Insights into salivary gland-like breast carcinomas: histological features, immunophenotypes, molecular pathogenesis and diagnostic advancements

Abstract

Both breast and salivary glands are composed of tubuloacinar glands with similar histological structures, so it is not surprising that similar neoplasms can arise in both organs. However, given the different functions of the two glands and the different stimuli to which they are subjected, apparently similar tumours may present substantial differences. This review aims to examine the morphological and molecular profiles of salivary-like breast carcinomas, focusing on similarities and differences. Data were obtained from a comprehensive literature review, selecting relevant studies based on their novelty, applicability, and impact. Salivary-like breast carcinomas have been recognized for many years, but recent advances in understanding their molecular pathogenesis have provided new diagnostic tools and insights into these rare tumors.