中国当代儿科杂志最新文献

{"title":"[A clinical study on the optimal placement depth for peripherally inserted central catheter through the great saphenous vein in preterm infants].","authors":"Na Jiang, Ling-Fang Qing, Bo Xiong, Ying Li, Li He, Tao Bo","doi":"10.7499/j.issn.1008-8830.2406005","DOIUrl":"10.7499/j.issn.1008-8830.2406005","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the correlation between optimal placement depth (OPD) and physical measurement parameters in preterm infants receiving placement of peripherally inserted central catheter (PICC) through the great saphenous vein (GSV), and to establish a predictive formula for OPD during the placement of PICC through the GSV.</p><p><strong>Methods: </strong>A retrospective analysis was performed for the preterm infants who received the placement of PICC through the GSV in the Neonatal Intensive Care Unit of the Third Xiangya Hospital of Central South University from December 2022 to February 2024. According to the site of puncture [GSV of the knee joint (KJ) or the ankle joint (AJ)], they were divided into a GSV-KJ placement group (<i>n</i>=38) and a GSV-AJ placement group (<i>n</i>=33). The infants were measured in terms of body weight (BW), body length, the length of the upper and lower parts of the body, head circumference, and abdominal circumference at the time of placement. The Pearson correlation analysis was used to investigate the correlation between the above variables and OPD. A predictive formula was established for OPD in the placement of PICC via the GSV in preterm infants, and the predicted residual between the predicted depth and the ideal OPD was compared between the conventional predictive formula and the new predictive formula.</p><p><strong>Results: </strong>The Pearson correlation analysis showed that PICC OPD was significantly positively correlated with BW, body length, the length of the upper and lower parts of the body, head circumference, and abdominal circumference in both the GSV-KJ placement group and GSV-AJ placement group (<i>P</i><0.05), with the highest degree of correlation between OPD and BW. The univariate linear regression analysis showed a linear relationship between PICC OPD and BW in both groups. The predictive formulas for OPD were as follows: GSV-KJ PICC OPD (cm) = 13.1 + 2.7 × BW (kg) and GSV-AJ PICC OPD (cm) = 13.4 + 6.0 × BW (kg), and the new predictive formulas had a significantly lower predicted residual than the conventional predictive formula (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>OPD for PICC through the GSV is positively correlated with BW, and the prediction results of the new predictive formula based on BW are closer to the ideal OPD.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1046-1052"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical features and risk factors of cholestasis in small for gestational age preterm infants].","authors":"Yu Chen, Xue-Ping Zhu","doi":"10.7499/j.issn.1008-8830.2404095","DOIUrl":"10.7499/j.issn.1008-8830.2404095","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical features and risk factors of cholestasis in small for gestational age (SGA) preterm infants.</p><p><strong>Methods: </strong>This study selected SGA preterm infants born at less than 37 weeks of gestation and admitted to the Department of Neonatology, Children's Hospital of Soochow Universitywithin 24 hours after birth. The infants were divided into two groups: a cholestasis group and a non-cholestasis group. Clinical data from July 2017 to June 2022 were collected and retrospectively analyzed.</p><p><strong>Results: </strong>Among the 553 SGA preterm infants included, 100 infants (18.1%) developed cholestasis. The incidence rates in different gestational age and birth weight groups were as follows: extremely preterm infants 50.0%, very preterm infants 46.6%, moderate preterm infants 32.7%, and late preterm infants 9.8%; birth weight (BW) <1 000 g 60.9%, 1 000 g≤BW<1 500 g 33.9%, and 1 500 g≤BW<2 500 g 10.7%. Multivariate regression analysis showed that low birth weight, intracranial hemorrhage, duration of invasive ventilation, total amino acid accumulation in the second week, total lipid emulsion accumulation in the first week, and total lipid emulsion accumulation in the second week were independent risk factors for cholestasis in SGA preterm infants (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>The incidence of cholestasis in SGA preterm infants increases with decreasing gestational age and birth weight. The occurrence of cholestasis in SGA preterm infants is influenced by multiple risk factors, including low birth weight, intracranial hemorrhage, invasive ventilation, and the accumulation of amino acids and lipid emulsions, highlighting the need for comprehensive treatment measures to reduce its occurrence.