中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2412163
{"title":"[Expert consensus on the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal vomiting (2025)].","authors":"","doi":"10.7499/j.issn.1008-8830.2412163","DOIUrl":"10.7499/j.issn.1008-8830.2412163","url":null,"abstract":"<p><p>To assist primary healthcare personnel in promptly and accurately identifying neonatal vomiting, providing precise diagnosis, standardized treatment, or timely referral for rescue, thereby reducing the occurrence of complications and ensuring the health of infants, the Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association has organized experts to formulate this consensus based on the latest clinical research advancements and thorough discussions. This consensus addresses eight common clinical issues faced by primary healthcare personnel and forms 21 recommendations.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"770-777"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2502018
Xiao-Jie Tian, Rui-Wei Gao, Chao Chen
{"title":"[Research advances in the inhibitory effect of chondroitin sulfate proteoglycans on axon growth after premature white matter injury and its underlying mechanisms].","authors":"Xiao-Jie Tian, Rui-Wei Gao, Chao Chen","doi":"10.7499/j.issn.1008-8830.2502018","DOIUrl":"10.7499/j.issn.1008-8830.2502018","url":null,"abstract":"<p><p>White matter injury (WMI) is a major form of brain injury in preterm infants. Its characteristic pathological features primarily involve impaired development of oligodendrocyte precursor cells and structural damage to axons, which can lead to the neurological sequelae such as motor, behavioral, and cognitive dysfunctions. Chondroitin sulfate proteoglycans (CSPGs), as the important components of extracellular matrix, can participate in neuroinflammatory response mediated by microglial cells and dynamically balance glial scar reconstruction and axon growth by regulating specific receptors and signaling pathways. This article reviews the relationship between CSPGs and WMI, as well as the mechanisms by which CSPGs inhibit axon growth, focusing on the role of multi-target regulation of CSPGs in promoting axon plasticity and functional brain recovery, thereby providing a theoretical basis for improving the prognosis of preterm infants with WMI.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"875-880"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Cardiofaciocutaneous syndrome caused by microdeletion of chromosome 19p13.3: a case report and literature review].","authors":"Cui-Yun Li, Ying Xu, Ru-En Yao, Ying Yu, Xue-Ting Chen, Wei Li, Hui Zeng, Li-Ting Chen","doi":"10.7499/j.issn.1008-8830.2502003","DOIUrl":"10.7499/j.issn.1008-8830.2502003","url":null,"abstract":"<p><p>This article reports a child with cardioaciocutaneous syndrome (CFCS) caused by a rare microdeletion of chromosome 19p13.3, and a literature review is conducted. The child had unusual facies, short stature, delayed mental and motor development, macrocephaly, and cardiac abnormalities. Whole-exome sequencing identified a 1 040 kb heterozygous deletion in the 19p13.3 region of the child, which was rated as a \"pathogenic variant\". This is the first case of CFCS caused by a loss-of-function mutation reported in China, which enriches the genotype characteristics of CFCS. It is imperative to enhance the understanding of CFCS in children. Early identification based on its clinical manifestations should be pursued, and genetic testing should be performed to facilitate diagnosis.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"854-858"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2411059
Lin-Xiao Teng, Qi An, Lei Wang, Nan Wang, Qing-Ling Kong, Rui Han, Yuan Wang, Lu Liu, Yan Wang, Shu-Mei Xu, Kun-Peng Shi, Fang-Shan Qiu, Xi-Xi DU, Jin-Rui Shi
