Results and Problems in Cell Differentiation最新文献_第7页

Intercellular Transfer of Immune Regulatory Molecules Via Trogocytosis. 免疫调节分子通过吞噬细胞进行细胞间转移

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_6

Soyeon Park, Jeonghyun Kim, Jae Hun Shin

引用次数: 0

Organelle Interactions in Plant Cells. 植物细胞中的细胞器相互作用

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_3

Maya-Renee Hall, Thomas Kadanthottu Kunjumon, Puja Puspa Ghosh, Laura Currie, Jaideep Mathur

引用次数: 0

Tunneling Nanotubes in Myeloid Cells: Perspectives for Health and Infectious Diseases. 髓系细胞中的隧道纳米管：健康和传染病的前景。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_17

Javier Rey-Barroso, Ophélie Dufrançais, Christel Vérollet

引用次数: 0

Tunneling Nanotubes: Implications for Chemoresistance. 隧道纳米管：对抗药性的影响

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_15

Sanyukta Padmanabhan, Karina Deniz, Akshat Sarkari, Emil Lou

{"title":"Tunneling Nanotubes: Implications for Chemoresistance.","authors":"Sanyukta Padmanabhan, Karina Deniz, Akshat Sarkari, Emil Lou","doi":"10.1007/978-3-031-62036-2_15","DOIUrl":"10.1007/978-3-031-62036-2_15","url":null,"abstract":"Tunneling nanotubes (TNTs) are thin, membranous protrusions that connect cells and allow for the transfer of various molecules, including proteins, organelles, and genetic material. TNTs have been implicated in a wide range of biological processes, including intercellular communication, drug resistance, and viral transmission. In cancer, they have been investigated more deeply over the past decade for their potentially pivotal role in tumor progression and metastasis. TNTs, as cell contact-dependent protrusions that form at short and long distances, enable the exchange of signaling molecules and cargo between cancer cells, facilitating communication and coordination of their actions. This coordination induces a synchronization that is believed to mediate the TNT-directed evolution of drug resistance by allowing cancer cells to coordinate, including through direct expulsion of chemotherapeutic drugs to neighboring cells. Despite advances in the overall field of TNT biology since the first published report of their existence in 2004 (Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH, Science. 303:1007-10, 2004), the mechanisms of formation and components vital for the function of TNTs are complex and not yet fully understood. However, several factors have been implicated in their regulation, including actin polymerization, microtubule dynamics, and signaling pathways. The discovery of TNT-specific components that are necessary and sufficient for their formation, maintenance, and action opens a new potential avenue for drug discovery in cancer. Thus, targeting TNTs may offer a promising therapeutic strategy for cancer treatment. By disrupting TNT formation or function, it may be possible to inhibit tumor growth and metastasis and overcome drug resistance.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"73 ","pages":"353-373"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Significance of Repressive Processes in Developmental Regulation. 抑制过程在发育调节中的意义

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-39027-2_8

Hisato Kondoh

引用次数: 0

Macrophages, Metabolism, Mitochondria, Circadian Rhythmicity and the Pathogen: The Multidimensional Nature of Tuberculosis. 巨噬细胞、新陈代谢、线粒体、昼夜节律和病原体：结核病的多面性。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_14

Paula Guzmán-Téllez, Miguel Angel Rivero-Silva, María Maximina Bertha Moreno-Altamirano, Francisco Javier Sánchez-García

{"title":"Macrophages, Metabolism, Mitochondria, Circadian Rhythmicity and the Pathogen: The Multidimensional Nature of Tuberculosis.","authors":"Paula Guzmán-Téllez, Miguel Angel Rivero-Silva, María Maximina Bertha Moreno-Altamirano, Francisco Javier Sánchez-García","doi":"10.1007/978-3-031-65944-7_14","DOIUrl":"10.1007/978-3-031-65944-7_14","url":null,"abstract":"Mycobacterium tuberculosis, the causative agent of tuberculosis (TB) was first identified in 1882 by Robert Koch, and it is estimated that this pathogen has been around for as long as 3 million years.The World Health Organization (WHO) reported that in 2022 alone an estimated 10.6 million people developed TB worldwide, making TB the world's second leading cause of death from a single infectious agent, just after coronavirus disease (COVID-19), despite TB being a preventable and usually curable disease.Moreover, epidemiological studies suggest that approximately a quarter of the global population has been infected with TB bacteria, of which 5-10% will eventually develop symptoms and TB disease. Poverty, obesity, diabetes, and alcohol use contribute to the burden of TB.Alveolar macrophages play a pivotal role in the clearance of airborne pathogenic microorganisms and are the primary target of M. tuberculosis.Macrophage activity depend on metabolism and circadian rhythmicity, and mitochondria are a central hub that coordinates the communication between metabolism, circadian rhythmicity, and the immune system.Recent evidence has thrown light on how M. tuberculosis metabolism may regulate macrophage activity and the overall host responses to M. tuberculosis infection.This chapter explores how all these biological domains relate to each other, highlighting the multidimensional nature of TB, and positioning macrophages at center stage.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"74 ","pages":"341-364"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage Polarization and Its Impact on Osteoporosis. 巨噬细胞极化及其对骨质疏松症的影响

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_11

Junwei Yan, Chenyu Huang, Dongdong Jiang, Yan Xu, Zhuoli Zhang, Liming Wang, Bin Liang

引用次数: 0

Macrophage Dysfunction in Respiratory Disease. 呼吸系统疾病中的巨噬细胞功能障碍

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_9

Shyreen Hassibi, Louise E Donnelly

{"title":"Macrophage Dysfunction in Respiratory Disease.","authors":"Shyreen Hassibi, Louise E Donnelly","doi":"10.1007/978-3-031-65944-7_9","DOIUrl":"10.1007/978-3-031-65944-7_9","url":null,"abstract":"Our understanding of the origin, phenotype, and function of pulmonary macrophages has evolved over recent years. The use of lineage tracing and single-cell RNA sequencing has led to a greater understanding of how these cells regulate homeostasis in the lung. The primary function of alveolar macrophages is to clear any inhaled particles or pathogens and they as well as tissue-resident cells also play a role in the clearance of apoptotic cells and the resolution of inflammation. Lung diseases affect over half a billion people globally and are attributable to 7% of all deaths each year. The common diseases are chronic obstructive pulmonary disease (COPD) and asthma but others that contribute to this statistic include cystic fibrosis and idiopathic pulmonary fibrosis (IPF). Macrophages are aberrant in all these diseases with a reduced phagocytic capacity and a high proinflammatory phenotype with changes to their capacity to resolve inflammation. The pathways leading to these macrophage dysfunctions differ with disease and may relate to the specific lung environment in each condition. However, there are clear changes in metabolic profiles and mitochondrial activity in many of these conditions that contribute to a change in macrophage phenotype towards a more proinflammatory, less homeostatic cell. Understanding the mechanisms that drive these changes will allow for more targeted therapies for the treatment of these long-term and debilitating conditions.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"74 ","pages":"239-256"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CENP-A: A Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States. CENP-A:在健康和患病状态中起着着丝粒结构关键作用的组蛋白H3变体

Results and Problems in Cell Differentiation Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-06573-6_7

Daniel Jeffery, Marina Lochhead, Geneviève Almouzni

引用次数: 1

Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer. 基因表达、DNA修复和癌症中的核肌动蛋白动力学。

Results and Problems in Cell Differentiation Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-06573-6_23

Yuanjian Huang, Shengzhe Zhang, Jae-Il Park

引用次数: 1