中国当代儿科杂志最新文献

{"title":"[Screen exposure status and related factors in children with epilepsy].","authors":"Shu-Jing Wang, Yan Li, Meng-Zhu Hu, Ying-Hong Zhu, Nai-Xue Cui","doi":"10.7499/j.issn.1008-8830.2404069","DOIUrl":"10.7499/j.issn.1008-8830.2404069","url":null,"abstract":"<p><strong>Objectives: </strong>To understand the status of screen exposure in children with epilepsy and analyze the influencing factors for screen exposure time, providing a scientific basis for managing screen exposure in these children.</p><p><strong>Methods: </strong>A convenience sampling method was used to select 275 children with epilepsy from outpatient clinics or those undergoing 24-hour electroencephalogram monitoring at two tertiary hospitals in Jinan from March to June 2023. Their parents (fathers or mothers) completed a questionnaire to collect data on screen exposure, parental screen regulation behaviors, and related information about the children and their families. The Wilcoxon rank-sum test or the Kruskal-Wallis <i>H</i> test was used to conduct a univariate analysis of the average screen exposure time of children on school days and weekends, as well as the daily average screen exposure time. A multivariate logistic regression analysis was used to identify the risk factors for children whose screen exposure time exceeded the recommended guidelines (average screen exposure time on school days >1 hour or average on weekends >2 hours).</p><p><strong>Results: </strong>The median screen exposure duration on school days was 40 minutes, while on weekends it was 120 minutes. Among the children studied, 23.1% (63/273) had average screen exposure time exceeding 1 hour on school days, and 42.5% (117/275) had average screen exposure time exceeding 2 hours on weekends. Four children experienced seizures while using screen devices. Multivariate logistic regression analysis indicated that using screen devices shortly before sleep, lower educational levels of parents, caregivers discussing screen content with children, and longer seizure durations in children were risk factors for exceeding recommended guidelines (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Some children with epilepsy have a screen exposure time exceeding the recommended guidelines. A longer seizure duration, lower parental education levels, and permissive digital parenting are closely associated with children's screen exposure time exceeding the recommended guidelines. Families and children exhibiting these characteristics should be prioritized for attention and health education.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1202-1210"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of interrupter resistance pulmonary function testing in the diagnosis of asthma in preschool children: a single-center study].","authors":"Ting-Ting Xu, Yong Feng, Yun-Xiao Shang","doi":"10.7499/j.issn.1008-8830.2407042","DOIUrl":"10.7499/j.issn.1008-8830.2407042","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the value of interrupter resistance (Rint) pulmonary function testing in the diagnosis of asthma in preschool children, and to compare the significance of Rint pulmonary function testing versus impulse oscillometry (IOS) in the diagnosis of asthma.</p><p><strong>Methods: </strong>A prospective study was conducted among 108 children with recurrent wheezing, aged 4 to <6 years, who were admitted from July 2022 to November 2023. According to the treatment outcome, they were divided into an asthmatic group (61 children) and a non-asthmatic group (47 children). Rint pulmonary function parameters and IOS parameters were analyzed for both groups, and the two tests were compared in terms of feasibility and diagnostic value.</p><p><strong>Results: </strong>Compared with the non-asthmatic group, the asthmatic group had significantly higher percentage of actual measured value to predicted value for Rint and percent changes in the measured value and predicted value of Rint (<i>P</i><0.05). The receiver operating characteristic curve analysis showed that the percent change in the predicted value of Rint had an optimal cut-off value of 32.0% in the diagnosis of asthma in preschool children, with an area under the curve (AUC) of 0.705, a sensitivity of 41.0%, and a specificity of 91.5% (<i>P</i><0.05). In terms of the degree of completion, 18 children (16.7%) failed to complete the IOS test, but they could successfully complete Rint pulmonary function testing with good quality control. Rint pulmonary function testing and IOS had a similar area under the curve in the diagnosis of asthma in preschool children (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>Rint pulmonary function testing can be used to assist in the diagnosis of asthma in preschool children, with a similar diagnostic value to IOS and a relatively high level of feasibility. A percent change of ≥32% in the predicted value of Rint in the bronchial dilation test can be used as a cut-off value for the diagnosis of asthma in preschool children.