奇异核甲状腺滤泡癌1例及甲状腺疾病异型性的探讨

Diagnostic Histopathology Pub Date : 2025-09-01 DOI:10.1016/j.mpdhp.2025.06.006

Paul Hankinson, Gayani Pitiyage, Stuart Richards, Fawzia Tahir

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引用次数: 0

摘要

核异型性的存在是甲状腺病理中一个潜在的陷阱，有几种原因，从良性疾病到侵袭性恶性肿瘤。我们报告一例滤泡性甲状腺癌伴奇异核异型。评估核异型性的类型和位置以及选择分子检测有助于本病例的诊断，排除其他实体，如甲状腺激素发育异常、甲状腺乳头状癌、间变性甲状腺癌和DICER1突变的滤泡性甲状腺癌（最近在文献中描述的实体）。了解甲状腺疾病的不同核特征和核异型性的原因可以防止对这一特征的误解，从而降低组织和细胞学标本中恶性肿瘤过度诊断的风险。

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A case of follicular thyroid carcinoma with bizarre nuclei and discussion of atypia in thyroid gland disease

The presence of nuclear atypia is a potential pitfall in thyroid pathology with several causes ranging from benign disease to aggressive malignant neoplasms. Here we present a case of follicular thyroid carcinoma with bizarre nuclear atypia. Assessment of the type and location of the nuclear atypia as well as select molecular testing aided in diagnosis of this case, excluding other entities such as dyshormonogenetic goitre, papillary thyroid carcinoma, anaplastic thyroid carcinoma and DICER1 mutated follicular thyroid carcinoma (a recently described entity in the literature). An awareness of the diverse nuclear features and the causes of nuclear atypia in thyroid disease can prevent misinterpretation of this feature reducing the risk of overdiagnosis of malignancy in tissue and cytology specimens.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.