{"title":"[Effects of <i>MTHFR</i> and <i>GGH</i> gene polymorphisms on plasma concentrations and toxicity following high-dose methotrexate therapy in children with acute lymphoblastic leukemia].","authors":"Lin-Xiao Teng, Qi An, Lei Wang, Nan Wang, Qing-Ling Kong, Rui Han, Yuan Wang, Lu Liu, Yan Wang, Shu-Mei Xu, Kun-Peng Shi, Fang-Shan Qiu, Xi-Xi DU, Jin-Rui Shi","doi":"10.7499/j.issn.1008-8830.2411059","DOIUrl":"10.7499/j.issn.1008-8830.2411059","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of methylenetetrahydrofolate reductase (<i>MTHFR</i>) rs1801133 and γ-glutamyl hydrolase (<i>GGH</i>) rs11545078 gene polymorphisms on plasma concentrations and toxicity following high-dose methotrexate (MTX) therapy in children with acute lymphoblastic leukemia (ALL).</p><p><strong>Methods: </strong>Children with ALL treated at the Xuzhou Children's Hospital of Xuzhou Medical University from January 2021 to April 2024 were selected for this study. Genotypes of <i>MTHFR</i> rs1801133 and <i>GGH</i> rs11545078 were determined using multiplex polymerase chain reaction. MTX plasma concentrations were measured by enzyme-multiplied immunoassay technique, and toxicity was graded according to the Common Terminology Criteria for Adverse Events version 5.0. The relationships between <i>MTHFR</i> rs1801133 and <i>GGH</i> rs11545078 genotypes and both MTX plasma concentrations and associated toxicities were analyzed.</p><p><strong>Results: </strong>In the low-risk ALL group, the <i>MTHFR</i> rs1801133 genotype was associated with increased MTX plasma concentrations at 72 hours (<i>P</i><0.05). In the intermediate- to high-risk group, the <i>MTHFR</i> rs1801133 genotype was associated with increased MTX plasma concentrations at 48 hours (<i>P</i><0.05), and the <i>GGH</i> rs11545078 genotype was associated with increased MTX plasma concentrations at 48 hours (<i>P</i><0.05). In the intermediate- to high-risk group, the <i>MTHFR</i> rs1801133 genotype was associated with the occurrence of reduced hemoglobin (<i>P</i><0.05), and the <i>GGH</i> rs11545078 genotype was associated with the occurrence of thrombocytopenia (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Detection of <i>MTHFR</i> rs1801133 and <i>GGH</i> rs11545078 genotypes can be used to predict increased MTX plasma concentrations and the occurrence of toxic reactions in high-dose MTX treatment of ALL, enabling timely interventions to enhance safety.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"802-807"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2501077
Ya-Hong Hu, Kai-Hu Yao
{"title":"[Potential impact of adjusting immunization procedure for diphtheria-tetanus-pertussis vaccine on pertussis in clinical practice].","authors":"Ya-Hong Hu, Kai-Hu Yao","doi":"10.7499/j.issn.1008-8830.2501077","DOIUrl":"10.7499/j.issn.1008-8830.2501077","url":null,"abstract":"<p><p>In recent years, the incidence rate of pertussis in China has been steadily increasing, presenting an increasingly severe challenge for disease prevention and control. To strengthen the immune barrier in the population and effectively curb the spread of pertussis, National Disease Control and Prevention Administration of China and other relevant authorities optimized the immunization procedure for diphtheria-tetanus-pertussis vaccine, with the new procedure implemented in 2025. This adjustment includes three key measures: advancing the initial dose of the vaccine from 3 months to 2 months of age, extending the interval between primary immunization doses from 1 month to 2 months, and adding an extra dose of acellular diphtheria-tetanus-pertussis vaccine at 6 years of age. This article discusses potential changes in the epidemiology and clinical manifestations of pertussis following such adjustments for immunization procedure, and awareness of these changes will facilitate the accurate identification of pertussis cases, which is crucial for evaluating the impact of these adjustments and further optimizing immunization strategies.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"786-791"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2412085
Shi-Fang Wen, Zhi-Yuan Tang, Xian-Juan Shen, Tao Chen, Jian-Mei Zhao
{"title":"[Role and mechanism of copper overload-mediated endoplasmic reticulum stress in vascular endothelial injury in Kawasaki disease].","authors":"Shi-Fang Wen, Zhi-Yuan Tang, Xian-Juan Shen, Tao Chen, Jian-Mei Zhao","doi":"10.7499/j.issn.1008-8830.2412085","DOIUrl":"10.7499/j.issn.1008-8830.2412085","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the role and mechanism of copper overload-mediated endoplasmic reticulum stress (ERS) in vascular endothelial injury in Kawasaki disease (KD).