中国当代儿科杂志最新文献

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[Beckwith-Wiedemann syndrome with ganglioneuroblastoma: a case report]. [beck - wiedemann综合征合并神经节神经母细胞瘤1例]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2502010
Jin-Fa Tou, Ci-Yuan Feng, Bin Xu, Jing-Jing Ye
{"title":"[Beckwith-Wiedemann syndrome with ganglioneuroblastoma: a case report].","authors":"Jin-Fa Tou, Ci-Yuan Feng, Bin Xu, Jing-Jing Ye","doi":"10.7499/j.issn.1008-8830.2502010","DOIUrl":"10.7499/j.issn.1008-8830.2502010","url":null,"abstract":"<p><p>This paper reports the case of a 10-month-old male infant with Beckwith-Wiedemann syndrome (BWS) who presented with a reducible right inguinal mass and an empty scrotum for 10 months and was admitted for elective surgery. Preoperative ultrasonography revealed a right adrenal mass, which was pathologically diagnosed as ganglioneuroblastoma (GNB) after surgical excision. The patient exhibited characteristic features of BWS, including omphalocele, flame-shaped nevus on the forehead, bilateral earlobe creases, and embryonal tumor. Next-generation sequencing identified a heterozygous mutation in the <i>CDKN1C</i> gene (chr11:2905365), confirming the diagnosis of BWS. Early diagnosis, standardized management, and tumor surveillance are crucial for improving prognosis in children with BWS. Ultrasonography enables early detection of tumors and informs clinical decision-making regarding intervention.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"1022-1026"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characteristics of bronchoalveolar lavage fluid microbial distribution at different disease stages and its relationship with immune function in children with refractory Mycoplasma pneumoniae pneumonia]. [难治性肺炎支原体肺炎患儿不同疾病阶段支气管肺泡灌洗液微生物分布特征及其与免疫功能的关系]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2411162
Chuan Yao, Xiao Zhang, Rui Xu
{"title":"[Characteristics of bronchoalveolar lavage fluid microbial distribution at different disease stages and its relationship with immune function in children with refractory <i>Mycoplasma pneumoniae</i> pneumonia].","authors":"Chuan Yao, Xiao Zhang, Rui Xu","doi":"10.7499/j.issn.1008-8830.2411162","DOIUrl":"10.7499/j.issn.1008-8830.2411162","url":null,"abstract":"<p><strong>Objectives: </strong>To study the characteristics of bronchoalveolar lavage fluid (BALF) microbial distribution at different stages of refractory <i>Mycoplasma pneumoniae</i> pneumonia (RMPP) in children and its relationship with immune function.</p><p><strong>Methods: </strong>A total of 108 children with RMPP were enrolled. The relative abundance, richness, and diversity of BALF microbiota, as well as immune function, were compared between the acute phase (<i>n</i>=61) and recovery phase (<i>n</i>=47). The correlations between the richness and diversity of BALF microbiota and immune function were analyzed.</p><p><strong>Results: </strong>The relative abundance of <i>Propionibacterium</i>, as well as the Simpson index, Shannon index, Chao1 index, and Observed species index of BALF microbiota in the acute phase were significantly lower than those in the recovery phase (<i>P</i><0.05). The relative abundances of <i>Streptococcus</i> and <i>Prevotella</i>, as well as the levels of complement C3, complement C4, immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM), were significantly higher in the acute phase than in the recovery phase (<i>P</i><0.05). Simpson, Shannon, Chao1, and Observed species indices were negatively correlated with levels of complement C3, complement C4, IgA, IgM, and IgG (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>In children with RMPP, the relative abundance of <i>Propionibacterium</i> and the richness and diversity of BALF microbiota in the acute phase are lower than those in the recovery phase, while the relative abundances of <i>Streptococcus</i> and <i>Prevotella</i> are higher in the acute phase. Microbial richness and diversity are closely related to immune function.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"945-950"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Colonoscopy in infants: procedure and disease spectrum analysis of 184 cases]. [婴儿结肠镜检查:184例程序和疾病谱分析]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2502085
