Diagnostic Histopathology最新文献_第5页

Infectious diseases of the male and female urogenital tract: a review of the histology of selected entities 男性和女性泌尿生殖道感染性疾病：部分病例的组织学回顾

Diagnostic Histopathology Pub Date : 2024-07-29 DOI: 10.1016/j.mpdhp.2024.07.003

Alexander Polson

{"title":"Infectious diseases of the male and female urogenital tract: a review of the histology of selected entities","authors":"Alexander Polson","doi":"10.1016/j.mpdhp.2024.07.003","DOIUrl":"10.1016/j.mpdhp.2024.07.003","url":null,"abstract":"<div><div>This review will describe histological features of infectious diseases involving the urogenital tract, and is organized by organ or location. Emphasis is placed on selected parasitic, viral and bacterial infections that either occur more frequently in the urogenital tract than elsewhere (schistosomiasis), or are of particular importance to the pathologist because of their common occurrence and relation to malignancy (human papillomavirus), or relationship to pelvic inflammatory disease (actinomycosis). Detailed discussions of the life cycle of schistosomiasis and the characteristics of human papillomavirus are included because knowledge of their interactions with the human host is important in order to understand the histological features seen in these infections. The histological features of these infections will be discussed, as well as selected inflammatory conditions that may mimic infection. Only brief comments will be made of bacterial and other viral infections, many of them sexually transmitted, that occur in the urogenital tract and are more commonly diagnosed by means other than histological examination, or may involve the urogenital tract as part of a systemic infection. Cervical cytology is not discussed.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 10","pages":"Pages 546-553"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological assessment for opportunistic infections in the iatrogenically immunosuppressed 对先天性免疫抑制患者机会性感染的组织病理学评估

Diagnostic Histopathology Pub Date : 2024-07-27 DOI: 10.1016/j.mpdhp.2024.07.005

Gerald Langman

{"title":"Histopathological assessment for opportunistic infections in the iatrogenically immunosuppressed","authors":"Gerald Langman","doi":"10.1016/j.mpdhp.2024.07.005","DOIUrl":"10.1016/j.mpdhp.2024.07.005","url":null,"abstract":"<div><div>The use of medication to alter the normal function of the immune system treads the fine balance between the body’s ability to fend off foreign or aberrant antigens and increased susceptibility to opportunistic infections as well as decreased cancer immunosurveillance. The expanding array of immunosuppressive drugs, targeting specific mediators or pathways in the immune system, has improved patient outcome both for transplantation and autoimmune disease, but opportunistic infections remain a serious risk. Whilst many of these infections are successfully treated without any histopathological input, pathology plays a significant role by excluding mimics of infection, identifying viral, bacterial, fungal and parasitic infection even before their clinical suspicion, and in the diagnosis of malignancy. In a field which spans all pathogens and every organ system, this paper addresses the more commonly encountered organisms at their usual site of infection with emphasis on establishing a diagnosis and highlighting potential diagnostic traps. Malignancy is also discussed, including recently described lymphoproliferative processes. In recent years immune therapy for the treatment of a range of cancers is becoming routine practice. This too is associated with an increased risk of infection which needs to be differentiated from the spectrum of changes seen in immune therapy related disease.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 10","pages":"Pages 564-575"},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A histopathological approach to diagnosis and classification of invasive fungal infections 侵袭性真菌感染的组织病理学诊断和分类方法

Diagnostic Histopathology Pub Date : 2024-07-27 DOI: 10.1016/j.mpdhp.2024.07.004

Vivek Sekhawat

引用次数: 0

Leydig-Sertoli collision sex-cord stromal tumor of the testis: a case report of an unusual entity 睾丸莱德-塞尔托利碰撞性索间质瘤：一个不寻常实体的病例报告

Diagnostic Histopathology Pub Date : 2024-07-20 DOI: 10.1016/j.mpdhp.2024.07.007

Ludovica Pepe , Vincenzo Fiorentino , Cristina Pizzimenti, Antonio Ieni, Maria Lentini, Giovanni Tuccari, Guido Fadda, Vincenzo Ficarra, Maurizio Martini

引用次数: 0

Obituary: Professor Naveena Singh, 7 December 1964–5 October 2023 讣告纳维娜-辛格教授，1964 年 12 月 7 日--2023 年 10 月 5 日