</p><p><strong>Methods: </strong>Four-week-old male C57BL/6 mice were randomly divided into four groups: control, KD, KD plus copper chelator tetrathiomolybdate (TTM), and KD plus ERS inhibitor AMG PERK 44 (AMG) (<i>n</i>=20 per group). A KD mouse model was established using Candida albicans extract. Human umbilical vein endothelial cells (HUVECs) were divided into control (intervention with healthy children's serum), KD (intervention with KD patients' serum), and KD+TTM (intervention with KD patients' serum plus 20 µmol/L TTM). Copper deposition in mouse heart tissue was assessed using rubeanic acid staining. Vascular pathological changes were observed using hematoxylin-eosin staining and measurement of abdominal aortic diameter and area. ERS activation was detected by transmission electron microscopy and immunofluorescence. HUVEC viability, apoptosis, and functional changes were evaluated using CCK8, flow cytometry, cell scratch assay, and angiogenesis experiments. ERS marker protein expression levels were measured by Western blot.</p><p><strong>Results: </strong>Compared to the KD group, the KD+TTM and KD+AMG groups showed reduced copper deposition in the vascular wall, decreased swelling of coronary endothelial cells and endoplasmic reticulum, reduced inflammatory cell infiltration, and less abdominal aortic lesion expansion. The abdominal aortic diameter and area, and the fluorescence intensity of ERS marker proteins (GRP78 and CHOP) were significantly lower (<i>P</i><0.05). Compared to the KD group, the KD+TTM group exhibited increased cell viability, tube number, and scratch healing rate, along with decreased apoptosis rate and expression of ERS marker proteins (GRP78, CHOP, ATF6, and p-PERK) (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Copper overload aggravates vascular endothelial injury in KD by activating the ERS pathway. TTM can exert protective effects on the endothelium by regulating copper metabolism and inhibiting the ERS pathway.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"842-849"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2412117
Dan Wang, Hu Guo, Chun-Feng Wu, Gang Zhang, Min Xu
{"title":"[Clinical features and prognosis of children with influenza-associated encephalopathy: an analysis of 23 cases].","authors":"Dan Wang, Hu Guo, Chun-Feng Wu, Gang Zhang, Min Xu","doi":"10.7499/j.issn.1008-8830.2412117","DOIUrl":"10.7499/j.issn.1008-8830.2412117","url":null,"abstract":"<p><strong>Objectives: </strong>To study the clinical and imaging features of children with influenza-associated encephalopathy (IAE), and to investigate the influencing factors for prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the medical data (clinical data, laboratory examinations, imaging data, and prognosis) of 23 children with IAE who were diagnosed and treated in Children's Hospital of Nanjing Medical University from May 2022 to April 2023.</p><p><strong>Results: </strong>Among the 23 patients, 18 (78%) had influenza A and 5 (22%) had influenza B. All patients had fever and encephalopathy, and 20 patients (87%) had seizures, while 11 patients (48%) had persistent convulsions. There were 10 patients (43%) with an increase in alanine aminotransferase, 14 (61%) with an increase in aspartate aminotransferase, and 18 (78%) with an increase in lactate dehydrogenase. Abnormal imaging findings were observed in 20 patients (87%), among whom 10 (43%) had acute necrotizing encephalopathy. All 23 patients received peramivir or oseltamivir. Of all patients, 12 (52%) achieved complete recovery, 5 (22%) had varying degrees of neurological dysfunction, and 6 (26%) died. Compared with the good prognosis group, the poor prognosis group had significantly higher levels of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Fever and convulsions are the most common symptoms of children with IAE, and acute necrotizing encephalopathy is the most common clinical imaging syndrome. Increases in alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase have a certain value in predicting poor prognosis.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"829-833"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2503021
Wen-Bin An, Wen-Yu Yang
{"title":"[How I treat pediatric chronic myeloid leukemia].","authors":"Wen-Bin An, Wen-Yu Yang","doi":"10.7499/j.issn.1008-8830.2503021","DOIUrl":"10.7499/j.issn.1008-8830.2503021","url":null,"abstract":"<p><p>Pediatric chronic myeloid leukemia (CML) is more aggressive than adult CML, with unique molecular characteristics and a higher propensity for lymphoid blast crisis. The application of tyrosine kinase inhibitors (TKIs) has significantly improved the prognosis of pediatric CML. Based on international consensus and clinical experience, this article proposes standardized diagnosis and treatment recommendations for pediatric CML, covering initial therapy selection, efficacy evaluation, drug switching, and management of adverse effects. