中国当代儿科杂志最新文献

{"title":"[Value of exercise challenge testing in the diagnosis of cough variant asthma in children].","authors":"Dong-Lin Zhuang, Yong Feng, Yun-Xiao Shang","doi":"10.7499/j.issn.1008-8830.2408044","DOIUrl":"10.7499/j.issn.1008-8830.2408044","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the value of exercise challenge testing (ECT) in the diagnosis of cough variant asthma (CVA) in children.</p><p><strong>Methods: </strong>A prospective study was conducted on 78 children with chronic cough who were admitted between January 2023 and January 2024. ECT was performed, and clinical data were collected. According to the effect of bronchodilator treatment, the children were divided into a CVA group (44 children) and a non-CVA group (34 children), and the two groups were compared in terms of clinical characteristics, pulmonary function, and ECT results before treatment.</p><p><strong>Results: </strong>Compared with the non-CVA group, the CVA group had a significantly higher proportion of boys, a significantly higher proportion of children with exercise-induced chronic cough, a significantly higher level of fractional exhaled nitric oxide, and a significantly greater reduction in forced expiratory volume in 1 second (FEV₁) after ECT (<i>P</i><0.05). The regression analysis showed that exercise-induced chronic cough and the reduction in FEV₁ were risk factors for CVA (<i>P</i><0.05). A reduction in FEV₁ of 8.44% was the optimal cut-off value for ECT in the diagnosis of CVA, with an area under the curve of 0.751 (<i>P</i><0.05), a sensitivity of 65.9%, and a specificity of 79.4%. For the children with exercise-induced chronic cough, a reduction in FEV₁ of 8.44% was the optimal cut-off value for ECT in the diagnosis of CVA, with an area under the curve of 0.810 (<i>P</i><0.05), a sensitivity of 77.1%, and a specificity of 77.8%.</p><p><strong>Conclusions: </strong>ECT has clinical application value in the etiological diagnosis of pediatric chronic cough, with a reduction in FEV1 of 8.44% serving as the optimal cut-off value for diagnosing CVA. It is particularly suitable for children with exercise-induced chronic cough, increasing the sensitivity for CVA diagnosis.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 12","pages":"1288-1293"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics of cytokine release syndrome after haploidentical hematopoietic stem cell transplantation for thalassemia major].","authors":"Xiao-Hui Zhou, Xiao-Dong Wang, Qi-Hong Lin, Chun-Jing Wang, Chun-Lan Yang, Yue Li, Xiao-Ling Zhang, Yu Zhang, Yue Yu, Si-Xi Liu","doi":"10.7499/j.issn.1008-8830.2406036","DOIUrl":"10.7499/j.issn.1008-8830.2406036","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical characteristics of cytokine release syndrome (CRS) in children with thalassemia major (TM) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT) and their prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was performed for the clinical data of 280 children with TM who underwent haplo-HSCT in the Department of Hematology and Oncology, Shenzhen Children's Hospital, from January 2019 to December 2021. According to the CRS criteria, they were divided into two groups: CRS grade <3 (260 children) and CRS grade ≥3 (20 children). The children with TM were analyzed in terms of clinical characteristics of CRS after haplo-HSCT and their prognosis.</p><p><strong>Results: </strong>There were significant differences between the two groups in neutrophil engraftment time, clinical manifestations of CRS, and the rate of use of glucocorticoids within 4 days after haplo-HSCT (<i>P</i>=0.012, 0.040, and <0.001 respectively). For the CRS grade <3 group, the incidence rate of acute graft-versus-host disease (aGVHD) was 9.6% within 3 months after transplantation, while no aGVHD was observed in the CRS grade ≥3 group within 3 months after transplantation, but there was no significant difference in the incidence of aGVHD between the two groups within 3 months after transplantation (<i>P</i>=0.146). No transplantation-related death was observed in either group within 3 months after haplo-HSCT.</p><p><strong>Conclusions: </strong>The children with CRS grade≥3 have an early neutrophil engraftment time, severe and diverse clinical manifestations of CRS, and a high rate of use of glucocorticoids within 4 days after haplo-HSCT. For these children, early use of low-dose glucocorticoids after transplantation may alleviate CRS response and reduce the incidence of aGVHD, thereby bringing more benefits to the children. CRS after haplo-HSCT has no significant impact on the prognosis of the children.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 12","pages":"1301-1307"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction of a diagnostic model and scoring system for central precocious puberty in girls, with external validation].","authors":"Shi-Chao Qiu, Zhi-Hua Wang, Na Song, Ting Zhao, Yi-Hua Lian, Jia Yu, Ma-Li Li, Chao Liu","doi":"10.7499/j.issn.1008-8830.2405079","DOIUrl":"10.7499/j.issn.1008-8830.2405079","url":null,"abstract":"<p><strong>Objectives: </strong>To establish an efficient and clinically applicable predictive model and scoring system for central precocious puberty (CPP) in girls, and to develop a diagnostic prediction application.