Nanomedicine: Nanotechnology, Biology and Medicine最新文献_第3页

Corrigendum to “Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy” [Nanomedicine Nanotechnol Biol Med 29 (2020) 102240] “沉默腺苷A2a受体增强树突状细胞为基础的癌症免疫治疗”的更正[纳米医学纳米技术生物医学29 (2020)102240]

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-07-01 DOI: 10.1016/j.nano.2023.102690

Ali Masjedi MSc , Armin Ahmadi PhD , Sepideh Ghanee PhD , Farinaz Malakotikhah PhD , Mohsen Nabi Afjadi PhD , Mahzad Irandoust PhD , Fariba Karoon Kiani MSc , Sima Heydarzadeh Asl MSc , Fatemeh Atyabi PhD , Hadi Hassannia PhD , Mohammad Hojjat-Farsangi PhD , Afshin Namdar PhD , Ghasem Ghalamfarsa PhD , Farhad Jadidi-Niaragh PhD

引用次数: 0

Nanoscale metal-organic framework delivers rapamycin to induce tissue immunogenic cell death and potentiates cancer immunotherapy 纳米级金属有机框架递送雷帕霉素诱导组织免疫原性细胞死亡并增强癌症免疫治疗

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102678

Jihua Tian PhD , Jing Wang MMSc , Huanyu Xu MMSc , Bocheng Zou MMSc , Weihao Chen MMSc , Yulong Liu PhD , Jingshu Chen MMSc , Ruiping Zhang PhD

{"title":"Nanoscale metal-organic framework delivers rapamycin to induce tissue immunogenic cell death and potentiates cancer immunotherapy","authors":"Jihua Tian PhD , Jing Wang MMSc , Huanyu Xu MMSc , Bocheng Zou MMSc , Weihao Chen MMSc , Yulong Liu PhD , Jingshu Chen MMSc , Ruiping Zhang PhD","doi":"10.1016/j.nano.2023.102678","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102678","url":null,"abstract":"<div><p><span><span>Rapamycin<span> has great potential in the antitumor application, but its therapeutic effect is seriously affected by poor water solubility, targeting ability, and low bioavailability. Here, we constructed a novel composite nanomaterial with PCN-224 as a drug carrier and loaded rapamycin, named R@BP@HA. The nanoplate not only improves targeting, but also synergizes rapamycin with PCN-224 to effectively promote tumor cell </span></span>apoptosis, which subsequently causes </span>immunogenic cell death<span> (ICD), and shows strong therapeutic effect in 4T1 breast cancer model. The treatment<span><span><span> effect depends on three main points:(i)Proapoptotic effect of rapamycin on tumor cells;(ii)ROS production by PCN-224-mediated photodynamic therapy;(iii)ICD induced DC maturation, increased immune response and promoted </span>T cell proliferation and differentiation. This nanoplate offers potential antitumor efficacy in combination with chemotherapy, photodynamic therapy, and </span>immunotherapy.</span></span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102678"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3341941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Neutralization of the new coronavirus by extracting their spikes using engineered liposomes 利用工程脂质体提取新型冠状病毒的尖峰来中和新型冠状病毒

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102674

Zhenjiang Zhang Ph.D., Michael R. King Ph.D.

引用次数: 0

Anti-stokes luminescent organic nanoparticles for frequency upconversion biomedical imaging 用于上变频生物医学成像的抗斯托克斯发光有机纳米颗粒

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102668

Guobo Chen M.S. , Yuhao Li PhD , Jinliang Liu M.S. , Gang Huang MD, PhD , Qiwei Tian PhD

{"title":"Anti-stokes luminescent organic nanoparticles for frequency upconversion biomedical imaging","authors":"Guobo Chen M.S. , Yuhao Li PhD , Jinliang Liu M.S. , Gang Huang MD, PhD , Qiwei Tian PhD","doi":"10.1016/j.nano.2023.102668","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102668","url":null,"abstract":"<div><p>Frequency upconversion optical imaging has attracted great attention due to its remarkable advantages over traditional down-conversion optical imaging. However, the development of frequency upconversion optical imaging is extremely limited. Herein, five derivatives with BODIPY structure (B1–B5) were developed to investigate its frequency upconversion luminescence (FUCL) performance by introducing electron-donating and electron-withdrawing groups. Except for the nitro group decorated derivative, the other derivatives have strong and stable FUCL around 520 nm under 635 nm light excitation. More importantly, B5 retains FUCL ability after self-assembly. When applied to FUCL imaging of cells, B5 nanoparticles can be enriched in the cytoplasm and show a good signal-to-noise ratio. Meanwhile, FUCL tumor imaging can be achieved after 1 h of injection. This study not only provides a potential agent for FUCL biomedical imaging but also develops a new strategy for designing FUCL agents that exhibit excellent performance.</p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102668"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3457434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis 肽功能化治疗纳米平台治疗原位三阴性乳腺癌及骨转移

