抑制过程在发育调节中的意义

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI:10.1007/978-3-031-39027-2_8

Hisato Kondoh

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引用次数: 0

摘要

当一个发育过程被限制在有限的时间窗口或有限的胚胎区域时，人们可能会认为启动该过程的机制在时间和空间上是如此精确。然而，在许多情况下，激活机制是在广阔的时间和空间内启动的，但只有当抑制机制解除时才会启动该机制。因此，抑制过程的运行对于精确的发育调控至关重要。抑制性调控发生在不同层面。下面将讨论具有代表性的抑制性调控及其在不同水平上的后果：细胞间信号传导、表观遗传调控、转录调控和转录后调控。

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The Significance of Repressive Processes in Developmental Regulation.

Encountering a developmental process confined to a limited time window or a restricted embryonic area, one may deem that the mechanism to activate the process occurs with such precision in temporal and spatial terms. However, in many instances, the activation mechanism is initiated in a broad time and space, but the mechanism is actuated only when repressive mechanisms are lifted. Thus, the operation of repressive processes is essential for precise developmental regulation. Repressive regulations occur at various levels. The following representative repressive regulations and their consequences at various levels will be discussed: intercellular signaling, epigenetic regulation, transcriptional regulation, and posttranscriptional regulation.

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.