中国当代儿科杂志最新文献

{"title":"[Meta analysis of the prevalence and risk factors of non-alcoholic fatty liver disease in overweight and obese children and adolescents in China].","authors":"Yi Xiao, Yu-Fan Pan, Yu Dai, Yu-Jian Sun, Yue Zhou, Yu-Feng Yu","doi":"10.7499/j.issn.1008-8830.2408148","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2408148","url":null,"abstract":"<p><strong>Objectives: </strong>To systematically evaluate the prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in overweight and obese children and adolescents in China.</p><p><strong>Methods: </strong>Databases including China National Knowledge Infrastructure, Wanfang Data, VIP Database, China Biomedical Literature Database, PubMed, Embase, Web of Science, and Cochrane Library were searched, from database inception to October 2024. Two researchers independently screened the literature, extracted data, and assessed the quality of the studies according to inclusion and exclusion criteria. A Meta analysis was conducted using Stata 16.0 software.</p><p><strong>Results: </strong>A total of 42 studies involving 16 481 overweight and obese children and adolescents were included. The Meta analysis results showed that the prevalence of NAFLD among overweight and obese children in China was 43% (95%<i>CI</i>: 37%-48%). Factors associated with NAFLD included being male (<i>OR</i>=1.61, 95%<i>CI</i>: 1.17-2.04), increased weight (<i>MD</i>=10.33, 95%<i>CI</i>: 9.08-11.57), increased waist circumference (<i>MD</i>=5.49, 95%<i>CI</i>: 3.36-7.62), longer duration of obesity (<i>MD</i>=0.31, 95%<i>CI</i>: 0.02-0.61), higher body mass index (<i>MD</i>=3.11, 95%<i>CI</i>: 2.07-4.16), elevated fasting blood glucose levels (<i>MD</i>=0.17, 95%<i>CI</i>: 0.06-0.29), higher triglyceride levels (<i>MD</i>=0.32, 95%<i>CI</i>: 0.17-0.47), elevated total cholesterol levels (<i>MD</i>=0.15, 95%<i>CI</i>: 0.10-0.21), higher low-density lipoprotein cholesterol levels (<i>MD</i>=0.14, 95%<i>CI</i>: 0.04-0.23), increased alanine aminotransferase levels (<i>MD</i>=24.39, 95%<i>CI</i>: 18.57-30.20), increased aspartate aminotransferase levels (<i>MD</i>=12.49, 95%<i>CI</i>: 9.67-15.32), elevated serum insulin levels (<i>MD</i>=4.47, 95%<i>CI</i>: 2.57-6.36), higher homeostasis model assessment-insulin resistance (<i>MD</i>=0.45, 95%<i>CI</i>: 0.30-0.59), and elevated uric acid levels (<i>MD</i>=55.91, 95%<i>CI</i>: 35.49-76.32) (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>The prevalence of NAFLD among overweight and obese children and adolescents in China is high. Male gender, increased weight, increased waist circumference, prolonged obesity duration, higher body mass index, dyslipidemia, and elevated levels of fasting blood glucose, liver enzymes, serum insulin, homeostasis model assessment-insulin resistance, and uric acid are potential risk factors for NAFLD in this population.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"410-419"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of hepatitis-associated aplastic anemia complicated by hemophagocytic lymphohistiocytosis and literature review].","authors":"Xin Zhou, Xiao-Yu Chen, Chuan Wen, Sen-Lin Luo","doi":"10.7499/j.issn.1008-8830.2409118","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2409118","url":null,"abstract":"<p><p>A 4-year-old boy was admitted to the hospital with a 3-day history of rash and intermittent abdominal pain, during which abnormal results from routine blood tests were discovered. Initially, he presented with acute jaundice hepatitis and pancytopenia. The patient's condition progressed rapidly, with recurrent fever, worsening jaundice of the skin and sclera, and progressively worsening hepatosplenomegaly. Liver function impairment and bone marrow failure continued to deteriorate, while cytokine levels continued to rise. After excluding infections, autoimmune diseases, tumors, genetic metabolic disorders, and toxicities, the patient was diagnosed with hepatitis-associated aplastic anemia (HAAA) complicated by hemophagocytic lymphohistiocytosis (HLH). Following treatment with corticosteroids, plasma exchange, intravenous immunoglobulin, and liver protection therapy, the patient's symptoms partially alleviated. Aplastic anemia complicated by HLH is relatively uncommon, and HAAA complicated by HLH is even rarer, often presenting insidiously and severely. This paper presents a case of HAAA complicated by HLH and summarizes previously reported cases in the literature, providing references for the early diagnosis and treatment of this condition.