutasim
{"title":"Clinical applications of genomic panel testing for salivary gland cancers","authors":"Orla Busby,&nbsp;N.N. Patel,&nbsp;I. Boon,&nbsp;K. Moutasim","doi":"10.1016/j.mpdhp.2026.01.010","DOIUrl":"10.1016/j.mpdhp.2026.01.010","url":null,"abstract":"","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 4","pages":"Pages 224-225"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance of tumour-infiltrating lymphocytes in head and neck cancer 肿瘤浸润淋巴细胞在头颈部肿瘤中的临床意义
Diagnostic Histopathology Pub Date : 2026-04-01 Epub Date: 2026-02-24 DOI: 10.1016/j.mpdhp.2026.01.012
Alhadi Almangush
{"title":"Clinical significance of tumour-infiltrating lymphocytes in head and neck cancer","authors":"Alhadi Almangush","doi":"10.1016/j.mpdhp.2026.01.012","DOIUrl":"10.1016/j.mpdhp.2026.01.012","url":null,"abstract":"","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 4","pages":"Page 225"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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