Diagnostic Histopathology最新文献_第2页

Investigating drugs of abuse at autopsy

Diagnostic Histopathology Pub Date : 2025-01-01 DOI: 10.1016/j.mpdhp.2024.10.002

Simon Elliott

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Significant and potentially overlooked causes of unexpected death outside the cardiovascular and central nervous system

Diagnostic Histopathology Pub Date : 2025-01-01 DOI: 10.1016/j.mpdhp.2024.10.006

Brian Hanley, Dominic Chambers

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Deaths related to stroke and cerebrovascular disease

Diagnostic Histopathology Pub Date : 2025-01-01 DOI: 10.1016/j.mpdhp.2024.10.005

Kieren Simon James Allinson

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Death by hanging: examination of autopsy findings and best approach to the post-mortem examination – an update

Diagnostic Histopathology Pub Date : 2025-01-01 DOI: 10.1016/j.mpdhp.2024.10.004

Brett Lockyer

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What has post-mortem computed tomography ever done for forensic pathology? Part deux

Diagnostic Histopathology Pub Date : 2025-01-01 DOI: 10.1016/j.mpdhp.2024.10.003

Guy N Rutty

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Post-mortem findings in a case of fatal vasculitis

Diagnostic Histopathology Pub Date : 2025-01-01 DOI: 10.1016/j.mpdhp.2024.10.007

Richard John Digby, Hannah Olivia Hawrot

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A history of forensic neuropathology 法医神经病理学史

Diagnostic Histopathology Pub Date : 2024-10-24 DOI: 10.1016/j.mpdhp.2024.09.004

Christopher Mark Milroy

{"title":"A history of forensic neuropathology","authors":"Christopher Mark Milroy","doi":"10.1016/j.mpdhp.2024.09.004","DOIUrl":"10.1016/j.mpdhp.2024.09.004","url":null,"abstract":"<div><div>Forensic neuropathology is a subspecialty of neuropathology involving those cases that may enter the criminal and civil justice courts and medico-legal death investigation systems. The cases involve trauma, poisons and diseases related to the central and peripheral nervous system. Though nervous system disorders and trauma to the brain are recorded in literature from Ancient Egypt, a better understanding of diseases, trauma and mechanisms of injury began to emerge with the writings of Renaissance surgeons with military experience. Further development came with the knowledge of cell theory and neurohistology in the nineteenth century, with the ability to examine the whole brain after fixation. Textbooks on forensic neuropathology were not produced until after World War Two. A better understanding of the pathology of neurotrauma and poisons affecting the central nervous system was developed in the twentieth century. Concepts of sudden death in epilepsy, paediatric head injury, vertebral artery trauma and hypoxic brain damage were all recognized in the last century. More recently immunohistochemistry has added to our knowledge of axonal injury. Neuroimaging, particularly CT scans have become regular tools for postmortem examinations. Recently genetic testing has become available for autopsy investigation, with applicability to vascular and thrombotic disorders as well as epilepsy. Forensic neuropathology has both an ancient and more recent history and continues to develop.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 12","pages":"Pages 699-711"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Update on the classification and diagnostic approach of pituitary neuroendocrine tumours 垂体神经内分泌肿瘤的最新分类和诊断方法

Diagnostic Histopathology Pub Date : 2024-10-15 DOI: 10.1016/j.mpdhp.2024.10.001

Federico Roncaroli, Carmine Antonio Donofrio, Liam Walker, Roger Laitt, Chiara Villa, Waseem Majeed

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Nanopore-based brain tumour classification: the harbinger of near-patient, ultra-rapid tumour sequencing 基于纳米孔的脑肿瘤分类：近距离、超快速肿瘤测序的先兆

Diagnostic Histopathology Pub Date : 2024-10-08 DOI: 10.1016/j.mpdhp.2024.09.001

Simon Deacon, Matt Loose, Stuart Smith, Simon Paine

{"title":"Nanopore-based brain tumour classification: the harbinger of near-patient, ultra-rapid tumour sequencing","authors":"Simon Deacon, Matt Loose, Stuart Smith, Simon Paine","doi":"10.1016/j.mpdhp.2024.09.001","DOIUrl":"10.1016/j.mpdhp.2024.09.001","url":null,"abstract":"<div><div>Advances in both our understanding of tumour biology and our technological capacity to interrogate these molecular characteristics have led to the ever-increasing use of genomic sequencing in routine diagnostic decision making, long offering the hope of more efficacious personalized cancer therapies. Yet, despite this fidelity, in order that genomic testing is truly able to deliver its promise of better outcomes for patients, it is vital that such testing can be performed within a clinically relevant timeframe. Presently, molecular diagnosis of brain tumours is largely delivered via an effectively centralized model as few institutes possess the necessary facilities. Yet, this approach has inherent delays that mean a wait, often of several weeks, before the diagnosis is available to the treating clinical team. This review introduces Nanopore sequencing, a long-read technology that can be used to enable rapid and comprehensive molecular diagnosis. The epigenetic signatures of brain tumours have been shown to reliably segregate tumour subtypes, and methylation-based tumour classification now forms a cornerstone of neuropathological diagnosis. Crucially, Nanopore is a direct-strand sequencing technology which can detect methyl DNA modifications, alongside base-calling, delivering methylation classification in parallel with copy number, fusion and mutation detection as well as single gene methylation analysis. This review summarises the present state of nanopore sequencing for brain tumour diagnostics and highlights areas for further development.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 12","pages":"Pages 691-698"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Giant cell arteritis: a not-so-straightforward diagnosis in routine practice 巨细胞动脉炎：常规诊疗中并不简单的诊断方法

Diagnostic Histopathology Pub Date : 2024-10-07 DOI: 10.1016/j.mpdhp.2024.09.006

Dilek Taze, Kathryn J Griffin, Aruna Chakrabarty

引用次数: 0