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1027-1033"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current research status of Peutz-Jeghers syndrome in children].","authors":"Qin Tong","doi":"10.7499/j.issn.1008-8830.2404054","DOIUrl":"10.7499/j.issn.1008-8830.2404054","url":null,"abstract":"<p><p>Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic disorder characterized by mucocutaneous pigmentation and multiple hamartomatous polyps, which leads to an increased susceptibility to tumors. The clinical incidence is rare, and the only currently identified pathogenic gene is the serine/threonine kinase 11/liver kinase B1 (<i>STK11/LKB1</i>) located on the short arm of chromosome 19 (19p13.3). This condition can lead to various complications, such as gastrointestinal bleeding, intussusception, intestinal obstruction, and malignancy. In childhood, the greatest risk is associated with intussusception, which increases the risk of surgical intervention and significantly impacts the growth, development, and quality of life of the children. This article provides an overview of the current research status regarding the clinical characteristics, etiology, pathogenesis, diagnosis, and treatment of PJS in children.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1122-1126"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of antenatal corticosteroids on outcomes of very premature infants and neurodevelopment during infancy].","authors":"Zhi Chen, Ming Li, Li-Li Zhang, De Wu","doi":"10.7499/j.issn.1008-8830.2405073","DOIUrl":"10.7499/j.issn.1008-8830.2405073","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the effects of antenatal corticosteroids (ACS) on the outcomes of very premature infants (VPIs) and neurodevelopment during infancy.</p><p><strong>Methods: </strong>A retrospective study was conducted on 190 VPIs admitted to the Department of Pediatrics of the First Affiliated Hospital of Anhui Medical University from January 2020 to December 2022. The infants were categorized into four groups based on ACS usage and dosage: no ACS group (<i>n</i>=18), single-course group (<i>n</i>=88), multi-course group (<i>n</i>=40), and partial-course group (<i>n</i>=44). The clinical outcomes, Neonatal Behavioral and Neurological Assessment (NBNA) scores at 40 weeks of corrected age, and Gesell Developmental Schedule (Gesell) scores at 1 year of corrected age were compared among the four groups. The impact of timing of ACS use on the Gesell scores of infants at 1 year of corrected age in VPIs with specific gestational ages was analyzed.</p><p><strong>Results: </strong>The incidence rates of neonatal respiratory distress syndrome, bronchopulmonary dysplasia, transient tachypnea of the newborn, and neonatal pneumonia were significantly lower in the partial-course, single-course, and multiple-course groups compared with the no ACS group (<i>P</i><0.008). However, there was no significant difference among the partial-course, single-course, and multiple-course groups (<i>P</i>>0.008). The NBNA scores (behavioral ability, active muscle tone, primitive reflexes, and general assessment) at 40 weeks of corrected age were significantly higher in the no ACS, partial-course, and single-course groups than in the multiple-course group (<i>P</i><0.008). The proportion of VPIs with normal neurodevelopment at 1 year of corrected age was significantly higher in the no ACS, partial-course, and single-course groups than in the multiple-course group (<i>P</i><0.008). The timing of ACS use had no significant effect on neurodevelopment at a corrected age of 1 year in infants with various gestational ages (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>ACS is crucial for the development of the respiratory system in VPIs, but multiple courses of ACS may cause neurodevelopmental abnormalities. The impact of ACS use on neurodevelopment is independent of gestational age and the timing of ACS use.