中国当代儿科杂志最新文献

{"title":"[Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal pertussis (2025)].","authors":"","doi":"10.7499/j.issn.1008-8830.2412132","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2412132","url":null,"abstract":"<p><p>In order to effectively assist primary healthcare providers in promptly identifying neonatal pertussis and administering effective treatment to reduce the incidence of severe neonatal pertussis, the Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association organized a panel of experts to develop the \"Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal pertussis (2025)\", based on the latest clinical evidence and expert consensus. This guideline provides primary healthcare providers with 14 recommendations addressing nine common clinical questions in neonatal pertussis.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"629-637"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of intelligent oxygen management system in neonatal intensive care units: a scoping review].","authors":"Huan He, Qiu-Yi Sun, Ying Tang, Jin-Li Dai, Han-Xin Zhang, Hua-Yun He","doi":"10.7499/j.issn.1008-8830.2412081","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2412081","url":null,"abstract":"<p><p>The intelligent oxygen management system is a software designed with various algorithms to automatically titrate inhaled oxygen concentration according to specific patterns. This system can be integrated into various ventilator devices and used during assisted ventilation processes, aiming to maintain the patient's blood oxygen saturation within a target range. This paper employs a scoping review methodology, focusing on research related to intelligent oxygen management systems in neonatal intensive care units. It reviews the fundamental principles, application platforms, and clinical outcomes of these systems, providing a theoretical basis for clinical implementation.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"753-758"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cohen syndrome in a child caused by compound heterozygous variants in <i>VPS13B</i> gene].","authors":"Xin Mei, Xiao-Liang He, Wei-Na Gao, Meng-Yao Wang, Jing-Wen Shen, Jing Wei, Yun Xue","doi":"10.7499/j.issn.1008-8830.2412119","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2412119","url":null,"abstract":"<p><p>A 7-year-old girl was admitted to the hospital with rapidly progressive vision loss. Since 1 year of age, she had exhibited developmental delay accompanied by visual impairment and neutropenia. Combined with genetic testing and molecular pathogenicity analysis, she was diagnosed with Cohen syndrome (CS) caused by compound heterozygous variants in <i>VPS13B</i> (c.6940+1G>T and c.2911C>T). The c.6940+1G>T variant resulted in exon 38 skipping, leading to a frameshift and premature termination. Reverse transcription quantitative polymerase chain reaction revealed significantly reduced <i>VPS13B</i> gene expression (<i>P</i><0.05). Bioinformatic analysis suggested that both variants likely produce truncated proteins. This case highlights that integrating clinical features with molecular pathogenicity assessment (DNA, RNA, and protein analysis) can improve early diagnostic accuracy for CS.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"740-745"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genetic screening and follow-up results in 3 001 newborns in the Yunnan region].","authors":"Ao-Yu Li, Bao-Sheng Zhu, Jin-Man Zhang, Ying Chan, Jun-Yue Lin, Jie Zhang, Xiao-Yan Zhou, Hong Chen, Su-Yun Li, Na Feng, Yin-Hong Zhang","doi":"10.7499/j.issn.1008-8830.2412134","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2412134","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the application value of genetic newborn screening (gNBS) in the Yunnan region.</p><p><strong>Methods: </strong>A prospective study was conducted with a random selection of 3 001 newborns born in the Yunnan region from February to December 2021. Traditional newborn screening (tNBS) was used to test biochemical indicators, and targeted next-generation sequencing was employed to screen 159 genes related to 156 diseases. Positive-screened newborns underwent validation and confirmation tests, and confirmed cases received standardized treatment and long-term follow-up.