Nanomedicine: Nanotechnology, Biology and Medicine最新文献_第10页

Peptide mediated targeted delivery of gold nanoparticles into the demyelination site ameliorates myelin impairment and gliosis 肽介导的靶向递送金纳米颗粒到脱髓鞘部位改善髓磷脂损伤和胶质瘤

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 Epub Date: 2022-10-10 DOI: 10.1016/j.nano.2022.102609

Sahar Farhangi MSc , Elham Karimi MSc , Khosro Khajeh PhD , Saman Hosseinkhani PhD , Mohammad Javan PhD

{"title":"Peptide mediated targeted delivery of gold nanoparticles into the demyelination site ameliorates myelin impairment and gliosis","authors":"Sahar Farhangi MSc , Elham Karimi MSc , Khosro Khajeh PhD , Saman Hosseinkhani PhD , Mohammad Javan PhD","doi":"10.1016/j.nano.2022.102609","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102609","url":null,"abstract":"<div>Drug development for multiple sclerosis (MS) clinical management focuses on both neuroprotection and repair strategies, and is challenging due to low permeability of the blood-brain barrier, off-target distribution, and the need for high doses of drugs. The changes in the extracellular matrix have been documented in MS patients. It has been shown that the expression of nidogen-1 increases in MS lesions. Laminin forms a stable complex with nidogen-1 through a heptapeptide which was selected to target the lesion area in this study. Here we showed that the peptide binding was specific to the injured area following lysophosphatidylcholine (LPC) induced demyelination. In vivo data showed enhanced delivery of the peptide-functionalized gold nanoparticles (Pep-GNPs) to the lesion area. In addition, Pep-GNPs administration significantly enhanced myelin content and reduced astrocyte/microglia activation. Results demonstrated the possibility of using this peptide to target and treat lesions in patients suffering from MS.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"47 ","pages":"Article 102609"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3342725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

PASylation improves pharmacokinetic of liposomes and attenuates anti-PEG IgM production: An alternative to PEGylation 聚乙二醇化改善脂质体的药代动力学和减弱抗peg IgM的产生:聚乙二醇化的替代品

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 Epub Date: 2022-10-21 DOI: 10.1016/j.nano.2022.102622

Qianyu Zhang PhD , Sai Li BS , Wen Wu PhD , Xuefeng Xia PhD , Jinqiang Zhang PhD

{"title":"PASylation improves pharmacokinetic of liposomes and attenuates anti-PEG IgM production: An alternative to PEGylation","authors":"Qianyu Zhang PhD , Sai Li BS , Wen Wu PhD , Xuefeng Xia PhD , Jinqiang Zhang PhD","doi":"10.1016/j.nano.2022.102622","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102622","url":null,"abstract":"<div>PASylation, which was recently reported as the conjugation of pharmacologically active compounds with polypeptide sequences mainly made of proline, alanine and serine, has been proposed as an alternative to PEGylation. In this study, we designed PAS-modified liposomes (PASylated liposomes) and studied the effect of the incorporation of PAS-lipid on the stability and pharmacokinetic properties of liposomes, and compared them both in vitro and in vivo to PEGylated liposomes. Results showed that PASylated liposomes modified with single-chained PAS-lipid C16-(PA3)7 (SC-PAS-Lip) showed comparable storage and serum stability to PEGylated liposomes (PEG-Lip), and a significantly decreased macrophage uptake compared with unmodified liposomes. SC-PAS-Lip displayed long circulating pharmacokinetic profile which was not impacted by the repeated administration of liposomes, and they were less likely to induce the production of anti-PEG IgM compared with PEGylated liposomes, presenting PASylation as an alternative liposome modification strategy to PEGylation.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"47 ","pages":"Article 102622"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1567238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging 一种新的表面功能化平台，为靶向治疗和诊断成像提供细胞外囊泡

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 Epub Date: 2022-09-24 DOI: 10.1016/j.nano.2022.102607

Besmira Sabani MSc , Michael Brand PhD , Ina Albert Dr. scient. med. , Joelle Inderbitzin MSc , Fritz Eichenseher PhD , Mathias Schmelcher PhD , Jack Rohrer PhD , Rainer Riedl PhD , Steffi Lehmann PhD