</p><p><strong>Methods: </strong>A total of 342 girls aged 4 to 9 years with precocious puberty were included, comprising 216 cases of CPP and 126 cases of isolated premature thelarche. Lasso regression was used to screen for predictive factors, and logistic regression was employed to establish the predictive model. Additionally, a scoring system was constructed using the evidence weight binning method. Data from 129 girls aged 4 to 9 years with precocious puberty were collected for external validation of the scoring system.</p><p><strong>Results: </strong>The logistic regression model incorporated five predictive factors: age, insulin-like growth factor-1 (IGF-1), serum follicle-stimulating hormone (FSH), the luteinizing hormone (LH)/FSH baseline ratio, and uterine thickness. The calculation formula was: ln(P/1-P)=-8.439 + 0.216 × age (years) + 0.008 × IGF-1 (ng/mL) + 0.159 × FSH (mIU/mL) + 9.779 × LH/FSH baseline ratio + 0.284 × uterine thickness (mm). This model demonstrated good discriminative ability (area under the curve=0.892) and calibration (Hosmer-Lemeshow test <i>P</i>>0.05). The scoring system based on this logistic regression model showed good discrimination in both the prediction model and external validation datasets, with areas under the curve of 0.895 and 0.805, respectively. Based on scoring system scores, the population was stratified into three risk levels: high, medium, and low. In the high-risk group, the prevalence of CPP exceeded 90%, while the proportion was lower in the medium and low-risk groups.</p><p><strong>Conclusions: </strong>The CPP diagnostic predictive model established for girls aged 4 to 9 years exhibits good diagnostic performance. The scoring system can effectively and rapidly stratify the risk of CPP, providing valuable reference for clinical decision-making.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 12","pages":"1267-1274"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of key points from the \"Expert Consensus on Diagnosis and Management of Neonatal Cow Milk Protein Allergy (2023)\"].","authors":"Xin-Yin Zhang, Li-Ting Liu, Lei Bao, Yuan Shi","doi":"10.7499/j.issn.1008-8830.2408079","DOIUrl":"10.7499/j.issn.1008-8830.2408079","url":null,"abstract":"<p><p>The clinical manifestations of cow's milk protein allergy (CMPA) in neonates are non-specific and involve multiple organ systems. CMPA may also adversely affect physical growth and central nervous system development in neonates, lead to functional disorders, and increase anxiety and stress among family members. Due to the lack of specific clinical manifestations and diagnostic methods, the diagnosis and management of CMPA in neonates continue to pose significant clinical challenges. To facilitate standardized diagnosis and treatment of CMPA in neonates, the Neonatology Group of the Pediatric Branch of the Chinese Medical Association and the Editorial Committee of the <i>Chinese Journal of Pediatrics</i> have jointly developed the \"Expert Consensus on Diagnosis and Management of Neonatal Cow's Milk Protein Allergy (2023)\". This article presents and interprets the key points of the consensus regarding dietary and nutritional management of CMPA in neonates.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1127-1134"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reflections on the clinical diagnosis and management of Turner syndrome].","authors":"Wei Gu, Xue Zhao","doi":"10.7499/j.issn.1008-8830.2407176","DOIUrl":"10.7499/j.issn.1008-8830.2407176","url":null,"abstract":"<p><p>There is a delay in the clinical diagnosis of Turner syndrome (TS), particularly for patients with mosaic karyotypes. This diagnostic delay can hinder age-appropriate treatments and lead to adverse health outcomes. Therefore, it is necessary to explore improvement measures for early diagnosis and treatment plans based on the current clinical situation. Furthermore, as research progresses, the focus of clinical diagnosis and treatment of TS is gradually expanding to multiple aspects, including cardiovascular health, fertility, and transitional care, in order to improve the prognosis and quality of life of the patients. This paper discusses the current clinical status and management key points of TS diagnosis and treatment, aiming to provide insights for improving the management of TS.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1135-1140"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Establishment of a population pharmacokinetic model for linezolid in neonates with sepsis].","authors":"Zong-Tai Feng, Lian Tang, Zu-Ming Yang, Chu-Chu Gao, Jia-Hui Li, Yan Cai, Lu-Fen Duan","doi":"10.7499/j.issn.1008-8830.2406078","DOIUrl":"10.7499/j.issn.1008-8830.2406078","url":null,"abstract":"<p><strong>Objectives: </strong>To establish the pharmacokinetic model of linezolid in neonates, and to optimize the administration regimen.