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1187-1193"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on neurodevelopmental disorders associated with congenital heart disease].","authors":"Yu-Mei Liu, Tian-Yu Liu, Shao-Han Nong, Xiao-Guang Zhou","doi":"10.7499/j.issn.1008-8830.2406063","DOIUrl":"10.7499/j.issn.1008-8830.2406063","url":null,"abstract":"<p><p>The incidence and disability rate of neurodevelopmental disorders in children are high, making it a significant public health issue affecting children's health globally. Neurodevelopmental disorders are particularly common in children with congenital heart disease (CHD), with clinical characteristics varying by type of CHD, surgical approach, age stage, and the presence of different complications or comorbidities. In recent years, based on the intervention model of \"early diagnosis and early treatment,\" foreign studies have begun to explore new techniques for preventive early intervention in high-risk children with neurodevelopmental disorders, achieving promising results. This paper reviews the clinical characteristics of neurodevelopmental disorders associated with CHD, aiming to provide a theoretical basis for implementing new preventive early intervention techniques for children with CHD, thereby further reducing the incidence of neurodevelopmental disorders associated with CHD.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1231-1237"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk factors for the occurrence of bronchiolitis obliterans in children with refractory <i>Mycoplasma pneumoniae</i> pneumonia and the predictive value of the factors].","authors":"Gui-Lan Cheng, Bei-Xue Xu, Lin Jia","doi":"10.7499/j.issn.1008-8830.2406097","DOIUrl":"10.7499/j.issn.1008-8830.2406097","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the risk factors for the occurrence of bronchiolitis obliterans (BO) in children with refractory <i>Mycoplasma pneumoniae</i> pneumonia (RMPP) and their predictive value of the factors.</p><p><strong>Methods: </strong>A retrospective analysis was performed for the medical records of 156 children with RMPP who were admitted to the hospital from May 2020 to March 2024. According to the diagnostic criteria for BO, they were divided into a BO group (<i>n</i>=76) and a non-BO group (<i>n</i>=80). A logistic regression analysis was used to investigate risk factors for the occurrence of BO, and the receiver operating characteristic (ROC) curve was used to assess the value of the model established based on the risk factors in predicting BO.</p><p><strong>Results: </strong>Compared with the non-BO group, the BO group had a significantly longer duration of fever, a significantly higher leukocyte count, and a significantly lower albumin level (<i>P</i><0.05). Compared with the non-BO group, the BO group had a significantly lower proportion of children with initiation of macrolide antibiotic therapy within 5 days, initiation of glucocorticoid therapy within 2 weeks, or initiation of bronchoscopic therapy within <2 weeks (<i>P</i><0.05). The ROC curve analysis showed that the logistic regression model established based on the above six indicators had an area under the curve of 0.901 (95%<i>CI</i>: 0.849-0.953, <i>P</i><0.001) in predicting the occurrence of BO, with a sensitivity of 0.893 and a specificity of 0.827 at the optimal cut-off value of 0.341.</p><p><strong>Conclusions: </strong>The logistic regression model established based on duration of fever, leukocyte count, albumin, initiation of macrolide antibiotic therapy within 5 days, initiation of glucocorticoid therapy within 2 weeks, and initiation of bronchoscopic therapy within 2 weeks has relatively high sensitivity and specificity in predicting the occurrence of BO in children with RMPP.