中国当代儿科杂志最新文献

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[Clinical analysis of 6 cases of diffuse panbronchiolitis in children]. 儿童弥漫性泛细支气管炎6例临床分析
中国当代儿科杂志 Pub Date : 2025-03-15 DOI: 10.7499/j.issn.1008-8830.2409125
Li-Xin Deng, De-Hui Chen, Yu-Neng Lin, Shang-Zhi Wu, Jia-Xing Xu, Zhan-Hang Huang, Ying-Ying Gu, Jun-Xiang Feng
{"title":"[Clinical analysis of 6 cases of diffuse panbronchiolitis in children].","authors":"Li-Xin Deng, De-Hui Chen, Yu-Neng Lin, Shang-Zhi Wu, Jia-Xing Xu, Zhan-Hang Huang, Ying-Ying Gu, Jun-Xiang Feng","doi":"10.7499/j.issn.1008-8830.2409125","DOIUrl":"10.7499/j.issn.1008-8830.2409125","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the clinical characteristics of diffuse panbronchiolitis (DPB) in children and to enhance the clinical diagnosis and treatment of this disease.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 6 children diagnosed with DPB who were hospitalized at The First Affiliated Hospital of Guangzhou Medical University from January 2011 to December 2019.</p><p><strong>Results: </strong>Among the 6 patients, there were 2 males and 4 females; the age at diagnosis ranged from 7 to 12 years. All patients presented with cough, sputum production, and exertional dyspnea, and all had a history of sinusitis. Two cases showed positive serum cold agglutinin tests, and 5 cases exhibited pathological changes consistent with chronic bronchiolitis. High-resolution chest CT in all patients revealed centrilobular nodules diffusely distributed throughout both lungs with a tree-in-bud appearance. Five patients received low-dose azithromycin maintenance therapy, but 3 showed inadequate treatment response. After empirical anti-tuberculosis treatment, non-tuberculous <i>Mycobacteria</i> were found in the bronchoalveolar lavage fluid. Follow-up over 2 years showed 1 case cured, 3 cases significantly improved, and 2 cases partially improved.</p><p><strong>Conclusions: </strong>The clinical presentation of DPB is non-specific and can easily lead to misdiagnosis. In cases where DPB is clinically diagnosed but does not show improvement with low-dose azithromycin treatment, special infections should be considered.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 3","pages":"334-339"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnosis of coronary artery lesions in children based on Z-score regression model]. [基于Z-score回归模型的儿童冠状动脉病变诊断]。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2405030
Yong Wang, Jia-Ying Jiang, Yan Deng, Bo Li, Ping Shuai, Xiao-Ping Hu, Yin-Yan Zhang, Han Wu, Lu-Wei Ye, Qian Peng
{"title":"[Diagnosis of coronary artery lesions in children based on Z-score regression model].","authors":"Yong Wang, Jia-Ying Jiang, Yan Deng, Bo Li, Ping Shuai, Xiao-Ping Hu, Yin-Yan Zhang, Han Wu, Lu-Wei Ye, Qian Peng","doi":"10.7499/j.issn.1008-8830.2405030","DOIUrl":"10.7499/j.issn.1008-8830.2405030","url":null,"abstract":"<p><strong>Objectives: </strong>To construct a Z-score regression model for coronary artery diameter based on echocardiographic data from children in Sichuan Province and to establish a Z-score calculation formula.</p><p><strong>Methods: </strong>A total of 744 healthy children who underwent physical examinations at Sichuan Provincial People's Hospital from January 2020 to December 2022 were selected as the modeling group, while 251 children diagnosed with Kawasaki disease at the same hospital from January 2018 to December 2022 were selected as the validation group. Pearson correlation analysis was conducted to analyze the relationships between coronary artery diameter values and age, height, weight, and body surface area. A regression model was constructed using function transformation to identify the optimal regression model and establish the Z-score calculation formula, which was then validated.</p><p><strong>Results: </strong>The Pearson correlation analysis showed that the correlation coefficients for the diameters of the left main coronary artery, left anterior descending artery, left circumflex artery, and right coronary artery with body surface area were 0.815, 0.793, 0.704, and 0.802, respectively (<i>P</i><0.05). Among the constructed regression models, the power function regression model demonstrated the best performance and was therefore chosen as the optimal model for establishing the Z-score calculation formula. Based on this Z-score calculation formula, the detection rate of coronary artery lesions was found to be 21.5% (54/251), which was higher than the detection rate based on absolute values of coronary artery diameter. Notably, in the left anterior descending and left circumflex arteries, the detection rate of coronary artery lesions using this Z-score calculation formula was higher than that of previous classic Z-score calculation formulas.