Rapamycin has great potential in the antitumor application, but its therapeutic effect is seriously affected by poor water solubility, targeting ability, and low bioavailability. Here, we constructed a novel composite nanomaterial with PCN-224 as a drug carrier and loaded rapamycin, named R@BP@HA. The nanoplate not only improves targeting, but also synergizes rapamycin with PCN-224 to effectively promote tumor cell apoptosis, which subsequently causes immunogenic cell death (ICD), and shows strong therapeutic effect in 4T1 breast cancer model. The treatment effect depends on three main points:(i)Proapoptotic effect of rapamycin on tumor cells;(ii)ROS production by PCN-224-mediated photodynamic therapy;(iii)ICD induced DC maturation, increased immune response and promoted T cell proliferation and differentiation. This nanoplate offers potential antitumor efficacy in combination with chemotherapy, photodynamic therapy, and immunotherapy.
公司名称 | 产品信息 | 采购帮参考价格 |
---|---|---|
麦克林 |
rapamycin
|
¥41.90~¥37500.00 |
上海吉至 |
DMF
|
¥20.00~¥28418.73 |
索莱宝 |
MTT
|
¥31.00~¥19724.00 |
麦克林 |
TCPP
|
¥27.00~¥8976.00 |
阿拉丁 |
BSA
|
¥9.00~¥3080.00 |
索莱宝 |
MTT
|
|
上海源叶 |
dialysis bag
|
|
上海源叶 |
dialysis bag
|
|
麦克林 |
rapamycin
|
|
麦克林 |
TCPP
|
|
阿拉丁 |
BSA
|
|
阿拉丁 |
ZrOCl? ? 8H?O
|
|
阿拉丁 |
Benzoicacid
|
|
阿拉丁 |
HA
|
|
阿拉丁 |
ZrOCl??8H?O
|
|
阿拉丁 |
Benzoicacid (BA)
|
|
阿拉丁 |
HA
|