{"title":"A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging","authors":"Besmira Sabani MSc , Michael Brand PhD , Ina Albert Dr. scient. med. , Joelle Inderbitzin MSc , Fritz Eichenseher PhD , Mathias Schmelcher PhD , Jack Rohrer PhD , Rainer Riedl PhD , Steffi Lehmann PhD","doi":"10.1016/j.nano.2022.102607","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102607","url":null,"abstract":"<div>Extracellular vesicles (EVs), nanovesicles released by cells to effectively exchange biological information, are gaining interest as drug delivery system. Yet, analogously to liposomes, they show short blood circulation times and accumulation in the liver and the spleen. For tissue specific delivery, EV surfaces will thus have to be functionalized. We present a novel platform for flexible modification of EVs with target-specific ligands based on the avidin-biotin system. Genetic engineering of donor cells with a glycosylphosphatidylinositol-anchored avidin (GPI-Av) construct allows the isolation of EVs displaying avidin on their surface, functionalized with any biotinylated ligand. For proof of concept, GPI-Av EVs were modified with i) a biotinylated antibody or ii) de novo designed and synthesized biotinylated ligands binding carbonic anhydrase IX (CAIX), a membrane associated enzyme overexpressed in cancer. Functionalized EVs showed specific binding and uptake by CAIX-expressing cells, demonstrating the power of the system to prepare EVs for cell-specific drug delivery.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"47 ","pages":"Article 102607"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3021364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Diethyldithiocarbamate copper nanoparticle overcomes resistance in cancer therapy without inhibiting P-glycoprotein 二乙基二硫代氨基甲酸铜纳米颗粒在不抑制p糖蛋白的情况下克服了癌症治疗的耐药性

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 Epub Date: 2022-10-18 DOI: 10.1016/j.nano.2022.102620

Xuejia Kang Ms , Junwei Wang Ms , Chung-Hui Huang Bs , Fajar Setyo Wibowo Ms , Rajesh Amin PhD , Pengyu Chen PhD , Feng Li PhD

{"title":"Diethyldithiocarbamate copper nanoparticle overcomes resistance in cancer therapy without inhibiting P-glycoprotein","authors":"Xuejia Kang Ms , Junwei Wang Ms , Chung-Hui Huang Bs , Fajar Setyo Wibowo Ms , Rajesh Amin PhD , Pengyu Chen PhD , Feng Li PhD","doi":"10.1016/j.nano.2022.102620","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102620","url":null,"abstract":"<div>Copper diethyldithiocarbamate [Cu(DDC)2] is a promising anticancer agent. However, its poor water solubility is a significant obstacle to clinical application. In previous studies, we developed a stabilized metal ion ligand complex (SMILE) method to prepare Cu(DDC)2 nanoparticle (NP) to address the drug delivery challenge. In the current study, we investigate the use of Cu(DDC)2 NP for treating P-glycoprotein (P-gp) mediated drug-resistant cancers. We tested its anticancer efficacy with extensive in vitro cell-based assays and in vivo xenograft tumor model. We also explored the mechanism of overcoming drug resistance by Cu(DDC)2 NP. Our results indicate that Cu(DDC)2 NP is not a substrate of P-gp and thus can avoid P-gp mediated drug efflux. Further, the Cu(DDC)2 NP does not inhibit the activity or the expression of P-gp.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"47 ","pages":"Article 102620"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3210034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Simultaneously ultrasensitive and quantitative detection of influenza A virus, SARS-CoV-2, and respiratory syncytial virus via multichannel magnetic SERS-based lateral flow immunoassay 基于多通道磁sers横向流动免疫分析法同时超灵敏定量检测甲型流感病毒、SARS-CoV-2和呼吸道合胞病毒

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 Epub Date: 2022-11-01 DOI: 10.1016/j.nano.2022.102624

Zhenzhen Liu MSc, Chongwen Wang PhD, Shuai Zheng PhD, Xingsheng Yang PhD, Han Han MSc, Yuwei Dai MSc, Rui Xiao PhD