</p><p><strong>Conclusions: </strong>The Z-score calculation formula established based on the power function regression model has a higher detection rate for coronary artery lesions, providing a strong reference for clinicians, particularly in assessing coronary artery lesions in children with Kawasaki disease.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"176-183"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A systematic review of childhood cancer-related fatigue assessment tools based on the COSMIN guidelines]. [基于COSMIN指南的儿童癌症相关疲劳评估工具的系统回顾]。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2408132
Qian Zhao, Yu Wang, Lan-Zheng Bian
{"title":"[A systematic review of childhood cancer-related fatigue assessment tools based on the COSMIN guidelines].","authors":"Qian Zhao, Yu Wang, Lan-Zheng Bian","doi":"10.7499/j.issn.1008-8830.2408132","DOIUrl":"10.7499/j.issn.1008-8830.2408132","url":null,"abstract":"<p><strong>Objectives: </strong>To systematically review the methodological quality and measurement properties of childhood cancer-related fatigue assessment tools based on the consensus-based standards for the selection of health measurement instruments (COSMIN) guidelines, providing a basis for clinical practitioners to select appropriate assessment tools.</p><p><strong>Methods: </strong>The databases searched included China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature, Weipu, PubMed, CINAHL, Embase, and Web of Science for studies published up to January 2024. Children under 12 years old and their primary caregivers were enrolled as subjects. Articles were screened based on inclusion criteria, and the key information regarding the assessment tools was extracted. The risk of bias checklist from the COSMIN guidelines and the quality standard rating scale were employed to evaluate measurement properties and formulate final recommendations.</p><p><strong>Results: </strong>A total of 18 articles were included, covering 7 fatigue measurement tools, consisting of 4 specific tools and 3 generic tools tools. Methodological differences were observed in measurement properties across these scales. The Chinese Version of the Pediatric Patient-Reported Outcomes Measurement Information System (C-Ped-PROMIS) was rated as grade A recommendation due to its adequate content validity and internal consistency, while the remaining six scales were rated as grade B recommendation since their content validity was assessed as \"insufficient\" based on moderate-level evidence or higher.</p><p><strong>Conclusions: </strong>The C-Ped-PROMIS scale demonstrates good reliability, validity, and cross-cultural validity as the preferred tool for measuring childhood cancer-related fatigue. The scale can serve as an auxiliary tool, and future research should focus on the applicability of various tools to enhance the effectiveness of interventions for assessing childhood cancer-related fatigue.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"184-191"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application of colloidal gold method and chemiluminescence method for detecting gonadotropins in morning urine to assess pubertal development status in children]. 【胶体金法和化学发光法检测晨尿促性腺激素在儿童青春期发育状况评估中的应用】。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2409066
Xue-Qi Zhao, Wen-Li Lu, Wen-Ying Li, Jun-Qi Wang, Zhi-Ya Dong, Yuan Xiao, Xiao-Fei Zhang, Li Jiang, Xiao-Yu Ma
{"title":"[Application of colloidal gold method and chemiluminescence method for detecting gonadotropins in morning urine to assess pubertal development status in children].","authors":"Xue-Qi Zhao, Wen-Li Lu, Wen-Ying Li, Jun-Qi Wang, Zhi-Ya Dong, Yuan Xiao, Xiao-Fei Zhang, Li Jiang, Xiao-Yu Ma","doi":"10.7499/j.issn.1008-8830.2409066","DOIUrl":"10.7499/j.issn.1008-8830.2409066","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the application of the colloidal gold method and chemiluminescence method in detecting gonadotropin (Gn) in morning urine for assessing pubertal development status in children.