中国当代儿科杂志Pub Date : 2025-05-15DOI: 10.7499/j.issn.1008-8830.2411113
Lei Yu, Mao-Lan Wu, Xiang-Rong Zheng
{"title":"[Research progress on the relationship between gut microbiota and childhood bronchial asthma].","authors":"Lei Yu, Mao-Lan Wu, Xiang-Rong Zheng","doi":"10.7499/j.issn.1008-8830.2411113","DOIUrl":"10.7499/j.issn.1008-8830.2411113","url":null,"abstract":"<p><p>Bronchial asthma (asthma) is a complex inflammatory airway disease affecting approximately 100 million children worldwide, imposing a heavy burden on society and families. Studies have shown that the gut microbiota plays a significant role in the occurrence and development of childhood asthma. This paper reviews the research progress on the relationship between gut microbiota and childhood asthma. By elucidating the composition, function, and relationship with the host of gut microbiota, the impact of changes in its composition and function on the development of asthma is revealed. Furthermore, the potential value and application prospects of modulating gut microbiota as a new strategy for asthma treatment are discussed, providing a theoretical reference for in-depth research on the relationship between gut microbiota and the onset of childhood asthma and the development of new therapeutic approaches.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 5","pages":"623-628"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[<i>PLCE1</i> mutation-induced end-stage renal disease presenting with massive proteinuria: a family analysis and literature review].","authors":"Reyila Abasi, Zhen-Chun Zhu, Zhi-Lang Lin, Hong-Jie Zhuang, Xiao-Yun Jiang, Yu-Xin Pei","doi":"10.7499/j.issn.1008-8830.2411029","DOIUrl":"10.7499/j.issn.1008-8830.2411029","url":null,"abstract":"<p><strong>Objectives: </strong>To summarize the clinical and genetic characteristics of end-stage renal disease caused by <i>PLCE1</i> gene mutations.</p><p><strong>Methods: </strong>A retrospective analysis of the clinical and genetic features of three children from a family with <i>PLCE1</i> gene mutations was conducted, along with a literature review of hereditary kidney disease cases caused by <i>PLCE1</i> gene mutations.</p><p><strong>Results: </strong>The proband was an 8-year-old male presenting with nephrotic syndrome stage 4 chronic kidney disease. Renal biopsy showed focal segmental glomerulosclerosis. Two years and five months after kidney transplantation, the patient had persistent negative proteinuria and normal renal function. Whole-exome sequencing identified two pathogenic heterozygous variants: c.961C>T and c.3255_3256delinsT, with c.3255_3256delinsT being a novel mutation. Family screening revealed no renal involvement in the parents, but among five siblings, one brother died at age of 4 years from end-stage renal disease. A 7-year-old sister presented with proteinuria and bilateral medullary sponge kidney, with proteinuria resolving after one year of follow-up. A 3-year-old brother died after kidney transplantation due to severe pneumonia. The literature review included 45 patients with hereditary kidney disease caused by <i>PLCE1</i> gene mutations. The main clinical phenotype was nephrotic syndrome (87%, 39/45), and renal pathology predominantly showed focal segmental glomerulosclerosis (57%, 16/28). No mutation hotspots were identified.</p><p><strong>Conclusions: </strong>Compound heterozygous mutations in the <i>PLCE1</i> gene can lead to rapid progression of the disease to end-stage renal disease, with favorable outcomes following kidney transplantation. Family screening is crucial for early diagnosis, and medullary sponge kidney may be a novel phenotype associated with these gene mutations.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 5","pages":"580-587"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-05-15DOI: 10.7499/j.issn.1008-8830.2409151
Cheng Cai, Wu Zhao, Hu Hao, Yuan Shi
{"title":"[Interpretation of the \"Expert consensus on the diagnosis and treatment of neonatal hyperammonemia\"].","authors":"Cheng Cai, Wu Zhao, Hu Hao, Yuan Shi","doi":"10.7499/j.issn.1008-8830.2409151","DOIUrl":"10.7499/j.issn.1008-8830.2409151","url":null,"abstract":"<p><p>This paper provides an interpretation of the \"Expert consensus on the diagnosis and treatment of neonatal hyperammonemia\" published in the May 2023 issue of the <i>Chinese Journal of Contemporary Pediatrics</i>. The interpretation focuses on key aspects such as the neurotoxicity of ammonia, classification of etiologies, diagnosis, nutritional management, and pharmacological treatment. The aim is to enhance awareness about ammonia testing and emphasize that treatment should not be delayed while awaiting etiological investigation, thereby advancing the diagnosis and treatment of neonatal hyperammonemia.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 5","pages":"515-523"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-04-15DOI: 10.7499/j.issn.1008-8830.2411034
Xiang-Hui Liu