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is recommended only for patients with disease progression or failure of multiple lines of TKI therapy. For children newly diagnosed with CML in accelerated phase, high-dose imatinib or second-generation TKIs are recommended as first-line therapy. Those achieving optimal responses should continue maintenance therapy, while non-responders require switching to alternative TKIs and consider allo-HSCT. For blast-phase CML, induction therapy requires a combination of TKIs and chemotherapy, with allo-HSCT serving as the core curative intervention. This article highlights common but challenging problems (poor response, drug intolerance, and disease progression) in pediatric CML treatment using three typical cases, aiming to optimize treatment strategies. Furthermore, the goal of achieving treatment-free remission needs to be further addressed through multi-center clinical studies.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"792-801"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-07-15DOI: 10.7499/j.issn.1008-8830.2412043
Yan-Yan Chen, Ting-Ting Cheng, Jie Yao, Long-Guang Huang, Xiu-Zhen Li, Wen Zhang, Hong Liang
{"title":"[Sequential therapy with carglumic acid in three cases of organic acidemia crisis].","authors":"Yan-Yan Chen, Ting-Ting Cheng, Jie Yao, Long-Guang Huang, Xiu-Zhen Li, Wen Zhang, Hong Liang","doi":"10.7499/j.issn.1008-8830.2412043","DOIUrl":"10.7499/j.issn.1008-8830.2412043","url":null,"abstract":"<p><p>Case 1: A 19-day-old male infant presented with poor feeding and decreased activity for 2 weeks, worsening with poor responsiveness for 3 days. At 5 days old, he developed poor feeding and poor responsiveness, was hospitalized, and was found to have elevated blood ammonia and thrombocytopenia. Whole-genome genetic analysis revealed a pathogenic homozygous mutation in the <i>PCCA</i> gene, NM-000282.4: c.1834-1835del (p.Arg612AspfsTer44), leading to a diagnosis of propionic acidemia. Case 2: A 4-day-old male infant presented with poor responsiveness and feeding difficulties since birth, with elevated blood ammonia for 1 day. He showed weak sucking and deteriorating responsiveness, with blood ammonia >200 µmol/L. Genetic testing identified two heterozygous mutations in the <i>MMUT</i> gene: NM_000255.4: c.1677-1G>A and NM_000255.4: ex.5del, confirming methylmalonic acidemia. Case 3: A 20-day-old male infant presented with poor feeding for 15 days and skin petechiae for 8 days. He developed feeding difficulties at 5 days old and lower limb petechiae at 12 days old, with blood ammonia measured at 551.6 µmol/L. Genetic analysis found two heterozygous mutations in the <i>PCCA</i> gene: NM_000282.4: c.1118T>A (p.Met373Lys) and NM_000282.4: ex.16-18del, confirming propionic acidemia. In the first two cases, continuous hemodiafiltration was performed for 30 hours and 20 hours, respectively, before administering carglumic acid. In the third case, carglumic acid was administered orally without continuous hemodiafiltration, resulting in a decrease in blood ammonia from 551.6 µmol/L to 72.0 µmol/L within 6 hours, with a reduction rate of approximately 20-25 µmol/(kg·h), similar to the first two cases. Carglumic acid was effective in all three cases, suggesting it may help optimize future treatment protocols for organic acidemia.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 7","pages":"850-853"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国当代儿科杂志Pub Date : 2025-06-15DOI: 10.7499/j.issn.1008-8830.2412132
{"title":"[Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal pertussis (2025)].","authors":"","doi":"10.7499/j.issn.1008-8830.2412132","DOIUrl":"10.7499/j.issn.1008-8830.2412132","url":null,"abstract":"<p><p>In order to effectively assist primary healthcare providers in promptly identifying neonatal pertussis and administering effective treatment to reduce the incidence of severe neonatal pertussis, the Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association organized a panel of experts to develop the \"Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal pertussis (2025)\", based on the latest clinical evidence and expert consensus. This guideline provides primary healthcare providers with 14 recommendations addressing nine common clinical questions in neonatal pertussis.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 6","pages":"629-637"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}