</p><p><strong>Methods: </strong>A total of 132 children diagnosed with central precocious puberty (CPP), early and fast puberty (EFP), and premature thelarche (PT) at Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from November 2021 to December 2022 were included, along with 685 healthy children who underwent routine health examinations at the hospital's pediatric health care department during the same period. All 132 patients underwent a gonadotropin-releasing hormone (GnRH) stimulation test. Both patients and healthy children had their urinary Gn levels measured using the colloidal gold method and chemiluminescence method, including levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The correlation between serum Gn and urinary Gn detected by the two methods, as well as the correlation between Tanner stages of healthy children and urinary Gn, was analyzed.</p><p><strong>Results: </strong>Urine Gn levels detected by both the colloidal gold method and chemiluminescence method showed a positive correlation with serum LH baseline values, LH peak values, baseline LH/FSH ratios, and peak LH/FSH ratios (<i>P</i><0.05). In healthy children, urinary LH levels detected by the chemiluminescence method gradually increased from Tanner stage Ⅰ to Ⅳ (<i>P</i><0.05), while urinary FSH levels were lower in Tanner stage I than in stages Ⅱ, Ⅲ, and IV (<i>P</i><0.05). Urinary LH levels detected by the colloidal gold method were lower in Tanner stage I compared to stages Ⅱ, Ⅲ, and IV, with the highest levels observed in Tanner stage Ⅳ (<i>P</i><0.05). Additionally, urinary FSH levels in Tanner stage Ⅲ were higher than in stages Ⅰ and Ⅱ (<i>P</i><0.05). The area under the receiver operating characteristic curve for evaluating Tanner stages I and II in healthy children using urinary LH and FSH levels by the chemiluminescence method and urinary LH levels by the colloidal gold method were 0.730, 0.699, and 0.783, respectively.</p><p><strong>Conclusions: </strong>The colloidal gold method and chemiluminescence method for detecting Gn in morning urine show good correlation with serum Gn levels. As a non-invasive and convenient detection method, the colloidal gold method can serve as a useful tool for screening the onset of pubertal development in children.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"199-204"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Expression of GATA1 in bronchial asthma and its effect on the transcription regulation of the ORMDL3 gene]. [GATA1在支气管哮喘中的表达及其对ORMDL3基因转录调控的影响]。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2408143
Hu Chen, Jiao-Jiao Li, Yue Yuan, Rui Jin
{"title":"[Expression of GATA1 in bronchial asthma and its effect on the transcription regulation of the <i>ORMDL3</i> gene].","authors":"Hu Chen, Jiao-Jiao Li, Yue Yuan, Rui Jin","doi":"10.7499/j.issn.1008-8830.2408143","DOIUrl":"10.7499/j.issn.1008-8830.2408143","url":null,"abstract":"<p><strong>Objectives: </strong>To study the expression of the transcription factor GATA1 in bronchial asthma (referred to as asthma) and its effect on the expression level of the asthma susceptibility gene orosomucoid 1-like protein 3 (ORMDL3), along with the underlying molecular mechanisms.</p><p><strong>Methods: </strong>The study included 28 cases of moderate asthma, 46 cases of severe asthma, and 12 normal controls from the Gene Expression Omnibus (GEO) database. The mRNA expression levels of GATA1 and ORMDL3 were analyzed among the asthma patients and the normal controls, including their correlation. The pGL-185/58 plasmid was co-transfected with <i>GATA1</i> gene siRNA (si-GATA1 group) and siRNA negative control (si-control group) into BEAS-2B cells. Bioinformatics methods were used to predict GATA1 binding sites in the promoter region of the <i>ORMDL3</i> gene. The dual-luciferase reporter gene system was employed to assess the promoter activity of ORMDL3, while real-time quantitative PCR and Western blotting were used to measure the mRNA and protein expression levels of GATA1 and ORMDL3. Chromatin immunoprecipitation (ChIP) assays were conducted to determine whether GATA1 binds to the promoter region of <i>ORMDL3</i>.