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1182-1186"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of exchange transfusion in neonates with severe pertussis and hyperleukocytosis].","authors":"Yang Hu, Yan Zhuang, Yun-Qin Wu, Zheng-Hui Xiao","doi":"10.7499/j.issn.1008-8830.2407018","DOIUrl":"10.7499/j.issn.1008-8830.2407018","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the efficacy and safety of exchange transfusion in neonates with severe pertussis.</p><p><strong>Methods: </strong>A retrospective analysis was performed for the medical data of five neonates with severe pertussis who underwent exchange transfusion in the Department of Neonatology, Hunan Children's Hospital, from August 2019 to March 2024. The clinical characteristics of the patients were summarized, and the efficacy and adverse reactions of exchange transfusion were analyzed.</p><p><strong>Results: </strong>All five neonates had the symptoms of hypoxemia, recurrent apnea, and heart failure and required invasive mechanical ventilation. Two cases of pulmonary hypertension were observed, one of which was complicated by decompensated shock. Before exchange transfusion, the five children had a median leukocyte count of 82.60×10⁹/L, a median absolute lymphocyte count of 28.20×10⁹/L, and a median absolute neutrophil count of 43.10×10⁹/L, and reexamination at 4 hours after exchange transfusion showed that these values decreased to 28.40×10⁹/L, 7.60×10⁹/L, and 15.40×10⁹/L, respectively. The four children who underwent exchange transfusion in the early stage of cardiopulmonary failure showed varying degrees of improvement in oxygenation and a reduction in the partial pressure of carbon dioxide, and they were discharged after improvement; the one child who underwent exchange transfusion in the late stage of cardiopulmonary failure ultimately died. No child experienced severe adverse reactions related to exchange transfusion.</p><p><strong>Conclusions: </strong>For neonates with severe pertussis, initiating exchange transfusion in the early stages of cardiopulmonary failure can effectively reduce leukocyte levels, potentially improve survival rates, and is relatively safe.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1155-1161"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Aggressive natural killer cell leukemia with hemophagocytic lymphohistiocytosis: a case report].","authors":"Jing-Hui Yang, Qing-Mei Zhou, Xin-Yu Xu, Xiang-Mei Yao, Yu-Mei Luo, Qian-Ting Chen, Zheng-Zheng Guo, Tian-He Li","doi":"10.7499/j.issn.1008-8830.2404140","DOIUrl":"10.7499/j.issn.1008-8830.2404140","url":null,"abstract":"<p><p>A boy, aged 14 years, was admitted due to recurrent cough and expectoration for more than 1 month, with aggravation and fever for 2 days. After admission, he presented with tachypnea and a significant reduction in transcutaneous oxygen saturation, and emergency chest CT examination showed large patchy exudation and consolidation of both lungs. The boy was given tracheal intubation and invasive mechanical ventilation immediately, and his condition was improved after active symptomatic treatment. On the 10th day of hospitalization, the boy experienced fever again, and the laboratory tests showed positive results for Epstein-Barr virus and <i>Mycoplasma</i> antibody IgM, along with pancytopenia, elevated triglycerides, decreased fibrinogen, and increased levels of ferritin and soluble CD25. The boy was diagnosed with hemophagocytic lymphohistiocytosis. Bone marrow biopsy showed the presence of atypical lymphocytes, and aggressive natural killer cell leukemia was considered according to clinical manifestations and flow cytometry immunophenotype. Therefore, the possibility of hemophagocytic lymphohistiocytosis should be suspected in case of severe infection with pancytopenia and rapid disease progression, and hematological malignancies should also be ruled out. Bone marrow biopsy should be performed as early as possible to make a confirmed diagnosis and perform timely treatment.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1225-1230"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mechanism by which mycobacterial antigen 85B inhibits autophagy and promotes apoptosis in Hodgkin lymphoma cells].","authors":"Yong-Feng Cheng, Yi-Ping Shen, Xue-Mei Wang, Dan-Lu Li, Chun-Yan Fan, Gulibaha Maimaiti, Mei Yan","doi":"10.7499/j.issn.1008-8830.2404153","DOIUrl":"10.7499/j.issn.1008-8830.2404153","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the mechanism by which mycobacterial antigen 85B (Ag85B) inhibits autophagy and promotes apoptosis in Hodgkin lymphoma (HL) cells.