cd5阳性毛细胞白血病

Diagnostic Histopathology Pub Date : 2025-10-01 DOI:10.1016/j.mpdhp.2025.07.007

Manas Dave, Lucia Lazzereschi, Muntasser Alsharabati, Ke Xu, Teresa Marafioti

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引用次数: 0

摘要

毛细胞白血病（HCL）因其独特的临床表现（细胞减少、脾肿大、肿瘤细胞呈毛发样细胞质突起）、特征性免疫表型和BRAF p.V600E突变而易于识别。它们通常对CD5， CD10和CD23呈阴性。然而，罕见病例可有CD5和/或CD23的异常表达，可与慢性淋巴细胞白血病/小淋巴细胞白血病（CD5+/CD23+）或套细胞淋巴瘤/白血病（CD5+/Cyclin D1+）混淆。我们描述了一个罕见的HCL与CD5异常表达的病例，说明了临床，形态学，免疫表型和分子研究对解决诊断挑战的重要性。

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CD5-positive hairy cell leukaemia

Hairy cell leukaemia (HCL) is readily recognized by its distinct clinical presentation (cytopenias, splenomegaly and neoplastic cells with hair-like cytoplasmic projections), characteristic immunophenotype and BRAF p.V600E mutation. They are typically negative for CD5, CD10 and CD23. Rare cases, however, can have aberrant expression of CD5 and/or CD23 which can be confused with chronic lymphocytic leukaemia/small lymphocytic leukaemia (CD5+/CD23+) or mantle cell lymphoma/leukaemia (CD5+/Cyclin D1+). We describe a rare case of HCL with aberrant expression of CD5 that illustrates the importance of clinical, morphological, immunophenotypical and molecular investigations to resolve the diagnostic challenge.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.