</p><p><strong>Results: </strong>The expression levels of GATA1 and ORMDL3 mRNA were significantly higher in the severe asthma group compared to the normal control group (<i>P</i><0.001). Positive correlations were observed between GATA1 mRNA and ORMDL3 mRNA expression levels in both the moderate and severe asthma groups (<i>r</i>=0.636 and 0.341, respectively; <i>P</i><0.05). In BEAS-2B cells, the dual-luciferase reporter assay revealed that <i>ORMDL3</i> promoter luciferase activity, as well as ORMDL3 mRNA and protein expression levels, were lower in the si-GATA1 group compared to the si-control group (<i>P</i><0.05). ChIP assay results demonstrated that GATA1 could bind to the promoter region of <i>ORMDL3</i>.</p><p><strong>Conclusions: </strong>The expression of GATA1 is increased in asthma patients, which may regulate the promoter activity and expression of the asthma susceptibility gene <i>ORMDL3</i>.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"212-218"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Risk factors for hypoxemia in children with severe Mycoplasma pneumoniae pneumonia]. [重症肺炎支原体肺炎患儿低氧血症的危险因素]。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2408094
Yu-Jie Qin, Yu-Xia Yang, Jun-Xiang Li, Jun Guan
{"title":"[Risk factors for hypoxemia in children with severe <i>Mycoplasma pneumoniae</i> pneumonia].","authors":"Yu-Jie Qin, Yu-Xia Yang, Jun-Xiang Li, Jun Guan","doi":"10.7499/j.issn.1008-8830.2408094","DOIUrl":"10.7499/j.issn.1008-8830.2408094","url":null,"abstract":"<p><strong>Objectives: </strong>To study the risk factors for hypoxemia in children with severe <i>Mycoplasma pneumoniae</i> pneumonia (SMPP).</p><p><strong>Methods: </strong>A retrospective collection of clinical data from children diagnosed with SMPP at the Third Affiliated Hospital of Zhengzhou University from June to December 2023 was conducted. The patients were categorized into hypoxemia and non-hypoxemia groups. Logistic regression analysis was used to assess the risk factors for hypoxemia, and receiver operating characteristic (ROC) curve analysis was employed to analyze the diagnostic performance of various indicators.</p><p><strong>Results: </strong>A total of 113 children with SMPP were included. Univariate logistic regression analysis showed that ferritin, aspartate aminotransferase, creatinine, creatine kinase isoenzyme, lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, immunoglobulin G, complement C3, complement C4, age, extrapulmonary complications, and a chest computed tomography (CT) scan showing a bronchiolitis pattern were significant factors for hypoxemia in children with SMPP (<i>P</i><0.05). Multivariate logistic regression analysis revealed that elevated ferritin levels, presence of extrapulmonary complications, and a bronchiolitis pattern on lung CT were independent risk factors for hypoxemia in these patients (<i>P</i><0.05). The ROC curve analysis indicated that the combination of these three indicators for predicting hypoxemia had a sensitivity of 71.9%, a specificity of 95.1%, and an area under the curve of 0.888 (95%<i>CI</i>: 0.809-0.968).</p><p><strong>Conclusions: </strong>In children with SMPP, when there are elevated ferritin levels, a bronchiolitis pattern on chest CT, and the presence of extrapulmonary complications, there should be a high level of vigilance for the potential development of hypoxemia.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"192-198"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A quality improvement study on improving the follow-up rate of preterm infants after discharge]. [提高早产儿出院后随访率的质量改进研究]。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2410046
He-Sheng Chang, Xue Yang, Jun Ju, Wen-Ya Xu, Di Wu, Xiao-Man Wan, Zheng-Hong Li
{"title":"[A quality improvement study on improving the follow-up rate of preterm infants after discharge].","authors":"He-Sheng Chang, Xue Yang, Jun Ju, Wen-Ya Xu, Di Wu, Xiao-Man Wan, Zheng-Hong Li","doi":"10.7499/j.issn.1008-8830.2410046","DOIUrl":"10.7499/j.issn.1008-8830.2410046","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the measures to improve the follow-up rate of preterm infants after discharge, and to evaluate the effectiveness of these measures using quality improvement methodology.</p><p><strong>Methods: </strong>The follow-up status of preterm infants discharged from March to May 2017 was used as the baseline before quality improvement, and a specific quality improvement goal for the follow-up rate was proposed. The Pareto chart was used to analyze the causes of follow-up failure, and a key driver diagram was constructed based on the links involved in improving follow-up rate. The causes of failure were analyzed to determine the key links and intervention measures for quality improvement, and the follow-up rate was monitored weekly using a control chart until the quality improvement goal was achieved.