{"title":"Simultaneously ultrasensitive and quantitative detection of influenza A virus, SARS-CoV-2, and respiratory syncytial virus via multichannel magnetic SERS-based lateral flow immunoassay","authors":"Zhenzhen Liu MSc, Chongwen Wang PhD, Shuai Zheng PhD, Xingsheng Yang PhD, Han Han MSc, Yuwei Dai MSc, Rui Xiao PhD","doi":"10.1016/j.nano.2022.102624","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102624","url":null,"abstract":"<div>Respiratory viruses usually induced similar clinical symptoms at early infection. Herein, we presented a multichannel surface-enhanced Raman scattering-based lateral flow immunoassay (SERS-based LFA) using high-performance magnetic SERS tags for the simultaneous ultrasensitive detection of respiratory viruses, namely influenza A virus (H1N1), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and respiratory syncytial virus (RSV) in biological samples. As-prepared magnetic SERS tags can directly enrich and capture target viruses without pretreatment of samples, avoiding the interference of impurities in the samples as well as improving the sensitivity. With the capture-detection method, the detection limits of the proposed assay reached 85 copies mL−1, 8 pg mL−1, and 8 pg mL−1 for H1N1, SARS-CoV-2 and RSV, respectively. Moreover, the detection properties of the proposed method for target viruses in throat swab samples were verified, suggesting its remarkable potential for the early and rapid differential diagnosis of respiratory viruses.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"47 ","pages":"Article 102624"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3457447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Corrigendum to “Novel oral nano-hepatic targeted anti-PCSK9 in hypercholesterolemia” [Nanomedicine 40 (2022 Feb); 102480. doi: 10.1016/j.nano.2021.102480] “新型口服纳米肝靶向抗pcsk9治疗高胆固醇血症”的勘误表[纳米医学40(2022年2月);102480. doi: 10.1016 / j.nano.2021.102480]

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2022-11-01 Epub Date: 2022-09-21 DOI: 10.1016/j.nano.2022.102602

Taher A. Salaheldin PhD , Kavitha Godugu PhD , Dhruba J. Bharali PhD , Kazutoshi Fujioka PhD , Nabil Elshourbagy PhD, FAHA , Shaker A. Mousa PhD, MBA, FACC, FACB

引用次数: 0

Downregulation of exosomal MHC-I promotes glioma cells escaping from systemic immunosurveillance 外泌体MHC-I的下调促进胶质瘤细胞逃离全身免疫监视

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2022-11-01 Epub Date: 2022-09-13 DOI: 10.1016/j.nano.2022.102605

Ting Sun PhD , Yanyan Li MSc , Jie Wu MA , Yufei Cao MA , Ying Yang MSc , Yuping He MSc , Wenpeng Huang MSc , Bin Liu MSc , Wei Yang MD, PhD

{"title":"Downregulation of exosomal MHC-I promotes glioma cells escaping from systemic immunosurveillance","authors":"Ting Sun PhD , Yanyan Li MSc , Jie Wu MA , Yufei Cao MA , Ying Yang MSc , Yuping He MSc , Wenpeng Huang MSc , Bin Liu MSc , Wei Yang MD, PhD","doi":"10.1016/j.nano.2022.102605","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102605","url":null,"abstract":"<div>Tumor-derived exosomes are capable of inducing immune dysfunction and favoring the formation and progression of tumor. The major histocompatibility complex class I (MHC-I) plays a key role in antitumor immune responses by presenting tumor antigens to cytotoxic T lymphocytes. However, the role of tumor-derived circulating exosomal MHC-I on immune system activation remains unclear. We demonstrated that low level of glioma cells-derived exosomal MHC-I was associated with the dysfunction of CD8+ T cells in immune activation and cytotoxicity. MHC-I upregulation in exosomes restored antigen presentation of glioma cells and activated CD8+ T cells to exert robust antitumor immune response in combination with immune checkpoint blockade. Collectively, these data provided evidences for an important interplay between exosomal MHC-I and CD8+ T cells to activate systemic antitumor immune response, and interpreted how glioma cells evaded immunosurveillance, induced immunosuppression and were resistant to immunotherapy from the perspective of systemic immunity.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"46 ","pages":"Article 102605"},"PeriodicalIF":5.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3342727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease 梅尼埃氏病潜在的基于纳米技术的诊断和治疗方法

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2022-11-01 Epub Date: 2022-09-05 DOI: 10.1016/j.nano.2022.102599

Afsaneh Kashizadeh MSc , Christopher Pastras PhD , Navid Rabiee PhD , Masoud Mohseni-Dargah MSc , Payal Mukherjee MD, PhD , Mohsen Asadnia PhD

