Diagnostic Histopathology最新文献

Gelatinous transformation of bone marrow in anorexia nervosa presenting with chronic cytopenia: a histopathological diagnostic pitfall 以慢性细胞减少症为表现的神经性厌食症患者骨髓胶质转化：一个组织病理学诊断缺陷

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-05 DOI: 10.1016/j.mpdhp.2026.07.008

Nadreen Mustafa, Mark Ong

{"title":"Gelatinous transformation of bone marrow in anorexia nervosa presenting with chronic cytopenia: a histopathological diagnostic pitfall","authors":"Nadreen Mustafa, Mark Ong","doi":"10.1016/j.mpdhp.2026.07.008","DOIUrl":"10.1016/j.mpdhp.2026.07.008","url":null,"abstract":"<div><div>Anorexia nervosa may be associated with significant haematological abnormalities, including anaemia, leucopenia and pancytopenia. Histopathological findings within the bone marrow range from mild hypocellularity to extensive gelatinous transformation. We present a 47-year-old female with long-standing anorexia nervosa referred for investigation of persistent macrocytic anaemia and leucopenia despite nutritional and haematinic optimisation. Extensive laboratory investigations excluded nutritional deficiency, autoimmune disease, haemolysis, plasma cell dyscrasia, viral infection and paroxysmal nocturnal haemoglobinuria. Bone marrow aspirate was hypocellular and haemodiluted. Trephine biopsy demonstrated marked hypocellularity, stromal oedema, and myxoid change, consistent with gelatinous transformation. Vacuolated signet-ring-like cells showed weak staining for epithelial markers and S100 positivity, initially raising concern for metastatic malignancy. Correlation with morphology and immunophenotype supported atrophied adipocytes within serous atrophy of bone marrow secondary to anorexia nervosa. This case showcases the characteristic histomorphology of anorexia-associated marrow injury, which may be a potential diagnostic pitfall by mimicking marrow failure syndromes or metastatic carcinoma.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 10","pages":"Pages 689-692"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification and a practical pattern-based approach to the diagnosis of adipocytic tumors 脂肪细胞瘤的分类和基于模式的诊断方法

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-07 DOI: 10.1016/j.mpdhp.2026.07.005

David Creytens

{"title":"Classification and a practical pattern-based approach to the diagnosis of adipocytic tumors","authors":"David Creytens","doi":"10.1016/j.mpdhp.2026.07.005","DOIUrl":"10.1016/j.mpdhp.2026.07.005","url":null,"abstract":"<div><div>Adipocytic tumors are among the most common mesenchymal neoplasms in general surgical pathology. These tumors encompass a broad histological spectrum with variable degrees of adipocytic differentiation and a wide range of clinical behaviour, varying from entirely benign lipomas to aggressive pleomorphic liposarcomas. The World Health Organization (WHO) classification of adipocytic tumors has evolved considerably in the last decades, largely due to important advances in understanding their pathogenetic basis. Although classic examples of lipomas and liposarcomas are straightforward diagnoses, primarily distinguished by their morphological characteristics, several lipomatous tumors are now known to show unique, recurrent molecular genetic aberrations, identification of which can be used in the diagnostic work-up of distinct (uncommon) lipomatous tumor variants and histologically ambiguous adipocytic tumors. This article will provide a practical pattern-based approach to the histological diagnosis of benign, intermediate and malignant adipocytic neoplasms. We will focus on the currently known morphological, immunohistochemical and molecular features of the different adipocytic tumor entities, discuss their differential diagnoses and update on recently described adipocytic tumor entities (lipoblastoma-like tumor, atypical spindle cell/pleomorphic lipomatous tumor, and myxoid pleomorphic liposarcoma).</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 10","pages":"Pages 638-653"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular anomalies: a comprehensive updated review 血管异常：全面更新的回顾

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-25 DOI: 10.1016/j.mpdhp.2026.07.006

Zeina Barakat, Karim Kheir, Roel W ten Broek, Carine JM van der Vleuten, Hala Kfoury Kassouf, Uta Flucke

