Diagnostic Histopathology最新文献_第5页

Advancements and challenges in biomarker testing for tumors of the luminal gastrointestinal tract: current practice guidelines and emerging markers 胃肠道肿瘤生物标志物检测的进展和挑战：当前实践指南和新兴标志物

Diagnostic Histopathology Pub Date : 2025-04-11 DOI: 10.1016/j.mpdhp.2025.03.011

Ashley Lauren Hein, Erika Hissong

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Beyond the mucosa: unveiling selected mesenchymal lesions of the gastrointestinal tract 粘膜外：揭示胃肠道间质病变

Diagnostic Histopathology Pub Date : 2025-04-09 DOI: 10.1016/j.mpdhp.2025.03.013

Domenika Ortiz Requena, Elizabeth A Montgomery

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Dysplastic lesions of the liver: two cases demonstrating the key pathological principles 肝脏发育不良病变：两例主要病理原理

Diagnostic Histopathology Pub Date : 2025-04-07 DOI: 10.1016/j.mpdhp.2025.03.016

Daniel T Field, Christopher OC Bellamy, Timothy J Kendall

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Novel anal lesions not to overlook 新的肛门病变不容忽视

Diagnostic Histopathology Pub Date : 2025-04-04 DOI: 10.1016/j.mpdhp.2025.03.014

Ozlem Kulak, Jacqueline E Birkness-Gartman

{"title":"Novel anal lesions not to overlook","authors":"Ozlem Kulak, Jacqueline E Birkness-Gartman","doi":"10.1016/j.mpdhp.2025.03.014","DOIUrl":"10.1016/j.mpdhp.2025.03.014","url":null,"abstract":"<div><div>Although the anal canal comprises only a small portion of the gastrointestinal tract, it can be affected by a variety of inflammatory and neoplastic processes. Inflammation of the anal mucosa can result from trauma, infections, and inflammatory bowel disease. Non-neoplastic lesions such as inflammatory cloacogenic polyps, hemorrhoids, and fibroepithelial polyps are relatively common, but may harbor other lesions, necessitating careful histologic assessment. The anogenital mammary-like glands and perianal skin can give rise to neoplasms including hidradenoma papilliferum and basal cell carcinoma. Human papillomavirus (HPV) is an important cause of squamous dysplasia and squamous cell carcinoma, as well as several recently described non-squamous neoplasms. Adenocarcinoma of the anus is divided into intestinal, anal gland, and fistula-associated types, which have unique morphologic features. Anal Paget's disease can occur as a primary neoplasm, or may be secondary to underlying adenocarcinoma. Less common neoplasms of the anus include neuroendocrine neoplasms, mucosal melanoma, and mesenchymal neoplasms such as granular cell tumor and gastrointestinal stromal tumor (GIST). This review will cover the clinical presentation, key histologic features, differential diagnosis, and relevant ancillary studies to consider for each condition. Recognition of inflammatory and neoplastic diseases of the anus is essential to guide appropriate treatment of patients.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 6","pages":"Pages 382-397"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spindle cell mesenchymal tumours of the head and neck: emerging and recently described entities characterised by molecular findings 头颈部梭形细胞间质肿瘤：新出现的和最近描述的以分子发现为特征的实体

Diagnostic Histopathology Pub Date : 2025-04-01 DOI: 10.1016/j.mpdhp.2025.02.002

Marguerite Carter, Adrienne M Flanagan

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Macroscopy of oral and maxillofacial specimens 口腔及颌面标本的显微观察

Diagnostic Histopathology Pub Date : 2025-04-01 DOI: 10.1016/j.mpdhp.2025.02.006

Adam V. Jones, Miranda Pring, Brendan Conn

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Two rare primary tumours of the thymus with differential immunohistochemical characterisation and a potential new entity 两种罕见的胸腺原发性肿瘤，具有不同的免疫组织化学特征和潜在的新实体

Diagnostic Histopathology Pub Date : 2025-04-01 DOI: 10.1016/j.mpdhp.2025.02.008

Monika Kondratowicz, Lucy Hamer, Sherin Jos Payyappilly

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Head and neck mucosal manifestations of microbial infection: clinical presentation, histological features and diagnostic aids 头颈部粘膜微生物感染的临床表现、组织学特征及诊断辅助

Diagnostic Histopathology Pub Date : 2025-04-01 DOI: 10.1016/j.mpdhp.2025.02.005

Amrita Jay, Oluyori Adegun, Kirsty Young

{"title":"Head and neck mucosal manifestations of microbial infection: clinical presentation, histological features and diagnostic aids","authors":"Amrita Jay, Oluyori Adegun, Kirsty Young","doi":"10.1016/j.mpdhp.2025.02.005","DOIUrl":"10.1016/j.mpdhp.2025.02.005","url":null,"abstract":"<div><div>Manifestations of microbial infection in the head and neck mucosa present significant challenges in diagnosis, often due to their non-specific clinical, imaging and histological appearances. Their presentation as ulcerated or necrotic lesions, combined with lymphadenopathy mimic malignant processes, resulting in further challenges in diagnosis. Additionally, the need for a microbial infection diagnosis is overshadowed by the urgency to confirm or exclude a cancer diagnosis, resulting in ancillary investigations catering mostly to the latter. The necessity for accurate and timely diagnosis of microbial infections is emphasized, especially for acute necrotizing infections due to anatomical proximity to vital structures of the cranial cavity and neck. To enable this, a reasonable level of experience and knowledge of the clinical and histological appearances of a range of microbial infections presenting in the head and neck region is essential. Histological skills, together with emphasis on detailed clinical and imaging features, and history should enable accurate diagnosis and targeted management. The salient features of a selection of viral, fungal, bacterial and protozoan infections presenting in the head and neck mucosal sites, their differential diagnoses and investigative tools are discussed.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 4","pages":"Pages 228-241"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory disorders of the sinonasal tract: a practical approach and recent updates 鼻窦炎的疾病：一个实用的方法和最近的更新

Diagnostic Histopathology Pub Date : 2025-04-01 DOI: 10.1016/j.mpdhp.2025.02.003

Umar A Hussain, Rajesh Rajendran, Guy Betts

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Head and neck tumours with neuroendocrine marker ‘expression’: pitfalls and learning points 头颈部肿瘤与神经内分泌标志物“表达”：陷阱和学习点

Diagnostic Histopathology Pub Date : 2025-04-01 DOI: 10.1016/j.mpdhp.2025.02.004

Ella-Grace Kirton, Karwan Moutasim

引用次数: 0