</p><p><strong>Results: </strong>Among the 3 001 newborns, 166 (5.53%) were initially positive for genetic screening, and 1 435 (47.82%) were genetic carriers. The top ten genes with the highest variation frequency were <i>GJB2</i> (21.29%), <i>DUOX2</i> (7.27%), <i>HBA</i> (6.14%), <i>GALC</i> (3.63%), <i>SLC12A3</i> (3.33%), <i>HBB</i> (3.03%), <i>G6PD</i> (2.94%), <i>SLC25A13</i> (2.90%), <i>PAH</i> (2.73%), and <i>UNC13D</i> (2.68%). Among the initially positive newborns from tNBS and gNBS, 33 (1.10%) and 47 (1.57%) cases were confirmed, respectively. A total of 48 (1.60%) cases were confirmed using gNBS+tNBS. The receiver operating characteristic curve analysis demonstrated that the areas under the curve for tNBS, gNBS, and gNBS+tNBS in diagnosing diseases were 0.866, 0.982, and 0.968, respectively (<i>P</i><0.05). DeLong's test showed that the area under the curve for gNBS and gNBS+tNBS was higher than that for tNBS (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>gNBS can expand the range of disease detection, and its combined use with tNBS can significantly shorten diagnosis time, enabling early intervention and treatment.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"654-660"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of nutritional status before and after different induction therapies in children with Crohn's disease].","authors":"Lei-Lei Chen, Yu Yu, You-You Luo, Jie Chen","doi":"10.7499/j.issn.1008-8830.2410125","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2410125","url":null,"abstract":"<p><strong>Objectives: </strong>To study the impact of different induction remission therapies on the nutritional status of children with Crohn's disease (CD).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the medical data of 188 children with CD who received induction remission therapy at the Children's Hospital, Zhejiang University School of Medicine from January 2013 to May 2023. The effects of three induction remission therapies-exclusive enteral nutrition (EEN), corticosteroids, and infliximab (IFX)-on height, weight, hemoglobin, and trace elements were compared.</p><p><strong>Results: </strong>After induction remission therapy, the weight-for-age Z scores and serum levels of hemoglobin and albumin in all three groups significantly increased (<i>P</i><0.05), while the height-for-age Z scores showed no change (<i>P</i>>0.05). The levels of folic acid, 25-hydroxy vitamin D, serum iron, and total calcium increased, and serum copper levels decreased in the EEN and IFX groups (<i>P</i><0.05). Vitamin B₁₂ levels improved in the EEN group (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>EEN, corticosteroids, and IFX may effectively improve the weight-for-age Z scores and serum levels of hemoglobin and albumin in children with CD. EEN and IFX seem to be superior to corticosteroid therapy in improving 25-hydroxy vitamin D, folic acid, serum iron, and total calcium levels.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"702-708"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of interleukin<i>-</i>17 gene polymorphism on susceptibility to cow's milk protein allergy in infants and its association with gut microbiota].","authors":"Wen-Ying Hao, Chun Zhu, Song Lu, Hong Wang","doi":"10.7499/j.issn.1008-8830.2412044","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2412044","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of interleukin-17 (<i>IL-17</i>) gene polymorphism on the susceptibility to cow's milk protein allergy (CMPA) in infants and its association with gut microbiota.</p><p><strong>Methods: </strong>A prospective study was conducted involving 100 infants diagnosed with CMPA at the Women and Children's Hospital of Ningbo University from January 2022 to October 2024. A total of 100 healthy infants undergoing routine check-ups at the same hospital during the same period was enrolled as the control group. Medical information was obtained through the electronic medical record system. <i>IL-17A</i> (rs2275913) and <i>IL-17F</i> (rs1889570) polymorphisms were detected using polymerase chain reaction-restriction fragment length polymorphism method. Serum IL-17 levels were measured using enzyme-linked immunosorbent assay, and high-throughput sequencing was employed to analyze the relative abundance of <i>Lactobacillus</i> and <i>Bifidobacterium</i>. Multivariate logistic regression analysis was used to explore the influencing factors of CMPA occurrence in infants.