{"title":"Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease","authors":"Afsaneh Kashizadeh MSc , Christopher Pastras PhD , Navid Rabiee PhD , Masoud Mohseni-Dargah MSc , Payal Mukherjee MD, PhD , Mohsen Asadnia PhD","doi":"10.1016/j.nano.2022.102599","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102599","url":null,"abstract":"<div>Meniere's disease (MD) is a progressive inner ear disorder involving recurrent and prolonged episodes or attacks of vertigo with associated symptoms, resulting in a significantly reduced quality of life for sufferers. In most cases, MD starts in one ear; however, in one-third of patients, the disorder progresses to the other ear. Unfortunately, the etiology of the disease is unknown, making the development of effective treatments difficult. Nanomaterials, including nanoparticles (NPs) and nanocarriers, offer an array of novel diagnostic and therapeutic applications related to MD. NPs have specific features such as biocompatibility, biochemical stability, targetability, and enhanced visualization using imaging tools. This paper provides a comprehensive and critical review of recent advancements in nanotechnology-based diagnostic and therapeutic approaches for MD. Furthermore, the crucial challenges adversely affecting the use of nanoparticles to treat middle ear disorders are investigated. Finally, this paper provides recommendations and future directions for improving the performances of nanomaterials on theragnostic applications of MD.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"46 ","pages":"Article 102599"},"PeriodicalIF":5.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3342728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Polymer nanomedicines with enzymatically triggered activation: A comparative study of in vitro and in vivo anti-cancer efficacy related to the spacer structure 酶促活化聚合物纳米药物:与间隔结构相关的体内外抗癌效果对比研究

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2022-11-01 Epub Date: 2022-09-05 DOI: 10.1016/j.nano.2022.102597

Michal Pechar PhD , Robert Pola PhD , Martin Studenovský PhD , Markéta Bláhová PhD , Eliška Grosmanová PhD , Aneta Dydowiczová PhD , Marcela Filipová PhD , Rayhanul Islam PhD , Shanghui Gao PhD , Jun Fang PhD , Tomáš Etrych PhD

{"title":"Polymer nanomedicines with enzymatically triggered activation: A comparative study of in vitro and in vivo anti-cancer efficacy related to the spacer structure","authors":"Michal Pechar PhD , Robert Pola PhD , Martin Studenovský PhD , Markéta Bláhová PhD , Eliška Grosmanová PhD , Aneta Dydowiczová PhD , Marcela Filipová PhD , Rayhanul Islam PhD , Shanghui Gao PhD , Jun Fang PhD , Tomáš Etrych PhD","doi":"10.1016/j.nano.2022.102597","DOIUrl":"https://doi.org/10.1016/j.nano.2022.102597","url":null,"abstract":"<div>Polymer nanomedicines with anti-tumor activity should exhibit sufficient stability during systemic circulation to the target tissue; however, they should release the active drug selectively in the tumor. Thus, choice of a tumor-specific stimuli-sensitive spacer between the drug and the carrier is critical. Here, a series of polymer conjugates of anti-cancer drugs doxorubicin and pirarubicin covalently bound to copolymers based on N-(2-hydroxypropyl)methacrylamide via various enzymatically cleavable oligopeptide spacers were prepared and characterized. The highest rate of the drug release from the polymer carriers in presence of the lysosomal protease cathepsin B was determined for the copolymers with Val-Cit-Aba spacer. Copolymers containing pirarubicin were more cytotoxic and showed higher internalization rate than the corresponding doxorubicin counterparts. The conjugates containing GFLG and Val-Cit-Aba spacers exhibited the highest anti-tumor efficacy in vivo against murine sarcoma S-180, the highest rate of the enzymatically catalyzed drug release, and the highest cytotoxicity in vitro.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"46 ","pages":"Article 102597"},"PeriodicalIF":5.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1567993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Pharmacokinetics derived from PET imaging of inspiring radio-enhancer platinum nanoparticles 激发放射增强剂铂纳米颗粒的PET成像所得的药代动力学

IF 5.5 4区医学

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2022-11-01 Epub Date: 2022-09-15 DOI: 10.1016/j.nano.2022.102603

Xiaomin Yang PhD , Vu Long Tran PhD , Hynd Remita PhD , Farah Savina B.S. , Caroline Denis B.S. , Dimitri Kereselidze B.S. , Benoit Jego B.S. , Sandrine Lacombe PhD , Erika Porcel PhD , Charles Truillet PhD

引用次数: 0