</p><p><strong>Methods: </strong>A prospective study was conducted among 64 neonates with sepsis who received linezolid as anti-infective therapy, and liquid chromatography-tandem mass spectrometry was used to measure the plasma concentration of the drug. Clinical data were collected, and nonlinear mixed effects modeling was used to establish a population pharmacokinetic (PPK) model. Monte Carlo simulation and evaluation was performed for the optimal administration regimen of children with different features.</p><p><strong>Results: </strong>The pharmacokinetic properties of linezolid in neonates could be described by a single-compartment model with primary elimination, and the population typical values for apparent volume of distribution and clearance rate were 0.79 L and 0.34 L/h, respectively. The results of goodness of fit, visualization verification, and the Bootstrap method showed that the model was robust with reliable results of parameter estimation and prediction. Monte Carlo simulation results showed that the optimal administration regimen for linezolid in neonates was as follows: 6 mg/kg, q8h, at 28 weeks of gestational age (GA); 8 mg/kg, q8h, at 32 weeks of GA; 9 mg/kg, q8h, at 34-37 weeks of GA; 11 mg/kg, q8h, at 40 weeks of GA.</p><p><strong>Conclusions: </strong>The PPK model established in this study can provide a reference for individual administration of linezolid in neonates. GA and body weight at the time of administration are significant influencing factors for the clearance rate of linezolid in neonates.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1162-1168"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[CHARGE syndrome in a neonate].","authors":"Bo Gao, Shu Xiao, Xiao-Wen Chen, Ru Li, Ling Wang","doi":"10.7499/j.issn.1008-8830.2406105","DOIUrl":"10.7499/j.issn.1008-8830.2406105","url":null,"abstract":"<p><p>A female infant, aged 11 days, was admitted due to dyspnea for 11 days after birth, with the main clinical manifestations of inspiratory dyspnea, feeding difficulties, and unusual facies (micrognathia, high palatal arch, cleft palate, glossoptosis, and oblique mouth to the right), and the preliminary diagnosis was Pierre-Robin syndrome. There was no marked improvement after treatment such as ventilator-assisted ventilation, nutrition, and surgical ligation of patent ductus arteriosus. Whole-exome sequencing of the family showed a heterozygous mutation of c.3082A>G (p.Ile1028 Val) in the <i>CHD7</i> gene, which was a pathogenic mutation of CHARGE syndrome. The neonate was ultimately diagnosed with CHARGE syndrome, and the family decided to withdraw treatment due to concerns about poor prognosis. This article reports a case of CHARGE syndrome caused by a mutation in the <i>CHD7</i> gene and the multidisciplinary diagnosis and treatment of this disease, in order to provide help for early disease identification and guide clinical decision-making.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1238-1244"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and nutritional status of children with Crohn's disease and risk factors for malnutrition].","authors":"Dong-Dan Li, Xiao-Lin Ye, Mei-Chen Wang, Hong-Mei Huang, Jie Yan, Tian-Zhuo Zhang, Fei-Hong Yu, De-Xiu Guan, Wen-Li Yang, Lu-Lu Xia, Jie Wu","doi":"10.7499/j.issn.1008-8830.2407056","DOIUrl":"10.7499/j.issn.1008-8830.2407056","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the nutritional status of children with Crohn's Disease (CD) at diagnosis and its association with clinical characteristics.</p><p><strong>Methods: </strong>A retrospective analysis was performed for the clinical data and nutritional status of 118 children with CD who were admitted to Beijing Children's Hospital, Capital Medical University, from January 2016 to January 2024. A multivariate logistic regression analysis was used to investigate the risk factors for malnutrition.</p><p><strong>Results: </strong>A total of 118 children with CD were included, among whom there were 68 boys (57.6%) and 50 girls (42.4%), with a mean age of (11±4) years. Clinical symptoms mainly included recurrent abdominal pain (73.7%, 87/118), diarrhea (37.3%, 44/118), and hematochezia (32.2%, 38/118), and 63.6% (75/118) of the children had weight loss at diagnosis. The incidence rate of malnutrition was 63.6% (75/118), and the children with moderate or severe malnutrition accounted for 67% (50/75). There were 50 children (42.4%) with emaciation, 8 (6.8%) with growth retardation, and 9 (7.6%) with overweight or obesity. Measurement of nutritional indices showed a reduction in serum albumin in 83 children (70.3%), anemia in 74 children (62.7%), and a reduction in 25 hydroxyvitamin D in 15 children (60%, 15/25). The children with malnutrition had significantly higher disease activity, proportion of children with intestinal stenosis, and erythrocyte sedimentation rate and a significant reduction in serum albumin (<i>P</i><0.05). The multivariate logistic regression analysis showed that intestinal stenosis was an independent risk factor for malnutrition in children with CD (<i>OR</i>=4.416, <i>P</i><0.05).