Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI:10.1016/j.nano.2023.102673

Senthilkumar Thirumurugan MSc , Pranjyan Dash MSc , Xinrui Liu MDPhD , Yuan-Yun Tseng MDPhD , Jui-Hua Chung MSc , Yunqian Li MDPhD , Gang Zhao MDPhD , Chingpo Lin PhD , Yu-Chien Lin PhD , Ren-Jei Chung PhD

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Abstract

Herein, we fabricated gold surface-coated iron titanium core-shell (FeTi@Au) nanoparticles (NPs) with conjugation of angiopep-2 (ANG) (FeTi@Au-ANG) NPs for targeted delivery and improved NPs penetration by receptor-mediated endocytosis to achieve hyperthermic treatment of gliomas. The synthesized “core-shell” FeTi@Au-ANG NPs exhibited spherical in shape with around 16 nm particle size and increased temperature upon alternating magnetic field (AMF) stimulation, rendering them effective for localized hyperthermic therapy of cancer cells. Effective targeted delivery of FeTi@Au-ANG NPs was demonstrated in vitro by improved transport and cellular uptake, and increased apoptosis in glioma cells (C6) compared with normal fibroblast cells (L929). FeTi@Au-ANG NPs exhibited higher deposition in brain tissues and a superior therapeutic effect in an orthotopic intracranial xenograft mouse model. Taken together, our data indicate that FeTi@Au-ANG NPs hold significant promise as a targeted delivery strategy for glioma treatment using hyperthermia.

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angiopep -2-共轭FeTi@Au核壳纳米颗粒用于肿瘤靶向双模磁共振成像和高温胶质瘤治疗

在此，我们制备了表面包覆的铁钛核壳纳米颗粒(FeTi@Au)，结合血管内皮素-2 (ANG) (FeTi@Au-ANG)纳米颗粒，用于靶向递送，并通过受体介导的内吞作用提高纳米颗粒的穿透性，从而实现对胶质瘤的高温治疗。合成的“核壳”FeTi@Au-ANG NPs在交变磁场(AMF)刺激下呈球形，粒径约为16 nm，温度升高，可用于局部热疗癌细胞。与正常成纤维细胞(L929)相比，通过改善神经胶质瘤细胞(C6)的转运和细胞摄取，证明了FeTi@Au-ANG NPs的有效靶向递送，并增加了胶质瘤细胞(C6)的凋亡。FeTi@Au-ANG在原位颅内异种移植小鼠模型中，NPs在脑组织中表现出更高的沉积和更好的治疗效果。综上所述，我们的数据表明FeTi@Au-ANG NPs作为使用热疗治疗胶质瘤的靶向递送策略具有重要的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.