{"title":"[Research progress on risk factors for poor prognosis in pediatric non-esophageal eosinophilic gastrointestinal disorder].","authors":"Xiang-Hui Liu","doi":"10.7499/j.issn.1008-8830.2411034","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2411034","url":null,"abstract":"<p><p>Non-esophageal eosinophilic gastrointestinal disorder (non-EoE EGID) is a group of immune-mediated gastrointestinal diseases characterized by infiltration of eosinophils. Although most patients experience symptom relief after treatment, some still face the risk of persistent symptoms or relapse. Improving the prognosis for this subset of patients remains an urgent challenge. Identifying risk factors that affect the prognosis of non-EoE EGID and providing timely effective interventions are crucial for improving outcomes. This paper reviews the risk factors related to the prognosis of pediatric non-EoE EGID, including genetic factors, allergies, environmental factors, clinical characteristics, endoscopic findings, and pathological manifestations, with the aim of providing references for clinical decision-making.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"493-499"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-04-15DOI: 10.7499/j.issn.1008-8830.2408084
Wen-Xin Hu, Lei Zhang, Cai Wang, Zi-Yue Wang, Jia-Min Xu, Jing-Yu Wang, Jia Zhou, Wen-Min Wang, Meng-Meng Yao, Xia Chi
{"title":"[Family socioeconomic status and children's reading fluency: the chain mediating role of family reading environment and children's living and learning styles].","authors":"Wen-Xin Hu, Lei Zhang, Cai Wang, Zi-Yue Wang, Jia-Min Xu, Jing-Yu Wang, Jia Zhou, Wen-Min Wang, Meng-Meng Yao, Xia Chi","doi":"10.7499/j.issn.1008-8830.2408084","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2408084","url":null,"abstract":"<p><strong>Objectives: </strong>To study the impact of family socioeconomic status on children's reading fluency and the chain mediation effect of family reading environment and children's living and learning styles in this relationship.</p><p><strong>Methods: </strong>A total of 473 children from grades 2 to 6 in two primary schools in Nanjing were selected through stratified random sampling. The children's reading fluency was assessed, and a questionnaire was used to collect information on family socioeconomic status, family reading environment, and children's living and learning styles. The mediation model was established using the Process macro in SPSS, and the Bootstrap method was employed to test the significance of the mediation effects.</p><p><strong>Results: </strong>Family socioeconomic status, family reading environment, and children's living and learning styles were significantly positively correlated with reading fluency (<i>P</i><0.001). The family reading environment and children's living and learning styles mediated the relationship between family socioeconomic status and children's reading fluency. Specifically, the independent mediation effect of family reading environment accounted for 11.02% of the total effect, while the independent mediation effect of children's living and learning styles accounted for 10.79%. The chain mediation effect of family reading environment and children's living and learning styles accounted for 7.41% of the total effect.</p><p><strong>Conclusions: </strong>Family socioeconomic status can affect children's reading fluency through three pathways: family reading environment, children's living and learning styles, and the chain mediation effect of family reading environment and children's living and learning styles.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"451-457"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Advances in research on gender differences in autism spectrum disorders].","authors":"Tong-Tong Jiang, Xiu-Qiong Li, Ting-Ting Zhao, Hong-Yu Li, Qiang Tang","doi":"10.7499/j.issn.1008-8830.2411142","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2411142","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, repetitive behaviors, and restricted interests. Studies have shown that it is more prevalent in males than females. Although this issue has attracted academic attention since the 20th century, the specific mechanisms underlying the gender differences in ASD remain unclear. This paper reviews the impact of gender differences in ASD, focusing on the female protective effect, DNA methylation, hormone levels, and clinical manifestations. It also discusses corresponding treatment options, particularly suggesting improvements in the diagnostic process, which is often overlooked, in order to provide valuable references for the clinical diagnosis and treatment of ASD.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"480-486"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-04-15DOI: 10.7499/j.issn.1008-8830.2501080
Xin Fan, Yi-Yun Huang
{"title":"[Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia].","authors":"Xin Fan, Yi-Yun Huang","doi":"10.7499/j.issn.1008-8830.2501080","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2501080","url":null,"abstract":"<p><p>Transfusion-dependent thalassemia (TDT) is a severe genetic chronic hemolytic disease, and growth retardation is a common clinical feature in patients with TDT. Due to the need for regular blood transfusions, these patients often experience iron overload, which leads to various endocrine dysfunctions, including abnormalities in the growth hormone/insulin-like growth factor axis, hypothyroidism, hypoparathyroidism, hypogonadism, adrenal insufficiency, and decreased bone density. This paper reviews the clinical monitoring and intervention measures for growth disorders and related endocrine functions in patients with TDT, providing references for clinicians.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"389-394"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-04-15DOI: 10.7499/j.issn.1008-8830.2411146