Xiao-Li Fu, Xu-Xia Wei, Jun-Jie Xu, Ning Xue, Hong-Ling Chen, Le Zhang
{"title":"[Colonoscopy in infants: procedure and disease spectrum analysis of 184 cases].","authors":"Xiao-Li Fu, Xu-Xia Wei, Jun-Jie Xu, Ning Xue, Hong-Ling Chen, Le Zhang","doi":"10.7499/j.issn.1008-8830.2502085","DOIUrl":"10.7499/j.issn.1008-8830.2502085","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the underlying causes and clinical manifestations in infants undergoing colonoscopy, and to analyze changes in disease spectrum.</p><p><strong>Methods: </strong>Clinical data from 180 infants who underwent a total of 184 colonoscopies at the Department of Gastroenterology, Children's Hospital Affiliated to Shandong University from January 2015 to December 2024 were retrospectively analyzed. Patients were grouped by age: ≤6 months (<i>n</i>=41) and >6-12 months (<i>n</i>=139); and by examination period: 2015-2019 (<i>n</i>=83) and 2020-2024 (<i>n</i>=97). Primary causes for performing colonoscopy, final diagnoses, and disease spectrum evolution were assessed.</p><p><strong>Results: </strong>Among 184 colonoscopies, the leading causes prompting examination were hematochezia (37.8%, 68/180), diarrhea (36.7%, 66/180), and co-occurring hematochezia and diarrhea (21.1%, 38/180). Causes for performing colonoscopy differed significantly by age group (<i>P</i><0.05). Colonic polyps were only detected in the >6-12 months group (<i>P</i><0.05). Compared to the 2015-2019 group, the 2020-2024 group had fewer food allergy-related gastrointestinal diseases (<i>P</i><0.05) but more colitis (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Colonoscopy is essential for diagnosing infantile digestive disorders, with disease spectra varying by age and time period.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"917-922"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The function of circular RNA-microRNA-messenger RNA immune regulatory network in childhood allergic asthma]. [环状RNA-微RNA-信使RNA免疫调节网络在儿童过敏性哮喘中的作用]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2411052
Sai-Hua Huang, Jin-Tao Zhou, Yan Wang, Xiao Han
{"title":"[The function of circular RNA-microRNA-messenger RNA immune regulatory network in childhood allergic asthma].","authors":"Sai-Hua Huang, Jin-Tao Zhou, Yan Wang, Xiao Han","doi":"10.7499/j.issn.1008-8830.2411052","DOIUrl":"10.7499/j.issn.1008-8830.2411052","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the potential circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) immune regulatory network in childhood allergic asthma by analyzing microarray datasets.</p><p><strong>Methods: </strong>GEO database was used to obtain the datasets of circRNA, miRNA, and mRNA from children with allergic asthma and healthy controls. The Limma package was used to identify differentially expressed circRNA (DEcircRNA), miRNA (DEmiRNA), and mRNA (DEmRNA). ENCORI and other tools were used to predict and construct the regulatory network of endogenous RNA. The DAVID database was used to perform GO and KEGG enrichment analyses, and CIBERSORT and Pearson were used to identify genes associated with immune cell infiltration.</p><p><strong>Results: </strong>A total of 130 DEcircRNAs, 40 DEmiRNAs, and 802 DEmRNAs were identified between the asthma and control groups, and a regulatory network consisting of 12 circRNAs, 7 miRNAs, and 75 mRNAs was established. The GO analysis showed that the differentially expressed genes were mainly involved in the regulation of growth and development, and the KEGG analysis showed that they were mainly involved in the mTOR signaling pathway. The CIBERSORT analysis showed that compared with the control group, the asthma group had higher percentages of CD8<sup>+</sup> T cells and resting NK cells and lower percentages of resting CD4<sup>+</sup> memory T cells and activated mast cells. In addition, the Pearson correlation analysis identified six key mRNAs that were positively correlated with immune cell infiltration.</p><p><strong>Conclusions: </strong>The ceRNA immune regulatory network constructed in this study provides a basis for research on the mechanism of childhood allergic asthma and potential therapeutic targets.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"936-944"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application of active glucose monitoring in the perioperative period of gastrointestinal endoscopy in children with glycogen storage disease type Ⅰb]. [糖原储存病Ⅰ型患儿胃肠内镜围手术期主动血糖监测的应用]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2412155