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102669

Daifeng Li Ph.D., M.D. , Shengnan Ma Ph.D., M.D. , Denghui Xu M.D. , Xiaocao Meng Ph.D. , Ningjing Lei Ph.D. , Chen Liu Ph.D. , Ying Zhao Ph.D. , Yingqiu Qi Ph.D. , Zhen Cheng Ph.D. , Fazhan Wang Ph.D.

{"title":"Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis","authors":"Daifeng Li Ph.D., M.D. , Shengnan Ma Ph.D., M.D. , Denghui Xu M.D. , Xiaocao Meng Ph.D. , Ningjing Lei Ph.D. , Chen Liu Ph.D. , Ying Zhao Ph.D. , Yingqiu Qi Ph.D. , Zhen Cheng Ph.D. , Fazhan Wang Ph.D.","doi":"10.1016/j.nano.2023.102669","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102669","url":null,"abstract":"<div><p><span><span>Epidermal Growth Factor Receptor (EGFR) is a promising therapeutic target for triple-negative breast cancer (TNBC). Recently, specific EGFR-targeting peptide GE11-based delivery nano-system shows excellent potential because of its chemical versatility and good targeting ability. However, no further research focusing on the downstream of EGFR after binding with GE11 was explored. Hence, we tailor-designed a self-assembled nanoplatform named GENP using </span>amphiphilic molecule of stearic acid-modified GE11. After loading </span>doxorubicin<span><span><span> (DOX), the resulted nanoplatform GENP@DOX demonstrated high loading efficiency and sustainable drug release. Importantly, our findings proved that GENP alone significantly suppressed the proliferation of MDA-MB-231 cells via EGFR-downstream PI3K/AKT signaling pathways, contributing to the synergistic </span>treatment with its DOX release. Further work illustrated remarkable therapeutic efficacy both in orthotopic TNBC and its </span>bone metastasis models with minimal biotoxicity. Together, the results highlight that our GENP-functionalized nanoplatform is a promising strategy for the synergistic therapeutic efficacy targeting EGFR-overexpressed cancer.</span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102669"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3457435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells 聚苯乙烯微塑料和纳米塑料对不含和含M细胞的人肠道类器官上皮组织模型的生物学效应

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102680

Ying Chen PhD , Ashleigh M. Williams MSc , Edward B. Gordon BS , Sara E. Rudolph BS , Brooke N. Longo MSc , Gang Li PhD , David L. Kaplan PhD

{"title":"Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells","authors":"Ying Chen PhD , Ashleigh M. Williams MSc , Edward B. Gordon BS , Sara E. Rudolph BS , Brooke N. Longo MSc , Gang Li PhD , David L. Kaplan PhD","doi":"10.1016/j.nano.2023.102680","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102680","url":null,"abstract":"<div><p>Micro- and nano-plastics (MPs and NPs) released from plastics in the environment can enter the food chain and target the human intestine. However, knowledge about the effects of these particles on the human intestine is still limited due to the lack of relevant human intestinal models to validate data obtained from animal studies or tissue models employing cancer cells<span><span>. In this study, human intestinal organoids<span> were used to develop epithelia to mimic the cell complexity and functions of native tissue. Microfold cells (M cells) were induced to distinguish their role when exposure to MPs and </span></span>NPs<span>. During the exposure, the M cells acted as sensors, capturers and transporters of larger sized particles. The epithelial cells internalized the particles in a size-, concentration-, and time-dependent manner. Importantly, high concentrations of particles significantly triggered the secretion of a panel of inflammatory cytokines<span> linked to human inflammatory bowel disease (IBD).</span></span></span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102680"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3457438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of local immunogenic cell death-inducing chemotherapy and DNA vaccine increases the survival of glioblastoma-bearing mice 局部免疫原性细胞死亡诱导化疗和DNA疫苗联合使用可提高患胶质母细胞瘤小鼠的存活率