</p><p><strong>Results: </strong>The follow-up rate of preterm infants after discharge was 57.92% (117/202) at baseline before quality improvement, and the quality improvement goal was set to increase the follow-up rate of preterm infants from baseline to more than 80% within 12 months. The Pareto chart analysis showed that the main causes of follow-up failure were deficiencies in follow-up file management and irregular follow-up times (33.70%, 31/92), insufficient follow-up education and poor communication (25.00%, 23/92), and the inability to meet the diverse needs of parents (18.48%, 17/92). Based on the key links for quality improvement and the main causes of follow-up failure, the following intervention measures were adopted: (1) strengthen follow-up publicity and education; (2) build a follow-up team; and (3) establish a follow-up platform and system. The control chart indicated that with the implementation of the above intervention measures, the weekly follow-up rate increased to 74.09% (306/413) in July 2017 and 83.09% (511/615) in December 2017, finally achieving the quality improvement goal. During the COVID-19 pandemic, the follow-up rate of preterm infants fluctuated between 23.54% (460/1 954) and 70.97% (1 931/2 721), and subsequently, it returned to pre-pandemic levels starting in February 2023.</p><p><strong>Conclusions: </strong>The application of quality improvement methodology can help to formulate intervention measures based on the main causes of follow-up failure, thereby improving the follow-up rate of preterm infants after discharge. This quality improvement method is feasible and practical and thus holds promise for clinical application.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"148-154"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of colostrum oral immune therapy on the the clinical outcomes in very low birth weight infants: a Meta analysis]. [初乳口服免疫治疗对极低出生体重儿临床结局的影响:Meta分析]。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2406104
Yan Lu, Li-Li Wang, Li Wang, Ke-Ran Zhu
{"title":"[Effect of colostrum oral immune therapy on the the clinical outcomes in very low birth weight infants: a Meta analysis].","authors":"Yan Lu, Li-Li Wang, Li Wang, Ke-Ran Zhu","doi":"10.7499/j.issn.1008-8830.2406104","DOIUrl":"10.7499/j.issn.1008-8830.2406104","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effect of colostrum oral immune therapy (COIT) on clinical outcomes in very low birth weight (VLBW) infants.</p><p><strong>Methods: </strong>A computer-based search was conducted in databases including China National Knowledge Infrastructure, Wanfang Data, Weipu Database, Chinese Biomedical Literature Service System, PubMed, Embase, Web of Science, the Cochrane Library, and CINAHL for randomized controlled trials regarding the application of COIT in VLBW infants published from the establishment of the database to February 2024. Meta analysis was performed using RevMan 5.3 software.</p><p><strong>Results: </strong>A total of 14 randomized controlled trials were included, involving 1 386 VLBW infants, with 690 in the COIT group and 696 in the control group. The results showed that COIT significantly reduced the incidence of clinical late-onset sepsis (LOS) (<i>RR</i>=0.75, 95%<i>CI</i>: 0.64-0.88, <i>P</i><0.001), the incidence of blood culture-proven LOS (<i>RR</i>=0.72, 95%<i>CI</i>: 0.57-0.92, <i>P</i>=0.008), mortality rate (<i>RR</i>=0.70, 95%<i>CI</i>: 0.52-0.95, <i>P</i>=0.020), the incidence of necrotizing enterocolitis (<i>RR</i>=0.65, 95%<i>CI</i>: 0.46-0.92, <i>P</i>=0.020), and the incidence of feeding intolerance (<i>RR</i>=0.49, 95%<i>CI</i>: 0.29-0.80, <i>P</i>=0.004). It also shortened the time to achieve full enteral nutrition (<i>MD</i>=-2.13, 95%<i>CI</i>: -4.03 to -0.23, <i>P</i>=0.030).</p><p><strong>Conclusions: </strong>COIT can reduce the incidence rates of LOS, necrotizing enterocolitis, and feeding intolerance, as well as the mortality rate, while also shortening the time to achieve full enteral nutrition in VLBW infants.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"155-164"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Explanation and interpretation of the compilation of blood transfusion provisions for children undergoing hematopoietic stem cell transplantation in the national health standard "Guideline for pediatric transfusion"]. 【对国家卫生标准《儿童输血指南》中关于儿童造血干细胞移植输血规定的编写进行说明和解读】。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2410094