Jing Yang, Hao-Tian Wu, Ni Ma, Jia-Xing Wu, Min Yang
{"title":"[Application of active glucose monitoring in the perioperative period of gastrointestinal endoscopy in children with glycogen storage disease type Ⅰb].","authors":"Jing Yang, Hao-Tian Wu, Ni Ma, Jia-Xing Wu, Min Yang","doi":"10.7499/j.issn.1008-8830.2412155","DOIUrl":"10.7499/j.issn.1008-8830.2412155","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the role of active glucose monitoring in preventing hypoglycemia during the perioperative period of gastrointestinal endoscopy in children with glycogen storage disease type Ⅰb (GSD-Ⅰb).</p><p><strong>Methods: </strong>A retrospective analysis was performed for the clinical data of children with GSD-Ⅰb who were diagnosed and treated in Guangdong Provincial People's Hospital from June 2021 to August 2024. The effect of active glucose monitoring on hypoglycemic episodes during the perioperative period of gastrointestinal endoscopy was analyzed.</p><p><strong>Results: </strong>A total of 14 children with GSD-Ⅰb were included, among whom there were 7 boys and 7 girls, with a mean age of 10.0 years. Among 34 hospitalizations, there were 15 cases of hypoglycemic episodes (44%), among which 6 symptomatic cases (1 case with blood glucose level of 1.6 mmol/L and 5 cases with blood glucose level of <1.1 mmol/L) occurred without active monitoring, while 9 asymptomatic cases (with blood glucose level of 1.2-3.9 mmol/L) were detected by active monitoring. The predisposing factors for hypoglycemic episodes included preoperative fasting (5 cases, 33%), delayed feeding (7 cases, 47%), vomiting (2 cases, 13%), and parental omission (1 case, 7%). Two children experienced two hypoglycemic episodes during the same period of hospitalization, and no child experienced subjective symptoms prior to hypoglycemic episodes. Treatment methods included nasogastric glucose administration (1 case, 7%), intravenous injection of glucose (14 cases, 93%), and continuous glucose infusion (4 cases, 27%). Blood glucose returned to 3.5-6.9 mmol/L within 10 minutes after intervention and remained normal after dietary resumption.</p><p><strong>Conclusions: </strong>Active glucose monitoring during the perioperative period of gastrointestinal endoscopy can help to achieve early detection of hypoglycemic states in children with GSD-Ⅰb, prevent hypoglycemic episodes, and enhance precise diagnosis and treatment.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"923-928"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Expert consensus on the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal sepsis (2025)]. 【初级卫生保健机构新生儿常见病诊治专家共识:新生儿败血症(2025)】。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2412179
{"title":"[Expert consensus on the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal sepsis (2025)].","authors":"","doi":"10.7499/j.issn.1008-8830.2412179","DOIUrl":"10.7499/j.issn.1008-8830.2412179","url":null,"abstract":"<p><p>Neonatal sepsis is one of the major life-threatening diseases in neonates, with significant regional variations in mortality. The Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association, together with the Editorial Board of the <i>Chinese Journal of Contemporary Pediatrics</i>, organized neonatology experts to integrate the latest advances in clinical research on neonatal sepsis. Taking into account the current situation of primary healthcare institutions in China, they addressed nine common clinical questions regarding the diagnosis, treatment, and referral of neonatal sepsis for primary healthcare providers, and resulting in 19 expert consensus recommendations. This consensus aims to help primary healthcare providers promptly identify neonatal sepsis, ensure timely intervention or referral, and improve clinical outcomes.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"897-907"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal resuscitation (2025)]. [初级卫生保健机构新生儿常见病诊治指南:新生儿复苏(2025年)]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2412161
