涎腺样乳腺癌的组织学特征、免疫表型、分子发病机制和诊断进展

Diagnostic Histopathology Pub Date : 2025-03-01 DOI:10.1016/j.mpdhp.2024.12.003

Giulia Querzoli, Adi S Levit, Zsuzsanna Varga, Maria Pia Foschini

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引用次数: 0

摘要

乳腺和唾液腺都是由具有相似组织结构的管状腺腺组成，因此在这两个器官中出现相似的肿瘤并不奇怪。然而，考虑到两个腺体的不同功能和它们所受到的不同刺激，显然类似的肿瘤可能呈现出实质性的差异。本文旨在研究唾液样乳腺癌的形态学和分子特征，重点讨论其异同。数据来源于全面的文献综述，根据其新颖性、适用性和影响力选择相关研究。涎样乳腺癌已被发现多年，但最近在了解其分子发病机制方面的进展为这些罕见肿瘤提供了新的诊断工具和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Insights into salivary gland-like breast carcinomas: histological features, immunophenotypes, molecular pathogenesis and diagnostic advancements

Both breast and salivary glands are composed of tubuloacinar glands with similar histological structures, so it is not surprising that similar neoplasms can arise in both organs. However, given the different functions of the two glands and the different stimuli to which they are subjected, apparently similar tumours may present substantial differences. This review aims to examine the morphological and molecular profiles of salivary-like breast carcinomas, focusing on similarities and differences. Data were obtained from a comprehensive literature review, selecting relevant studies based on their novelty, applicability, and impact. Salivary-like breast carcinomas have been recognized for many years, but recent advances in understanding their molecular pathogenesis have provided new diagnostic tools and insights into these rare tumors.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.