Diagnostic Histopathology Pub Date : 2024-07-14 DOI: 10.1016/j.mpdhp.2024.06.005

Asma Z Faruqi

引用次数: 0

Molecular basis of uterine mesenchymal tumours 子宫间质瘤的分子基础

Diagnostic Histopathology Pub Date : 2024-07-12 DOI: 10.1016/j.mpdhp.2024.06.002

Zarius Ferozepurwalla, Angela Ralte

{"title":"Molecular basis of uterine mesenchymal tumours","authors":"Zarius Ferozepurwalla, Angela Ralte","doi":"10.1016/j.mpdhp.2024.06.002","DOIUrl":"10.1016/j.mpdhp.2024.06.002","url":null,"abstract":"<div>Uterine mesenchymal tumours present significant management challenges due to their varied histological subtypes and clinical behaviours. This review explores the recent advances in the molecular pathology of uterine mesenchymal tumours. Leiomyosarcoma, the most common malignant uterine mesenchymal tumour, exhibits complex genomic alterations, with subtypes including spindled, myxoid, epithelioid and the emerging lipoleiomyosarcoma. Smooth Muscle Tumours of Uncertain Malignant Potential (STUMP) and low-grade endometrial stromal sarcomas (LGESS) show diverse morphologies and molecular profiles. High-grade endometrial stromal sarcomas (HGESS) are distinguished by molecular subtypes like YWHAE:: NUTM2, BCOR rearrangements and BCOR internal tandem duplications (ITDs). Rarer tumours, including inflammatory myofibroblastic tumours (IMT) with ALK rearrangements, NTRK-rearranged spindle cell tumours, and perivascular epithelioid cell tumours with TSC1/TSC2 alterations and TFE3 rearrangements, expand the spectrum of uterine mesenchymal neoplasms. Newer fusion sarcomas, such as MEIS1::NCOA2/1, COL1A1::PDGFB, KAT6B/A::KANSL1 and RAD51B fusion sarcoma further our understanding of the various tumour types. Molecular diagnostics are crucial for identifying targetable pathways, accurate tumour classification, and guiding treatment decisions. Understanding these molecular alterations is essential for advancing therapeutic strategies and improving prognosis for patients with uterine mesenchymal tumours.</div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 9","pages":"Pages 487-498"},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of molecular testing in malignancies of the female genital tract 女性生殖道恶性肿瘤分子检测概述

Diagnostic Histopathology Pub Date : 2024-07-05 DOI: 10.1016/j.mpdhp.2024.06.004

Matthew Evans

{"title":"An overview of molecular testing in malignancies of the female genital tract","authors":"Matthew Evans","doi":"10.1016/j.mpdhp.2024.06.004","DOIUrl":"10.1016/j.mpdhp.2024.06.004","url":null,"abstract":"<div>Management of cancers in the twenty-first century has been defined by personalization. This has involved making more fine-grained distinctions between otherwise similar cancers on the basis of their genomic alterations, and providing more personalized therapies based on the presence or absence of particular biomarkers. This precision testing came relatively late to gynecological cancers, but we are now seeing an explosion in the number and variety of these tests. This review provides a practical overview of molecular and biomarker testing in solid cancers generally. It lays out the different types of alteration and the techniques used to test for them, comparing their strengths and weaknesses. It then explores how pathologists can ensure that the material which they submit for testing is optimized to provide the best results possible, including issues of ischemia, formalin fixation, decalcification and sample assessment. Finally, it explains how a genomic report should be interpreted with a particular focus on potential causes of misleading results. The second part of this review applies the general principles of molecular and biomarker testing to the specific cases of lower gynecological tract neoplasms: specifically PD-L1 immunohistochemical testing in cervical cancer and genomic testing of gynecological melanomas.</div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 9","pages":"Pages 511-528"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of the molecular pathology of ovarian carcinomas 卵巢癌分子病理学概述

Diagnostic Histopathology Pub Date : 2024-07-03 DOI: 10.1016/j.mpdhp.2024.06.001

Sarah Bell, Claire McKeeve, Patricia Roxburgh, C. Simon Herrington

引用次数: 0

A morphology-based approach to mesenchymal tumours of the thorax 基于形态学的胸部间质瘤治疗方法

Diagnostic Histopathology Pub Date : 2024-07-01 DOI: 10.1016/j.mpdhp.2024.04.005

Katherine Elizabeth Quiohilag, Carol Kwon, Jonathan GN. Davey, David Andrew Dorward

引用次数: 0

Cytomorphological assessment of small cell lung carcinoma in a malignant pleural effusion 恶性胸腔积液中小细胞肺癌的细胞形态学评估

Diagnostic Histopathology Pub Date : 2024-07-01 DOI: 10.1016/j.mpdhp.2024.04.007

Ka Wing Eric Wong, Charlotte Flynn, Terence Gordon Smith, Richard Bishop

引用次数: 0