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1040-1045"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics of intestinal microbiota in the acute phase of Kawasaki disease in infants and children].","authors":"Hong-Mao Wang, Ming-Ming Zhang, Yao Lin, Yang Liu, Guan-Hua Xue, Lin Shi, Jing Yuan, Xiao-Hui Li","doi":"10.7499/j.issn.1008-8830.2405111","DOIUrl":"10.7499/j.issn.1008-8830.2405111","url":null,"abstract":"<p><strong>Objectives: </strong>To study the composition, abundance, and functional profiles of the intestinal microbiota in infants and young children with Kawasaki disease (KD) during the acute phase, and to explore the potential role of intestinal microbiota in the pathogenesis of KD.</p><p><strong>Methods: </strong>Six children aged 0-3 years with acute KD admitted to the Department of Cardiology, Children's Hospital Affiliated to Capital Institute of Pediatrics from July to October 2021 were prospectively included as the KD group. Six age- and sex-matched healthy children who underwent physical examinations at the hospital during the same period were selected as the healthy control group. Metagenomics sequencing was used to detect and compare the differences in the microflora structure and functional profiles of fecal samples between the two groups.</p><p><strong>Results: </strong>There were significant differences in the structural composition and diversity of intestinal microbiota between the two groups (<i>P</i><0.05). Compared with the healthy control group, the abundance of <i>Listeria</i>_<i>monocytogenes</i> (family <i>Listeriaceae</i> and genus <i>Listeria</i>), <i>Bifidobacterium</i>_<i>rousetti</i>, <i>Enterococcus</i>_<i>avium</i>, and <i>Enterococcus</i>_<i>hirae</i> was significantly higher in the intestinal microbiota in the KD group (<i>|</i>LDA<i>|</i>>2.0, <i>P</i><0.05). The steroid degradation and apoptosis pathways were significantly upregulated in the KD group compared with the healthy control group, while the Bacterial_secretion_system, Sulfur_metabolism, Butanoate_metabolism, Benzoate_degradation, β-alanine metabolism, and α-linolenic acid pathways were significantly downregulated (|LDA|>2, <i>P</i><0.05).</p><p><strong>Conclusions: </strong>There are significant differences in the structure and diversity of intestinal microbiota between children aged 0-3 years with acute KD and healthy children, suggesting that disturbances in intestinal microbiota occur during the acute phase of KD. In particular, <i>Listeria</i>_<i>monocytogenes</i>, <i>Enterococcus</i>_<i>avium</i>, and <i>Enterococcus</i>_<i>hirae</i> may be involved in the pathogenesis of KD through steroid degradation and apoptosis pathways.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1101-1107"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of propranolol on the biological behavior of human umbilical vein endothelial cells and the expression of SOX18, MMP-7, and VEGFA].","authors":"Pei Zhou, Si-Qing Xie, Li-Li Zhong, Xiao-Fang Ding","doi":"10.7499/j.issn.1008-8830.2407088","DOIUrl":"10.7499/j.issn.1008-8830.2407088","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of propranolol on the proliferation, apoptosis, migration, and tube formation ability of human umbilical vein endothelial cells (HUVEC), as well as its impact on the expression of sex-determining region Y-box 18 (SOX18), matrix metalloproteinase-7 (MMP-7), and vascular endothelial growth factor A (VEGFA).</p><p><strong>Methods: </strong>HUVEC were treated with different concentrations of propranolol, and cell viability was assessed using the CCK-8 method to determine the optimal concentration and treatment duration. The experiment consisted of a control group and groups treated with different concentrations of propranolol (50, 100, 150 μmol/L). Apoptosis, migration, and tube formation of HUVEC were observed using flow cytometry, wound healing assays, and tube formation assays. Western blot and real-time quantitative PCR were used to detect the expression levels of SOX18, MMP-7, and VEGFA proteins and mRNA.</p><p><strong>Results: </strong>Compared to the control group, the apoptosis rate in the propranolol treatment groups increased significantly (<i>P</i><0.05), and it rose significantly with increasing drug concentration (<i>P</i><0.05). The wound healing rate decreased in the propranolol treatment groups, and both the number of tube formation nodes and total tube length were reduced (<i>P</i><0.05). The expression levels of SOX18, MMP-7, and VEGFA proteins and mRNA were downregulated in the propranolol treatment groups (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Propranolol can inhibit the proliferation, migration, and tube formation ability of HUVEC and promote cell apoptosis, resulting in decreased expression levels of SOX18, MMP-7, and VEGFA.