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"465-471"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty].","authors":"Hong-Ru Zhang, Ya Xiao, Shu-Qin Jiang, Jun Sun, Wen-Hui Shi, Jin-Bo Li, Ying Yang, Wei Wang","doi":"10.7499/j.issn.1008-8830.2411003","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2411003","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty (ICPP).</p><p><strong>Methods: </strong>A retrospective study was conducted involving 61 girls diagnosed with ICPP who visited the pediatric growth and development clinic of the Third Affiliated Hospital of Zhengzhou University between January 2022 and September 2024, designated as the ICPP group, and 61 normally developing girls as the control group. The differences in insulin resistance index (homeostasis model assessment of insulin resistance, HOMA-IR), uterine volume, and other indicators between the two groups were compared, and the relationship between insulin resistance and uterine volume in these girls was analyzed.</p><p><strong>Results: </strong>The uterine volume and HOMA-IR level in the ICPP group were significantly higher than those in the control group (<i>P</i><0.05). Correlation analysis revealed that there was a positive correlation between HOMA-IR level and uterine volume in the ICPP group (<i>r_s</i>=0.643, <i>P</i><0.001). Multiple linear regression analysis indicated that as HOMA-IR increased,uterine volume in the girls tended to increase (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>There is an association between insulin resistance and uterine volume in girls with ICPP, and as HOMA-IR increases, uterine volume in the girls also increases.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"404-409"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk factors for cardiopulmonary dysfunction after ligation of hemodynamically significant patent ductus arteriosus in preterm infants].","authors":"Chong-Chong Liu, Yong Liu, Yi Zhang, Dai-Cheng Han, Rui-Jing He, Shi-Wen Xia","doi":"10.7499/j.issn.1008-8830.2411050","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2411050","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the risk factors for the occurrence of cardiopulmonary dysfunction following ligation of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants.</p><p><strong>Methods: </strong>A retrospective collection of clinical data was conducted on preterm infants with a gestational age of <34 weeks who were admitted to the Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology from January 2018 to August 2024. These infants underwent hsPDA ligation after 1-2 courses of failed ibuprofen treatment. Based on the occurrence of blood pressure changes and oxygenation or ventilation failure postoperatively, the infants were divided into a cardiopulmonary dysfunction group (19 cases) and a non-cardiopulmonary dysfunction group (40 cases). Binary logistic regression analysis was performed to explore risk factors for postoperative cardiopulmonary dysfunction.</p><p><strong>Results: </strong>Binary logistic regression analysis indicated that a faster average weight gain rate preoperatively and low levels of free triiodothyronine (FT₃) within one week before surgery were risk factors for cardiopulmonary dysfunction following hsPDA ligation (<i>P</i><0.05). Receiver operating characteristic curve analysis showed that an average weight gain rate >11.45 g/(kg·d) and FT₃ levels <2.785 pmol/L within one week before surgery had predictive value for postoperative cardiopulmonary dysfunction (<i>P</i><0.05). The combination of these two indicators provided the highest predictive value (<i>P</i><0.05), with an area under the curve of 0.825, a sensitivity of 79%, and a specificity of 75%.</p><p><strong>Conclusions: </strong>An average weight gain rate exceeding 11.45 g/(kg·d) and FT₃ levels below 2.785 pmol/L within one week before surgery are risk factors affecting cardiopulmonary function after hsPDA ligation. Preoperative assessment and intervention should be strengthened to reduce the risk of postoperative complications.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"425-431"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Causal association between gut microbiota and food allergy: a Mendelian randomization analysis].","authors":"Li-Xin Hu, Guo-Zhen Fan, Hui Ma, Lei Li, Fang Wang, Zheng-Hai Qu, Ren-Zheng Guan","doi":"10.7499/j.issn.1008-8830.2409021","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2409021","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the potential causal relationship between gut microbiota and food allergy (FA) using two-sample Mendelian randomization (MR) methods.