【小剂量美罗华维持治疗儿童原发性肾病综合征的临床研究】。

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-08-15 DOI:10.7499/j.issn.1008-8830.2409131

Wen-Ting Peng, Xiao-Zhong Li

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引用次数: 0

摘要

目的：探讨低剂量利妥昔单抗（RTX）的临床疗效和安全性。方法：回顾性分析2016年7月至2024年3月苏州大学儿童医院肾免疫科接受低剂量利妥昔单抗治疗的PNS患儿的临床资料。分析RTX治疗前后的缓解率、复发率、皮质类固醇和他克莫司的使用情况及不良反应。结果：与治疗前相比，低剂量RTX维持了PNS的缓解，减少了复发频率，减少了糖皮质激素和他克莫司的剂量(pp结论：低剂量RTX治疗儿童PNS有效且安全。

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[Clinical study on low-dose rituximab maintenance therapy in children with primary nephrotic syndrome].

Objectives: To investigate the clinical efficacy and safety of low-dose rituximab (RTX) (<375 mg/m²) maintenance therapy in children with primary nephrotic syndrome (PNS).

Methods: A retrospective analysis was conducted on the clinical data of PNS children who received low-dose RTX therapy at the Department of Renal Immunology, Children's Hospital of Soochow University from July 2016 to March 2024. Remission rate, recurrence frequency, corticosteroid and tacrolimus usage, and adverse reactions before and after RTX treatment were analyzed.

Results: Compared with before treatment, low-dose RTX maintained remission in PNS, reduced the relapse frequency, and decreased the dosage of corticosteroids and tacrolimus (P<0.05). IgG levels did not significantly decrease, and no additional preventive anti-infective treatment was required.

Conclusions: Low-dose RTX therapy is effective and safe for treating PNS in children.

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.