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102681

Mathilde Bausart PhD, Giulia Rodella MsC, Mathilde Dumont Student, Bernard Ucakar Technician, Kevin Vanvarenberg Technician, Alessio Malfanti PhD, Véronique Préat PhD

{"title":"Combination of local immunogenic cell death-inducing chemotherapy and DNA vaccine increases the survival of glioblastoma-bearing mice","authors":"Mathilde Bausart PhD, Giulia Rodella MsC, Mathilde Dumont Student, Bernard Ucakar Technician, Kevin Vanvarenberg Technician, Alessio Malfanti PhD, Véronique Préat PhD","doi":"10.1016/j.nano.2023.102681","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102681","url":null,"abstract":"<div><p><span><span>Immunotherapy efficacy as </span>monotherapy is negligible for </span>glioblastoma<span><span><span> (GBM). We hypothesized that combining therapeutic vaccination using a plasmid encoding an epitope derived from GBM-associated antigen (pTOP) with local delivery of immunogenic chemotherapy using mitoxantrone-loaded PEGylated PLGA-based nanoparticles (NP-MTX) would improve the survival of GBM-bearing mice by stimulating an antitumor immune response. We first proved that </span>MTX retained its ability to induce cytotoxicity and </span>immunogenic cell death<span><span> of GBM cells after encapsulation. Intratumoral delivery of MTX or NP-MTX increased the frequency of IFN-γ-secreting CD8 T cells<span>. NP-MTX mixed with free MTX in combination with pTOP DNA vaccine increased the median survival of GL261-bearing mice and increased M1-like macrophages in the brain. The addition of </span></span>CpG to this combination abolished the survival benefit but led to increased M1 to M2 macrophage ratio and IFN-γ-secreting CD4 T cell frequency. These results highlight the benefits of combination strategies to potentiate immunotherapy and improve GBM outcome.</span></span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102681"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3457439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The influence of pure (ligandless) magnetite nanoparticles functionalization on blood gases and electrolytes in acute blood loss 纯(无配体)磁铁矿纳米颗粒功能化对急性失血血气和电解质的影响

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102675

Elena Vazhnichaya D.Sc. , Stanislav Lytvyn Ph.D. , Yurii Kurapov Ph.D. , Oleksandr Semaka M.D., Ph.D. , Ruslan Lutsenko D.Sc. , Alexander Chunikhin Ph.D.

{"title":"The influence of pure (ligandless) magnetite nanoparticles functionalization on blood gases and electrolytes in acute blood loss","authors":"Elena Vazhnichaya D.Sc. , Stanislav Lytvyn Ph.D. , Yurii Kurapov Ph.D. , Oleksandr Semaka M.D., Ph.D. , Ruslan Lutsenko D.Sc. , Alexander Chunikhin Ph.D.","doi":"10.1016/j.nano.2023.102675","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102675","url":null,"abstract":"<div><p>Objective was to compare the effect of functionalization of magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles (NPs) with sodium chloride (NaCl), or its combination with ethylmethylhydroxypyrydine succinate (EMHPS) and polyvinylpyrrolidone (PVP) on blood gases and electrolytes in acute blood loss. Ligandless magnetite NPs were synthesized by the electron beam technology and functionalized by mentioned agents. Size of NPs in colloidal solutions Fe<sub>3</sub>O<sub>4</sub>@NaCl, Fe<sub>3</sub>O<sub>4</sub>@NaCl@EMHPS, Fe<sub>3</sub>O<sub>4</sub>@NaCl@PVP, Fe<sub>3</sub>O<sub>4</sub>@NaCl@EMHPS@PVP (nanosystems 1–4) was determined by dynamic light scattering. <em>In vivo</em> experiments were performed on 27 Wistar rats. Acute blood loss was modeled by removal 25 % circulating blood. Nanosystems 1–4 were administered to animals intaperitoneally after the blood loss with followed determination of blood gases, pH and electrolytes. In blood loss, nanosystems Fe<sub>3</sub>O<sub>4</sub>@NaCl and Fe<sub>3</sub>O<sub>4</sub>@NaCl@PVP were able to improve the state of blood gases, pH, and the ratio of sodium/potassium in the blood. So, magnetite NPs with a certain surface modification can promote oxygen transport under hypoxic conditions.</p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102675"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2377482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy angiopep -2-共轭FeTi@Au核壳纳米颗粒用于肿瘤靶向双模磁共振成像和高温胶质瘤治疗

