The influence of pure (ligandless) magnetite nanoparticles functionalization on blood gases and electrolytes in acute blood loss

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-06-01 DOI:10.1016/j.nano.2023.102675

Elena Vazhnichaya D.Sc. , Stanislav Lytvyn Ph.D. , Yurii Kurapov Ph.D. , Oleksandr Semaka M.D., Ph.D. , Ruslan Lutsenko D.Sc. , Alexander Chunikhin Ph.D.

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Abstract

Objective was to compare the effect of functionalization of magnetite (Fe₃O₄) nanoparticles (NPs) with sodium chloride (NaCl), or its combination with ethylmethylhydroxypyrydine succinate (EMHPS) and polyvinylpyrrolidone (PVP) on blood gases and electrolytes in acute blood loss. Ligandless magnetite NPs were synthesized by the electron beam technology and functionalized by mentioned agents. Size of NPs in colloidal solutions Fe₃O₄@NaCl, Fe₃O₄@NaCl@EMHPS, Fe₃O₄@NaCl@PVP, Fe₃O₄@NaCl@EMHPS@PVP (nanosystems 1–4) was determined by dynamic light scattering. In vivo experiments were performed on 27 Wistar rats. Acute blood loss was modeled by removal 25 % circulating blood. Nanosystems 1–4 were administered to animals intaperitoneally after the blood loss with followed determination of blood gases, pH and electrolytes. In blood loss, nanosystems Fe₃O₄@NaCl and Fe₃O₄@NaCl@PVP were able to improve the state of blood gases, pH, and the ratio of sodium/potassium in the blood. So, magnetite NPs with a certain surface modification can promote oxygen transport under hypoxic conditions.

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纯(无配体)磁铁矿纳米颗粒功能化对急性失血血气和电解质的影响

目的比较磁铁矿(Fe3O4)纳米颗粒(NPs)与氯化钠(NaCl)、与琥珀酸乙甲基羟吡啶(EMHPS)和聚乙烯吡罗烷酮(PVP)联合功能化对急性失血患者血气和电解质的影响。采用电子束技术合成了无配体磁铁矿NPs，并采用上述试剂进行功能化。胶体溶液Fe3O4@NaCl, Fe3O4@NaCl@ emhps, Fe3O4@NaCl@ pvp, Fe3O4@NaCl@EMHPS@PVP(纳米系统1-4)中NPs的大小通过动态光散射测定。在体实验27只Wistar大鼠。急性失血模型取25%循环血液。纳米系统1-4在动物失血后腹腔注射，随后测定血气、pH值和电解质。在失血方面，纳米系统Fe3O4@NaCl和Fe3O4@NaCl@PVP能够改善血气状态、pH值和血液中钠/钾的比例。因此，经过一定表面修饰的磁铁矿NPs可以促进缺氧条件下的氧转运。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.