{"title":"Vascular anomalies: a comprehensive updated review","authors":"Zeina Barakat, Karim Kheir, Roel W ten Broek, Carine JM van der Vleuten, Hala Kfoury Kassouf, Uta Flucke","doi":"10.1016/j.mpdhp.2026.07.006","DOIUrl":"10.1016/j.mpdhp.2026.07.006","url":null,"abstract":"<div><div>Vascular anomalies can be divided into two broad groups: vascular malformations being congenital defects in vascular morphogenesis that tend to grow with age, and vascular tumors, neoplastic proliferations that tend to regress with age when benign. These two categories have long imposed immense confusion among both clinicians and pathologists due to their overlapping clinical presentation and histopathology. The erroneous use of the term hemangioma for etiopathologically different entities is a common phenomenon. This poses a major risk to patients’ safety, as vascular malformations and tumors have different therapeutic approaches. From the pathological point of view, previous studies have focused on the histomorphological, immunohistochemical, and lately the genetic characterization of these lesions. The International Society for the Study of Vascular Anomalies (ISSVA) proposed a multidisciplinary approach, including the most recent discovered genetics. In this comprehensive review we consider the current etiopathological classification of vascular anomalies in correlation with their clinical and radiological characteristics.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 10","pages":"Pages 654-670"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary osteosarcoma of the jaw: clinicopathological characterization of a rare tumour 颌骨原发性骨肉瘤：一种罕见肿瘤的临床病理特征

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-14 DOI: 10.1016/j.mpdhp.2026.07.009

Sarah Ruane, Guy Betts

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Calcified chondroid mesenchymal neoplasm: a rose by any other name would still smell as sweet 钙化软骨间充质肿瘤：玫瑰不管叫什么名字，闻起来还是一样甜

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-04 DOI: 10.1016/j.mpdhp.2026.07.010

Sarah Ruane, Michael Toss, David Hughes

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Recent topics in skeletal muscle tumours 骨骼肌肿瘤的最新研究课题

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-08 DOI: 10.1016/j.mpdhp.2026.07.002

Peipei Zhu, Jian Wang

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New and emerging entities of soft tissue sarcomas with uncertain differentiation 新的和新兴实体的软组织肉瘤与不确定分化

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-20 DOI: 10.1016/j.mpdhp.2026.07.003

Florian Puls

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Updates on superficial mesenchymal neoplasms: emerging novel entities and an old foe revisited 浅表间充质肿瘤的最新进展：新出现的实体和旧日的敌人

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-08 DOI: 10.1016/j.mpdhp.2026.07.004

Kyriakos Chatzopoulos, Konstantinos Linos

{"title":"Updates on superficial mesenchymal neoplasms: emerging novel entities and an old foe revisited","authors":"Kyriakos Chatzopoulos, Konstantinos Linos","doi":"10.1016/j.mpdhp.2026.07.004","DOIUrl":"10.1016/j.mpdhp.2026.07.004","url":null,"abstract":"<div><div>Understanding the molecular underpinnings of oncogenesis has led to an expansion of the spectrum of superficial mesenchymal neoplasms. The present review aims to provide an overview of the clinicopathologic and molecular characteristics of emerging entities with disease-defining molecular alterations. These include benign and indolent tumors such as hemangioma with epithelioid features harboring <em>TPM3/4::ALK</em> fusions, <em>OGT</em>-rearranged mesenchymal neoplasm, acral fibrochondromyxoid tumor, superficial FET::ETS neurocristic tumor, as well as hybrid peripheral nerve sheath tumors (hPNSTs), a subset of which harbor recurrent <em>VGLL3</em> rearrangements or alternative rare and unique fusions. A concise review of the main characteristics of recently described biologically aggressive to overtly malignant tumors is also presented, including nodular necrotizing fibroblastic tumor, superficial <em>GLI1</em>-altered mesenchymal tumor, <em>CRTC1::TRIM11</em> cutaneous tumor, and <em>TFCP2</em>-rearranged rhabdomyosarcoma. The review concludes with an update on dermatofibrosarcoma protuberans (DFSP). A subset of DFSPs harbor <em>PDGFD</em> rearrangements, and approximately 5% of both <em>PDGFB</em>- and <em>PDGFD</em>-rearranged DFSPs show S100 expression, which may pose a diagnostic challenge for practicing pathologists. These findings have further elucidated the molecular background and associated morphologic characteristics of superficial mesenchymal tumors, leading to the recognition of novel entities and further subclassification of existing ones, with important implications for diagnosis and patient management.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 10","pages":"Pages 625-637"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Classic and recently described fibroblastic tumors 经典和最近描述的纤维母细胞肿瘤