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1115-1121"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A prospective randomized controlled study of neurofeedback combined with learning style profile intervention training in children with high-functioning autism].","authors":"Ming-Xin Huang, Qing Yu, Yuan-Yuan Li","doi":"10.7499/j.issn.1008-8830.2405054","DOIUrl":"10.7499/j.issn.1008-8830.2405054","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the application of neurofeedback (NFB) combined with learning style profile (LSP) intervention training in children with high-functioning autism (HFA).</p><p><strong>Methods: </strong>A prospective study was conducted to select 86 children with HFA admitted to the hospital from February 2022 to February 2024. They were divided into two groups according to the random number table method, with 43 cases in each group. In this double-blind study, the control group was given LSP intervention training, and the observation group was given NFB intervention on the basis of the treatment used in the control group. Both groups were treated for 6 months. The scores of Autism Behavior Checklist (ABC), Autism Treatment Evaluation Checklist (ATEC), Social Responsiveness Scale (SRS), and Pediatric Quality of Life (PedsQL) were compared between the two groups before intervention and at 6 months after intervention. The relationship of PedsQL score with ABC, ATEC, and SRS scores was analyzed in children with HFA.</p><p><strong>Results: </strong>After 6 months of intervention, the scores of ABC, ATEC, and SRS in the observation group were significantly lower than those in the control group, while the PedsQL score in the observation group was significantly higher than that in the control group (<i>P</i><0.05). The PedsQL score was negatively correlated with the ABC, ATEC, and SRS scores in children with HFA (<i>r</i>=-0.238, -0.381, -0.219 respectively; <i>P</i><0.001).</p><p><strong>Conclusions: </strong>NFB combined with LSP can effectively improve the clinical symptoms and social ability, control the development of the disease, and improve the quality of life in children with HFA.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1066-1071"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prognostic factors in children with acute T-lymphoblastic leukemia: a single-center clinical study of the CCCG-ALL-2015 protocol].","authors":"Wen-Feng Fu, Yong-Jun Fang","doi":"10.7499/j.issn.1008-8830.2402079","DOIUrl":"10.7499/j.issn.1008-8830.2402079","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the clinical characteristics of children with acute T-lymphoblastic leukemia (T-ALL) and analyze their relationship with prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data and follow-up results of 50 children with T-ALL who were treated using the CCCG-ALL-2015 protocol at the Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University from November 2015 to December 2019. Kaplan-Meier survival analysis and Cox regression analysis were employed to identify factors affecting prognosis.</p><p><strong>Results: </strong>Among the 50 T-ALL patients, there were 7 cases of relapse. There was no statistically significant difference in the baseline clinical data between the relapse group and the non-relapse group (<i>P</i>>0.05). However, the positive rate of minimal residual disease (MRD) (≥0.01%) on day 46 after induction remission therapy in the relapse group was significantly higher than that in the non-relapse group (<i>P</i>=0.037). The 5-year overall survival rate for the 50 patients was (87±5)%, and the 5-year event-free survival rate was (86±5)%. Multivariate Cox regression analysis indicated that the MRD level on day 46 after induction remission therapy was an independent prognostic factor (<i>HR</i>=0.104, 95%<i>CI</i>: 0.015-0.740, <i>P</i>=0.024).</p><p><strong>Conclusions: </strong>MRD is of significant importance for the prognosis of T-ALL children. Personalized treatment should be provided based on MRD levels to prevent relapse and improve prognosis in these patients.