{"title":"[Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal resuscitation (2025)].","authors":"","doi":"10.7499/j.issn.1008-8830.2412161","DOIUrl":"10.7499/j.issn.1008-8830.2412161","url":null,"abstract":"<p><p>In order to further enhance the capacity of primary healthcare providers to perform neonatal resuscitation, and to reduce the incidence and mortality of asphyxia-related complications, the Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association, in collaboration with the Editorial Board of the <i>Chinese Journal of Contemporary Pediatrics</i>, organized experts to integrate the latest clinical research advances in neonatal resuscitation. Considering the realities of primary healthcare institutions, this guideline was developed after thorough expert discussion. The guideline addresses nine common issues concerning neonatal resuscitation faced by primary healthcare providers and provides 22 recommendations.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"887-896"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Correlation between bone mineral density and bone metabolic markers in preschool children and the influencing factors for bone mineral density]. [学龄前儿童骨密度与骨代谢指标的相关性及骨密度影响因素]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2501097
Luopa Ni, Ailipati Tailaiti, Kereman Paerhati, Min-Nan Wang, Yan Guo, Zumureti Yimin, Gulijianati Abulakemu, Rena Maimaiti
{"title":"[Correlation between bone mineral density and bone metabolic markers in preschool children and the influencing factors for bone mineral density].","authors":"Luopa Ni, Ailipati Tailaiti, Kereman Paerhati, Min-Nan Wang, Yan Guo, Zumureti Yimin, Gulijianati Abulakemu, Rena Maimaiti","doi":"10.7499/j.issn.1008-8830.2501097","DOIUrl":"10.7499/j.issn.1008-8830.2501097","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the correlation between bone mineral density (BMD) and bone metabolic markers in preschool children and the influencing factors for BMD, and to provide a clinical basis for promoting bone health in children.</p><p><strong>Methods: </strong>A retrospective analysis was performed for the data of 127 preschool children who underwent physical examination in the Department of Child Health Care of the First Affiliated Hospital of Xinjiang Medical University, from June to December 2024. BMD and bone metabolic markers were measured, and physical examination was performed. A multiple linear regression analysis was used to investigate the effect of general information on BMD Z-score in preschool children. Spearman's rank correlation test was used to investigate the correlation of BMD Z-score with 25-hydroxyvitamin D (25-OHD), serum bone Gla protein (BGP), and parathyroid hormone (PTH).</p><p><strong>Results: </strong>BMD Z-score significantly differed by ethnicity, weight category, and height category (all <i>P</i><0.05). The multiple linear regression analysis indicated that weight and height significantly influenced BMD Z-score (<i>P</i><0.05), whereas sex, age, ethnicity, and parental education level did not (<i>P</i>>0.05). In children, BMD Z-score was positively correlated with 25-OHD level (<i>r<sub>s</sub></i>=0.260, <i>P</i><0.001) and BGP level (<i>r<sub>s</sub></i>=0.075, <i>P</i>=0.025) and was negatively correlated with PTH level (<i>r<sub>s</sub></i>=-0.043, <i>P=</i>0.032).</p><p><strong>Conclusions: </strong>Weight, height, 25-OHD, BGP, and PTH are influencing factors for BMD in preschool children. In clinical practice, combined measurement of bone metabolic markers may provide a scientific basis for early identification of children with abnormal BMD and prevention of osteoporosis and osteomalacia.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"989-993"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interferon-λ1 improves glucocorticoid resistance caused by respiratory syncytial virus by regulating the p38 mitogen-activated protein kinase signaling pathway]. [干扰素- κ 1通过调节p38丝裂原活化蛋白激酶信号通路改善呼吸道合胞病毒糖皮质激素耐药]。
中国当代儿科杂志 Pub Date : 2025-08-15 DOI: 10.7499/j.issn.1008-8830.2501095
Li Peng, Yao Liu, Fang-Cai Li, Xiao-Fang Ding, Xiao-Juan Lin, Tu-Hong Yang, Li-Li Zhong