Diagnostic Histopathology Pub Date : 2026-10-01 Epub Date: 2026-08-10 DOI: 10.1016/j.mpdhp.2026.07.007

Ludovic Merck, Gustavo Caballero, Aurélien Bourdon, Nathalène Truffaux, Francois Le Loarer

{"title":"Classic and recently described fibroblastic tumors","authors":"Ludovic Merck, Gustavo Caballero, Aurélien Bourdon, Nathalène Truffaux, Francois Le Loarer","doi":"10.1016/j.mpdhp.2026.07.007","DOIUrl":"10.1016/j.mpdhp.2026.07.007","url":null,"abstract":"<div><div>In this review, we discuss classic and recently described fibroblastic tumors, emphasizing practical aspects of their diagnostic approach in routine practice. The fibroblastic lineage is a fuzzy term that refers to a bland cytomorphology of small cells with small elongated, monotonous nuclei and inconspicuous cytoplasm, arranged in short fascicles frequently associated with a collagenous stroma. These morphological features are hardly specific; for many of these entities, there is limited evidence to definitively assert a fibroblastic lineage. To illustrate the complexity of assigning a definitive fibroblastic lineage to a neoplasm, recent studies have speculated on the fibroblastic lineage of atypical fibroxanthomas based on their proteomic profiles and expression analysis. The list of fibroblastic tumors keeps evolving. We will mention the various clinical, morphological, phenotypic, and molecular aspects of fibroblastic tumors that occur exclusively in children—lipofibromatosis and calcifying aponeurotic fibroma—as well as fibroblastic tumors found at any age or sometimes exclusively in adults: superficial CD34-positive pleomorphic fibroblastic tumors and PRDM10-rearranged tumors; EWSR1::SMAD3-rearranged fibroblastic tumors; nodular necrotizing fibroblastic sarcoma associated with MAML2 fusions; sclerosing epithelioid fibrosarcoma; KMT2A-rearranged tumor; MUC4-positive fibroblastoma; PRRX1-rearranged fibroblastic tumors and acral fibrochondromyxoid tumors.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 10","pages":"Pages 671-688"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Diagnosis of infectious granulomas: an integrated histomolecular approach 传染性肉芽肿的诊断：综合组织分子方法

Diagnostic Histopathology Pub Date : 2026-09-01 Epub Date: 2026-07-11 DOI: 10.1016/j.mpdhp.2026.06.014

Luis Felipe Arias-Ruiz, Rita Dorantes-Heredia, Paul Hofman, Homa Adle-Biassette, Arnault Tauziède-Espariat, Alexis Trecourt

{"title":"Diagnosis of infectious granulomas: an integrated histomolecular approach","authors":"Luis Felipe Arias-Ruiz, Rita Dorantes-Heredia, Paul Hofman, Homa Adle-Biassette, Arnault Tauziède-Espariat, Alexis Trecourt","doi":"10.1016/j.mpdhp.2026.06.014","DOIUrl":"10.1016/j.mpdhp.2026.06.014","url":null,"abstract":"<div><div>Granulomatous inflammation is frequently encountered by surgical pathologists in daily practice. Multiple morphological patterns have been described, caused by various etiologies, including infectious diseases, which represent three quarters of the causes. The distinction between infectious diseases and other etiologies, such as autoimmune diseases/auto-inflammatory disorders, is crucial since treatments are completely different. Although microbiological culture is traditionally considered as the gold standard for main pathogen identification, its sensitivity may be limited, there may be a risk of contamination, and turnaround time is sometime prolonged. Moreover, infections causing granulomatous inflammation often have a misleading pseudotumor clinical presentation, implying absence of fresh tissue sent to the microbiology laboratory for pathogen identification. In this context, the formalin-fixed, paraffin-embedded (FFPE) sample is the only sample available for disease characterization, and surgical pathologists are in the first line to render a final diagnosis. Recent advances in molecular biology applied to FFPE tissues have significantly improved pathogen identification. The present article will discuss two different histopathological situations: when pathogens are visualized within the granulomas and when pathogens are not visualized within the granuloma but with a clinical suspicion of infection. For each situation, a diagnostic approach based on morphological assessment, special stains, immunohistochemistry, and/or molecular techniques will be proposed.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"32 9","pages":"Pages 556-572"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148949402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0