An update on the classification and molecular pathology of the adrenal cortex

Aria Kazerouni, Runjan Chetty
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引用次数: 0

Abstract

New terminology has been introduced for adrenocortical nodular disease. These include: sporadic nodular-, bilateral micronodular-, bilateral macronodular-adrenocortical disease, and bilateral diffuse adrenocortical hyperplasia. Several genes (PRKAR1A, PDE11A/8B) are implicated in the pathogenesis and they principally impact the c-AMP pathway.
Similarly, aldosterone-producing adenomas are classified according to the HISTALDO classification into: aldosterone-producing: adenoma >1 cm, nodule <1 cm, nodule <1 cm and usually mm in size, and carcinoma. The key genes in aldosterone-producing adenomas are: KCNJ5, ATP1A1, CACNA1D and CTNNB1. Cortisol-producing adenomas are principally caused by mutations in PRKACA, GNAS and CTNNB1 genes. P53 and CTNNB1 are the key genes that are mutated in most adrenocortical carcinomas.
肾上腺皮质的分类和分子病理学的最新进展
介绍了肾上腺皮质结节性疾病的新术语。这些疾病包括:散发性结节性、双侧小结节性、双侧大结节性肾上腺皮质疾病和双侧弥漫性肾上腺皮质增生。几个基因(PRKAR1A, PDE11A/8B)与发病机制有关,它们主要影响c-AMP途径。同样,根据HISTALDO分类,产生醛固酮的腺瘤分为:产生醛固酮的腺瘤,大小为1cm,结节大小为1cm,结节大小为1cm,通常为mm,以及癌。醛固酮产生腺瘤的关键基因有:KCNJ5、ATP1A1、CACNA1D和CTNNB1。产生皮质醇的腺瘤主要由PRKACA、GNAS和CTNNB1基因突变引起。P53和CTNNB1是大多数肾上腺皮质癌发生突变的关键基因。
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来源期刊
Diagnostic Histopathology
Diagnostic Histopathology Medicine-Pathology and Forensic Medicine
CiteScore
1.30
自引率
0.00%
发文量
64
期刊介绍: This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.
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