A neuroglial neoplasm in retroperitoneal lymph nodes: metastasis from a testicular teratoma with embryonic-type neuroectodermal tumour

Diagnostic Histopathology Pub Date : 2025-08-01 DOI:10.1016/j.mpdhp.2025.05.005

Jonathan Callaghan, Caroline Cartlidge, Selina Bhattarai, Azzam Ismail, Jo-An Roulson

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引用次数: 0

Abstract

Testicular germ cell tumours are a common solid malignancy amongst young men. Most non-seminomatous germ cell tumours in adults display mixed histological types, although can be purely one type. Rarely, some non-seminomatous germ cell tumours undergo somatic malignant transformation, whereby they can differentiate into diverse malignant phenotypes, which might resemble tumours found elsewhere in the body. Although uncommon, these transformations carry significant implications for prognosis and treatment. We present a case of a testicular teratoma with somatic malignant transformation to embryonic type neuroectodermal tumour. Unusually, the associated metastases to retroperitoneal lymph nodes show neuroglial differentiation without aggressive features. This case highlights the diagnostic challenges of teratomas with somatic malignant transformation, emphasizing the role of histopathology, immunohistochemistry, and molecular techniques in diagnosis and clinical decision-making.

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腹膜后淋巴结的神经胶质肿瘤：睾丸畸胎瘤伴胚胎型神经外胚层肿瘤转移

睾丸生殖细胞瘤是青年男性常见的实体恶性肿瘤。大多数成人非半瘤性生殖细胞肿瘤显示混合的组织学类型，尽管可以是纯粹的一种类型。很少，一些非半瘤性生殖细胞肿瘤经历体细胞恶性转化，由此它们可以分化成各种恶性表型，这可能类似于在身体其他地方发现的肿瘤。虽然不常见，但这些转变对预后和治疗具有重要意义。我们报告一例睾丸畸胎瘤伴体细胞恶性转化为胚胎型神经外胚层肿瘤。不同寻常的是，相关的转移到腹膜后淋巴结表现为神经胶质分化而无侵袭性特征。本病例强调了畸胎瘤伴躯体恶性转化的诊断挑战，强调了组织病理学、免疫组织化学和分子技术在诊断和临床决策中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.