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102673

Senthilkumar Thirumurugan MSc , Pranjyan Dash MSc , Xinrui Liu MDPhD , Yuan-Yun Tseng MDPhD , Jui-Hua Chung MSc , Yunqian Li MDPhD , Gang Zhao MDPhD , Chingpo Lin PhD , Yu-Chien Lin PhD , Ren-Jei Chung PhD

{"title":"Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy","authors":"Senthilkumar Thirumurugan MSc , Pranjyan Dash MSc , Xinrui Liu MDPhD , Yuan-Yun Tseng MDPhD , Jui-Hua Chung MSc , Yunqian Li MDPhD , Gang Zhao MDPhD , Chingpo Lin PhD , Yu-Chien Lin PhD , Ren-Jei Chung PhD","doi":"10.1016/j.nano.2023.102673","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102673","url":null,"abstract":"<div><p><span>Herein, we fabricated gold surface-coated iron titanium core-shell (FeTi@Au) nanoparticles<span><span> (NPs) with conjugation of angiopep-2 (ANG) (FeTi@Au-ANG) NPs for targeted delivery and improved NPs penetration by receptor-mediated endocytosis to achieve hyperthermic </span>treatment<span><span> of gliomas. The synthesized “core-shell” FeTi@Au-ANG NPs exhibited spherical in shape with around 16 </span>nm particle size and increased temperature upon alternating magnetic field (AMF) stimulation, rendering them effective for localized hyperthermic therapy of </span></span></span>cancer cells<span><span>. Effective targeted delivery of FeTi@Au-ANG NPs was demonstrated in vitro by improved transport and cellular uptake, and increased apoptosis<span> in glioma cells<span> (C6) compared with normal fibroblast cells (L929). FeTi@Au-ANG NPs exhibited higher deposition in brain tissues and a superior therapeutic effect in an orthotopic intracranial </span></span></span>xenograft mouse model. Taken together, our data indicate that FeTi@Au-ANG NPs hold significant promise as a targeted delivery strategy for glioma treatment using hyperthermia.</span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102673"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1567231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ursolic acid nanoparticles for glioblastoma therapy 熊果酸纳米颗粒用于胶质母细胞瘤治疗

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI: 10.1016/j.nano.2023.102684

Yong Li MD , Linyao Zhao MSc , Qingyu Zhao MSc, Youdong Zhou MD, Long Zhou MD, Ping Song MD, Baohui Liu PhD, Qianxue Chen PhD, Gang Deng MD

{"title":"Ursolic acid nanoparticles for glioblastoma therapy","authors":"Yong Li MD , Linyao Zhao MSc , Qingyu Zhao MSc, Youdong Zhou MD, Long Zhou MD, Ping Song MD, Baohui Liu PhD, Qianxue Chen PhD, Gang Deng MD","doi":"10.1016/j.nano.2023.102684","DOIUrl":"https://doi.org/10.1016/j.nano.2023.102684","url":null,"abstract":"<div><h3>Background</h3><p><span>Glioblastoma multiforme (GBM) is the most common and fatal primary tumor in the </span>central nervous system<span><span><span> (CNS). The effect of chemotherapy of GBM is limited due to the existence of blood-brain barrier (BBB). The aim of this study is to develop self-assembled nanoparticles (NPs) of </span>ursolic acid (UA) for GBM </span>treatment.</span></p></div><div><h3>Methods</h3><p><span>UA NPs were synthesized by solvent volatilization<span> method. Western blot analysis<span> fluorescent staining and flow cytometry were launched to explore the anti-glioblastoma mechanism of UA NPs. The antitumor effects of UA NPs were further confirmed in vivo using intracranial </span></span></span>xenograft models.</p></div><div><h3>Results</h3><p>UA were successfully prepared. In vitro, UA NPs could significantly increase the protein levels of cleaved-caspase 3 and LC3-II to strongly eliminate glioblastoma cells through autophagy and apoptosis. In the intracranial xenograft models, UA NPs could further effectively enter the BBB, and greatly improve the survival time of the mice.</p></div><div><h3>Conclusions</h3><p>We successfully synthesized UA NPs which could effectively enter the BBB and show strong anti-tumor effect which may have great potential in the treatment of human glioblastoma.</p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"50 ","pages":"Article 102684"},"PeriodicalIF":5.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3341939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1