</p><p><strong>Methods: </strong>Data from genome-wide association studies on gut microbiota and FA were utilized. MR analysis was conducted employing inverse variance weighting, MR-Egger regression, and weighted median methods to assess the causal relationship between gut microbiota and FA. Cochrane's <i>Q</i> test was used to evaluate heterogeneity of instrumental variables, MR-PRESSO analysis was conducted to test for outliers and pleiotropy, and MR-Egger regression was employed to assess horizontal pleiotropy. The \"leave-one-out\" method was used to evaluate the impact of removing individual single nucleotide polymorphisms on the causal relationship.</p><p><strong>Results: </strong>Inverse variance weighting analysis revealed that the phylum <i>Verrucomicrobia</i>, family <i>Verrucomicrobiaceae</i>, order <i>Verrucomicrobiales</i>, genus <i>Ruminococcaceae UCG013</i>, and genus <i>Akkermansia</i> were negatively associated with FA (<i>P</i><0.05). Sensitivity analyses confirmed the reliability of the findings, indicating no heterogeneity or pleiotropy present.</p><p><strong>Conclusions: </strong>There is a causal relationship between gut microbiota and FA, with <i>Verrucomicrobia</i>, <i>Verrucomicrobiaceae</i>, <i>Verrucomicrobiales</i>, <i>Ruminococcaceae UCG013</i>, and <i>Akkermansia</i> potentially reducing the risk of developing FA. These findings provide potential targets for the treatment and prevention of FA; however, further research is needed to explore the specific mechanisms by which the microbiota influence FA.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"444-450"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic value of endoscopic findings under white light gastroscopy for <i>Helicobacter pylori</i> infection in children].","authors":"Ren-Min Zhou, Ying Chen, Qiong Lin","doi":"10.7499/j.issn.1008-8830.2411069","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2411069","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the clinical value of endoscopic findings under white light gastroscopy in diagnosing <i>Helicobacter pylori</i> (Hp) infection in children.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 340 children who underwent gastroscopy and gastric mucosa tissue Hp culture from July 2022 to June 2023 in the Department of Gastroenterology at Wuxi Children's Hospital due to upper gastrointestinal symptoms. Based on the results of Hp culture, the children were categorized into an Hp-infected group (146 cases) and a non-infected group (194 cases). The detection rates of various endoscopic findings in the gastric mucosa between the two groups were compared, and the association between each endoscopic finding and different Hp infection statuses was analyzed, as well as the diagnostic value of each endoscopic finding under different Hp infection statuses.</p><p><strong>Results: </strong>The proportions of white mucus, diffuse redness, mucosal edema, enlarged folds, chicken skin-like changes, and ulcers in the Hp-infected group were higher than those in the non-infected group (<i>P</i><0.05), while the proportions of regular arrangement of collecting venules (RAC) and ridge-like redness were lower in the Hp-infected group compared to the non-infected group (<i>P</i><0.05). Multivariate logistic regression analysis showed that diffuse redness, enlarged folds, mucosal edema, and chicken skin-like changes were closely associated with Hp infection (<i>P</i><0.05), while RAC and ridge-like redness were closely associated with the absence of Hp infection (<i>P</i><0.05). Receiver operating characteristic curve analysis indicated that the area under the curve for diffuse redness, enlarged folds, mucosal edema, and chicken skin-like changes in predicting Hp infection was 0.798, 0.731, 0.782, and 0.760, respectively (<i>P</i><0.05). The area under the curve for RAC and ridge-like redness in predicting the absence of Hp infection was 0.861 and 0.589, respectively (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Endoscopic findings under white light gastroscopy are associated with Hp infection in children, with diffuse redness, mucosal edema, chicken skin-like changes, and enlarged folds showing significant diagnostic value for Hp infection.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"438-443"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of respiratory training combined with swallowing function training on infants with bronchopulmonary dysplasia at a corrected gestational age of 6 months: a prospective study].","authors":"Ya-Qin Duan, Zhen-Yu Liao, Ji-Hong Hu, Shun-Qiu Ruan","doi":"10.7499/j.issn.1008-8830.2410122","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2410122","url":null,"abstract":"<p><strong>Objectives: </strong>To study the effects of early respiratory training combined with swallowing function training on physical development and neurodevelopment at a corrected gestational age of 6 months in infants with bronchopulmonary dysplasia (BPD).