Yue DU, Jing-Hua Zhang, Jun-Liang Li, Zhou-Ping Wang, Mei-Gui Wu
{"title":"[Dural arteriovenous fistula in a neonate presenting with respiratory distress].","authors":"Yue DU, Jing-Hua Zhang, Jun-Liang Li, Zhou-Ping Wang, Mei-Gui Wu","doi":"10.7499/j.issn.1008-8830.2411146","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2411146","url":null,"abstract":"<p><p>The patient, a 20-day-old male, was admitted due to respiratory distress that had persisted for 20 days after birth. The main clinical manifestations included gradually worsening respiratory distress and edema. The patient received treatment including mechanical ventilation and diuretics. Echocardiography indicated cardiomegaly, pulmonary hypertension, and heart failure. A comprehensive systemic examination revealed a significant blowing vascular murmur upon auscultation over the anterior fontanelle and bilateral temporal regions. Further imaging studies including cranial magnetic resonance imaging, magnetic resonance angiography, and magnetic resonance venography showed marked dilation of the superior sagittal sinus, transverse sinus, and sigmoid sinus, leading to a definitive diagnosis of dural arteriovenous fistula. After a multidisciplinary consultation, the patient underwent cerebral angiography and partial embolization of the left parietal arteriovenous fistula. Postoperatively, the patient was treated with positive inotropes, diuretics, and fluid restriction. Ultimately, the patient was weaned off the ventilator and discharged in improved condition. This article reports a case of neonatal dural arteriovenous fistula presenting with respiratory distress and discusses the multidisciplinary approach to managing this condition, which aids in early disease recognition and guides clinical decision-making.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"500-504"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-04-15DOI: 10.7499/j.issn.1008-8830.2501073
Rong Huang, Qing-Nan He, Ming-Yan Hei, Ming-Hua Yang, Xiao-Fan Zhu, Jun Lu, Xiao-Jun Xu, Tian-Ming Yuan, Rong Zhang, Xu Wang, Jin-Ping Liu, Jing Wang, Zhi-Li Shao, Ming-Yi Zhao, Yong-Jian Guo, Xin-Yin Wu, Jia-Rui Chen, Qi-Rong Chen, Jia Guo, Rong Gui
{"title":"[Explanation and interpretation of blood transfusion provisions for critically ill and severely bleeding pediatric patients in the national health standard \"Guideline for pediatric transfusion\"].","authors":"Rong Huang, Qing-Nan He, Ming-Yan Hei, Ming-Hua Yang, Xiao-Fan Zhu, Jun Lu, Xiao-Jun Xu, Tian-Ming Yuan, Rong Zhang, Xu Wang, Jin-Ping Liu, Jing Wang, Zhi-Li Shao, Ming-Yi Zhao, Yong-Jian Guo, Xin-Yin Wu, Jia-Rui Chen, Qi-Rong Chen, Jia Guo, Rong Gui","doi":"10.7499/j.issn.1008-8830.2501073","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2501073","url":null,"abstract":"<p><p>To guide clinical blood transfusion practices for pediatric patients, the National Health Commission has issued the health standard \"Guideline for pediatric transfusion\" (WS/T 795-2022). Critically ill children often present with anemia and have a higher demand for transfusions compared to other pediatric patients. This guideline provides guidance and recommendations for blood transfusions in cases of general critical illness, septic shock, acute brain injury, extracorporeal membrane oxygenation, non-life-threatening bleeding, and hemorrhagic shock. This article interprets the background and evidence of the blood transfusion provisions for critically ill and severely bleeding children in the \"Guideline for pediatric transfusion\", aiming to enhance understanding and implementation of this aspect of the guidelines. <b>Citation:Chinese Journal of Contemporary Pediatrics, 2025, 27(4): 395-403</b>.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"395-403"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-04-15DOI: 10.7499/j.issn.1008-8830.2409146
Yue Han
{"title":"[Progress in the clinical application of cord blood transfusion in neonates].","authors":"Yue Han","doi":"10.7499/j.issn.1008-8830.2409146","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2409146","url":null,"abstract":"<p><p>The primary source of blood transfusions for neonates is allogeneic adult blood. While allogeneic adult blood can provide timely and effective transfusion support for neonates, there are differences in hemoglobin types and coagulation systems between adults and neonates, along with potential infection risks. In recent years, the clinical value of cord blood transfusion in early surgical interventions and anemia management for neonates has been increasingly recognized. Studies have shown that cord blood transfusion not only reduces the incidence of complications in preterm infants but also provides a safer alternative transfusion source for neonates. However, cord blood transfusion has not yet been widely adopted. This article reviews the advantages, clinical application progress, and significance of cord blood transfusion in neonates, to provide evidence supporting its broader clinical implementation.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"487-492"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}