</p><p><strong>Results: </strong>The proportions of infants with a family history of allergy and those with vitamin D deficiency or insufficiency were significantly higher in the CMPA group compared to those in the control group (<i>P</i><0.05). The distribution of <i>IL-17F</i> (rs1889570) genotypes showed significant differences between the CMPA and control groups (<i>P</i><0.05), with the frequency of the A allele being significantly higher in the CMPA group (<i>P</i><0.05). Multivariate logistic regression analysis revealed that a family history of allergy, vitamin D deficiency or insufficiency, and carrying the <i>IL-17F</i> (rs1889570) AA genotype were independent influencing factors for CMPA in infants (<i>P</i><0.05). Infants in the CMPA group with the <i>IL-17F</i> (rs1889570) AA genotype had significantly higher serum IL-17 levels compared to those with AG/GG genotypes (<i>P</i><0.05), while the relative abundance of <i>Lactobacillus</i> and <i>Bifidobacterium</i> was significantly lower (<i>P</i><0.05).</p><p><strong>Conclusions: </strong><i>IL-17F</i> (rs1889570) gene polymorphism influences susceptibility to CMPA in infants, potentially through mechanisms involving IL-17 expression and the relative abundance of gut probiotics.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"696-701"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and survival analysis of pediatric Hodgkin lymphoma: a multicenter study].","authors":"Ying Lin, Li-Li Pan, Shao-Hua LE, Jian Li, Bi-Yun Guo, Yu Zhu, Kai-Zhi Weng, Jin-Hong Luo, Gao-Yuan Sun, Yong-Zhi Zheng","doi":"10.7499/j.issn.1008-8830.2412144","DOIUrl":"10.7499/j.issn.1008-8830.2412144","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinicopathological characteristics and prognostic factors of pediatric Hodgkin lymphoma (HL).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of children with newly diagnosed HL from January 2011 to December 2023 at four hospitals: Fujian Medical University Union Hospital, Fujian Medical University Zhangzhou Hospital, First Affiliated Hospital of Xiamen University, and Fujian Children's Hospital. Patients were categorized into low-risk (R1), intermediate-risk (R2), and high-risk (R3) groups based on HL staging and pre-treatment risk factors. The patients received ABVD regimen or Chinese Pediatric HL-2013 regimen chemotherapy. Early treatment response and long-term efficacy were assessed, and prognostic factors were analyzed using the Cox proportional hazards regression model.</p><p><strong>Results: </strong>The overall complete response (CR) rates after 2 and 4 cycles of chemotherapy were 42% and 68%, respectively. Compared with the ABVD regimen group, patients treated with the HL-2013 regimen in the R1 group showed significantly higher CR rates after both 2 and 4 cycles (<i>P</i><0.05). However, no statistically significant differences in CR rates were observed between the two regimens in the R2 and R3 groups (<i>P</i>>0.05). The 5-year event-free survival (EFS) rate, overall survival rate, and freedom from treatment failure rate were 83%±4%, 97%±2%, and 88%±4%, respectively. Cox analysis indicated that the presence of a large tumor mass at diagnosis and failure to achieve CR after 4 cycles of chemotherapy were independent risk factors for lower EFS rates (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Pediatric HL generally has a favorable prognosis. The presence of a large tumor mass at diagnosis and failure to achieve CR after 4 cycles of chemotherapy indicate poor prognosis.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"668-674"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal seizures (2025)].","authors":"","doi":"10.7499/j.issn.1008-8830.2412160","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2412160","url":null,"abstract":"<p><p>Seizures are common clinical emergencies in neonatology, potentially leading to severe complications and directly impacting the neurodevelopmental prognosis of the infants with this condition. For primary healthcare providers, key clinical challenges include standardized emergency management, precise clinical diagnosis and treatment, and accurate assessment of referral indications. To assist primary healthcare providers in the prompt identification and standardized management of neonatal seizures, the Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association organized a panel of experts to develop the \"Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal seizures (2025)\", based on the latest clinical evidence and expert consensus. This guideline provides primary healthcare providers with 17 recommendations addressing nine common clinical questions in neonatal seizures.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"638-647"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Role of <i>Brg1</i> in regulating the Wnt/β-catenin signaling pathway in a bronchopulmonary dysplasia model].","authors":"Ling Guan, Mao-Zhu Xu, Yao-Zheng Ling, Li-Li Yang, Ling-Huan Zhang, Sha Liu, Wen-Jing Zou, Zhou Fu","doi":"10.7499/j.issn.1008-8830.2411078","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2411078","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the role and mechanism of Brahma-related gene 1 (<i>Brg1</i>) in regulating the Wnt/β-catenin signaling pathway in a bronchopulmonary dysplasia (BPD) model.