</p><p><strong>Methods: </strong>A total of 69 BPD infants who could not be fed completely orally were prospectively selected from the Department of Neonatology of Hunan Children's Hospital between January 2018 and January 2021. Based on a random number table, the infants were divided into a conventional group (35 cases) and a training group (34 cases) (with 8 cases lost to follow-up; the final follow-up included 31 cases in the training group and 30 cases in the conventional group). Both groups received routine clinical treatment and care, while the training group additionally received respiratory and swallowing function training until the infants could independently feed orally. The weight, length, Gesell Developmental Schedule (GDS) results, readmission rate, and multiple readmission rate (two or more admissions) were compared between the two groups at a corrected age of 6 months.</p><p><strong>Results: </strong>At corrected gestational age of 6 months, the training group had higher weight, length, and GDS scores in personal-social, language, gross motor, fine motor, and adaptive development compared to the conventional group (<i>P</i><0.05). The readmission rate and multiple readmission rate were lower in the training group compared to the conventional group (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Early respiratory training combined with swallowing function training for BPD infants in a neonatal intensive care unit setting helps improve physical and neurological development and reduces the readmission rate.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"420-424"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical application of next-generation sequencing in early screening of neonatal diseases].","authors":"Li-Hong Jiang, Ben-Qing Wu, Zheng-Yan Zhao","doi":"10.7499/j.issn.1008-8830.2409107","DOIUrl":"https://doi.org/10.7499/j.issn.1008-8830.2409107","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the clinical value of next-generation sequencing (NGS) in neonatal disease screening, particularly its advantages when combined with tandem mass spectrometry (MS/MS).</p><p><strong>Methods: </strong>A prospective study was conducted involving blood samples from 1 999 neonates born at the Shenzhen Guangming District People's Hospital, between May and August 2021. All samples were initially screened using MS/MS and fluorescence immunoassay, followed by NGS to detect high-frequency variation sites in 135 related pathogenic genes. Suspected positive variants were validated using Sanger sequencing or multiplex ligation-dependent probe amplification in family studies.</p><p><strong>Results: </strong>No confirmed positive cases were found in the MS/MS analysis of the 1 999 neonates. Genetic screening identified 58 positive cases (2.90%), 732 carriers of pathogenic genes (36.62%), and 1 209 negative cases (60.48%). One case of neonatal intrahepatic cholestasis was diagnosed (0.05%, 1/1 999). Fluorescence immunoassay identified 39 cases of glucose-6-phosphate dehydrogenase (G6PD) deficiency (1.95%, 39/1 999), while genetic screening identified 43 cases of G6PD deficiency (2.15%, 43/1 999). The fluorescence immunoassay also detected 6 cases of hyperthyrotropinemia (0.30%, 6/1 999), all of whom carried <i>DUOX2</i> gene variants. The top ten pathogenic gene carrier rates were <i>G6PD</i> (12.8%), <i>DUOX2</i> (8.7%), <i>HBB</i> (8.2%), <i>ATP7B</i> (6.6%), <i>GJB2</i> (5.7%), <i>SLC26A4</i> (5.6%), <i>PAH</i> (5.6%), <i>ACADSB</i> (4.6%), <i>SLC25A13</i> (4.2%), and <i>SLC22A5</i> (4.1%).</p><p><strong>Conclusions: </strong>NGS can serve as an effective complement to MS/MS, significantly improving the detection rate of inherited metabolic disorders in neonates. When combined with family validation, it enables precise diagnosis, particularly demonstrating complementary advantages in screening for monogenic diseases such as G6PD deficiency.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 4","pages":"432-437"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mediating effect of sleep duration between depression symptoms and myopia in middle school students].","authors":"Wei DU, Xu-Xiang Yang, Ru-Shuang Zeng, Chun-Yao Zhao, Zhi-Peng Xiang, Yuan-Chun Li, Jie-Song Wang, Xiao-Hong Su, Xiao Lu, Yu Li, Jing Wen, Dang Han, Qun DU, Jia He","doi":"10.7499/j.issn.1008-8830.2409011","DOIUrl":"10.7499/j.issn.1008-8830.2409011","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the mediating role of sleep duration in the relationship between depression symptoms and myopia among middle school students.