Rong Huang, Qing-Nan He, Ming-Yan Hei, Xiao-Fan Zhu, Jun Lu, Xiao-Jun Xu, Tian-Ming Yuan, Rong Zhang, Xu Wang, Jin-Ping Liu, Jing Wang, Zhi-Li Shao, Ming-Yi Zhao, Yong-Jian Guo, Xin-Yin Wu, Jia-Rui Chen, Qi-Rong Chen, Jia Guo, Rong Gui, Ming-Hua Yang
{"title":"[Explanation and interpretation of the compilation of blood transfusion provisions for children undergoing hematopoietic stem cell transplantation in the national health standard \"Guideline for pediatric transfusion\"].","authors":"Rong Huang, Qing-Nan He, Ming-Yan Hei, Xiao-Fan Zhu, Jun Lu, Xiao-Jun Xu, Tian-Ming Yuan, Rong Zhang, Xu Wang, Jin-Ping Liu, Jing Wang, Zhi-Li Shao, Ming-Yi Zhao, Yong-Jian Guo, Xin-Yin Wu, Jia-Rui Chen, Qi-Rong Chen, Jia Guo, Rong Gui, Ming-Hua Yang","doi":"10.7499/j.issn.1008-8830.2410094","DOIUrl":"10.7499/j.issn.1008-8830.2410094","url":null,"abstract":"<p><p>To guide clinical blood transfusion practices for pediatric patients, the National Health Commission has issued the health standard \"Guideline for pediatric transfusion\" (WS/T 795-2022). Blood transfusion for children undergoing hematopoietic stem cell transplantation is highly complex and challenging. This guideline provides recommendations on transfusion thresholds and the selection of blood components for these children. This article presents the evidence and interpretation of the transfusion provisions for children undergoing hematopoietic stem cell transplantation, with the aim of enhancing the understanding and implementation of the \"Guideline for pediatric transfusion\".</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"139-143"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Combined oxidative phosphorylation deficiency type 7 caused by C12orf65 gene mutations: a case report and literature review]. 【C12orf65基因突变引起的复合氧化磷酸化缺陷7型1例报告及文献复习】。
中国当代儿科杂志 Pub Date : 2025-02-15 DOI: 10.7499/j.issn.1008-8830.2409063
Xiao-Yi Chen, Yong-Jie Zhu, Jie Deng, Yan-Li Ma, Jun-Fang Suo, Yuan Wang, Yuan-Ning Ma
{"title":"[Combined oxidative phosphorylation deficiency type 7 caused by <i>C12orf65</i> gene mutations: a case report and literature review].","authors":"Xiao-Yi Chen, Yong-Jie Zhu, Jie Deng, Yan-Li Ma, Jun-Fang Suo, Yuan Wang, Yuan-Ning Ma","doi":"10.7499/j.issn.1008-8830.2409063","DOIUrl":"10.7499/j.issn.1008-8830.2409063","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical features and gene mutation characteristics of combined oxidative phosphorylation deficiency type 7 (COXPD7) caused by mutations in the <i>C12orf65</i> gene, and to enhance the awareness of this disease.</p><p><strong>Methods: </strong>A child diagnosed with COXPD7 in the Department of Neurology, Children's Hospital Affiliated to Zhengzhou University in 2021 was included, along with 10 patients reported in the literature. All subjects were analyzed for their genotypes and clinical phenotypes.</p><p><strong>Results: </strong>A total of 11 patients with COXPD7 were included, comprising 1 reported in this study and 10 from the literature. Among the 11 patients, 9 had homozygous mutations in the <i>C12orf65</i> gene, while 2 had compound heterozygous mutations, which were identified as frameshift or nonsense mutations. The age of onset ranged from 1 day to 2 years, and clinical manifestations included optic nerve atrophy and delays in intellectual and motor development. Eight patients exhibited external ophthalmoplegia, and five patients displayed spastic paralysis. Cranial magnetic resonance imaging revealed optic nerve atrophy in all 11 patients, abnormal brainstem signals in 10 patients, and a lactate peak on brainstem magnetic resonance spectroscopy scans in 3 patients.</p><p><strong>Conclusions: </strong>COXPD7 associated with the <i>C12orf65</i> gene results from homozygous or compound heterozygous mutations, with primary clinical manifestations of optic nerve atrophy and delays in intellectual and motor development. Some patients may also present with spastic paralysis or external ophthalmoplegia. Cranial imaging reveals symmetrical abnormal signals in bilateral basal ganglia and brainstem, and a lactate peak is observed on brainstem magnetic resonance spectroscopy scans.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 2","pages":"205-211"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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