</p><p><strong>Methods: </strong>Wild-type C57BL/6 and <i>Brg1</i>^f1/f1 mice were randomly divided into four groups: wild-type control, wild-type BPD, <i>Brg1</i>^f1/f1 control, and <i>Brg1</i>^f1/f1 BPD (<i>n</i>=5 each). Immortalized mouse pulmonary alveolar type 2 cells (imPAC2) were cultured, and <i>Brg1</i> gene was knocked down using lentivirus transfection technology. Cells were divided into three groups: control, empty vector, and <i>Brg1</i> knockdown. Hematoxylin and eosin staining and immunofluorescence were used to detect pathological changes in mouse lung tissue. Western blot and real-time fluorescent quantitative PCR were used to measure Brg1 protein and mRNA expression levels in mouse lung tissue. Western blot and immunofluorescence were used to detect the expression of homeodomain-containing protein homeobox (HOPX), surfactant protein C (SPC), and Wnt/β-catenin signaling pathway proteins in mouse lung tissue and imPAC2 cells. The CCK8 assay was used to assess the proliferation of imPAC2 cells, and co-immunoprecipitation was performed to verify the interaction between Brg1 and β-catenin proteins in imPAC2 cells.</p><p><strong>Results: </strong>Compared to the <i>Brg1</i>^f1/f1 control group and wild-type BPD group, the <i>Brg1</i>^f1/f1 BPD group showed increased alveolar diameter and SPC protein expression, and decreased relative density of pulmonary vasculature and HOPX protein expression (<i>P</i><0.05). Compared to the control group, the <i>Brg1</i> knockdown group showed increased cell proliferation ability, protein expression levels of SPC, Wnt5a and β-catenin, and β-catenin protein fluorescence intensity, along with decreased HOPX protein expression (<i>P</i><0.05). An interaction between Brg1 and β-catenin proteins was confirmed.</p><p><strong>Conclusions: </strong>The <i>Brg1</i> gene may promote the proliferation of alveolar type 2 epithelial cells by regulating the Wnt/β-catenin signaling pathway, thus influencing the occurrence and development of BPD.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"731-739"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multicenter study on etiological characteristics of bacterial meningitis in infants aged < 90 days].","authors":"Ying Liu, Xue Feng, Jin Gao, Ying Xiong, Chang Liu, Xin-Lin Hou","doi":"10.7499/j.issn.1008-8830.2412038","DOIUrl":"10.7499/j.issn.1008-8830.2412038","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the etiological characteristics of bacterial meningitis (BM) in infants aged <90 days.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the etiology and outcomes of BM in infants aged <90 days admitted to five collaborating hospitals between January 2007 and December 2021. The overall etiological profile was described, and pathogen distributions were compared across different age groups, regions, and years. The prognosis of BM caused by common pathogens was also evaluated.</p><p><strong>Results: </strong>A total of 197 infants with bacteriologically confirmed BM were included. The most common pathogens were <i>Escherichia coli</i> (E. coli) (72 cases, 36.5%), group B <i>Streptococcus</i> (GBS) (49 cases, 24.9%), and <i>Listeria monocytogenes</i> (LM) (11 cases, 5.6%). The detection rate of E. coli was significantly higher in the neonatal group than in the infant group (40.2% vs 18.2%, <i>P</i><0.05). E. coli was the predominant pathogen in Beijing (31.7%) and Kunming (54.1%), while GBS and E. coli were equally prevalent in Shenzhen (33.3%). From 2018 to 2021, the detection rates of E. coli were 46.4%, 47.2%, 45.2%, and 36.8%, respectively, whereas those of GBS were 25.0%, 27.8%, 22.6%, and 31.6%. No significant difference was observed in the overall complication rates among BM cases caused by E. coli, GBS, and LM (<i>P</i>>0.05). However, ventriculitis and hydrocephalus were more frequent in LM meningitis than in GBS meningitis (<i>P</i><0.017).</p><p><strong>Conclusions: </strong>E. coli is the most common pathogen in BM among young infants, particularly neonates. GBS is predominant in Shenzhen, with an increasing trend. LM meningitis accounts for a notable proportion of cases and is associated with poorer outcomes.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"648-653"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}