{"title":"Recognizing non-neoplastic mimics of myeloid malignancies in the bone marrow and peripheral blood: pearls and pitfalls","authors":"Margaret Moore, Elizabeth L Courville","doi":"10.1016/j.mpdhp.2025.07.004","DOIUrl":null,"url":null,"abstract":"<div><div>In this review, we outline benign conditions of bone marrow and blood that can mimic myeloid neoplasms. We discuss diagnostic pearls that we utilize in our daily clinical practice to avoid overdiagnosis or premature diagnosis of malignancy. Furthermore, we highlight pre-malignant conditions that pose diagnostic difficulties due to their overlapping features with myeloid neoplasms. Integration of bone marrow and peripheral blood findings with clinical and laboratory data is essential for accurate diagnosis, and we advocate for a stepwise approach with an internal “diagnostic checklist” to avoid misclassification.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 10","pages":"Pages 609-622"},"PeriodicalIF":0.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Histopathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756231725001276","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In this review, we outline benign conditions of bone marrow and blood that can mimic myeloid neoplasms. We discuss diagnostic pearls that we utilize in our daily clinical practice to avoid overdiagnosis or premature diagnosis of malignancy. Furthermore, we highlight pre-malignant conditions that pose diagnostic difficulties due to their overlapping features with myeloid neoplasms. Integration of bone marrow and peripheral blood findings with clinical and laboratory data is essential for accurate diagnosis, and we advocate for a stepwise approach with an internal “diagnostic checklist” to avoid misclassification.
期刊介绍:
This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.