Diagnostic Histopathology最新文献_第2页

Diagnostic challenges of endocrine pathology: three cases highlighting potential diagnostic pitfalls in endocrine glands 内分泌病理诊断的挑战：三个病例突出内分泌腺的潜在诊断缺陷

Diagnostic Histopathology Pub Date : 2025-09-01 DOI: 10.1016/j.mpdhp.2025.06.002

Dinuke Shehan de Silva, Tristan Rutland

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引用次数: 0

An overview of pertinent immunohistochemistry and molecular pathology of phaeochromocytoma 嗜铬细胞瘤的相关免疫组织化学和分子病理学综述

Diagnostic Histopathology Pub Date : 2025-09-01 DOI: 10.1016/j.mpdhp.2025.06.005

Runjan Chetty

{"title":"An overview of pertinent immunohistochemistry and molecular pathology of phaeochromocytoma","authors":"Runjan Chetty","doi":"10.1016/j.mpdhp.2025.06.005","DOIUrl":"10.1016/j.mpdhp.2025.06.005","url":null,"abstract":"<div><div>While morphologically distinct, immunohistochemistry for tyrosine hydroxlase is a sensitive and specific immunohistochemical marker for phaeochrmocytomas. Other useful negative routine markers include cytokeratin, melanocytic markers, TTF-1 and PAX-8. Markers that indicate specific genetic syndromic cases include succinate dehydrogenase A and B, myc-associated factor X, fumarate hydratase and 2-Succinocysteine. Prognostic markers include: Ki-67, p53, heat shock protein-90, TERT and N-cadherin. Hereditary phaeochromocytomas with germline gene mutations are grouped into several pathways: pseudohypoxia, kinase signalling, wnt signalling, mitochondrial pathways and miscellaneous. Key genes in these pathways include: HRAS, HIF2A, RET and NF1. Prognostic genes are SDHB, ATRX and TERT. Understanding the pathological, immunohistochemical and genetic landscape of phaeochromocytomas enables a multimodal approach to determining behaviour and targeted therapy.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 9","pages":"Pages 521-523"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infiltrating epitheliosis of the breast: a case report on an uncommon and challenging complex sclerosing lesion 乳腺浸润性上皮增生：罕见复杂硬化病变1例报告

Diagnostic Histopathology Pub Date : 2025-09-01 DOI: 10.1016/j.mpdhp.2025.06.007

Ankurita Kuppasad, Gayathri Wathuge

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A case of follicular thyroid carcinoma with bizarre nuclei and discussion of atypia in thyroid gland disease 奇异核甲状腺滤泡癌1例及甲状腺疾病异型性的探讨

Diagnostic Histopathology Pub Date : 2025-09-01 DOI: 10.1016/j.mpdhp.2025.06.006

Paul Hankinson, Gayani Pitiyage, Stuart Richards, Fawzia Tahir

引用次数: 0

Artificial intelligence in thoracic pathology: diagnostic and predictive applications 人工智能在胸腔病理学中的诊断和预测应用

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.06.008

Jan von der Thüsen

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Staging in patients with multiple tumours: integrating morphology and molecular profiling 多发性肿瘤患者的分期：整合形态学和分子谱

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.003

Matthew Evans

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引用次数: 0

The pulmonary pathology of air pollution: a review 空气污染的肺部病理：综述

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.001

Jessica K Maguire, Aurelie Fabre

{"title":"The pulmonary pathology of air pollution: a review","authors":"Jessica K Maguire, Aurelie Fabre","doi":"10.1016/j.mpdhp.2025.05.001","DOIUrl":"10.1016/j.mpdhp.2025.05.001","url":null,"abstract":"<div><div>Exposure to ambient and household air pollution causes respiratory disease at all stages of life and is globally responsible for 6.7 million premature deaths annually. The major known contributory pollutants are PM, SO2, O3, NO2 and CO. Extensive evidence has been published describing their various pathological effects. The WHO report that 99% of the earth's population breathe air with pollution levels outside the global air quality guidelines. Lack of access to clean fuel is a major risk factor, particularly in low- and middle-income countries. The effects of pollution on the respiratory system are broad, identified from intrauterine life to old age, with most risk at the extremes of age. Many pollutants damage the airways by the same mechanism; the induction of oxidative stress and production of reactive oxygen and nitrogen species, leading to chronic airway changes. Pathologies related to environmental pollution include, but are not limited to, defects in lung development, asthma and COPD, infectious disease and respiratory tract malignancies. While the cardiovascular effects of exposure to pollution have been well described, the purpose of this review article is to outline the major ambient air pollutant types associated with respiratory disease, and describe the pulmonary pathology associated with their exposure.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 8","pages":"Pages 451-457"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neuroglial neoplasm in retroperitoneal lymph nodes: metastasis from a testicular teratoma with embryonic-type neuroectodermal tumour 腹膜后淋巴结的神经胶质肿瘤：睾丸畸胎瘤伴胚胎型神经外胚层肿瘤转移

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.005

Jonathan Callaghan, Caroline Cartlidge, Selina Bhattarai, Azzam Ismail, Jo-An Roulson

引用次数: 0

Histological predictors of outcome in non-small cell lung cancer 非小细胞肺癌预后的组织学预测因素

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.004

Reena Khiroya

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Pulmonary adenofibroma: a rare biphasic lung tumour in a young male 肺腺纤维瘤：一种罕见的年轻男性双相肺肿瘤

Diagnostic Histopathology Pub Date : 2025-08-01 DOI: 10.1016/j.mpdhp.2025.05.006

Caroline Cartlidge, Edward E Carling, Bipin Mathew, Laura Wastall

引用次数: 0