CENP-A: A Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States.

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2022-01-01 DOI:10.1007/978-3-031-06573-6_7

Daniel Jeffery, Marina Lochhead, Geneviève Almouzni

引用次数: 1

Abstract

Centromeres are key architectural components of chromosomes. Here, we examine their construction, maintenance, and functionality. Focusing on the mammalian centromere- specific histone H3 variant, CENP-A, we highlight its coevolution with both centromeric DNA and its chaperone, HJURP. We then consider CENP-A de novo deposition and the importance of centromeric DNA recently uncovered with the added value from new ultra-long-read sequencing. We next review how to ensure the maintenance of CENP-A at the centromere throughout the cell cycle. Finally, we discuss the impact of disrupting CENP-A regulation on cancer and cell fate.

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CENP-A:在健康和患病状态中起着着丝粒结构关键作用的组蛋白H3变体

着丝粒是染色体的关键组成部分。在这里，我们将检查它们的构造、维护和功能。重点关注哺乳动物着丝粒特异性组蛋白H3变异，CENP-A，我们强调了它与着丝粒DNA及其伴侣HJURP的共同进化。然后，我们考虑了CENP-A从头沉积和最近发现的着丝粒DNA的重要性，以及新的超长读测序的附加价值。接下来，我们将回顾如何确保在整个细胞周期中中心点维持CENP-A。最后，我们讨论了破坏CENP-A调控对癌症和细胞命运的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.