Diagnostic Histopathology最新文献

Artificial intelligence in thoracic pathology: diagnostic and predictive applications 人工智能在胸腔病理学中的诊断和预测应用

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.06.008

Jan von der Thüsen

引用次数: 0

Staging in patients with multiple tumours: integrating morphology and molecular profiling 多发性肿瘤患者的分期：整合形态学和分子谱

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.003

Matthew Evans

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引用次数: 0

The pulmonary pathology of air pollution: a review 空气污染的肺部病理：综述

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.001

Jessica K Maguire, Aurelie Fabre

{"title":"The pulmonary pathology of air pollution: a review","authors":"Jessica K Maguire, Aurelie Fabre","doi":"10.1016/j.mpdhp.2025.05.001","DOIUrl":"10.1016/j.mpdhp.2025.05.001","url":null,"abstract":"<div><div>Exposure to ambient and household air pollution causes respiratory disease at all stages of life and is globally responsible for 6.7 million premature deaths annually. The major known contributory pollutants are PM, SO<sub>2</sub>, O<sub>3</sub>, NO<sub>2</sub> and CO. Extensive evidence has been published describing their various pathological effects. The WHO report that 99% of the earth's population breathe air with pollution levels outside the global air quality guidelines. Lack of access to clean fuel is a major risk factor, particularly in low- and middle-income countries. The effects of pollution on the respiratory system are broad, identified from intrauterine life to old age, with most risk at the extremes of age. Many pollutants damage the airways by the same mechanism; the induction of oxidative stress and production of reactive oxygen and nitrogen species, leading to chronic airway changes. Pathologies related to environmental pollution include, but are not limited to, defects in lung development, asthma and COPD, infectious disease and respiratory tract malignancies. While the cardiovascular effects of exposure to pollution have been well described, the purpose of this review article is to outline the major ambient air pollutant types associated with respiratory disease, and describe the pulmonary pathology associated with their exposure.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 8","pages":"Pages 451-457"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neuroglial neoplasm in retroperitoneal lymph nodes: metastasis from a testicular teratoma with embryonic-type neuroectodermal tumour 腹膜后淋巴结的神经胶质肿瘤：睾丸畸胎瘤伴胚胎型神经外胚层肿瘤转移

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.005

Jonathan Callaghan, Caroline Cartlidge, Selina Bhattarai, Azzam Ismail, Jo-An Roulson

引用次数: 0

Histological predictors of outcome in non-small cell lung cancer 非小细胞肺癌预后的组织学预测因素

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.004

Reena Khiroya

引用次数: 0

Pulmonary adenofibroma: a rare biphasic lung tumour in a young male 肺腺纤维瘤：一种罕见的年轻男性双相肺肿瘤

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.006

Caroline Cartlidge, Edward E Carling, Bipin Mathew, Laura Wastall

引用次数: 0

Neoadjuvant chemo-immunotherapy in non-small cell lung cancer: clinical rationale and methods of pathological assessment 非小细胞肺癌的新辅助化疗-免疫治疗：临床基础和病理评估方法

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.002

Carol Kwon , Karin Purshouse , Iain D Phillips, David A Dorward

{"title":"Neoadjuvant chemo-immunotherapy in non-small cell lung cancer: clinical rationale and methods of pathological assessment","authors":"Carol Kwon , Karin Purshouse , Iain D Phillips, David A Dorward","doi":"10.1016/j.mpdhp.2025.05.002","DOIUrl":"10.1016/j.mpdhp.2025.05.002","url":null,"abstract":"<div><div>Non-small cell lung cancer (NSCLC) remains a common cancer with poor outcomes, with even early stage, resectable tumours having a high recurrence rate. Over the past decade immunotherapy has been paradigm-changing in advanced, metastatic NSCLC while more recent evidence has demonstrated its important role as a neoadjuvant agent in surgically resectable disease. This has led to a significant shift in clinical practice and, in doing so, has altered requirements in the pathological assessment of surgical resection specimens. In this paper, we summarize the clinical, biological and pathological rationale behind neoadjuvant immunotherapy, describe the evidence base for this change in clinical practice and detail the central role of histopathology. Clinical trials have demonstrated marked event-free and overall survival advantages for combined immunotherapy and chemotherapy with pathological response an important surrogate marker of long-term outcome. We describe the key histopathological and molecular characteristics that render a patient eligible for neoadjuvant treatment as well as the requirements for assessment of surgical specimens to enable the accurate quantification of pathological response. In addition, the potential future roles for alternative measures of disease response are discussed, including circulating tumour DNA, immune cell phenotyping and artificial intelligence-based analyses.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 8","pages":"Pages 458-465"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of artificial intelligence in kidney neoplasms: usability of pathological data in enhancing classification, grading and prognostic and predictive models 人工智能在肾肿瘤中的应用：病理数据在增强分类、分级和预后预测模型中的可用性

Diagnostic Histopathology Pub Date : 2025-05-10 DOI: 10.1016/j.mpdhp.2025.04.005

Johannes Kläger, Maximilian C Koeller, Eva Compérat

引用次数: 0

The use of artificial intelligence in bladder cancer: a histopathologic perspective 人工智能在膀胱癌中的应用：组织病理学视角

Diagnostic Histopathology Pub Date : 2025-05-06 DOI: 10.1016/j.mpdhp.2025.04.004

Maximilian C Koeller, Garbiel Wasinger, Eva Compérat

引用次数: 0

Atrophic-pattern prostatic adenocarcinoma: a diagnostic pitfall 萎缩型前列腺癌：一个诊断缺陷

Diagnostic Histopathology Pub Date : 2025-05-05 DOI: 10.1016/j.mpdhp.2025.04.009

Ka Wing Eric Wong, Tanjot Singh, Jo-An Roulson

引用次数: 0