</p><p><strong>Conclusions: </strong>There is a high incidence rate of malnutrition in children with CD at diagnosis, which is associated with disease activity and disease behavior. The nutritional status of children with CD should be closely monitored.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1194-1201"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and risk factors of carbapenem-resistant <i>Pseudomonas aeruginosa</i> infection in children].","authors":"Yi-Lu Peng, Hong-Mei Wang, Chi Li, Jiao-Sheng Zhang, Li-Feng Qi","doi":"10.7499/j.issn.1008-8830.2407020","DOIUrl":"10.7499/j.issn.1008-8830.2407020","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical characteristics of carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CRPA) infection in children and the risk factors for such infection.</p><p><strong>Methods: </strong>A retrospective analysis was conducted among 60 children with CRPA infection (CRPA group) who were hospitalized in Shenzhen Children's Hospital, China Medical University, from January 2018 to September 2023, and 82 children with carbapenem-sensitive <i>Pseudomonas aeruginosa</i> infection during the same period were randomly selected as the control group. A multivariate logistic regression analysis was used to investigate the risk factors for CRPA infection.</p><p><strong>Results: </strong>Among the 60 children with CRPA infection, 31 (52%) were admitted to the intensive care unit (ICU), and the lower respiratory tract was the main detection site in 32 children (53%). The univariate analysis showed that sex, history of invasive treatment within 1 year, antibiotic use before admission, presence of underlying condition, ICU admission, invasive procedure after admission, antibiotic use for >14 days, and the type of antibiotics used of ≥3 were associated with CRPA infection (<i>P</i><0.05). The multivariate logistic regression analysis showed that the history of invasive treatment within 1 year (<i>OR</i>=3.228, <i>P</i><0.05), antibiotic use before admission (<i>OR</i>=4.052, <i>P</i><0.05), antibiotic use for >14 days (<i>OR</i>=4.961, <i>P</i><0.05), and the type of antibiotics used of ≥3 (<i>OR</i>=3.687, <i>P</i><0.05) were independent risk factors for CRPA infection in children.</p><p><strong>Conclusions: </strong>CRPA infection in children may be associated with a history of invasive treatment within the past year, antibiotic use before admission, duration of antibiotic use after admission, and the diversity of antibiotic types used.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1169-1175"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Neurodevelopmental catch-up status and correction termination age in preterm infants of different gestational ages].","authors":"Wang Cheng, Cheng-Ju Wang, Ya-Li Shen, Zhi-Feng Wu, Yu-Ping Zhang","doi":"10.7499/j.issn.1008-8830.2406049","DOIUrl":"10.7499/j.issn.1008-8830.2406049","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the status of neurodevelopmental catch-up and suitable correction termination age in preterm infants of different gestational ages.</p><p><strong>Methods: </strong>A total of 918 preterm infants without significant high-risk factors who attended the outpatient service of the Second Affiliated Hospital of Army Medical University from January 1, 2018 to March 1, 2023 were included. The data on developmental quotient (DQ) in Gesell Developmental Schedule (GDS) were collected, while 6 684 full-term infants were included as controls. According to the gestational age, the infants were divided into preterm groups (early preterm, moderate preterm, and late preterm births) and a full-term group, and these groups were compared in terms of DQ of each functional area and its changing trend with 48 months of chronological age.</p><p><strong>Results: </strong>The DQ values of all functional areas showed a catch-up trend from 6 months to 48 months of chronological age in each preterm group (<i>P</i><0.05). There were no significant differences in the DQ values of all functional areas between the late preterm and full-term groups at the chronological age of 36 months (<i>P</i>>0.05). There were significant differences in the DQ values of most functional areas between the moderately/early preterm groups and the full-term group at the chronological age of 36 months (<i>P</i><0.05), but no significant differences were found in the DQ values of all functions areas at the chronological age of 48 months (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>The correction termination age for neurodevelopment in preterm infants may need to extend beyond 36 months, and the smaller the gestational age, the longer the time required for correction.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 11","pages":"1141-1147"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}