{"title":"[Interferon-λ1 improves glucocorticoid resistance caused by respiratory syncytial virus by regulating the p38 mitogen-activated protein kinase signaling pathway].","authors":"Li Peng, Yao Liu, Fang-Cai Li, Xiao-Fang Ding, Xiao-Juan Lin, Tu-Hong Yang, Li-Li Zhong","doi":"10.7499/j.issn.1008-8830.2501095","DOIUrl":"10.7499/j.issn.1008-8830.2501095","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of interferon-λ1 (IFN-λ1) on glucocorticoid (GC) resistance in human bronchial epithelial cells (HBECs) stimulated by respiratory syncytial virus (RSV).</p><p><strong>Methods: </strong>HBECs were divided into five groups: control, dexamethasone, IFN-λ1, RSV, and RSV+IFN-λ1. CCK-8 assay was used to measure the effect of different concentrations of IFN-λ1 on the viability of HBECs, and the sensitivity of HBECs to dexamethasone was measured in each group. Quantitative real-time PCR was used to measure the mRNA expression levels of p38 mitogen-activated protein kinase (p38 MAPK), glucocorticoid receptor (GR), and MAPK phosphatase-1 (MKP-1). Western blot was used to measure the protein expression level of GR in cell nucleus and cytoplasm, and the nuclear/cytoplasmic ratio of GR was calculated.</p><p><strong>Results: </strong>At 24 and 72 hours, the proliferation activity of HBECs increased with the increase in IFN-λ1 concentration in a dose- and time-dependent manner (<i>P</i>˂0.05). Compared with the RSV group, the RSV+IFN-λ1 group had significant reductions in the half-maximal inhibitory concentration of dexamethasone and the mRNA expression level of p38 MAPK (<i>P</i><0.05), as well as significant increases in the mRNA expression levels of GR and MKP-1, the level of GR in cell nucleus and cytoplasm, and the nuclear/cytoplasmic GR ratio (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>IFN-λ1 can inhibit the p38 MAPK pathway by upregulating MKP-1, promote the nuclear translocation of GR, and thus ameliorate GC resistance in HBECs.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 8","pages":"1011-1016"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interpretation of "Physical therapy management of congenital muscular torticollis: a 2024 evidence-based clinical practice guideline from the American Physical Therapy Association Academy of Pediatric Physical Therapy"]. [对《先天性肌性斜颈的物理治疗管理:美国物理治疗协会儿科物理治疗学会2024循证临床实践指南》的解读]。
中国当代儿科杂志 Pub Date : 2025-07-15 DOI: 10.7499/j.issn.1008-8830.2502066
Wan-Qiu Tang, Xiao-Hong Luo, Yu-Ping Zhang
{"title":"[Interpretation of \"Physical therapy management of congenital muscular torticollis: a 2024 evidence-based clinical practice guideline from the American Physical Therapy Association Academy of Pediatric Physical Therapy\"].","authors":"Wan-Qiu Tang, Xiao-Hong Luo, Yu-Ping Zhang","doi":"10.7499/j.issn.1008-8830.2502066","DOIUrl":"10.7499/j.issn.1008-8830.2502066","url":null,"abstract":"<p><p>Early screening, diagnosis, and intervention for congenital muscular torticollis (CMT) in infants are crucial for improving clinical outcomes. However, in China, limited awareness of CMT among child healthcare institutions and caregivers, as well as inconsistent professional standards among rehabilitation personnel, pose significant challenges to the effective diagnosis and management of CMT. The \"Physical therapy management of congenital muscular torticollis: a 2024 evidence-based clinical practice guideline from the American Physical Therapy Association Academy of Pediatric Physical Therapy\" includes 17 action statements, primarily addressing the prevention, identification, assessment, and intervention of CMT. This guideline is expected to facilitate early detection of CMT in infants, enhance the treatment capabilities of physical therapists, and improve clinical outcomes. This article provides an interpretation of the guideline in the context of the current status of CMT diagnosis and management in China, aiming to offer a reference for improving the ability of primary child healthcare providers and physical therapists to recognize and manage CMTropriately.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 9","pages":"1045-1049"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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