</p><p><strong>Methods: </strong>This study was a cross-sectional research conducted using a stratified cluster random sampling method. A total of 1 728 middle school students were selected from two junior high schools and two senior high schools in certain urban areas and farms of the Xinjiang Production and Construction Corps. Questionnaire surveys and vision tests were conducted among the students. Spearman analysis was used to analyze the correlation between depression symptoms, sleep duration, and myopia. The Bootstrap method was employed to investigate the mediating effect of sleep duration between depression symptoms and myopia.</p><p><strong>Results: </strong>The prevalence of myopia in the overall population was 74.02% (1 279/1 728), with an average sleep duration of (7.6±1.0) hours. The rate of insufficient sleep was 83.62% (1 445/1 728), and the proportion of students exhibiting depression symptoms was 25.29% (437/1 728). Correlation analysis showed significant negative correlations between visual acuity in both eyes and sleep duration with depressive emotions as measured by the Center for Epidemiologic Studies Depression Scale (with correlation coefficients of -0.064, -0.084, and -0.199 respectively; <i>P</i><0.01), as well as with somatic symptoms and activities (with correlation coefficients of -0.104, -0.124, and -0.233 respectively; <i>P</i><0.01) and interpersonal relationships (with correlation coefficients of -0.052, -0.059, and -0.071 respectively; <i>P</i><0.05). The correlation coefficients for left and right eye visual acuity and sleep duration were 0.206 and 0.211 respectively (<i>P</i><0.001). Sleep duration exhibited a mediating effect between depression symptoms and myopia (indirect effect=0.056, 95%<i>CI</i>: 0.029-0.088), with the mediating effect value for females (indirect effect=0.066, 95%<i>CI</i>: 0.024-0.119) being higher than that for males (indirect effect=0.042, 95%<i>CI</i>: 0.011-0.081).</p><p><strong>Conclusions: </strong>Sleep duration serves as a partial mediator between depression symptoms and myopia in middle school students.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 3","pages":"359-365"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impact of different treatment attitudes on survival and risk factors for poor clinical outcomes in extremely preterm infants: a retrospective real-world study].","authors":"Meng-Meng Li, Shu-Shu Li, Miao Qian, Min Zhang, Shu-Ping Han","doi":"10.7499/j.issn.1008-8830.2410006","DOIUrl":"10.7499/j.issn.1008-8830.2410006","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the impact of different treatment attitudes on the survival status of extremely preterm infants (EPIs) and evaluate the mortality and occurrence of severe complications in actively treated infants, as well as their risk factors.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on perinatal data of EPIs born between January 1, 2016, and December 31, 2023, who were admitted to the neonatal intensive care unit of Nanjing Women and Children's Healthcare Hospital within 24 hours after birth. The analysis focused on the attributable risk of mortality associated with different treatment attitudes in EPIs of varying gestational ages and birth weights. A multivariate logistic regression model was used to analyze the risk factors for mortality and severe complications in the actively treated group.</p><p><strong>Results: </strong>A total of 485 EPIs were included. As gestational age or birth weight increased, the attributable risk of mortality with care withdrawal increased. Active treatment significantly improved the survival status of EPIs born at a gestational age of ≥24 weeks. Multivariate logistic regression analysis indicated that lower gestational age and the need for mechanical ventilation within 72 hours after birth were independent risk factors for mortality or severe complications in EPIs (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Active treatment can significantly extend the survival time of EPIs born at a gestational age of ≥24 weeks. Lower gestational age and the need for mechanical ventilation within 72 hours after birth are closely associated with poor survival outcomes in EPIs.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 3","pages":"269-278"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}