</p><p><strong>Methods: </strong>The clinical data and pathological tissue slides were retrospectively collected from 80 HL children and 30 children with reactive lymphadenopathy (control group) treated at the First Affiliated Hospital of Xinjiang Medical University. Immunohistochemical analysis was performed to assess the expression of microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (P62/SQSTM1), and Beclin-1 in the pathological tissues of HL and control groups. Human Hodgkin lymphoma cells (HDLM-2) were divided into the HDLM-2 group and the HDLM-2+Ag85B groups (with Ag85B concentrations of 0.5, 1, 2, and 4 μg/mL). The CCK8 method was used to measure HDLM-2 cell proliferation; qRT-PCR was employed to detect the expression of LC3, P62, Beclin-1, Akt, and mTOR mRNA in cells. An apoptosis kit was used to detect cell apoptosis.</p><p><strong>Results: </strong>The positive expression of LC3 and Beclin-1 in the HL group were higher than those in the control group (<i>P</i><0.05), while the positive expression of P62 was lower than that in the control group (<i>P</i><0.05). In stages III-IV compared to stages I-II, the positive expression of LC3 and Beclin-1 increased, while the positive expression of P62 decreased (<i>P</i><0.05). Cell experiment results showed that the HDLM-2+Ag85B group had suppressed cell proliferation compared to the HDLM-2 group, with decreased mRNA expression of LC3 and Beclin-1, and increased mRNA expression of P62, PI3K, Akt, and mTOR, leading to increased cell apoptosis. Notably, when Ag85B was at a concentration of 2 μg/mL, it had the strongest effect on HDLM-2 cells after 24 hours (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Autophagy is enhanced in children with HL and increases with disease stage. Ag85B can inhibit the proliferation and autophagy of HL tumor cells and promote apoptosis, possibly related to the activation of the PI3K/Akt/mTOR pathway.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1218-1224"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk factors for bronchopulmonary dysplasia in preterm infants and establishment of a prediction model].","authors":"Yi-Bo Liu, Chong-Bing Yan, Yuan-Yang Zhang, Bo-Wen Weng, Cheng Cai","doi":"10.7499/j.issn.1008-8830.2404065","DOIUrl":"10.7499/j.issn.1008-8830.2404065","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the risk factors for bronchopulmonary dysplasia (BPD) in preterm infants, and to establish a risk prediction model.</p><p><strong>Methods: </strong>A total of 120 preterm infants who were admitted to the neonatal intensive care unit of Shanghai Children's Hospital from January to December 2022 were included. According to the diagnostic criteria for BPD released by the National Institute of Child Health and Human Development in 2018, they were divided into a non-BPD group (84 infants) and a BPD group (36 infants). The clinical data of the infants and their mothers were compared between the two groups. The univariate analysis and the stepwise multivariate regression analysis were used to identify the risk factors for BPD and establish a risk prediction model.</p><p><strong>Results: </strong>The results showed that a gestational age of <28 weeks, duration of noninvasive respiratory support, comorbidity with infectious pneumonia, and chorioamnionitis in the mother were independent risk factors for BPD in preterm infants (<i>P</i><0.05). A nomogram model for predicting the development of BPD was established based on the risk factors, with an area under the receiver operating characteristic curve of 0.93, and the calibration curve of this nomogram had a slope of about 1. The goodness-of-fit test indicated the model fitted well (<i>χ²</i>=8.287, <i>P</i>=0.406).</p><p><strong>Conclusions: </strong>A gestational age of <28 weeks, duration of noninvasive respiratory support, comorbidity with infectious pneumonia, and chorioamnionitis in the mother are independent risk factors for BPD in preterm infants.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1148-1154"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Childhood acute lymphoblastic leukemia with <i>CREBBP</i> gene mutation: a clinical analysis of 14 cases].","authors":"Xiao-Pei Jia, An-Na Lian, Ding-Ding Cui, Ye-Qing Tao, Ping Zhu, Wen-Jing Qi, Chun-Mei Wang","doi":"10.7499/j.issn.1008-8830.2407029","DOIUrl":"10.7499/j.issn.1008-8830.2407029","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical features and prognosis of childhood acute lymphoblastic leukemia (ALL) with <i>CREBBP</i> gene mutation.