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1078-1085"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of high-throughput drug sensitivity testing in children with relapsed and refractory acute leukemia].","authors":"Wen-Jing Qi, Xue-Ju Xu, Bai Li, Tao Wang, Guang-Yao Sheng, Ping Zhu, Chun-Mei Wang","doi":"10.7499/j.issn.1008-8830.2406014","DOIUrl":"10.7499/j.issn.1008-8830.2406014","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the current application of high-throughput drug sensitivity (HDS) testing in children with relapsed and refractory acute leukemia (RR-AL) and analyze the feasibility of salvage treatment plans.</p><p><strong>Methods: </strong>A retrospective collection of clinical data from children with RR-AL who underwent HDS testing at the Department of Children's Hematology and Oncology of the First Affiliated Hospital of Zhengzhou University from November 2021 to October 2023 was conducted, followed by an analysis of drug sensitivity results and treatment outcomes.</p><p><strong>Results: </strong>A total of 17 children with RR-AL underwent HDS testing, including 7 cases of relapsed refractory acute myeloid leukemia and 10 cases of relapsed refractory acute lymphoblastic leukemia. The detection rate of highly sensitive chemotherapy drugs/regimens was 53% (9/17), while the detection rate of moderately sensitive chemotherapy drugs/regimens was 100% (17/17). Among the 17 RR-AL patients with highly and moderately sensitive chemotherapy drugs and regimens, the MOACD regimen (mitoxantrone + vincristine + cytarabine + cyclophosphamide + dexamethasone) accounted for 100%, with the highest inhibition rate for single-agent mitoxantrone (94%, 16/17), and the highest inhibition rate for targeted therapy being bortezomib (94%, 16/17). Nine patients adjusted their chemotherapy based on HDS testing results, with 4 undergoing hematopoietic stem cell transplantation. Four patients achieved disease-free survival, while 5 died. Eight patients received empirical chemotherapy, with 2 undergoing hematopoietic stem cell transplantation; 4 achieved disease-free survival, while 4 died.</p><p><strong>Conclusions: </strong>HDS testing can identify highly sensitive drugs/regimens for children with RR-AL, improving the rate of re-remission and creating conditions for subsequent hematopoietic stem cell transplantation.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1093-1100"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical features and prognosis of children with fungal bloodstream infection following chemotherapy for acute leukemia].","authors":"Kai-Zhi Weng, Chun-Ping Wu, Shu-Quan Zhuang, Shu-Xian Huang, Xiao-Fang Wang, Yong-Zhi Zheng","doi":"10.7499/j.issn.1008-8830.2406021","DOIUrl":"10.7499/j.issn.1008-8830.2406021","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical features and prognosis of children with fungal bloodstream infection (BSI) following chemotherapy for acute leukemia (AL).</p><p><strong>Methods: </strong>A retrospective analysis was performed on 23 children with fungal BSI following chemotherapy for AL in three hospitals in Fujian Province, China, from January 2015 to December 2023. Their clinical features and prognosis were analyzed.</p><p><strong>Results: </strong>Among all children following chemotherapy for AL, the incidence rate of fungal BSI was 1.38% (23/1 668). At the time of fungal BSI, 87% (20/23) of the children had neutrophil deficiency for more than one week, and all the children presented with fever, while 22% (5/23) of them experienced septic shock. All 23 children exhibited significant increases in C-reactive protein and procalcitonin levels. A total of 23 fungal isolates were detected in peripheral blood cultures, with <i>Candida tropicalis</i> being the most common isolate (52%, 12/23). Caspofungin or micafungin combined with liposomal amphotericin B had a relatively high response rate (75%, 12/16), and the median duration of antifungal therapy was 3.0 months. The overall mortality rate in the patients with fungal BSI was 35% (8/23), and the attributable death rate was 22% (5/23).</p><p><strong>Conclusions: </strong>Fungal BSI following chemotherapy in children with AL often occurs in children with persistent neutrophil deficiency and lacks specific clinical manifestations. The children with fungal BSI following chemotherapy for AL experience a prolonged course of antifungal therapy and have a high mortality rate, with <i>Candida tropicalis</i> being the most common pathogen.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 10","pages":"1086-1092"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}