CENP-A:在健康和患病状态中起着着丝粒结构关键作用的组蛋白H3变体

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2022-01-01 DOI:10.1007/978-3-031-06573-6_7

Daniel Jeffery, Marina Lochhead, Geneviève Almouzni

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引用次数: 1

摘要

着丝粒是染色体的关键组成部分。在这里，我们将检查它们的构造、维护和功能。重点关注哺乳动物着丝粒特异性组蛋白H3变异，CENP-A，我们强调了它与着丝粒DNA及其伴侣HJURP的共同进化。然后，我们考虑了CENP-A从头沉积和最近发现的着丝粒DNA的重要性，以及新的超长读测序的附加价值。接下来，我们将回顾如何确保在整个细胞周期中中心点维持CENP-A。最后，我们讨论了破坏CENP-A调控对癌症和细胞命运的影响。

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CENP-A: A Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States.

Centromeres are key architectural components of chromosomes. Here, we examine their construction, maintenance, and functionality. Focusing on the mammalian centromere- specific histone H3 variant, CENP-A, we highlight its coevolution with both centromeric DNA and its chaperone, HJURP. We then consider CENP-A de novo deposition and the importance of centromeric DNA recently uncovered with the added value from new ultra-long-read sequencing. We next review how to ensure the maintenance of CENP-A at the centromere throughout the cell cycle. Finally, we discuss the impact of disrupting CENP-A regulation on cancer and cell fate.

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.