</p><p><strong>Methods: </strong>A retrospective analysis was performed for the clinical data of 14 ALL children with <i>CREBBP</i> gene mutation who were admitted to Children's Hospital of the First Affiliated Hospital of Zhengzhou University from January 2016 to December 2023.</p><p><strong>Results: </strong>The ALL patients with <i>CREBBP</i> gene mutation accounted for 1.5% (14/963) among all children diagnosed with ALL during the same period of time, among whom there were 4 boys (29%) and 10 girls (71%), with a median age of 4 years and 3.5 months. All children had an immunological type of B-cell ALL and concurrent mutations in other genes including <i>NRAS</i>, <i>KRAS</i>, <i>ETV6</i>, <i>FLT3</i>, <i>PAX5</i>, <i>SH2B3</i>, <i>CDKN2A</i>, and <i>CDKN2B</i>, and 4 children had karyotype abnormality. All 14 children received induction therapy with the VDLP regimen, with a complete remission (CR) rate of 79% (11/14) after the first course of treatment. Three children experienced bone marrow recurrence alone, with a recurrence rate of 21% (3/14), among whom 1 child achieved CR after blinatumomab therapy and 2 received bridging hematopoietic stem cell transplantation after chemotherapy for recurrence. Among the 14 children, 1 died due to treatment discontinuation and 13 achieved disease-free survival. The 5-year overall survival rate was 92%±7%, and the event-free survival rate was 73%±13%.</p><p><strong>Conclusions: </strong>ALL with <i>CREBBP</i> gene mutation is more common in girls and has a low induction remission rate and a high recurrence rate, and it is often accompanied by other types of gene mutations and abnormal karyotypes. Most children with recurrence can achieve long-term survival after immunotherapy or hematopoietic stem cell transplantation.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1211-1217"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of multidrug resistance gene locus mutations and clinical significance in children with <i>Mycoplasma pneumoniae</i> pneumonia].","authors":"Wei Zhang, Yang Wang, Li-Jun Cai","doi":"10.7499/j.issn.1008-8830.2407129","DOIUrl":"10.7499/j.issn.1008-8830.2407129","url":null,"abstract":"<p><strong>Objectives: </strong>To detect multidrug resistance gene locus mutations in children with <i>Mycoplasma pneumoniae</i> pneumonia through targeted high-throughput sequencing and to explore its clinical significance.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 2 899 children with <i>Mycoplasma pneumoniae</i> pneumonia, who underwent respiratory pathogen-targeted high-throughput sequencing, treated at Hubei Maternal and Child Health Care Hospital between January and December 2023. The patients were divided into a mutation group (<i>n</i>=885) and a non-mutation group (<i>n</i>=2 014) based on whether there was a mutation in the 23SrRNA macrolide-resistant gene of <i>Mycoplasma pneumoniae</i>. Multivariate logistic regression analysis was used to investigate the risk factors for multidrug resistance gene locus mutations in children with <i>Mycoplasma pneumoniae</i> pneumonia.</p><p><strong>Results: </strong>Among the 2 899 children, 885 cases (30.53%) had mutations in the 23SrRNA resistance gene, including 884 cases with the A2063G mutation and 1 case with the A2064G mutation. In children with 23SrRNA resistance gene mutations, treatment with doxycycline or ofloxacin was more effective than with azithromycin or clarithromycin, and doxycycline was more effective than ofloxacin (<i>P</i><0.05). The mutation rate of resistance genes in children with <i>Mycoplasma pneumoniae</i> pneumonia increased with age (<i>P</i><0.001). Multivariate logistic regression analysis showed that increased age, extrapulmonary infection, lung consolidation, prolonged fever, prolonged hospitalization, and elevated CRP levels were risk factors for 23SrRNA gene locus mutations (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Age, extrapulmonary infections, lung consolidation, duration of fever, length of hospitalization, and CRP levels are closely related to 23SrRNA resistance gene locus mutations. Detecting multidrug resistance gene locus mutations in children with <i>Mycoplasma pneumoniae</i> pneumonia can aid in early diagnosis and prediction of treatment efficacy, promoting rational clinical treatment.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1176-1181"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}